Curtis J Donskey

Summary

Publications

  1. doi request reprint Does improving surface cleaning and disinfection reduce health care-associated infections?
    Curtis J Donskey
    Geriatric Research, Education, and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA
    Am J Infect Control 41:S12-9. 2013
  2. pmc Evaluation of a hand-held far-ultraviolet radiation device for decontamination of Clostridium difficile and other healthcare-associated pathogens
    Michelle M Nerandzic
    Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA
    BMC Infect Dis 12:120. 2012
  3. ncbi request reprint Effect of parenteral antibiotic administration on the establishment of colonization with vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract
    C J Donskey
    Division of Infectious Diseases, Louis Stokes Dept of Veterans Affairs Medical Center, Cleveland, OH 44106
    J Infect Dis 181:1830-3. 2000
  4. ncbi request reprint Effect of antibiotic therapy on the density of vancomycin-resistant enterococci in the stool of colonized patients
    C J Donskey
    Infectious Diseases Section, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA
    N Engl J Med 343:1925-32. 2000
  5. ncbi request reprint Inhibition of vancomycin-resistant enterococci by an in vitro continuous-flow competitive exclusion culture containing human stool flora
    C J Donskey
    Infectious Diseases Section, Louis Stokes Cleveland Dept of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    J Infect Dis 184:1624-7. 2001
  6. ncbi request reprint Oral administration of beta-lactamase preserves colonization resistance of piperacillin-treated mice
    Usha Stiefel
    Division of Infectious Diseases, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Infect Dis 188:1605-9. 2003
  7. ncbi request reprint Antibiotic regimens and intestinal colonization with antibiotic-resistant gram-negative bacilli
    Curtis J Donskey
    Infectious Diseases Section, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    Clin Infect Dis 43:S62-9. 2006
  8. ncbi request reprint The role of the intestinal tract as a reservoir and source for transmission of nosocomial pathogens
    Curtis J Donskey
    Infectious Diseases Section, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA
    Clin Infect Dis 39:219-26. 2004
  9. ncbi request reprint Use of denaturing gradient gel electrophoresis for analysis of the stool microbiota of hospitalized patients
    Curtis J Donskey
    Infectious Diseases Section 111 W, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    J Microbiol Methods 54:249-56. 2003
  10. ncbi request reprint Asymptomatic carriers are a potential source for transmission of epidemic and nonepidemic Clostridium difficile strains among long-term care facility residents
    Michelle M Riggs
    Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA
    Clin Infect Dis 45:992-8. 2007

Collaborators

Detail Information

Publications96

  1. doi request reprint Does improving surface cleaning and disinfection reduce health care-associated infections?
    Curtis J Donskey
    Geriatric Research, Education, and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA
    Am J Infect Control 41:S12-9. 2013
    ..This review examines the evidence that improving environmental disinfection can reduce health care-associated infections...
  2. pmc Evaluation of a hand-held far-ultraviolet radiation device for decontamination of Clostridium difficile and other healthcare-associated pathogens
    Michelle M Nerandzic
    Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA
    BMC Infect Dis 12:120. 2012
    ..The Sterilray™ Disinfection Wand device is a hand-held room decontamination technology that utilizes far-ultraviolet radiation (185-230 nm) to kill pathogens...
  3. ncbi request reprint Effect of parenteral antibiotic administration on the establishment of colonization with vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract
    C J Donskey
    Division of Infectious Diseases, Louis Stokes Dept of Veterans Affairs Medical Center, Cleveland, OH 44106
    J Infect Dis 181:1830-3. 2000
    ..Thus, in this mouse model, beta-lactam antibiotics with minimal anti-enterococcal activity promoted establishment of high-level VRE colonization, but Pip-Taz (a beta-lactam antibiotic with more potent activity against VRE) did not...
  4. ncbi request reprint Effect of antibiotic therapy on the density of vancomycin-resistant enterococci in the stool of colonized patients
    C J Donskey
    Infectious Diseases Section, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA
    N Engl J Med 343:1925-32. 2000
    ..In mice that have intestinal colonization with vancomycin-resistant enterococci, these agents promote high-density colonization, whereas antibiotics with minimal antianaerobic activity do not...
  5. ncbi request reprint Inhibition of vancomycin-resistant enterococci by an in vitro continuous-flow competitive exclusion culture containing human stool flora
    C J Donskey
    Infectious Diseases Section, Louis Stokes Cleveland Dept of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    J Infect Dis 184:1624-7. 2001
    ..These data support the hypothesis that the indigenous intestinal flora inhibit growth of VRE and suggest that CFCE cultures may be a useful means to study interactions between the indigenous flora and VRE...
  6. ncbi request reprint Oral administration of beta-lactamase preserves colonization resistance of piperacillin-treated mice
    Usha Stiefel
    Division of Infectious Diseases, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Infect Dis 188:1605-9. 2003
    ..Oral administration of beta-lactamase reduced piperacillin-associated alteration of the indigenous microflora and prevented overgrowth of pathogens...
