Evaluation of a hand-held far-ultraviolet radiation device for decontamination of Clostridium difficile and other healthcare-associated pathogensMichelle M Nerandzic
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA
BMC Infect Dis 12:120. 2012
..The Sterilray™ Disinfection Wand device is a hand-held room decontamination technology that utilizes far-ultraviolet radiation (185-230 nm) to kill pathogens...
Effect of parenteral antibiotic administration on the establishment of colonization with vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tractC J Donskey
Division of Infectious Diseases, Louis Stokes Dept of Veterans Affairs Medical Center, Cleveland, OH 44106
J Infect Dis 181:1830-3. 2000
..Thus, in this mouse model, beta-lactam antibiotics with minimal anti-enterococcal activity promoted establishment of high-level VRE colonization, but Pip-Taz (a beta-lactam antibiotic with more potent activity against VRE) did not...
- The role of the intestinal tract as a reservoir and source for transmission of nosocomial pathogens
Curtis J Donskey
Infectious Diseases Section, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA
Clin Infect Dis 39:219-26. 2004
..Infection-control measures that are implemented to control individual pathogens may have a positive or negative impact on efforts to control other pathogens that colonize the intestinal tract...
- Oral administration of beta-lactamase preserves colonization resistance of piperacillin-treated mice
Usha Stiefel
Division of Infectious Diseases, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
J Infect Dis 188:1605-9. 2003
..Oral administration of beta-lactamase reduced piperacillin-associated alteration of the indigenous microflora and prevented overgrowth of pathogens...
- Use of denaturing gradient gel electrophoresis for analysis of the stool microbiota of hospitalized patients
Curtis J Donskey
Infectious Diseases Section 111 W, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
J Microbiol Methods 54:249-56. 2003
..Thus, our findings are consistent with previous studies that utilized culture techniques, and suggest that DGGE is a useful technique for analysis of the stool microbiota of hospitalized patients...
- Antibiotic regimens and intestinal colonization with antibiotic-resistant gram-negative bacilli
Curtis J Donskey
Infectious Diseases Section, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
Clin Infect Dis 43:S62-9. 2006
..Additional research is needed to clarify the role of strategies such as selective decontamination of the digestive tract and decontamination of environmental surfaces and of patients' skin and wounds...
- Inhibition of vancomycin-resistant enterococci by an in vitro continuous-flow competitive exclusion culture containing human stool flora
C J Donskey
Infectious Diseases Section, Louis Stokes Cleveland Dept of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
J Infect Dis 184:1624-7. 2001
..These data support the hypothesis that the indigenous intestinal flora inhibit growth of VRE and suggest that CFCE cultures may be a useful means to study interactions between the indigenous flora and VRE...
- Effect of antibiotic therapy on the density of vancomycin-resistant enterococci in the stool of colonized patients
C J Donskey
Infectious Diseases Section, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA
N Engl J Med 343:1925-32. 2000
..In mice that have intestinal colonization with vancomycin-resistant enterococci, these agents promote high-density colonization, whereas antibiotics with minimal antianaerobic activity do not...
- Asymptomatic carriers are a potential source for transmission of epidemic and nonepidemic Clostridium difficile strains among long-term care facility residents
Michelle M Riggs
Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA
Clin Infect Dis 45:992-8. 2007
..Asymptomatic fecal carriage of Clostridium difficile is common in patients staying in health care facilities, but the importance of asymptomatic carriers with regard to disease transmission is unclear...
- Multihospital outbreak of Clostridium difficile infection, Cleveland, Ohio, USA
Robin L P Jump
University Hospitals of Cleveland, Cleveland, Ohio, USA
Emerg Infect Dis 16:827-9. 2010
..difficile-infected patients. Use of fluoroquionolones with enhanced antianaerobic activity was not associated with increased infection rates...
Orally administered beta-lactamase enzymes represent a novel strategy to prevent colonization by Clostridium difficileUsha Stiefel
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA
J Antimicrob Chemother 62:1105-8. 2008
..difficile in mice...
