Alejandro Dopico



  1. North K, Chang J, Bukiya A, Dopico A. Extra-endothelial TRPV1 channels participate in alcohol and caffeine actions on cerebral artery diameter. Alcohol. 2018;73:45-55 pubmed publisher
  2. McMillan J, Bukiya A, Terrell C, Patil S, Miller D, Dopico A, et al. Multi-generational pharmacophore modeling for ligands to the cholane steroid-recognition site in the β₁ modulatory subunit of the BKCa channel. J Mol Graph Model. 2014;54:174-83 pubmed publisher
    ..One of these activators, sobetirome, differs substantially in structure from any previously reported activator. ..
  3. Dopico A, Bukiya A, Jaggar J. Calcium- and voltage-gated BK channels in vascular smooth muscle. Pflugers Arch. 2018;470:1271-1289 pubmed publisher
    ..Lastly, we describe the functional changes in smooth muscle BK channels that contribute to, or are triggered by, common physiological conditions and pathologies, including obesity, diabetes, and systemic hypertension. ..
  4. Dopico A, Bukiya A, Singh A. Large conductance, calcium- and voltage-gated potassium (BK) channels: regulation by cholesterol. Pharmacol Ther. 2012;135:133-50 pubmed publisher
    ..Finally, we review studies of BK channel function during hypercholesterolemia, and underscore the many consequences that the CLR-BK channel interaction brings to cell physiology and human disease. ..
  5. Dopico A, Bukiya A, Kuntamallappanavar G, Liu J. Modulation of BK Channels by Ethanol. Int Rev Neurobiol. 2016;128:239-79 pubmed publisher
    ..Unveiling the mechanisms underlying tolerance is of major importance, as tolerance to ethanol has been proposed as predictor of risk for alcoholism. ..
  6. Chang J, Fedinec A, Kuntamallappanavar G, Leffler C, Bukiya A, Dopico A. Endothelial Nitric Oxide Mediates Caffeine Antagonism of Alcohol-Induced Cerebral Artery Constriction. J Pharmacol Exp Ther. 2016;356:106-15 pubmed publisher
  7. Kuntamallappanavar G, Bisen S, Bukiya A, Dopico A. Differential distribution and functional impact of BK channel beta1 subunits across mesenteric, coronary, and different cerebral arteries of the rat. Pflugers Arch. 2017;469:263-277 pubmed publisher
    ..Supporting a major role of enhanced BK ?1 transcripts in artery dilation, LCA-induced dilation of MCA transfected with BK ?1 complementary DNA (cDNA) was as high as LCA-induced dilation of untransfected BA or CA. ..
  8. Dopico A, Bukiya A. Regulation of Ca2+-Sensitive K+ Channels by Cholesterol and Bile Acids via Distinct Channel Subunits and Sites. Curr Top Membr. 2017;80:53-93 pubmed publisher
    ..Finally, we will present novel computational data that provide a chemical basis for differential recognition of CLR vs lithocholic acid by distinct BK channel subunits and recognition sites. ..
  9. Ye Y, Jian K, Jaggar J, Bukiya A, Dopico A. Type 2 ryanodine receptors are highly sensitive to alcohol. FEBS Lett. 2014;588:1659-65 pubmed publisher
    ..Alcohol directly targets RyR2 and its lipid microenvironment, leading to stabilization of RyR2 closed states. ..

More Information


  1. Bukiya A, McMillan J, Liu J, Shivakumar B, Parrill A, Dopico A. Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4. J Biol Chem. 2014;289:35314-25 pubmed publisher
    ..Moreover, the identification of LTB4 as a highly potent ligand for BK channels is critical for the future development of β1-specific BK channel activators. ..
  2. Kuntamallappanavar G, Dopico A. Alcohol modulation of BK channel gating depends on ? subunit composition. J Gen Physiol. 2016;148:419-440 pubmed
    ..Decreased allosteric coupling leads to diminished BK activity. Thus, we have identified critical gating modifications that lead to the differential actions of ethanol on slo1 with and without different ? subunits. ..
  3. Dopico A, Bukiya A, Bettinger J. Voltage-Sensitive Potassium Channels of the BK Type and Their Coding Genes Are Alcohol Targets in Neurons. Handb Exp Pharmacol. 2017;: pubmed publisher
    ..We finally discuss genetic results on BK obtained in invertebrate organisms and rodents in light of possible extrapolation to human AUD. ..