  7. ncbi request reprint Antibiotic regimens and intestinal colonization with antibiotic-resistant gram-negative bacilli
    Curtis J Donskey
    Infectious Diseases Section, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    Clin Infect Dis 43:S62-9. 2006
    ..Additional research is needed to clarify the role of strategies such as selective decontamination of the digestive tract and decontamination of environmental surfaces and of patients' skin and wounds...
  8. ncbi request reprint The role of the intestinal tract as a reservoir and source for transmission of nosocomial pathogens
    Curtis J Donskey
    Infectious Diseases Section, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA
    Clin Infect Dis 39:219-26. 2004
    ..Infection-control measures that are implemented to control individual pathogens may have a positive or negative impact on efforts to control other pathogens that colonize the intestinal tract...
  9. ncbi request reprint Use of denaturing gradient gel electrophoresis for analysis of the stool microbiota of hospitalized patients
    Curtis J Donskey
    Infectious Diseases Section 111 W, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    J Microbiol Methods 54:249-56. 2003
    ..Thus, our findings are consistent with previous studies that utilized culture techniques, and suggest that DGGE is a useful technique for analysis of the stool microbiota of hospitalized patients...
  10. ncbi request reprint Asymptomatic carriers are a potential source for transmission of epidemic and nonepidemic Clostridium difficile strains among long-term care facility residents
    Michelle M Riggs
    Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA
    Clin Infect Dis 45:992-8. 2007
    ..Asymptomatic fecal carriage of Clostridium difficile is common in patients staying in health care facilities, but the importance of asymptomatic carriers with regard to disease transmission is unclear...
  11. pmc In vitro killing of nosocomial pathogens by acid and acidified nitrite
    Agam Rao
    Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH 44106, USA
    Antimicrob Agents Chemother 50:3901-4. 2006
    ..Nitrite enhanced killing under acidic conditions, but significant killing of C. difficile spores required nitrite concentrations above usual physiological levels...
  12. doi request reprint Persistence of skin contamination and environmental shedding of Clostridium difficile during and after treatment of C. difficile infection
    Ajay K Sethi
    Department of Epidemiology and Biostatistics, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Infect Control Hosp Epidemiol 31:21-7. 2010
    ..However, limited information is available regarding the frequency of skin contamination and environmental shedding of C. difficile during and after treatment...
  13. pmc Multihospital outbreak of Clostridium difficile infection, Cleveland, Ohio, USA
    Robin L P Jump
    University Hospitals of Cleveland, Cleveland, Ohio, USA
    Emerg Infect Dis 16:827-9. 2010
    ..difficile-infected patients. Use of fluoroquionolones with enhanced antianaerobic activity was not associated with increased infection rates...
  14. doi request reprint Orally administered beta-lactamase enzymes represent a novel strategy to prevent colonization by Clostridium difficile
    Usha Stiefel
    Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA
    J Antimicrob Chemother 62:1105-8. 2008
    ..difficile in mice...
  15. doi request reprint Antibiotic resistance determinants in Acinetobacter spp and clinical outcomes in patients from a major military treatment facility
    Federico Perez
    Division of Infectious Diseases and HIV Medicine, University Hospitals Case Medical Center, Cleveland, OH, USA
    Am J Infect Control 38:63-5. 2010
    ..The presence of bla(OXA-23) also correlated with longer hospital and ICU stay. Associations between bla(OXA-23) and complexity, duration, and changes made to antibiotic regimens also existed...
  16. doi request reprint Comparison of clinical and microbiological response to treatment of Clostridium difficile-associated disease with metronidazole and vancomycin
    Wafa N Al-Nassir
    Department of Infectious Diseases, University Hospitals of Cleveland, Cleveland, Ohio, USA
    Clin Infect Dis 47:56-62. 2008
    ..We tested the hypothesis that treatment failure with metronidazole is associated with a suboptimal microbiological response in comparison with that of vancomycin...
  17. doi request reprint Skin and environmental contamination with vancomycin-resistant Enterococci in patients receiving oral metronidazole or oral vancomycin treatment for Clostridium difficile-associated disease
    Ajay K Sethi
    Department of Epidemiology and Biostatistics, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Infect Control Hosp Epidemiol 30:13-7. 2009
    ..The objective of our study was to compare the frequency of skin and environmental VRE contamination associated with metronidazole treatment for CDAD with such frequency associated with vancomycin treatment for CDAD...
  18. pmc Reduction of Clostridium Difficile and vancomycin-resistant Enterococcus contamination of environmental surfaces after an intervention to improve cleaning methods
    Brittany C Eckstein
    Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
    BMC Infect Dis 7:61. 2007
    ....
  19. doi request reprint Contamination of hospital curtains with healthcare-associated pathogens
    Floyd Trillis
    Research Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    Infect Control Hosp Epidemiol 29:1074-6. 2008
    ..Hand imprint cultures demonstrated that these pathogens were easily acquired on hands. Hospital curtains are a potential source for dissemination of healthcare-associated pathogens...
  20. doi request reprint Evaluation of an alcohol-based power sanitizing system for decontamination of hospital rooms of patients with methicillin-resistant Staphylococcus aureus carriage
    Lucy A Jury
    Geriatric Research Education and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, OH, USA
    Am J Infect Control 38:234-6. 2010
    ..However, it was not as consistently effective for elimination of pathogens as 10% bleach solution...
