Tom Donnem

Summary

Publications

  1. doi Diverging prognostic impacts of hypoxic markers according to NSCLC histology
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Norway
    Lung Cancer 72:294-302. 2011
  2. pmc Prognostic impacts of angiopoietins in NSCLC tumor cells and stroma: VEGF-A impact is strongly associated with Ang-2
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    PLoS ONE 6:e19773. 2011
  3. pmc The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas
    Andrej Valkov
    Dept of Clinical Pathology, University Hospital of Northern Norway, Tromsø, Norway
    J Transl Med 9:200. 2011
  4. doi Strategies for clinical implementation of TNM-Immunoscore in resected nonsmall-cell lung cancer
    T Donnem
    Department of Oncology, University Hospital of North Norway, Tromso Institute of Clinical Medicine, The Arctic University of Norway, Tromso
    Ann Oncol 27:225-32. 2016
  5. doi Stromal CD8+ T-cell Density—A Promising Supplement to TNM Staging in Non-Small Cell Lung Cancer
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso, Norway Institute of Clinical Medicine, The Arctic University of Norway, Tromso, Norway
    Clin Cancer Res 21:2635-43. 2015
  6. doi Bridging the distance: a prospective tele-oncology study in Northern Norway
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso, Norway
    Support Care Cancer 20:2097-103. 2012
  7. pmc MicroRNA signatures in tumor tissue related to angiogenesis in non-small cell lung cancer
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromsφ, Norway
    PLoS ONE 7:e29671. 2012
  8. doi Prognostic impact of angiogenic markers in non-small-cell lung cancer is related to tumor size
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso
    Clin Lung Cancer 12:106-15. 2011
  9. doi Independent and tissue-specific prognostic impact of miR-126 in nonsmall cell lung cancer: coexpression with vascular endothelial growth factor-A predicts poor survival
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso, Norway
    Cancer 117:3193-200. 2011
  10. pmc Prognostic impact of MiR-155 in non-small cell lung cancer evaluated by in situ hybridization
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso, Norway
    J Transl Med 9:6. 2011

Collaborators

Detail Information

Publications45

  1. doi Diverging prognostic impacts of hypoxic markers according to NSCLC histology
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Norway
    Lung Cancer 72:294-302. 2011
    ....
  2. pmc Prognostic impacts of angiopoietins in NSCLC tumor cells and stroma: VEGF-A impact is strongly associated with Ang-2
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    PLoS ONE 6:e19773. 2011
    ..This study evaluates the prognostic impact of all known human angiopoietins (Ang-1, Ang-2 and Ang-4) and their receptor Tie-2, as well as their relation to the prognostic expression of VEGF-A...
  3. pmc The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas
    Andrej Valkov
    Dept of Clinical Pathology, University Hospital of Northern Norway, Tromsø, Norway
    J Transl Med 9:200. 2011
    ....
  4. doi Strategies for clinical implementation of TNM-Immunoscore in resected nonsmall-cell lung cancer
    T Donnem
    Department of Oncology, University Hospital of North Norway, Tromso Institute of Clinical Medicine, The Arctic University of Norway, Tromso
    Ann Oncol 27:225-32. 2016
    ..This review will focus on the TNM-I potential in NSCLC and propose strategies for clinical implementation of a TNM-I in resected NSCLC. ..
  5. doi Stromal CD8+ T-cell Density—A Promising Supplement to TNM Staging in Non-Small Cell Lung Cancer
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso, Norway Institute of Clinical Medicine, The Arctic University of Norway, Tromso, Norway
    Clin Cancer Res 21:2635-43. 2015
    ..Hence, we validate the impact of stromal CD8(+) TIL density as an immunoscore in NSCLC...
  6. doi Bridging the distance: a prospective tele-oncology study in Northern Norway
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso, Norway
    Support Care Cancer 20:2097-103. 2012
    ..In this study, we aimed to evaluate the feasibility of these VCs...