- Persistence of skin contamination and environmental shedding of Clostridium difficile during and after treatment of C. difficile infection
Ajay K Sethi
Department of Epidemiology and Biostatistics, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Infect Control Hosp Epidemiol 31:21-7. 2010
..However, limited information is available regarding the frequency of skin contamination and environmental shedding of C. difficile during and after treatment...
- In vitro killing of nosocomial pathogens by acid and acidified nitrite
Agam Rao
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH 44106, USA
Antimicrob Agents Chemother 50:3901-4. 2006
..Nitrite enhanced killing under acidic conditions, but significant killing of C. difficile spores required nitrite concentrations above usual physiological levels...
- Comparison of clinical and microbiological response to treatment of Clostridium difficile-associated disease with metronidazole and vancomycin
Wafa N Al-Nassir
Department of Infectious Diseases, University Hospitals of Cleveland, Cleveland, Ohio, USA
Clin Infect Dis 47:56-62. 2008
..We tested the hypothesis that treatment failure with metronidazole is associated with a suboptimal microbiological response in comparison with that of vancomycin...
- Skin and environmental contamination with vancomycin-resistant Enterococci in patients receiving oral metronidazole or oral vancomycin treatment for Clostridium difficile-associated disease
Ajay K Sethi
Department of Epidemiology and Biostatistics, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Infect Control Hosp Epidemiol 30:13-7. 2009
..The objective of our study was to compare the frequency of skin and environmental VRE contamination associated with metronidazole treatment for CDAD with such frequency associated with vancomycin treatment for CDAD...
- Contamination of hospital curtains with healthcare-associated pathogens
Floyd Trillis
Research Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
Infect Control Hosp Epidemiol 29:1074-6. 2008
..Hand imprint cultures demonstrated that these pathogens were easily acquired on hands. Hospital curtains are a potential source for dissemination of healthcare-associated pathogens...
Reduction of Clostridium Difficile and vancomycin-resistant Enterococcus contamination of environmental surfaces after an intervention to improve cleaning methodsBrittany C Eckstein
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
BMC Infect Dis 7:61. 2007
....
- Contamination of hands with methicillin-resistant Staphylococcus aureus after contact with environmental surfaces and after contact with the skin of colonized patients
Usha Stiefel
Research Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
Infect Control Hosp Epidemiol 32:185-7. 2011
..These findings suggest that contaminated surfaces may be an important source of MRSA transmission...
- Antibiotic resistance determinants in Acinetobacter spp and clinical outcomes in patients from a major military treatment facility
Federico Perez
Division of Infectious Diseases and HIV Medicine, University Hospitals Case Medical Center, Cleveland, OH, USA
Am J Infect Control 38:63-5. 2010
..The presence of bla(OXA-23) also correlated with longer hospital and ICU stay. Associations between bla(OXA-23) and complexity, duration, and changes made to antibiotic regimens also existed...
- Efficacy of oral ramoplanin for inhibition of intestinal colonization by vancomycin-resistant enterococci in mice
Usha Stiefel
Division of Infectious Diseases, University Hospitals of Cleveland, Case Western Reserve University, Ohio 44106, USA
Antimicrob Agents Chemother 48:2144-8. 2004
..Ramoplanin treatment may be associated with overgrowth of gram-negative bacilli...
- Antianaerobic antibiotic therapy promotes overgrowth of antibiotic-resistant, gram-negative bacilli and vancomycin-resistant enterococci in the stool of colonized patients
Anita Bhalla
Infectious Diseases Division, University Hospitals of Cleveland, OH, USA
Infect Control Hosp Epidemiol 24:644-9. 2003
..4 and 3.9 +/- 0.71 log10 organisms/g; P < .001). CONCLUSION: Limiting the use of antianaerobic antibiotics in VRE-colonized patients may reduce the density of colonization with coexisting antibiotic-resistant, gram-negative bacilli...