  21. doi request reprint Contamination of hands with methicillin-resistant Staphylococcus aureus after contact with environmental surfaces and after contact with the skin of colonized patients
    Usha Stiefel
    Research Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
    Infect Control Hosp Epidemiol 32:185-7. 2011
    ..These findings suggest that contaminated surfaces may be an important source of MRSA transmission...
  22. pmc Efficacy of oral ramoplanin for inhibition of intestinal colonization by vancomycin-resistant enterococci in mice
    Usha Stiefel
    Division of Infectious Diseases, University Hospitals of Cleveland, Case Western Reserve University, Ohio 44106, USA
    Antimicrob Agents Chemother 48:2144-8. 2004
    ..Ramoplanin treatment may be associated with overgrowth of gram-negative bacilli...
  23. ncbi request reprint Antianaerobic antibiotic therapy promotes overgrowth of antibiotic-resistant, gram-negative bacilli and vancomycin-resistant enterococci in the stool of colonized patients
    Anita Bhalla
    Infectious Diseases Division, University Hospitals of Cleveland, OH, USA
    Infect Control Hosp Epidemiol 24:644-9. 2003
    ..We tested the hypothesis that antibiotic regimens with potent antianaerobic activity promote overgrowth of coexisting antibiotic-resistant, gram-negative bacilli in the stool of VRE-colonized patients...
  24. pmc Triggering germination represents a novel strategy to enhance killing of Clostridium difficile spores
    Michelle M Nerandzic
    Research Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, United States of America
    PLoS ONE 5:e12285. 2010
    ..difficile spores to radiation or other stressors...
  25. ncbi request reprint Coexistence of vancomycin-resistant enterococci and Staphylococcus aureus in the intestinal tracts of hospitalized patients
    Amy J Ray
    Department of Medicine, University Hospitals of Cleveland, Ohio, USA
    Clin Infect Dis 37:875-81. 2003
    ..34). No S. aureus isolates were resistant to vancomycin. S. aureus and VRE often coexist in the intestinal tract, providing a potential reservoir for the emergence of vancomycin-resistant S. aureus isolates...
  26. pmc Evaluation of an automated ultraviolet radiation device for decontamination of Clostridium difficile and other healthcare-associated pathogens in hospital rooms
    Michelle M Nerandzic
    Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, Ohio, USA
    BMC Infect Dis 10:197. 2010
    ..Environmental surfaces play an important role in transmission of healthcare-associated pathogens. There is a need for new disinfection methods that are effective against Clostridium difficile spores, but also safe, rapid, and automated...
  27. doi request reprint What is on that keyboard? Detecting hidden environmental reservoirs of Clostridium difficile during an outbreak associated with North American pulsed-field gel electrophoresis type 1 strains
    Donald M Dumford
    Department of Medicine, University Hospitals of Cleveland, Cleveland, OH, USA
    Am J Infect Control 37:15-9. 2009
    ..However, less information is available regarding the frequency of contamination of environmental surfaces outside of CDI isolation rooms...
  28. pmc Both oral metronidazole and oral vancomycin promote persistent overgrowth of vancomycin-resistant enterococci during treatment of Clostridium difficile-associated disease
    Wafa N Al-Nassir
    Department of Infectious Diseases, University Hospitals of Cleveland, Case Western Reserve University School of Medicine, 10000 Euclid Avenue, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 52:2403-6. 2008
    ..New CDAD treatments are needed that are less likely to disrupt the intestinal microflora and promote overgrowth of healthcare-associated pathogens...
  29. pmc Emergence and acquisition of fluoroquinolone-resistant gram-negative bacilli in the intestinal tracts of mice treated with fluoroquinolone antimicrobial agents
    Michael J Pultz
    Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 52:3457-60. 2008
    ..No emergence of fluoroquinolone-resistant gram-negative bacilli was detected in the mice during or after treatment with the fluoroquinolone antimicrobial agents...
  30. pmc Vegetative Clostridium difficile survives in room air on moist surfaces and in gastric contents with reduced acidity: a potential mechanism to explain the association between proton pump inhibitors and C. difficile-associated diarrhea?
    Robin L P Jump
    Louis Stokes Cleveland Veterans Affairs Medical Center, Infectious Diseases Section, Cleveland, OH 44106, USA
    Antimicrob Agents Chemother 51:2883-7. 2007
    ..The ability of the vegetative form of C. difficile to survive on moist surfaces and in gastric contents with an elevated pH suggests a potential mechanism by which PPI therapy could increase the risk of acquiring C. difficile...
  31. pmc Effects of daptomycin, linezolid, and vancomycin on establishment of intestinal colonization with vancomycin-resistant enterococci and extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae in mice
    Nicole J Pultz
    Infectious Diseases Section 111 W, Louis Stokes Cleveland VA Medical Center, 10701 East Blvd, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 49:3513-6. 2005
    ..However, the effects varied depending on dose and duration of treatment. Daptomycin treatment did not disrupt the anaerobic microflora or promote either pathogen...
