Michael W Donnino

..The objective of this study was to examine the prevalence of elevated cTnI levels in asymptomatic patients with ESRD on hemodialysis...

..We tested whether hospital-independent factors would account for the difference in outcome between 2 geographically distinct hospitals...

..The presence of systemic inflammatory response criteria aids in recognition of infection, although the reliability of these markers is variable...

..The study's objective was to determine the proportion and patient characteristics of patients in vasopressor-dependent septic shock who presented without lactatemia...

..Further, physician knowledge of this disease is vital because the failure to diagnose results in severe neurologic morbidity and possible mortality, but the treatment is safe and effective...

..No study has defined the role of these markers in the triage and management of the normotensive injured elderly patient...

..Misdiagnosis of acute stroke may result in significant morbidity and mortality. Magnetic resonance imaging (MRI) is superior to computer tomography (CT) for diagnosis of acute stroke but is costly with limited availability...

..Observation of this acid-base disturbance should prompt clinicians to consider thiamine deficiency disorders as a possible cause...

..The objective was to investigate the association between statin therapy and mortality in emergency department (ED) patients with suspected infection...

..We sought to investigate current clinical practice pertaining to the evaluation for relative adrenal insufficiency in post-cardiac arrest shock...

..8% of patients had clinically significant abnormalities identified. The exact role of neuroimaging in this population is still in evolution, and further prospective evaluation is warranted...

..Substitution of a central for a mixed venous-arterial pCO(2) difference provides an accurate alternative method for calculation of cardiac output...

..The stress of surgery and critical disease depletes electrolytes, minerals, and essential biochemical substrates. We hypothesized that critical illness (represented by major surgery) would result in decreased thiamine levels over time...

..Traditionally, cannabinoids have been used recreationally or as antiemetics; however, recent reports suggest that chronic abuse can result in the paradoxical effect of a cyclic vomiting syndrome, termed cannabinoid hyperemesis...

..The current case series reveals the unexpected and initially unrecognized CT finding of a pulmonary infarct in two patients presenting with flank pain; a third patient presented with flank pain and was also found to have a PE...

..Clinicians may wish to consider the use of these devices when attempting to warm patients suffering from severe environmental hypothermia...

..Resuscitation strategies (delayed resuscitation, damage control resuscitation), end points of resuscitation, and the role of blood products and pro-coagulants for resuscitation are discussed...

..Because volume remains the most important determinant for the optimal yield of organisms, these findings raise an important quality assurance issue...

..Moreover, statin therapy may decrease CoQ10 levels, but whether this occurs acutely remains unknown. We measured CoQ10 levels in septic shock patients enrolled in a randomized trial of simvastatin versus placebo...

..We undertook the following investigation to determine whether HCT aids in the diagnostic investigation of syncope...

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..We investigated whether early, high lactate clearance was associated with reduced mortality in post-cardiac arrest patients...