James Dooley

Summary

Publications

  1. pmc Models of aire-dependent gene regulation for thymic negative selection
    Dina Danso-Abeam
    VIB Autoimmune Genetics Laboratory Leuven, Belgium
    Front Immunol 2:14. 2011
  2. doi request reprint Molecular control over thymic involution: from cytokines and microRNA to aging and adipose tissue
    James Dooley
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Belgium
    Eur J Immunol 42:1073-9. 2012
  3. doi request reprint Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism
    Dina Danso-Abeam
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Eur J Immunol 43:75-84. 2013
  4. doi request reprint MicroRNA-29 in the adaptive immune system: setting the threshold
    Adrian Liston
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium
    Cell Mol Life Sci 69:3533-41. 2012
  5. doi request reprint Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice
    Lei Tian
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium
    J Autoimmun 38:39-48. 2012
  6. doi request reprint MicroRNA regulation of T-cell development
    James Dooley
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Immunol Rev 253:53-64. 2013
  7. ncbi request reprint Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells
    Wim Pierson
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Nat Immunol 14:959-65. 2013
  8. pmc Olmsted syndrome: exploration of the immunological phenotype
    Dina Danso-Abeam
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Orphanet J Rare Dis 8:79. 2013

Collaborators

Detail Information

Publications8

  1. pmc Models of aire-dependent gene regulation for thymic negative selection
    Dina Danso-Abeam
    VIB Autoimmune Genetics Laboratory Leuven, Belgium
    Front Immunol 2:14. 2011
    ..In this review, we evaluate each of these models and discuss their relative strengths and weaknesses...
  2. doi request reprint Molecular control over thymic involution: from cytokines and microRNA to aging and adipose tissue
    James Dooley
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Belgium
    Eur J Immunol 42:1073-9. 2012
    ..This review outlines the disparate pathways through which involution can be mediated, from the transient infection-mediated pathway, tightly controlled by microRNA, to the chronic changes that occur through aging...
  3. doi request reprint Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism
    Dina Danso-Abeam
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Eur J Immunol 43:75-84. 2013
    ..These findings suggest that the capacity of Aire to regulate expression of a huge array of TRAs relies solely on an unconventional transcriptional mechanism, without intermediary transcription factors...
  4. doi request reprint MicroRNA-29 in the adaptive immune system: setting the threshold
    Adrian Liston
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium
    Cell Mol Life Sci 69:3533-41. 2012
    ..These results identify the miR-29 family as potent immune modulators which have already been exploited through the evolution of a viral mimic and could potentially be exploited further for therapeutic intervention...
  5. doi request reprint Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice
    Lei Tian
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium
    J Autoimmun 38:39-48. 2012
    ..These results reverse the original conclusions of microRNA function in T cells by revealing a systemic pro-autoimmune function...
  6. doi request reprint MicroRNA regulation of T-cell development
    James Dooley
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Immunol Rev 253:53-64. 2013
    ..In this review, we focus on integrating the research on individual microRNA into a more global understanding of the function of the microRNA regulatory network in T cells...
  7. ncbi request reprint Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells
    Wim Pierson
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Nat Immunol 14:959-65. 2013
    ..Together, these data define the active processes by which Treg cells maintain homeostasis via critical survival pathways...
  8. pmc Olmsted syndrome: exploration of the immunological phenotype
    Dina Danso-Abeam
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Orphanet J Rare Dis 8:79. 2013
    ..A recent study identified de novo mutations causing constitutive activation of TRPV3 as a cause of the keratotic manifestations of Olmsted syndrome...