  32. doi request reprint Potential for transmission of spores by patients awaiting laboratory testing to confirm suspected Clostridium difficile infection
    Venkata C K Sunkesula
    Department of Medicine, Infectious Diseases Division, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Infect Control Hosp Epidemiol 34:306-8. 2013
    ..Preemptive isolation of patients with suspected CDI may reduce the risk of transmission...
  33. pmc Effect of a selective decontamination of the digestive tract regimen including parenteral cefepime on establishment of intestinal colonization with vancomycin-resistant Enterococcus spp. and Klebsiella pneumoniae in mice
    David L Paterson
    Division of Infectious Diseases, University of Pittsburg Medical Center, Pittsburg Pennslyvania, USA
    Antimicrob Agents Chemother 50:2537-40. 2006
    ..VRE) colonization. However, concurrent administration of subcutaneous ampicillin-sulbactam resulted in promotion of VRE...
  34. pmc Effect of fluoroquinolone treatment on growth of and toxin production by epidemic and nonepidemic clostridium difficile strains in the cecal contents of mice
    Daniel A Adams
    Louis Stokes Cleveland Veterans Affairs Medical Center, Infectious Diseases Section, Cleveland, OH 44106, USA
    Antimicrob Agents Chemother 51:2674-8. 2007
    ....
  35. ncbi request reprint Mechanisms by which anaerobic microbiota inhibit the establishment in mice of intestinal colonization by vancomycin-resistant Enterococcus
    Nicole J Pultz
    Research Section, Louis Stokes Cleveland Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Infect Dis 191:949-56. 2005
    ..These results suggest that colonic microbiota inhibit VRE by producing inhibitory substances or conditions rather than by depleting nutrients. The colonic mucus layer provides a potential niche for growth of VRE...
  36. pmc Effect of parenteral antibiotic administration on establishment of intestinal colonization in mice by Klebsiella pneumoniae strains producing extended-spectrum beta-lactamases
    Claudia K Hoyen
    Pediatric Infectious Diseases, Rainbow Babies and Childrens Hospital, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 47:3610-2. 2003
    ....
  37. pmc Novel strategies for enhanced removal of persistent Bacillus anthracis surrogates and Clostridium difficile spores from skin
    Michelle M Nerandzic
    Research Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, United States of America
    PLoS ONE 8:e68706. 2013
    ..We hypothesized that hygiene interventions incorporating a sporicidal electrochemically generated hypochlorous acid solution (Vashe(®)) would reduce the burden of spores on skin...
  38. pmc Outpatient healthcare settings and transmission of Clostridium difficile
    Lucy A Jury
    Geriatric Research Education and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, United States of America
    PLoS ONE 8:e70175. 2013
    ..e., no healthcare facility admission within 90 days) may be increasing in frequency. We hypothesized that outpatient clinics could be an important source for acquisition of community-associated CDI...
  39. pmc Specialty care delivery: bringing infectious disease expertise to the residents of a Veterans Affairs long-term care facility
    Robin L P Jump
    Geriatric Research, Education and Clinical Center, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    J Am Geriatr Soc 61:782-7. 2013
    ..To initiate a long-term care facility (LTCF) infectious disease (LID) service that provides on-site consultations to LTCF residents to improve the care of residents with possible infections...
  40. doi request reprint Acquisition of spores on gloved hands after contact with the skin of patients with Clostridium difficile infection and with environmental surfaces in their rooms
    Dubert M Guerrero
    University Hospitals of Cleveland Case Medical Center, Cleveland, OH
    Am J Infect Control 40:556-8. 2012
    ....
  41. doi request reprint Skin and environmental contamination with methicillin-resistant Staphylococcus aureus among carriers identified clinically versus through active surveillance
    Shelley Chang
    Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Clin Infect Dis 48:1423-8. 2009
    ..aureus carriage was identified clinically, which suggests that strategies to limit transmission must address colonized patients, as well as infected patients...
  42. ncbi request reprint Effect of the increasing use of piperacillin/tazobactam on the incidence of vancomycin-resistant enterococci in four academic medical centers
    Usha Stiefel
    Infectious Diseases Division, University Hospitals of Cleveland, Cleveland, Ohio, USA
    Infect Control Hosp Epidemiol 25:380-3. 2004
    ....
  43. pmc Effect of carbapenem administration on establishment of intestinal colonization by vancomycin-resistant enterococci and Klebsiella pneumoniae in mice
    Usha Stiefel
    Infectious Diseases Section 111 W, Louis Stokes Cleveland Department of VA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    Antimicrob Agents Chemother 51:372-5. 2007
    ..Neither agent promoted colonization with extended-spectrum beta-lactamase-producing Klebsiella pneumoniae...
  44. pmc Examination of potential mechanisms to explain the association between proton pump inhibitors and Clostridium difficile infection
    Michelle M Nerandzic
    Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA
    Antimicrob Agents Chemother 53:4133-7. 2009
    ..Our results suggest that the effects of PPIs in the stomach do not contribute to the pathogenesis of CDI...
  45. doi request reprint Occurrence of skin and environmental contamination with methicillin-resistant Staphylococcus aureus before results of polymerase chain reaction at hospital admission become available
    Shelley Chang
    Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Infect Control Hosp Epidemiol 31:607-12. 2010
    ..However, inpatients may already become sources of transmission before appropriate precautions are implemented...