- Coexistence of vancomycin-resistant enterococci and Staphylococcus aureus in the intestinal tracts of hospitalized patients
Amy J Ray
Department of Medicine, University Hospitals of Cleveland, Ohio, USA
Clin Infect Dis 37:875-81. 2003
..34). No S. aureus isolates were resistant to vancomycin. S. aureus and VRE often coexist in the intestinal tract, providing a potential reservoir for the emergence of vancomycin-resistant S. aureus isolates...
- Triggering germination represents a novel strategy to enhance killing of Clostridium difficile spores
Michelle M Nerandzic
Research Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, United States of America
PLoS ONE 5:e12285. 2010
..difficile spores to radiation or other stressors...
- Evaluation of an automated ultraviolet radiation device for decontamination of Clostridium difficile and other healthcare-associated pathogens in hospital rooms
Michelle M Nerandzic
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, Ohio, USA
BMC Infect Dis 10:197. 2010
..Environmental surfaces play an important role in transmission of healthcare-associated pathogens. There is a need for new disinfection methods that are effective against Clostridium difficile spores, but also safe, rapid, and automated...
- What is on that keyboard? Detecting hidden environmental reservoirs of Clostridium difficile during an outbreak associated with North American pulsed-field gel electrophoresis type 1 strains
Donald M Dumford
Department of Medicine, University Hospitals of Cleveland, Cleveland, OH, USA
Am J Infect Control 37:15-9. 2009
..However, less information is available regarding the frequency of contamination of environmental surfaces outside of CDI isolation rooms...
- Effects of daptomycin, linezolid, and vancomycin on establishment of intestinal colonization with vancomycin-resistant enterococci and extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae in mice
Nicole J Pultz
Infectious Diseases Section (111 W, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, Ohio 44106, USA
Antimicrob Agents Chemother 49:3513-6. 2005
..However, the effects varied depending on dose and duration of treatment. Daptomycin treatment did not disrupt the anaerobic microflora or promote either pathogen...
- Emergence and acquisition of fluoroquinolone-resistant gram-negative bacilli in the intestinal tracts of mice treated with fluoroquinolone antimicrobial agents
Michael J Pultz
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
Antimicrob Agents Chemother 52:3457-60. 2008
..No emergence of fluoroquinolone-resistant gram-negative bacilli was detected in the mice during or after treatment with the fluoroquinolone antimicrobial agents...
- Vegetative Clostridium difficile survives in room air on moist surfaces and in gastric contents with reduced acidity: a potential mechanism to explain the association between proton pump inhibitors and C. difficile-associated diarrhea?
Robin L P Jump
Louis Stokes Cleveland Veterans Affairs Medical Center, Infectious Diseases Section, Cleveland, OH 44106, USA
Antimicrob Agents Chemother 51:2883-7. 2007
..The ability of the vegetative form of C. difficile to survive on moist surfaces and in gastric contents with an elevated pH suggests a potential mechanism by which PPI therapy could increase the risk of acquiring C. difficile...
- Evaluation of an alcohol-based power sanitizing system for decontamination of hospital rooms of patients with methicillin-resistant Staphylococcus aureus carriage
Lucy A Jury
Geriatric Research Education and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA
Am J Infect Control 38:234-6. 2010
..However, it was not as consistently effective for elimination of pathogens as 10% bleach solution...
- Both oral metronidazole and oral vancomycin promote persistent overgrowth of vancomycin-resistant enterococci during treatment of Clostridium difficile-associated disease
Wafa N Al-Nassir
Department of Infectious Diseases, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, 10000 Euclid Avenue, Cleveland, Ohio, USA
Antimicrob Agents Chemother 52:2403-6. 2008
..New CDAD treatments are needed that are less likely to disrupt the intestinal microflora and promote overgrowth of healthcare-associated pathogens...