  7. pmc MicroRNA signatures in tumor tissue related to angiogenesis in non-small cell lung cancer
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromsφ, Norway
    PLoS ONE 7:e29671. 2012
    ..MicroRNAs (miRs) are small non-coding, endogenous, single stranded RNAs that regulate gene expression. In this study we aimed to identify significantly altered miRs related to angiogenesis in NSCLC...
  8. doi Prognostic impact of angiogenic markers in non-small-cell lung cancer is related to tumor size
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso
    Clin Lung Cancer 12:106-15. 2011
    ....
  9. doi Independent and tissue-specific prognostic impact of miR-126 in nonsmall cell lung cancer: coexpression with vascular endothelial growth factor-A predicts poor survival
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso, Norway
    Cancer 117:3193-200. 2011
    ..miR-126 has been related to tumor angiogenesis and in the regulation of VEGF-A. The authors aimed to investigate the prognostic impact of miR-126 and its co-expression with VEGF-A in nonsmall cell lung cancer (NSCLC) patients...
  10. pmc Prognostic impact of MiR-155 in non-small cell lung cancer evaluated by in situ hybridization
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso, Norway
    J Transl Med 9:6. 2011
    ..MiR-155 is one of the miRNAs most consistently involved in various neoplastic diseases. We aimed to investigate the prognostic impact of the multifunctional miR-155 in non-small cell lung cancer (NSCLC) patients...
  11. doi Co-expression of PDGF-B and VEGFR-3 strongly correlates with lymph node metastasis and poor survival in non-small-cell lung cancer
    T Donnem
    Department of Oncology, Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    Ann Oncol 21:223-31. 2010
    ..We aimed to study the PDGFs/PDGFRs and correlations with lymph node metastasis (LNM) and investigate the prognostic impact of the co-expression of PDGF-B and VEGFR-3 and its correlation with LNM...
  12. doi Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer: coexpression of Notch-1 and vascular endothelial growth factor-A predicts poor survival
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    Cancer 116:5676-85. 2010
    ..The authors aimed to study the prognostic role of the angiogenesis-related Notch ligands and receptors and investigate the prognostic impact of the coexpression of vascular endothelial growth factor-A (VEGF-A) and Notch signaling...
  13. doi Combination of low vascular endothelial growth factor A (VEGF-A)/VEGF receptor 2 expression and high lymphocyte infiltration is a strong and independent favorable prognostic factor in patients with nonsmall cell lung cancer
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    Cancer 116:4318-25. 2010
    ..The authors of this report investigated the prognostic role of angiogenic markers in coexpression with immune system markers in patients with nonsmall cell lung cancer (NSCLC)...
  14. doi Prognostic impact of fibroblast growth factor 2 in non-small cell lung cancer: coexpression with VEGFR-3 and PDGF-B predicts poor survival
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, Norway
    J Thorac Oncol 4:578-85. 2009
    ..This study investigates the prognostic impact of FGF2 and FGFR-1 in tumor cells and tumor stroma of resected non-small cell lung carcinomas (NSCLC) and explores the importance of their coexpression with VEGFR-3 or PDGF-B...
  15. doi Prognostic impact of platelet-derived growth factors in non-small cell lung cancer tumor and stromal cells
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, Norway
    J Thorac Oncol 3:963-70. 2008
    ..This study investigates the prognostic impact of these molecular markers in tumor cells and tumor stroma of resected non-small cell lung cancer (NSCLC) tumors...
  16. doi VEGF-A and VEGFR-3 correlate with nodal status in operable non-small cell lung cancer: inverse correlation between expression in tumor and stromal cells
    Tom Donnem
    Department of Oncology, Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    Lung Cancer 63:277-83. 2009
    ..We aimed to explore the correlations between nodal metastasis and the expression of VEGFs and VEGFRs in tumor cells and in tumor-related stroma...
  17. pmc Fibroblast growth factor 2 orchestrates angiogenic networking in non-GIST STS patients
    Thomas K Kilvaer
    Institute of Medical Biology, University of Tromso, PB 9037, Tromso, Norway
    J Transl Med 9:104. 2011
    ..This study investigates the prognostic impact of FGF2 and FGFR-1 and explores the impact of their co-expression with PDGF-B and VEGFR-3 in widely resected tumors from non-GIST STS patients...
