North K, Chang J, Bukiya A, Dopico A. Extra-endothelial TRPV1 channels participate in alcohol and caffeine actions on cerebral artery diameter. Alcohol. 2018;73:45-55 pubmed publisher
McMillan J, Bukiya A, Terrell C, Patil S, Miller D, Dopico A, et al
. Multi-generational pharmacophore modeling for ligands to the cholane steroid-recognition site in the Î²â‚ modulatory subunit of the BKCa channel. J Mol Graph Model. 2014;54:174-83 pubmed publisher
..One of these activators, sobetirome, differs substantially in structure from any previously reported activator. ..
Dopico A, Bukiya A, Jaggar J. Calcium- and voltage-gated BK channels in vascular smooth muscle. Pflugers Arch. 2018;470:1271-1289 pubmed publisher
..Lastly, we describe the functional changes in smooth muscle BK channels that contribute to, or are triggered by, common physiological conditions and pathologies, including obesity, diabetes, and systemic hypertension. ..
Dopico A, Bukiya A, Singh A. Large conductance, calcium- and voltage-gated potassium (BK) channels: regulation by cholesterol. Pharmacol Ther. 2012;135:133-50 pubmed publisher
..Finally, we review studies of BK channel function during hypercholesterolemia, and underscore the many consequences that the CLR-BK channel interaction brings to cell physiology and human disease. ..
Dopico A, Bukiya A, Kuntamallappanavar G, Liu J. Modulation of BK Channels by Ethanol. Int Rev Neurobiol. 2016;128:239-79 pubmed publisher
..Unveiling the mechanisms underlying tolerance is of major importance, as tolerance to ethanol has been proposed as predictor of risk for alcoholism. ..
Chang J, Fedinec A, Kuntamallappanavar G, Leffler C, Bukiya A, Dopico A. Endothelial Nitric Oxide Mediates Caffeine Antagonism of Alcohol-Induced Cerebral Artery Constriction. J Pharmacol Exp Ther. 2016;356:106-15 pubmed publisher
Kuntamallappanavar G, Bisen S, Bukiya A, Dopico A. Differential distribution and functional impact of BK channel beta1 subunits across mesenteric, coronary, and different cerebral arteries of the rat. Pflugers Arch. 2017;469:263-277 pubmed publisher
..Supporting a major role of enhanced BK ?1 transcripts in artery dilation, LCA-induced dilation of MCA transfected with BK ?1 complementary DNA (cDNA) was as high as LCA-induced dilation of untransfected BA or CA. ..
Dopico A, Bukiya A. Regulation of Ca2+-Sensitive K+ Channels by Cholesterol and Bile Acids via Distinct Channel Subunits and Sites. Curr Top Membr. 2017;80:53-93 pubmed publisher
..Finally, we will present novel computational data that provide a chemical basis for differential recognition of CLR vs lithocholic acid by distinct BK channel subunits and recognition sites. ..
Ye Y, Jian K, Jaggar J, Bukiya A, Dopico A. Type 2 ryanodine receptors are highly sensitive to alcohol. FEBS Lett. 2014;588:1659-65 pubmed publisher
..Alcohol directly targets RyR2 and its lipid microenvironment, leading to stabilization of RyR2 closed states. ..