- Effect of a selective decontamination of the digestive tract regimen including parenteral cefepime on establishment of intestinal colonization with vancomycin-resistant Enterococcus spp. and Klebsiella pneumoniae in mice
David L Paterson
Division of Infectious Diseases, University of Pittsburg Medical Center, Pittsburg Pennslyvania, USA
Antimicrob Agents Chemother 50:2537-40. 2006
..VRE) colonization. However, concurrent administration of subcutaneous ampicillin-sulbactam resulted in promotion of VRE...
- Mechanisms by which anaerobic microbiota inhibit the establishment in mice of intestinal colonization by vancomycin-resistant Enterococcus
Nicole J Pultz
Research Section, Louis Stokes Cleveland Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Infect Dis 191:949-56. 2005
..These results suggest that colonic microbiota inhibit VRE by producing inhibitory substances or conditions rather than by depleting nutrients. The colonic mucus layer provides a potential niche for growth of VRE...
- Effect of parenteral antibiotic administration on establishment of intestinal colonization in mice by Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases
Claudia K Hoyen
Pediatric Infectious Diseases, Rainbow Babies and Childrens Hospital, Cleveland, Ohio 44106, USA
Antimicrob Agents Chemother 47:3610-2. 2003
....
- Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice
Daniel A Adams
Louis Stokes Cleveland Veterans Affairs Medical Center, Infectious Diseases Section, Cleveland, OH 44106, USA
Antimicrob Agents Chemother 51:2674-8. 2007
....
- Skin and environmental contamination with methicillin-resistant Staphylococcus aureus among carriers identified clinically versus through active surveillance
Shelley Chang
Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Clin Infect Dis 48:1423-8. 2009
..aureus carriage was identified clinically, which suggests that strategies to limit transmission must address colonized patients, as well as infected patients...
- Effect of the increasing use of piperacillin/tazobactam on the incidence of vancomycin-resistant enterococci in four academic medical centers
Usha Stiefel
Infectious Diseases Division, University Hospitals of Cleveland, Cleveland, Ohio, USA
Infect Control Hosp Epidemiol 25:380-3. 2004
..CONCLUSION: Increasing the hospital use of piperacillin/tazobactam and other beta-lactams with relatively enhanced anti-enterococcal activity may not be an effective control measure for VRE...
- Effect of carbapenem administration on establishment of intestinal colonization by vancomycin-resistant enterococci and Klebsiella pneumoniae in mice
Usha Stiefel
Infectious Diseases Section 111 W, Louis Stokes Cleveland Department of VA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
Antimicrob Agents Chemother 51:372-5. 2007
..Neither agent promoted colonization with extended-spectrum beta-lactamase-producing Klebsiella pneumoniae...
- Occurrence of skin and environmental contamination with methicillin-resistant Staphylococcus aureus before results of polymerase chain reaction at hospital admission become available
Shelley Chang
Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Infect Control Hosp Epidemiol 31:607-12. 2010
..However, inpatients may already become sources of transmission before appropriate precautions are implemented...
- Increased susceptibility to vancomycin-resistant Enterococcus intestinal colonization persists after completion of anti-anaerobic antibiotic treatment in mice
Usha Stiefel
Division of Infectious Diseases, University Hospitals of Cleveland, OH, USA
Infect Control Hosp Epidemiol 25:373-9. 2004
..001). CONCLUSION: Patients receiving anti-anaerobic antibiotics, including piperacillin/tazobactam, may be susceptible to the establishment of high-density VRE colonization during the period of recovery of the anaerobic microflora...
- Colonization and infection with multiple nosocomial pathogens among patients colonized with vancomycin-resistant Enterococcus
Curtis J Donskey
Infectious Diseases Section, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Ohio 44106, USA
Infect Control Hosp Epidemiol 24:242-5. 2003
..This suggests that isolation measures implemented to control VRE could help limit the dissemination of other, coexisting pathogens...
- Examination of potential mechanisms to explain the association between proton pump inhibitors and Clostridium difficile infection
Michelle M Nerandzic
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA
Antimicrob Agents Chemother 53:4133-7. 2009
..Our results suggest that the effects of PPIs in the stomach do not contribute to the pathogenesis of CDI...