  46. ncbi request reprint Increased susceptibility to vancomycin-resistant Enterococcus intestinal colonization persists after completion of anti-anaerobic antibiotic treatment in mice
    Usha Stiefel
    Division of Infectious Diseases, University Hospitals of Cleveland, OH, USA
    Infect Control Hosp Epidemiol 25:373-9. 2004
    ....
  47. ncbi request reprint Colonization and infection with multiple nosocomial pathogens among patients colonized with vancomycin-resistant Enterococcus
    Curtis J Donskey
    Infectious Diseases Section, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Ohio 44106, USA
    Infect Control Hosp Epidemiol 24:242-5. 2003
    ..To test the hypothesis that patients colonized with vancomycin-resistant Enterococcus (VRE) have a higher frequency of colonization or infection with other nosocomial pathogens than do patients who are not colonized with VRE...
  48. doi request reprint Appropriateness of empiric therapy in patients with suspected Clostridium difficile infection
    Elie Saade
    Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Curr Med Res Opin 29:985-8. 2013
    ..The objective of this study was to test the hypothesis that many patients with suspected Clostridium difficile infection (CDI) receive inappropriate empiric therapy and/or receive continued therapy despite negative test results...
  49. pmc Easily modified factors contribute to delays in diagnosis of Clostridium difficile infection: a cohort study and intervention
    Sirisha Kundrapu
    Department of Medicine, Infectious Diseases Division, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Clin Microbiol 51:2365-70. 2013
    ..These findings suggest that health care facilities may benefit from a review of their processes for CDI testing to identify and address modifiable factors that contribute to delays in diagnosis and treatment of CDI...
  50. doi request reprint Utility of perirectal swab specimens for diagnosis of Clostridium difficile infection
    Sirisha Kundrapu
    Department of Medicine, Infectious Diseases Division, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Clin Infect Dis 55:1527-30. 2012
    ..7%, 100%, 100%, and 99.1%, respectively. For selected patients, perirectal swabs provide an accurate toxigenic C. difficile detection strategy...
  51. pmc Staphylococcus aureus intestinal colonization is associated with increased frequency of S. aureus on skin of hospitalized patients
    Anita Bhalla
    Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, Ohio, USA
    BMC Infect Dis 7:105. 2007
    ..We hypothesized that S. aureus intestinal colonization is associated with increased frequency of S. aureus on patients' skin and nearby environmental surfaces...
  52. pmc Effect of parenteral fluoroquinolone administration on persistence of vancomycin-resistant Enterococcus faecium in the mouse gastrointestinal tract
    Curtis J Donskey
    Research Service Medical Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 48:326-8. 2004
    ..Levofloxacin and ciprofloxacin did not promote colonization in comparison to saline controls, whereas moxifloxacin and gatifloxacin promoted persistent overgrowth in a dose-dependent fashion...
  53. doi request reprint Clostridium difficile infection in a Department of Veterans Affairs long-term care facility
    Dubert M Guerrero
    University Hospitals of Cleveland Case Medical Center, Cleveland, Ohio, USA
    Infect Control Hosp Epidemiol 32:513-5. 2011
    ..Eighty-five percent of LTCF-onset patients had been transferred from the hospital within the past month. Delays in diagnosis and treatment were common for LTCF-onset patients...
  54. doi request reprint Clinical and infection control implications of Clostridium difficile infection with negative enzyme immunoassay for toxin
    Dubert M Guerrero
    Department of Infectious Diseases, University Hospitals of Cleveland, OH, USA
    Clin Infect Dis 53:287-90. 2011
    ..EIA-negative patients with CDI did not differ in clinical presentation from EIA-positive patients and presented a similar risk for transmission of spores...
  55. ncbi request reprint Acquisition of nosocomial pathogens on hands after contact with environmental surfaces near hospitalized patients
    Anita Bhalla
    Infectious Diseases Division, University Hospitals of Cleveland, Ohio, USA
    Infect Control Hosp Epidemiol 25:164-7. 2004
    ..Hand imprint cultures were positive for one or more pathogens after contacting surfaces near 34 (53%) of 64 study patients, with Staphylococcus aureus and vancomycin-resistant Enterococcus being the most common isolates...
  56. pmc Effect of parenteral antibiotic administration on establishment of intestinal colonization by Candida glabrata in adult mice
    Nicole J Pultz
    Infectious Diseases Section, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    Antimicrob Agents Chemother 49:438-40. 2005
    ..These findings suggest that antibiotics that inhibit intestinal anaerobes promote C. glabrata colonization...
  57. ncbi request reprint Inhibition of methicillin-resistant Staphylococcus aureus by an in vitro continuous-flow culture containing human stool microflora
    Nicole J Pultz
    Research Section, Louis Stokes Cleveland Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    FEMS Microbiol Lett 241:201-5. 2004
    ..Our findings also suggest that inhibition of MRSA in continuous-flow cultures is due to depletion of nutrients rather than production of inhibitory conditions...