  18. ncbi Correlation and coexpression of HIFs and NOTCH markers in NSCLC
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Norway
    Anticancer Res 31:1603-6. 2011
    ..NOTCH and hypoxia pathways are both known to be highly involved in cancer. Because of the close interplay between both of these pathways, we investigated correlation and co-expression of molecules in these pathways...
  19. doi Angiogenic markers show high prognostic impact on survival in marginally operable non-small cell lung cancer patients treated with adjuvant radiotherapy
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    J Thorac Oncol 4:463-71. 2009
    ..Both expression and its prognostic impact may be associated with patient selection. Data addressing the prognostic relevance of angiogenic marker expression in NSCLC patients treated with postoperative radiotherapy (PORT) is warranted...
  20. doi Clinical significance of epidermal growth factor receptors in non-small cell lung cancer and a prognostic role for HER2 gene copy number in female patients
    Samer Al-Saad
    Institute of Medical Biology, Faculty of Health Sciences, University of Tromso, Norway
    J Thorac Oncol 5:1536-43. 2010
    ....
  21. pmc Prognostic impact of Jab1, p16, p21, p62, Ki67 and Skp2 in soft tissue sarcomas
    Sveinung W Sorbye
    Department of Clinical Pathology, University Hospital of North Norway, Tromso, Norway
    PLoS ONE 7:e47068. 2012
    ..Optimised treatment of STS requires better identification of high risk patients who will benefit from adjuvant therapy. The prognostic significance of Jab1, p16, p21, p62, Ki67 and Skp2 in STS has not been sufficiently investigated...
  22. ncbi In NSCLC, VEGF-A response to hypoxia may differ between squamous cell and adenocarcinoma histology
    Marte Eilertsen
    Department of Clinical Medicine, University of Tromso, Norway
    Anticancer Res 32:4729-36. 2012
    ..To investigate if hypoxia induces vascular endothelial growth factor (VEGF)-A and VEGF-C secretion in non-small cell lung cancer (NSCLC) cells and if the secretion is cell type-dependent...
  23. doi Overexpression of matrix metalloproteinase-7 and -9 in NSCLC tumor and stromal cells: correlation with a favorable clinical outcome
    Helge Stenvold
    Institute of Clinical Medicine, University of Tromso, Norway
    Lung Cancer 75:235-41. 2012
    ..As both malignant cells and cells of the surrounding stroma contribute to tumor growth, we have explored the impact of MMP-2, -7 and -9 expression in both the tumor and stromal compartment of non-small-cell lung cancers (NSCLC)...
  24. pmc Overexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survival
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    PLoS ONE 6:e23847. 2011
    ..HIFs are regulated by four hydroxylases; Prolyl hydroxylase (PHD)-1,-2,-3 and factor inhibiting HIF (FIH). We aimed to investigate the prognostic impact of these oxygen sensors in NSCLC...
  25. ncbi Diverse prognostic roles of Akt isoforms, PTEN and PI3K in tumor epithelial cells and stromal compartment in non-small cell lung cancer
    Samer Al-Saad
    Institute of Medical Biology, University of Tromso, Norway
    Anticancer Res 29:4175-83. 2009
    ..By tissue microarray methodology, the expression of altered Akt isoforms, PTEN and PI3K and their prognostic significance in 335 non-small cell lung cancer (NSCLC) tumors were investigated...
  26. doi Prognostic impact of CXCL16 and CXCR6 in non-small cell lung cancer: combined high CXCL16 expression in tumor stroma and cancer cells yields improved survival
    Sigurd M Hald
    Department of Clinical Medicine, UiT The Arctic University of Norway, 9037, Tromso, Norway
    BMC Cancer 15:441. 2015
    ..We aimed to explore their prognostic significance in NSCLC, in addition to examining associations with previously investigated markers...