- Staphylococcus aureus intestinal colonization is associated with increased frequency of S. aureus on skin of hospitalized patients
Anita Bhalla
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, Ohio, USA
BMC Infect Dis 7:105. 2007
..We hypothesized that S. aureus intestinal colonization is associated with increased frequency of S. aureus on patients' skin and nearby environmental surfaces...
- Effect of parenteral fluoroquinolone administration on persistence of vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract
Curtis J Donskey
Research Service Medical Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Antimicrob Agents Chemother 48:326-8. 2004
..Levofloxacin and ciprofloxacin did not promote colonization in comparison to saline controls, whereas moxifloxacin and gatifloxacin promoted persistent overgrowth in a dose-dependent fashion...
- Clinical and infection control implications of Clostridium difficile infection with negative enzyme immunoassay for toxin
Dubert M Guerrero
Department of Infectious Diseases, University Hospitals of Cleveland, OH, USA
Clin Infect Dis 53:287-90. 2011
..EIA-negative patients with CDI did not differ in clinical presentation from EIA-positive patients and presented a similar risk for transmission of spores...
- Clostridium difficile infection in a Department of Veterans Affairs long-term care facility
Dubert M Guerrero
University Hospitals of Cleveland Case Medical Center, Cleveland, Ohio, USA
Infect Control Hosp Epidemiol 32:513-5. 2011
..Eighty-five percent of LTCF-onset patients had been transferred from the hospital within the past month. Delays in diagnosis and treatment were common for LTCF-onset patients...
- Inhibition of methicillin-resistant Staphylococcus aureus by an in vitro continuous-flow culture containing human stool microflora
Nicole J Pultz
Research Section, Louis Stokes Cleveland Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
FEMS Microbiol Lett 241:201-5. 2004
..Our findings also suggest that inhibition of MRSA in continuous-flow cultures is due to depletion of nutrients rather than production of inhibitory conditions...
- Effect of parenteral antibiotic administration on establishment of intestinal colonization by Candida glabrata in adult mice
Nicole J Pultz
Infectious Diseases Section, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
Antimicrob Agents Chemother 49:438-40. 2005
..These findings suggest that antibiotics that inhibit intestinal anaerobes promote C. glabrata colonization...
- Role of fecal incontinence in contamination of the environment with vancomycin-resistant enterococci
Richard A Mayer
Division of Infectious Diseases, University Hospitals of Cleveland, Cleveland, Ohio, USA
Am J Infect Control 31:221-5. 2003
..Our findings suggest that similar infection control measures should be implemented for patients who are continent and incontinent...
- Acquisition of nosocomial pathogens on hands after contact with environmental surfaces near hospitalized patients
Anita Bhalla
Infectious Diseases Division, University Hospitals of Cleveland, Ohio, USA
Infect Control Hosp Epidemiol 25:164-7. 2004
..Hand imprint cultures were positive for one or more pathogens after contacting surfaces near 34 (53%) of 64 study patients, with Staphylococcus aureus and vancomycin-resistant Enterococcus being the most common isolates...
- Reduced acquisition and overgrowth of vancomycin-resistant enterococci and Candida species in patients treated with fidaxomicin versus vancomycin for Clostridium difficile infection
Michelle M Nerandzic
Research Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
Clin Infect Dis 55:S121-6. 2012
..However, selection of preexisting subpopulations of VRE with elevated fidaxomicin MICs was common during fidaxomicin therapy...
- Undetected vancomycin-resistant Enterococcus stool colonization in a Veterans Affairs Hospital using a Clostridium difficile-focused surveillance strategy
Amy J Ray
University Hospitals of Cleveland, Ohio, USA
Infect Control Hosp Epidemiol 23:474-7. 2002
..Of 112 patients not known to be colonized, 10 (9%) had rectal VRE colonization. A prospective algorithm was effective for identification of colonized patients...