  58. ncbi request reprint Role of fecal incontinence in contamination of the environment with vancomycin-resistant enterococci
    Richard A Mayer
    Division of Infectious Diseases, University Hospitals of Cleveland, Cleveland, Ohio, USA
    Am J Infect Control 31:221-5. 2003
    ..We tested the hypothesis that patients with vancomycin-resistant Enterococcus (VRE) stool colonization who are continent of feces contaminate the environment less frequently than patients who are colonized and incontinent...
  59. doi request reprint Does empirical Clostridium difficile infection (CDI) therapy result in false-negative CDI diagnostic test results?
    Venkata C K Sunkesula
    Division of Infectious Diseases and HIV Medicine, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Clin Infect Dis 57:494-500. 2013
    ..The likelihood that such empirical therapy might result in false-negative CDI test results is unknown...
  60. doi request reprint Effective antimicrobial stewardship in a long-term care facility through an infectious disease consultation service: keeping a LID on antibiotic use
    Robin L P Jump
    Geriatric Research Education and Clinical Center GRECC, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    Infect Control Hosp Epidemiol 33:1185-92. 2012
    ..We determined the impact of the LID service on antimicrobial use and Clostridium difficile infections at the LTCF...
  61. doi request reprint A negative nares screen in combination with absence of clinical risk factors can be used to identify patients with very low likelihood of methicillin-resistant Staphylococcus aureus infection in a Veterans Affairs hospital
    Sadao Jinno
    University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Am J Infect Control 40:782-6. 2012
    ..However, recent studies suggest that negative results of nares surveillance testing are not reliable to predict a low risk for MRSA infection...
  62. pmc Reduced acquisition and overgrowth of vancomycin-resistant enterococci and Candida species in patients treated with fidaxomicin versus vancomycin for Clostridium difficile infection
    Michelle M Nerandzic
    Research Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    Clin Infect Dis 55:S121-6. 2012
    ..However, selection of preexisting subpopulations of VRE with elevated fidaxomicin MICs was common during fidaxomicin therapy...
  63. ncbi request reprint Undetected vancomycin-resistant Enterococcus stool colonization in a Veterans Affairs Hospital using a Clostridium difficile-focused surveillance strategy
    Amy J Ray
    University Hospitals of Cleveland, Ohio, USA
    Infect Control Hosp Epidemiol 23:474-7. 2002
    ..Of 112 patients not known to be colonized, 10 (9%) had rectal VRE colonization. A prospective algorithm was effective for identification of colonized patients...
  64. doi request reprint High proportion of false-positive Clostridium difficile enzyme immunoassays for toxin A and B in pediatric patients
    Philip Toltzis
    Rainbow Babies and Children s Hospital, Cleveland, Ohio, USA
    Infect Control Hosp Epidemiol 33:175-9. 2012
    ..To determine the frequency of false-positive Clostridium difficile toxin enzyme immunoassay (EIA) results in hospitalized children and to examine potential reasons for this false positivity...
  65. pmc Suppression of gastric acid production by proton pump inhibitor treatment facilitates colonization of the large intestine by vancomycin-resistant Enterococcus spp. and Klebsiella pneumoniae in clindamycin-treated mice
    Usha Stiefel
    Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    Antimicrob Agents Chemother 50:3905-7. 2006
    ..These findings demonstrate a mechanism by which proton pump inhibitor therapy could contribute to the dissemination of nosocomial pathogens...
  66. doi request reprint Effectiveness of routine patient bathing to decrease the burden of spores on the skin of patients with Clostridium difficile infection
    Lucy A Jury
    Geriatric Research Education and Clinical Center, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
    Infect Control Hosp Epidemiol 32:181-4. 2011
    ..Routine bathing practices had limited efficacy in decreasing the burden of spores on skin; however, showers were more effective than bed baths...
  67. pmc Tigecycline exhibits inhibitory activity against Clostridium difficile in the colon of mice and does not promote growth or toxin production
    Robin L P Jump
    Geriatric Research, Education and Clinical Center, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH 44106, USA
    Antimicrob Agents Chemother 55:546-9. 2011
    ..In summary, tigecycline did not promote the growth of or toxin production by C. difficile, probably due to inhibitory activity against C. difficile and relative sparing of indigenous anaerobic microflora...
  68. doi request reprint Clostridium difficile skin contamination in patients with C. difficile-associated disease
    Greg S Bobulsky
    Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    Clin Infect Dis 46:447-50. 2008
    ..Skin contamination often persisted on patients' chest and abdomen after resolution of diarrhea...
  69. doi request reprint Daily disinfection of high-touch surfaces in isolation rooms to reduce contamination of healthcare workers' hands
    Sirisha Kundrapu
    Research Service, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    Infect Control Hosp Epidemiol 33:1039-42. 2012
    ....
  70. ncbi request reprint Recurrence of vancomycin-resistant Enterococcus stool colonization during antibiotic therapy
    Curtis J Donskey
    Infectious Diseases Section, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Ohio 44106, USA
    Infect Control Hosp Epidemiol 23:436-40. 2002
    ....