  27. doi CD45RO(+) Memory T Lymphocytes - a Candidate Marker for TNM-Immunoscore in Squamous Non-Small Cell Lung Cancer
    Erna Elise Paulsen
    Department of Oncology, University Hospital of North Norway, Mailbox 100, N 9038 Tromso, Norway Department of Clinical Medicine, UiT The Arctic University of Norway, Mailbox 6050 Langnes, N 9037 Tromso, Norway Electronic address
    Neoplasia 17:839-48. 2015
    ..When combined with S-CD8, the prognostic impact increased and was significant within each pathological stage. We propose CD45RO as a candidate marker for TNM-Immunoscore in SCC NSCLC. ..
  28. pmc Monocarboxylate transporters 1-4 in NSCLC: MCT1 is an independent prognostic marker for survival
    Marte Eilertsen
    Department of Clinical Medicine, University of Tromso, Tromso, Norway
    PLoS ONE 9:e105038. 2014
    ..Herein, we aimed to explore their prognostic impact on disease-specific survival (DSS) in both cancer and tumor stromal cells in NSCLC...
  29. doi The role of tumor-infiltrating immune cells and chronic inflammation at the tumor site on cancer development, progression, and prognosis: emphasis on non-small cell lung cancer
    Roy M Bremnes
    Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway
    J Thorac Oncol 6:824-33. 2011
    ..This review reports on the tumor stroma and in particular tumor-suppressing and -promoting roles of the immune system. Furthermore, it presents recent literature on relevant immune cell-related research in NSCLC...
  30. pmc Prognostic impact of lymphocytes in soft tissue sarcomas
    Sveinung W Sorbye
    Department of Clinical Pathology, University Hospital of North Norway, Tromso, Norway
    PLoS ONE 6:e14611. 2011
    ..The immune status at the time of resection may be important, but the prognostic significance of tumor infiltrating lymphocytes is controversial as the immune system has conflicting roles during cancer development...
  31. doi Organized metabolic crime in prostate cancer: The coexpression of MCT1 in tumor and MCT4 in stroma is an independent prognosticator for biochemical failure
    Sigve Andersen
    Department of Clinical Medicine, Translational Cancer Research Group, The Arctic University of Norway, Tromso, Norway Department of Oncology, University Hospital of North Norway, Tromso Electronic address
    Urol Oncol 33:338.e9-17. 2015
    ..We aimed to explore expression of MCT1 and MCT4 in PC cells and surrounding stroma in a large cohort. Additionally, we wanted to find out if distinct expression profiles were associated with biochemical failure-free survival (BFFS)...
  32. pmc Prognostic impact of CD57, CD68, M-CSF, CSF-1R, Ki67 and TGF-beta in soft tissue sarcomas
    Sveinung W Sorbye
    Dept of Clinical Pathology, University Hospital of North Norway, Tromso, 9038, Norway
    BMC Clin Pathol 12:7. 2012
    ..abstract:..
  33. pmc Prognostic impact of Skp2, ER and PGR in male and female patients with soft tissue sarcomas
    Sveinung W Sorbye
    Department of Clinical Pathology, University Hospital of North Norway, Tromso, Norway
    BMC Clin Pathol 13:9. 2013
    ..Optimized treatment of STS requires better identification of high-risk patients who will benefit from adjuvant therapy. The prognostic significance of Skp2 related to ER and PGR in STS has not been sufficiently investigated...
  34. pmc Prognostic impact of peritumoral lymphocyte infiltration in soft tissue sarcomas
    Sveinung W Sorbye
    Dept of Clinical Pathology, University Hospital of North Norway, 9038 Tromso, Norway
    BMC Clin Pathol 12:5. 2012
    ..abstract:..
  35. pmc Prognostic impacts of hypoxic markers in soft tissue sarcoma
    Eivind Smeland
    Institute of Clinical Medicine, University of Tromso, 9037 Tromso, Norway
    Sarcoma 2012:541650. 2012
    ..7, CI 95% 1.1-2.7, P = 0.021) was a significant independent prognostic indicator of poor DSS. Conclusion. GLUT-1 is a significant independent negative prognostic factor in non-GIST STS...
  36. ncbi Inverse prognostic impact of angiogenic marker expression in tumor cells versus stromal cells in non small cell lung cancer
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, University Hospital of Northern Norway, Tromso, Norway
    Clin Cancer Res 13:6649-57. 2007
    ..This study elucidates the prognostic significance of these molecular markers in tumor cells as well as in the tumor stroma of resected non-small cell lung cancer tumors...
