THOMAS DOOLEY

Summary

Publications

  1. ncbi Expression profiling of human sulfotransferase and sulfatase gene superfamilies in epithelial tissues and cultured cells
    T P Dooley
    IntegriDerm, Inc, 2130 Memorial Parkway, South West, Huntsville, Alabama, 35801, USA
    Biochem Biophys Res Commun 277:236-45. 2000
  2. ncbi DNA microarrays and likelihood ratio bioinformatic methods: discovery of human melanocyte biomarkers
    Thomas P Dooley
    IntegriDerm Inc, Birmingham, AL 35211 6908, USA
    Pigment Cell Res 16:245-53. 2003
  3. ncbi Biomarkers of human cutaneous squamous cell carcinoma from tissues and cell lines identified by DNA microarrays and qRT-PCR
    Thomas P Dooley
    IntegriDerm Inc 2800 Milan Court, Birmingham, AL 35211 6908, USA
    Biochem Biophys Res Commun 306:1026-36. 2003
  4. ncbi Biomarkers of human skin cells identified using DermArray DNA arrays and new bioinformatics methods
    Ernest V Curto
    IntegriDerm Inc, 2130 Memorial Parkway SW, Huntsville, Alabama 35801, USA
    Biochem Biophys Res Commun 291:1052-64. 2002
  5. ncbi A method to improve selection of molecular targets by circumventing the ADME pharmacokinetic system utilizing PharmArray DNA microarrays
    Thomas P Dooley
    IntegriDerm Inc, 2800 Milan Court, Birmingham, AL 35211 6908, USA
    Biochem Biophys Res Commun 303:828-41. 2003
  6. ncbi Cross-species application of cDNA microarrays to profile gene expression using UV-induced melanoma in Monodelphis domestica as the model system
    Zhiqiang Wang
    Department of Genetics, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, TX 78227 5301, USA
    Genomics 83:588-99. 2004
  7. ncbi Regulation of gene expression in inflammatory bowel disease and correlation with IBD drugs: screening by DNA microarrays
    Thomas P Dooley
    IntegriDerm Inc, Birmingham, Alabama 35211, USA
    Inflamm Bowel Dis 10:1-14. 2004
  8. ncbi Methods for gene expression profiling in dermatology research using DermArray nylon filter DNA microarrays
    Richard L Davis
    NRC Division, Midwest Research Institute, Rockland, MD, USA
    Methods Mol Biol 289:399-412. 2005

Research Grants

Collaborators

Detail Information

Publications8

  1. ncbi Expression profiling of human sulfotransferase and sulfatase gene superfamilies in epithelial tissues and cultured cells
    T P Dooley
    IntegriDerm, Inc, 2130 Memorial Parkway, South West, Huntsville, Alabama, 35801, USA
    Biochem Biophys Res Commun 277:236-45. 2000
    ....
  2. ncbi DNA microarrays and likelihood ratio bioinformatic methods: discovery of human melanocyte biomarkers
    Thomas P Dooley
    IntegriDerm Inc, Birmingham, AL 35211 6908, USA
    Pigment Cell Res 16:245-53. 2003
    ..Some of the melanocytic biomarkers identified here may be useful in molecular diagnostics, as potential molecular targets for drug discovery, and for understanding the biochemistry of melanocytic cells...
  3. ncbi Biomarkers of human cutaneous squamous cell carcinoma from tissues and cell lines identified by DNA microarrays and qRT-PCR
    Thomas P Dooley
    IntegriDerm Inc 2800 Milan Court, Birmingham, AL 35211 6908, USA
    Biochem Biophys Res Commun 306:1026-36. 2003
    ..These biomarker lists may be useful in molecular diagnostics of non-melanoma skin cancer, and a subset of the biomarkers might serve as suitable targets for drug discovery efforts of therapies for SCC...
  4. ncbi Biomarkers of human skin cells identified using DermArray DNA arrays and new bioinformatics methods
    Ernest V Curto
    IntegriDerm Inc, 2130 Memorial Parkway SW, Huntsville, Alabama 35801, USA
    Biochem Biophys Res Commun 291:1052-64. 2002
    ..A total of 158 biomarkers of normal human skin cells were identified, many of which may be valuable in diagnostic applications and as molecular targets for drug discovery and therapeutic intervention...
  5. ncbi A method to improve selection of molecular targets by circumventing the ADME pharmacokinetic system utilizing PharmArray DNA microarrays
    Thomas P Dooley
    IntegriDerm Inc, 2800 Milan Court, Birmingham, AL 35211 6908, USA
    Biochem Biophys Res Commun 303:828-41. 2003
    ..In addition to biomarker discovery per se, this demonstration suggests that our model method may be viable to help restrict gene lists during selection of potential molecular targets for subsequent drug discovery...
  6. ncbi Cross-species application of cDNA microarrays to profile gene expression using UV-induced melanoma in Monodelphis domestica as the model system
    Zhiqiang Wang
    Department of Genetics, Southwest Foundation for Biomedical Research, 7620 NW Loop 410, San Antonio, TX 78227 5301, USA
    Genomics 83:588-99. 2004
    ..These results provide evidence that cross-species application of cDNA microarrays is a useful strategy for investigating gene expression patterns in animal models for which species-specific cDNA microarrays are not available...
  7. ncbi Regulation of gene expression in inflammatory bowel disease and correlation with IBD drugs: screening by DNA microarrays
    Thomas P Dooley
    IntegriDerm Inc, Birmingham, Alabama 35211, USA
    Inflamm Bowel Dis 10:1-14. 2004
    ..This affordable in vitro methodology is promising for expanded studies of IBD and other diseases...
  8. ncbi Methods for gene expression profiling in dermatology research using DermArray nylon filter DNA microarrays
    Richard L Davis
    NRC Division, Midwest Research Institute, Rockland, MD, USA
    Methods Mol Biol 289:399-412. 2005
    ..As an example, gene expression profiling was performed with hydroquinone-treated SKMel-28 cells, a melanoma cell line. Also included are the methods for bioinformatic analysis using Pathwaystrade mark software...

Research Grants3

  1. SULFOTRANSFERASE EXPRESSION IN EPITHELIA AND CARCINOMAS
    THOMAS DOOLEY; Fiscal Year: 2001
    ..The anticipated results will provide valuable insights into the roles of the human ST gene superfamily in the metabolism and bioavailability of drugs and endogenous compounds in human epithelia and cancers. ..