  71. pmc Effect of antibiotic treatment on growth of and toxin production by Clostridium difficile in the cecal contents of mice
    Nicole J Pultz
    Louis Stokes Cleveland Veterans Affairs Medical Center, Infectious Diseases Section, 10701 East Blvd, Cleveland, OH 44106, USA
    Antimicrob Agents Chemother 49:3529-32. 2005
    ..e., levofloxacin, cefepime, and aztreonam) did not...
  72. pmc Effect of antibiotic treatment on establishment and elimination of intestinal colonization by KPC-producing Klebsiella pneumoniae in mice
    Federico Perez
    Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 55:2585-9. 2011
    ..The administration of nonabsorbed oral antibiotics may be an effective strategy to suppress colonization with KPC-Kp...
  73. ncbi request reprint Beta-lactam antibiotics and gastrointestinal colonization with vancomycin-resistant enterococci
    Louis B Rice
    Medical and Research Services, Louis Stokes Cleveland VA Medical Center, The Cleveland Veterans Affairs Research and Education Foundation, and Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Infect Dis 189:1113-8. 2004
    ..These data suggest that the risk of VRE colonization varies during exposure to different beta-lactam antimicrobial agents and that the risk is related to biliary concentration and antienterococcal activity of the specific beta-lactam...
  74. pmc Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp. isolates from military and civilian patients treated at the Walter Reed Army Medical Center
    Kristine M Hujer
    Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 50:4114-23. 2006
    ..from the WRAMC. Identifying genes associated with the MDR phenotype and defining patterns of transmission serve as a starting point for devising strategies to limit the clinical impact of these serious infections...
  75. ncbi request reprint Clostridium difficile infection and concurrent vancomycin-resistant Enterococcus stool colonization in a health care worker: case report and review of the literature
    Amy J Ray
    Department of Medicine, University Hospitals of Cleveland, Ohio 44106, USA
    Am J Infect Control 31:54-6. 2003
    ..Health care workers should be aware that antibiotic therapy may place them at increased risk for colonization and infection with nosocomial pathogens such as Clostridium difficile and vancomycin-resistant Enterococcus...
  76. doi request reprint Sustained reduction in inappropriate treatment of asymptomatic bacteriuria in a long-term care facility through an educational intervention
    Trina F Zabarsky
    Infection Control Department, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Am J Infect Control 36:476-80. 2008
    ..In long-term care facilities, treatment of asymptomatic bacteriuria (ASB) is common. However, randomized, controlled trials suggest that such treatment offers no benefit and may promote antimicrobial resistance...
  77. pmc Unnecessary use of fluoroquinolone antibiotics in hospitalized patients
    Nicole L Werner
    School of Medicine, Case Western Reserve University, 10, 000 Euclid Avenue, Cleveland, Ohio, USA
    BMC Infect Dis 11:187. 2011
    ....
  78. ncbi request reprint Vancomycin-resistant Enterococci may obtain nutritional support by scavenging carbohydrate fragments generated during mucin degradation by the anaerobic microbiota of the colon
    Nicole J Pultz
    Research Section, Louis Stokes Cleveland Veterans Affairs Medical Center, and Case Western Reserve University, Cleveland, OH 44106, USA
    Microb Drug Resist 12:63-7. 2006
    ..These results suggest that enzymatic breakdown of complex polysaccharides such as mucin by members of the indigenous microbiota may provide a source of nutritional support for VRE...
  79. pmc Effect of ceftobiprole treatment on growth of and toxin production by Clostridium difficile in cecal contents of mice
    Michelle M Nerandzic
    Research Service, Cleveland VA Medical Center, 10701 East Blvd, Cleveland, OH 44106, USA
    Antimicrob Agents Chemother 55:2174-7. 2011
    ..The relatively low propensity of ceftobiprole to promote C. difficile was attributable to inhibitory activity against C. difficile and sparing of anaerobic microflora...
  80. doi request reprint Evaluation of patient participation in a patient empowerment initiative to improve hand hygiene practices in a Veterans Affairs medical center
    Victoria Lent
    Infection Control Department, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH 44106, USA
    Am J Infect Control 37:117-20. 2009
    ..In patient empowerment initiatives, patients are encouraged to ask caregivers if they have washed their hands. However, relatively little is known about the willingness of patients to participate in such initiatives...
  81. pmc Cefotaxime-resistant bacteria colonizing older people admitted to an acute care hospital
    Robert A Bonomo
    Infectious Disease Section, Geriatric and Extended Care, Louis Stokes Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    J Am Geriatr Soc 51:519-22. 2003
    ..To determine the frequency of fecal colonization by cefotaxime-resistant gram-negative bacilli in older patients living in the community and in long-term care facilities (LTCFs) admitted to an acute care hospital...
  82. ncbi request reprint Unnecessary use of antimicrobials in hospitalized patients: current patterns of misuse with an emphasis on the antianaerobic spectrum of activity
    Michelle T Hecker
    Division of Infectious Diseases, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    Arch Intern Med 163:972-8. 2003
    ....
