James Dooley

Summary

Publications

  1. pmc Rapamycin increases survival in ALS mice lacking mature lymphocytes
    Kim A Staats
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Mol Neurodegener 8:31. 2013
  2. pmc Models of aire-dependent gene regulation for thymic negative selection
    Dina Danso-Abeam
    VIB Autoimmune Genetics Laboratory Leuven, Belgium
    Front Immunol 2:14. 2011
  3. doi request reprint Molecular control over thymic involution: from cytokines and microRNA to aging and adipose tissue
    James Dooley
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Belgium
    Eur J Immunol 42:1073-9. 2012
  4. doi request reprint Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism
    Dina Danso-Abeam
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Eur J Immunol 43:75-84. 2013
  5. pmc Premature thymic involution is independent of structural plasticity of the thymic stroma
    Dean Franckaert
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Eur J Immunol 45:1535-47. 2015
  6. doi request reprint MicroRNA-29 in the adaptive immune system: setting the threshold
    Adrian Liston
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium
    Cell Mol Life Sci 69:3533-41. 2012
  7. doi request reprint Transcriptional upregulation of myelin components in spontaneous myelin basic protein-deficient mice
    Kim A Staats
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium
    Brain Res 1606:125-32. 2015
  8. doi request reprint Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice
    Lei Tian
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium
    J Autoimmun 38:39-48. 2012
  9. pmc Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells
    Wim Pierson
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Nat Immunol 14:959-65. 2013
  10. doi request reprint MicroRNA regulation of T-cell development
    James Dooley
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Immunol Rev 253:53-64. 2013

Collaborators

  • Adrian Liston
  • Dina Danso-Abeam
  • Isabelle Meyts
  • Gert De Hertogh
  • Michelle A Linterman
  • David Hildeman
  • Jason Gill
  • Casey T Weaver
  • Li Fan Lu
  • Philippe Bouillet
  • Kim A Staats
  • Susann Schonefeldt
  • Dean Franckaert
  • Ludo Van Den Bosch
  • Stephanie Humblet-Baron
  • Diana Pombal
  • Lien Van Eyck
  • Susan M Schlenner
  • Wim Pierson
  • Lei Tian
  • Lawrence Van Helleputte
  • Olov Ekwall
  • Heidi Schaballie
  • Nancy J Ganson
  • Kristof Govaerts
  • Fred Van Leuven
  • Karen Put
  • Gabriel Skogberg
  • Tom Dresselaers
  • Glynis Frans
  • Michael S Hershfield
  • Leen Moens
  • Carine Wouters
  • Uwe Himmelreich
  • Susan J Kelly
  • Hervé Maurin
  • Nathalie Heirman
  • Xavier Bossuyt
  • Antonio A Freitas
  • Rita J Luther
  • Patrick Matthys
  • Bénédicte Cauwe
  • Daniel H D Gray
  • André Bento-Abreu
  • Andreas Strasser
  • Wim Robberecht
  • Sara Hernandez
  • Marco J Herold
  • Philip Van Damme
  • Julien Berges
  • Antonia Policheni
  • Maya Fedeli
  • Paolo Dellabona

Detail Information

Publications12

  1. pmc Rapamycin increases survival in ALS mice lacking mature lymphocytes
    Kim A Staats
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Mol Neurodegener 8:31. 2013
    ..Rapamycin is frequently used to increase autophagy, but is also a potent immune suppressor. To properly assess the role of rapamycin-induced autophagy, the immune suppressive role of rapamycin should be negated...
  2. pmc Models of aire-dependent gene regulation for thymic negative selection
    Dina Danso-Abeam
    VIB Autoimmune Genetics Laboratory Leuven, Belgium
    Front Immunol 2:14. 2011
    ..In this review, we evaluate each of these models and discuss their relative strengths and weaknesses...
  3. doi request reprint Molecular control over thymic involution: from cytokines and microRNA to aging and adipose tissue
    James Dooley
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Belgium
    Eur J Immunol 42:1073-9. 2012
    ..This review outlines the disparate pathways through which involution can be mediated, from the transient infection-mediated pathway, tightly controlled by microRNA, to the chronic changes that occur through aging...
  4. doi request reprint Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism
    Dina Danso-Abeam
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Eur J Immunol 43:75-84. 2013
    ..These findings suggest that the capacity of Aire to regulate expression of a huge array of TRAs relies solely on an unconventional transcriptional mechanism, without intermediary transcription factors...
  5. pmc Premature thymic involution is independent of structural plasticity of the thymic stroma
    Dean Franckaert
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Eur J Immunol 45:1535-47. 2015
    ..These results identify pro-T-cell loss as the main driver of premature thymic involution, and highlight the plasticity of the thymic stroma, capable of maintaining function across diverse interstrain architectures...
  6. doi request reprint MicroRNA-29 in the adaptive immune system: setting the threshold
    Adrian Liston
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium
    Cell Mol Life Sci 69:3533-41. 2012
    ..These results identify the miR-29 family as potent immune modulators which have already been exploited through the evolution of a viral mimic and could potentially be exploited further for therapeutic intervention...
  7. doi request reprint Transcriptional upregulation of myelin components in spontaneous myelin basic protein-deficient mice
    Kim A Staats
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium
    Brain Res 1606:125-32. 2015
    ..Further research will clarify the role and specifications of this myelin feedback loop, as well as determine its potential role in therapeutic strategies for demyelinating disorders. ..
  8. doi request reprint Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice
    Lei Tian
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium
    J Autoimmun 38:39-48. 2012
    ..These results reverse the original conclusions of microRNA function in T cells by revealing a systemic pro-autoimmune function...
  9. pmc Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells
    Wim Pierson
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Nat Immunol 14:959-65. 2013
    ..Together, these data define the active processes by which Treg cells maintain homeostasis via critical survival pathways...
  10. doi request reprint MicroRNA regulation of T-cell development
    James Dooley
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Immunol Rev 253:53-64. 2013
    ..In this review, we focus on integrating the research on individual microRNA into a more global understanding of the function of the microRNA regulatory network in T cells...
  11. pmc Hematopoietic stem cell transplantation rescues the immunologic phenotype and prevents vasculopathy in patients with adenosine deaminase 2 deficiency
    Lien Van Eyck
    Department of Immunology and Microbiology, Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium
    J Allergy Clin Immunol 135:283-287.e5. 2015
  12. pmc Olmsted syndrome: exploration of the immunological phenotype
    Dina Danso-Abeam
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Orphanet J Rare Dis 8:79. 2013
    ..A recent study identified de novo mutations causing constitutive activation of TRPV3 as a cause of the keratotic manifestations of Olmsted syndrome...