- High proportion of false-positive Clostridium difficile enzyme immunoassays for toxin A and B in pediatric patients
Philip Toltzis
Rainbow Babies and Children s Hospital, Cleveland, Ohio, USA
Infect Control Hosp Epidemiol 33:175-9. 2012
..To determine the frequency of false-positive Clostridium difficile toxin enzyme immunoassay (EIA) results in hospitalized children and to examine potential reasons for this false positivity...
- Suppression of gastric acid production by proton pump inhibitor treatment facilitates colonization of the large intestine by vancomycin-resistant Enterococcus spp. and Klebsiella pneumoniae in clindamycin-treated mice
Usha Stiefel
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
Antimicrob Agents Chemother 50:3905-7. 2006
..These findings demonstrate a mechanism by which proton pump inhibitor therapy could contribute to the dissemination of nosocomial pathogens...
- Tigecycline exhibits inhibitory activity against Clostridium difficile in the colon of mice and does not promote growth or toxin production
Robin L P Jump
Geriatric Research, Education and Clinical Center, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA
Antimicrob Agents Chemother 55:546-9. 2011
..In summary, tigecycline did not promote the growth of or toxin production by C. difficile, probably due to inhibitory activity against C. difficile and relative sparing of indigenous anaerobic microflora...
- Clostridium difficile skin contamination in patients with C. difficile-associated disease
Greg S Bobulsky
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
Clin Infect Dis 46:447-50. 2008
..Skin contamination often persisted on patients' chest and abdomen after resolution of diarrhea...
- Effectiveness of routine patient bathing to decrease the burden of spores on the skin of patients with Clostridium difficile infection
Lucy A Jury
Geriatric Research Education and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
Infect Control Hosp Epidemiol 32:181-4. 2011
..Routine bathing practices had limited efficacy in decreasing the burden of spores on skin; however, showers were more effective than bed baths...
- Recurrence of vancomycin-resistant Enterococcus stool colonization during antibiotic therapy
Curtis J Donskey
Infectious Diseases Section, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Ohio 44106, USA
Infect Control Hosp Epidemiol 23:436-40. 2002
..These patients should be screened for recurrent stool colonization when antibiotic therapy is administered...
- Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center
Kristine M Hujer
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
Antimicrob Agents Chemother 50:4114-23. 2006
..from the WRAMC. Identifying genes associated with the MDR phenotype and defining patterns of transmission serve as a starting point for devising strategies to limit the clinical impact of these serious infections...
- Beta-lactam antibiotics and gastrointestinal colonization with vancomycin-resistant enterococci
Louis B Rice
Medical and Research Services, Louis Stokes Cleveland VA Medical Center, The Cleveland Veterans Affairs Research and Education Foundation, and Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
J Infect Dis 189:1113-8. 2004
..These data suggest that the risk of VRE colonization varies during exposure to different beta-lactam antimicrobial agents and that the risk is related to biliary concentration and antienterococcal activity of the specific beta-lactam...
- Effect of antibiotic treatment on growth of and toxin production by Clostridium difficile in the cecal contents of mice
Nicole J Pultz
Louis Stokes Cleveland Veterans Affairs Medical Center, Infectious Diseases Section, 10701 East Blvd, Cleveland, OH 44106, USA
Antimicrob Agents Chemother 49:3529-32. 2005
..e., levofloxacin, cefepime, and aztreonam) did not...
- Effect of antibiotic treatment on establishment and elimination of intestinal colonization by KPC-producing Klebsiella pneumoniae in mice
Federico Perez
Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA
Antimicrob Agents Chemother 55:2585-9. 2011
..The administration of nonabsorbed oral antibiotics may be an effective strategy to suppress colonization with KPC-Kp...
- Clostridium difficile infection and concurrent vancomycin-resistant Enterococcus stool colonization in a health care worker: case report and review of the literature
Amy J Ray
Department of Medicine, University Hospitals of Cleveland, Ohio 44106, USA
Am J Infect Control 31:54-6. 2003
..Health care workers should be aware that antibiotic therapy may place them at increased risk for colonization and infection with nosocomial pathogens such as Clostridium difficile and vancomycin-resistant Enterococcus...