  83. ncbi request reprint Adhesion of vancomycin-resistant enterococcus to human intestinal mucus
    Nicole J Pultz
    Research Section, Louis Stokes Cleveland Veterans Affairs Medical Center, Case Western Reserve University, Cleveland, OH, 44106, USA
    Curr Microbiol 52:221-4. 2006
    ..rhamnosus GG demonstrated 20- to 130-times higher affinity than the VREF strains. These results demonstrate that VREF strains may adhere to human intestinal mucus and suggest that L. rhamnosus GG might be able to displace VREF strains...
  84. pmc Effective and reduced-cost modified selective medium for isolation of Clostridium difficile
    Michelle M Nerandzic
    Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    J Clin Microbiol 47:397-400. 2009
    ..difficile spores, at a rate comparable to that in cycloserine-cefoxitin-fructose broth. Our results suggest that CDBA and CDBB are sensitive, selective, and reduced-cost media for the recovery of C. difficile from stool samples...
  85. ncbi request reprint Enterococcal surface protein Esp does not facilitate intestinal colonization or translocation of Enterococcus faecalis in clindamycin-treated mice
    Nicole J Pultz
    Infectious Diseases Section 111W, Louis Stokes Cleveland Veterans Affairs Medical Center, Case Western Reserve University, 10701 East Blvd, Cleveland, OH 44106, USA
    FEMS Microbiol Lett 242:217-9. 2005
    ..faecalis strain JH2) with or without the esp gene failed to establish colonization of clindamycin-treated mice. These results suggest that Esp does not facilitate intestinal colonization or translocation of E. faecalis...
  86. pmc Effects of imipenem-cilastatin, ertapenem, piperacillin-tazobactam, and ceftriaxone treatments on persistence of intestinal colonization by extended-spectrum-beta-lactamase-producing Klebsiella pneumoniae strains in mice
    Michael J Pultz
    Antimicrob Agents Chemother 51:3044-5. 2007
  87. pmc Orally administered targeted recombinant Beta-lactamase prevents ampicillin-induced selective pressure on the gut microbiota: a novel approach to reducing antimicrobial resistance
    Jaana Harmoinen
    Faculty of Veterinary Medicine, Department of Clinical Veterinary Sciences, 00014 University of Helsinki, Helsinki, Finland
    Antimicrob Agents Chemother 48:75-9. 2004
    ..These results suggest a new strategy for reducing antimicrobial resistance in humans...
  88. doi request reprint Recurrent infection with epidemic Clostridium difficile in a peripartum woman whose infant was asymptomatically colonized with the same strain
    Michelle T Hecker
    Clin Infect Dis 46:956-7. 2008
  89. pmc Acquisition of rectal colonization by vancomycin-resistant Enterococcus among intensive care unit patients treated with piperacillin-tazobactam versus those receiving cefepime-containing antibiotic regimens
    David L Paterson
    Royal Brisbane and Women s Hospital, University of Queensland, Brisbane, Australia
    Antimicrob Agents Chemother 52:465-9. 2008
    ..Although piperacillin-tazobactam inhibits the establishment of VRE colonization in mice when exposure occurs during treatment, our data suggest that this agent may not prevent the acquisition of VRE in patients...
  90. ncbi request reprint Nosocomial transmission of vancomycin-resistant enterococci from surfaces
    Amy J Ray
    JAMA 287:1400-1. 2002
  91. doi request reprint Antimicrobial-associated risk factors for Clostridium difficile infection
    Robert C Owens
    Maine Medical Center, Portland, ME 04102, USA
    Clin Infect Dis 46:S19-31. 2008
    ....
  92. pmc Orally administered recombinant metallo-beta-lactamase preserves colonization resistance of piperacillin-tazobactam-treated mice
    Usha Stiefel
    Antimicrob Agents Chemother 49:5190-1. 2005
  93. ncbi request reprint Inhibition of vancomycin-resistant enterococcus by continuous-flow cultures of human stool microflora with and without anaerobic gas supplementation
    Michael E Hume
    United States Department of Agriculture, Agricultural Research Service, Southern Plains Agricultural Research Center, Food and Feed Safety Research Unit, College Station, TX 77845, USA
    Curr Microbiol 48:364-7. 2004
    ..001). These data demonstrate that human stool CFCE cultures maintain high levels of obligate anaerobes and inhibit VRE without the addition of supplemental anaerobic gas...
  94. ncbi request reprint Growth in cecal mucus facilitates colonization of the mouse intestinal tract by methicillin-resistant Staphylococcus aureus
    Delores M Gries
    Department of Pediatrics, Madigan Army Medical Center, Tacoma, Washington, USA
    J Infect Dis 192:1621-7. 2005
    ..These results suggest that the cecal mucus layer provides an important niche that facilitates intestinal colonization by MRSA. Oral nonabsorbed antibiotics may be ineffective in eradicating some MRSA strains from the intestinal tract...
  95. ncbi request reprint Clostridium difficile infection among health care workers receiving antibiotic therapy
    Lisa Arfons
    Clin Infect Dis 40:1384-5. 2005
  96. ncbi request reprint Role of environmental surveillance in determining the risk of hospital-acquired legionellosis: a national surveillance study with clinical correlations
    Janet E Stout
    VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Infect Control Hosp Epidemiol 28:818-24. 2007
    ..None of these hospitals had previously experienced endemic hospital-acquired Legionella pneumonia...