  37. pmc High tumor cell expression of microRNA-21 in node positive non-small cell lung cancer predicts a favorable clinical outcome
    Helge Stenvold
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    BMC Clin Pathol 14:9. 2014
    ..We aimed to explore the impact of miR-21 expression in both tumor and stromal compartments of non-small cell lung cancer (NSCLC), and correlations between miR-21 and angiogenic protein markers...
  38. pmc High progesterone receptor expression in prostate cancer is associated with clinical failure
    Thea Grindstad
    Dept of Medical Biology, UiT The Arctic University of Norway, Tromso, Norway
    PLoS ONE 10:e0116691. 2015
    ..The aim of this study was to evaluate the prognostic significance of progesterone receptor in tumor tissue of T1-3N0 prostate cancer patients undergoing prostatectomy...
  39. pmc Profiling of VEGFs and VEGFRs as prognostic factors in soft tissue sarcoma: VEGFR-3 is an independent predictor of poor prognosis
    Thomas K Kilvaer
    Institute of Medical Biology, University of Tromso, and Department of Clinical Pathology, University Hospital of North Norway, Tromso, Norway
    PLoS ONE 5:e15368. 2010
    ..This study investigates the prognostic impact of VEGFs and VEGFRs in non-GIST STS with wide and non-wide resection margins...
  40. doi Lymphangiogenic Markers and Their Impact on Nodal Metastasis and Survival in Non-Small Cell Lung Cancer--A Structured Review with Meta-Analysis
    Thomas K Kilvaer
    Department of Oncology, University Hospital of North Norway, Tromso, Norway Institute of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway
    PLoS ONE 10:e0132481. 2015
    ..However, study results differ. In this structured review and meta-analysis we explore the published literature on commonly recognized pathways for molecular regulation of lymphatic metastasis in NSCLC...
  41. doi Cancer Associated Fibroblasts in Stage I-IIIA NSCLC: Prognostic Impact and Their Correlations with Tumor Molecular Markers
    Thomas K Kilvaer
    Department of Oncology, University Hospital of North Norway, Tromso, Norway Institute of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway
    PLoS ONE 10:e0134965. 2015
    ..This study investigates the prognostic impact of FAP-1 and α-SMA in non-small cell lung cancer (NSCLC) patients and correlates their expression to 105 proteins investigated in the same cohort...
  42. pmc Stage and tissue-specific prognostic impact of miR-182 in NSCLC
    Helge Stenvold
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    BMC Cancer 14:138. 2014
    ..We aimed to explore what impact miR-182 has in non-small cell lung cancer (NSCLC), and more explicitly its correlation with angiogenic markers...
  43. pmc Disease-specific outcomes of radical prostatectomies in Northern Norway; a case for the impact of perineural infiltration and postoperative PSA-doubling time
    Sigve Andersen
    Institute of Clinical Medicine, The Arctic University of Norway, Tromso, Norway
    BMC Urol 14:49. 2014
    ....
  44. pmc Platelet-Derived Growth Factors in Non-GIST Soft-Tissue Sarcomas Identify a Subgroup of Patients with Wide Resection Margins and Poor Disease-Specific Survival
    Thomas Karsten Kilvaer
    Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    Sarcoma 2010:751304. 2010
    ..015) were independent negative prognostic markers for disease-specific survival. Conclusion. PDGF-B and the coexpression of PDGF-B and PDGFR-α are strong and independent prognostic factors in non-GIST STSs with wide resection margins...
  45. pmc Vessel co-option in primary human tumors and metastases: an obstacle to effective anti-angiogenic treatment?
    Tom Donnem
    Department of Oncology, University Hospital of North Norway Tromso, Norway Institute of Clinical Medicine, University of Tromso Tromso, Norway
    Cancer Med 2:427-36. 2013
    ..In this review we discuss tumor vessel co-option with specific examples of vessel co-option in primary and secondary tumors and a consideration of the clinical implications of this alternative tumor blood supply...