James Dooley

Summary

Publications

  1. doi request reprint The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity
    James Dooley
    VIB, Leuven, Belgium Department of Microbiology and Immunology, KUL University of Leuven, Leuven, Belgium
    Diabetes 65:53-61. 2016
  2. pmc Models of aire-dependent gene regulation for thymic negative selection
    Dina Danso-Abeam
    VIB Autoimmune Genetics Laboratory Leuven, Belgium
    Front Immunol 2:14. 2011
  3. doi request reprint Molecular control over thymic involution: from cytokines and microRNA to aging and adipose tissue
    James Dooley
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Belgium
    Eur J Immunol 42:1073-9. 2012
  4. doi request reprint Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice
    Lei Tian
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium
    J Autoimmun 38:39-48. 2012
  5. doi request reprint Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism
    Dina Danso-Abeam
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Eur J Immunol 43:75-84. 2013
  6. pmc Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells
    Wim Pierson
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Nat Immunol 14:959-65. 2013
  7. doi request reprint MicroRNA-29 in the adaptive immune system: setting the threshold
    Adrian Liston
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium
    Cell Mol Life Sci 69:3533-41. 2012
  8. pmc Rapamycin increases survival in ALS mice lacking mature lymphocytes
    Kim A Staats
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Mol Neurodegener 8:31. 2013
  9. pmc Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells
    Dean Franckaert
    1 Autoimmune Genetics Laboratory, VIB, Leuven, Belgium 2 Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium
    Immunol Cell Biol 93:417-23. 2015
  10. doi request reprint MicroRNA regulation of T-cell development
    James Dooley
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Immunol Rev 253:53-64. 2013

Collaborators

Detail Information

Publications17

  1. doi request reprint The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity
    James Dooley
    VIB, Leuven, Belgium Department of Microbiology and Immunology, KUL University of Leuven, Leuven, Belgium
    Diabetes 65:53-61. 2016
    ..These results demonstrate strong regulatory functions for the miR-29 family in obesity and diabetes, culminating in a hierarchical and dose-dependent effect on premature lethality. ..
  2. pmc Models of aire-dependent gene regulation for thymic negative selection
    Dina Danso-Abeam
    VIB Autoimmune Genetics Laboratory Leuven, Belgium
    Front Immunol 2:14. 2011
    ..In this review, we evaluate each of these models and discuss their relative strengths and weaknesses...
  3. doi request reprint Molecular control over thymic involution: from cytokines and microRNA to aging and adipose tissue
    James Dooley
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Belgium
    Eur J Immunol 42:1073-9. 2012
    ..This review outlines the disparate pathways through which involution can be mediated, from the transient infection-mediated pathway, tightly controlled by microRNA, to the chronic changes that occur through aging...
  4. doi request reprint Loss of T cell microRNA provides systemic protection against autoimmune pathology in mice
    Lei Tian
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium
    J Autoimmun 38:39-48. 2012
    ..These results reverse the original conclusions of microRNA function in T cells by revealing a systemic pro-autoimmune function...
  5. doi request reprint Aire mediates thymic expression and tolerance of pancreatic antigens via an unconventional transcriptional mechanism
    Dina Danso-Abeam
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Eur J Immunol 43:75-84. 2013
    ..These findings suggest that the capacity of Aire to regulate expression of a huge array of TRAs relies solely on an unconventional transcriptional mechanism, without intermediary transcription factors...
  6. pmc Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells
    Wim Pierson
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Nat Immunol 14:959-65. 2013
    ..Together, these data define the active processes by which Treg cells maintain homeostasis via critical survival pathways...
  7. doi request reprint MicroRNA-29 in the adaptive immune system: setting the threshold
    Adrian Liston
    Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium
    Cell Mol Life Sci 69:3533-41. 2012
    ..These results identify the miR-29 family as potent immune modulators which have already been exploited through the evolution of a viral mimic and could potentially be exploited further for therapeutic intervention...
  8. pmc Rapamycin increases survival in ALS mice lacking mature lymphocytes
    Kim A Staats
    Laboratory of Neurobiology, Vesalius Research Center, VIB, Leuven, Belgium
    Mol Neurodegener 8:31. 2013
    ..Rapamycin is frequently used to increase autophagy, but is also a potent immune suppressor. To properly assess the role of rapamycin-induced autophagy, the immune suppressive role of rapamycin should be negated...
  9. pmc Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3⁺ and Foxp3⁻ T cells
    Dean Franckaert
    1 Autoimmune Genetics Laboratory, VIB, Leuven, Belgium 2 Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium
    Immunol Cell Biol 93:417-23. 2015
    ..This hypomorphism and 'leaky' expression of the Foxp3-CreYFP allele should be considered when analysing the conditionally mutated Treg. ..
  10. doi request reprint MicroRNA regulation of T-cell development
    James Dooley
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Immunol Rev 253:53-64. 2013
    ..In this review, we focus on integrating the research on individual microRNA into a more global understanding of the function of the microRNA regulatory network in T cells...
  11. pmc Premature thymic involution is independent of structural plasticity of the thymic stroma
    Dean Franckaert
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Eur J Immunol 45:1535-47. 2015
    ..These results identify pro-T-cell loss as the main driver of premature thymic involution, and highlight the plasticity of the thymic stroma, capable of maintaining function across diverse interstrain architectures...
  12. pmc The thymoprotective function of leptin is indirectly mediated via suppression of obesity
    Jayasree Sreenivasan
    VIB, Leuven, Belgium
    Immunology 146:122-9. 2015
    ....
  13. pmc The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor
    Aikaterini S Papadopoulou
    VIB, Leuven, Belgium
    Nat Immunol 13:181-7. 2012
    ..In the absence of Dicer or the miR-29a cluster in the thymic epithelium, expression of the IFN-α receptor by the thymic epithelium was higher, which allowed suboptimal signals to trigger rapid loss of thymic cellularity...
  14. doi request reprint Transcriptional upregulation of myelin components in spontaneous myelin basic protein-deficient mice
    Kim A Staats
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium Department of Microbiology and Immunology, University of Leuven, Leuven, Belgium
    Brain Res 1606:125-32. 2015
    ..Further research will clarify the role and specifications of this myelin feedback loop, as well as determine its potential role in therapeutic strategies for demyelinating disorders. ..
  15. pmc Hematopoietic stem cell transplantation rescues the immunologic phenotype and prevents vasculopathy in patients with adenosine deaminase 2 deficiency
    Lien Van Eyck
    Department of Immunology and Microbiology, Autoimmune Genetics Laboratory, VIB and University of Leuven, Leuven, Belgium
    J Allergy Clin Immunol 135:283-287.e5. 2015
  16. pmc Olmsted syndrome: exploration of the immunological phenotype
    Dina Danso-Abeam
    Autoimmune Genetics Laboratory, VIB, Leuven, Belgium
    Orphanet J Rare Dis 8:79. 2013
    ..A recent study identified de novo mutations causing constitutive activation of TRPV3 as a cause of the keratotic manifestations of Olmsted syndrome...
  17. pmc Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis
    Lei Tian
    VIB, Leuven, Belgium
    Blood 118:1845-53. 2011
    ..These results indicate that the Th2 arm of the immune system is under tighter control by regulatory T cells than the Th1 arm, suggesting that Th2-driven diseases may be more responsive to regulatory T-cell manipulation...