- Sustained reduction in inappropriate treatment of asymptomatic bacteriuria in a long-term care facility through an educational intervention
Trina F Zabarsky
Infection Control Department, Case Western Reserve University School of Medicine, Cleveland, OH, USA
Am J Infect Control 36:476-80. 2008
..In long-term care facilities, treatment of asymptomatic bacteriuria (ASB) is common. However, randomized, controlled trials suggest that such treatment offers no benefit and may promote antimicrobial resistance...
- Unnecessary use of fluoroquinolone antibiotics in hospitalized patients
Nicole L Werner
School of Medicine, Case Western Reserve University, 10, 000 Euclid Avenue, Cleveland, Ohio, USA
BMC Infect Dis 11:187. 2011
....
- Effect of ceftobiprole treatment on growth of and toxin production by Clostridium difficile in cecal contents of mice
Michelle M Nerandzic
Research Service, Cleveland VA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
Antimicrob Agents Chemother 55:2174-7. 2011
..The relatively low propensity of ceftobiprole to promote C. difficile was attributable to inhibitory activity against C. difficile and sparing of anaerobic microflora...
- Vancomycin-resistant Enterococci may obtain nutritional support by scavenging carbohydrate fragments generated during mucin degradation by the anaerobic microbiota of the colon
Nicole J Pultz
Research Section, Louis Stokes Cleveland Veterans Affairs Medical Center, and Case Western Reserve University, Cleveland, OH 44106, USA
Microb Drug Resist 12:63-7. 2006
..These results suggest that enzymatic breakdown of complex polysaccharides such as mucin by members of the indigenous microbiota may provide a source of nutritional support for VRE...
- Evaluation of patient participation in a patient empowerment initiative to improve hand hygiene practices in a Veterans Affairs medical center
Victoria Lent
Infection Control Department, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA
Am J Infect Control 37:117-20. 2009
..In patient empowerment initiatives, patients are encouraged to ask caregivers if they have washed their hands. However, relatively little is known about the willingness of patients to participate in such initiatives...
- Cefotaxime-resistant bacteria colonizing older people admitted to an acute care hospital
Robert A Bonomo
Infectious Disease Section, Geriatric and Extended Care, Louis Stokes Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
J Am Geriatr Soc 51:519-22. 2003
..To determine the frequency of fecal colonization by cefotaxime-resistant gram-negative bacilli in older patients living in the community and in long-term care facilities (LTCFs) admitted to an acute care hospital...
- Unnecessary use of antimicrobials in hospitalized patients: current patterns of misuse with an emphasis on the antianaerobic spectrum of activity
Michelle T Hecker
Division of Infectious Diseases, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
Arch Intern Med 163:972-8. 2003
..CONCLUSIONS: In our institution, hospitalized patients frequently received unnecessary antimicrobial therapy, and antianaerobic agents were often prescribed when this spectrum of activity was not indicated...
- Adhesion of vancomycin-resistant enterococcus to human intestinal mucus
Nicole J Pultz
Research Section, Louis Stokes Cleveland Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, OH, 44106, USA
Curr Microbiol 52:221-4. 2006
..rhamnosus GG demonstrated 20- to 130-times higher affinity than the VREF strains. These results demonstrate that VREF strains may adhere to human intestinal mucus and suggest that L. rhamnosus GG might be able to displace VREF strains...
- Effective and reduced-cost modified selective medium for isolation of Clostridium difficile
Michelle M Nerandzic
Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
J Clin Microbiol 47:397-400. 2009
..difficile spores, at a rate comparable to that in cycloserine-cefoxitin-fructose broth. Our results suggest that CDBA and CDBB are sensitive, selective, and reduced-cost media for the recovery of C. difficile from stool samples...
- Enterococcal surface protein Esp does not facilitate intestinal colonization or translocation of Enterococcus faecalis in clindamycin-treated mice
Nicole J Pultz
Infectious Diseases Section (111W, Louis Stokes Cleveland Veterans Affairs Medical Center, Case Western Reserve University, 10701 East Blvd, Cleveland, OH 44106, USA
FEMS Microbiol Lett 242:217-9. 2005
..faecalis strain JH2) with or without the esp gene failed to establish colonization of clindamycin-treated mice. These results suggest that Esp does not facilitate intestinal colonization or translocation of E. faecalis...
- Orally administered targeted recombinant Beta-lactamase prevents ampicillin-induced selective pressure on the gut microbiota: a novel approach to reducing antimicrobial resistance
Jaana Harmoinen
Faculty of Veterinary Medicine, Department of Clinical Veterinary Sciences, 00014 University of Helsinki, Helsinki, Finland
Antimicrob Agents Chemother 48:75-9. 2004
..These results suggest a new strategy for reducing antimicrobial resistance in humans...
- Nosocomial transmission of vancomycin-resistant enterococci from surfaces
Amy J Ray
JAMA 287:1400-1. 2002
- Antimicrobial-associated risk factors for Clostridium difficile infection
Robert C Owens
Maine Medical Center, Portland, ME 04102, USA
Clin Infect Dis 46:S19-31. 2008
....
- Recurrent infection with epidemic Clostridium difficile in a peripartum woman whose infant was asymptomatically colonized with the same strain
Michelle T Hecker
Clin Infect Dis 46:956-7. 2008
- Effects of imipenem-cilastatin, ertapenem, piperacillin-tazobactam, and ceftriaxone treatments on persistence of intestinal colonization by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae strains in mice
Michael J Pultz
Antimicrob Agents Chemother 51:3044-5. 2007
- Orally administered recombinant metallo-beta-lactamase preserves colonization resistance of piperacillin-tazobactam-treated mice
Usha Stiefel
Antimicrob Agents Chemother 49:5190-1. 2005
- Inhibition of vancomycin-resistant enterococcus by continuous-flow cultures of human stool microflora with and without anaerobic gas supplementation
Michael E Hume
United States Department of Agriculture, Agricultural Research Service, Southern Plains Agricultural Research Center, Food and Feed Safety Research Unit, College Station, TX 77845, USA
Curr Microbiol 48:364-7. 2004
..001). These data demonstrate that human stool CFCE cultures maintain high levels of obligate anaerobes and inhibit VRE without the addition of supplemental anaerobic gas...
- Acquisition of rectal colonization by vancomycin-resistant Enterococcus among intensive care unit patients treated with piperacillin-tazobactam versus those receiving cefepime-containing antibiotic regimens
David L Paterson
Royal Brisbane and Women s Hospital, University of Queensland, Brisbane, Australia
Antimicrob Agents Chemother 52:465-9. 2008
..Although piperacillin-tazobactam inhibits the establishment of VRE colonization in mice when exposure occurs during treatment, our data suggest that this agent may not prevent the acquisition of VRE in patients...
- Role of environmental surveillance in determining the risk of hospital-acquired legionellosis: a national surveillance study with clinical correlations
Janet E Stout
VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
Infect Control Hosp Epidemiol 28:818-24. 2007
..None of these hospitals had previously experienced endemic hospital-acquired Legionella pneumonia...
- Growth in cecal mucus facilitates colonization of the mouse intestinal tract by methicillin-resistant Staphylococcus aureus
Delores M Gries
Department of Pediatrics, Madigan Army Medical Center, Tacoma, Washington, USA
J Infect Dis 192:1621-7. 2005
..These results suggest that the cecal mucus layer provides an important niche that facilitates intestinal colonization by MRSA. Oral nonabsorbed antibiotics may be ineffective in eradicating some MRSA strains from the intestinal tract...
- Clostridium difficile infection among health care workers receiving antibiotic therapy
Lisa Arfons
Clin Infect Dis 40:1384-5. 2005
