Tom Donnem

Summary

Publications

  1. doi Diverging prognostic impacts of hypoxic markers according to NSCLC histology
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Norway
    Lung Cancer 72:294-302. 2011
  2. pmc Prognostic impacts of angiopoietins in NSCLC tumor cells and stroma: VEGF-A impact is strongly associated with Ang-2
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    PLoS ONE 6:e19773. 2011
  3. pmc The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas
    Andrej Valkov
    Dept of Clinical Pathology, University Hospital of Northern Norway, Tromsø, Norway
    J Transl Med 9:200. 2011
  4. doi Bridging the distance: a prospective tele-oncology study in Northern Norway
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso, Norway
    Support Care Cancer 20:2097-103. 2012
  5. pmc MicroRNA signatures in tumor tissue related to angiogenesis in non-small cell lung cancer
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromsφ, Norway
    PLoS ONE 7:e29671. 2012
  6. pmc Prognostic impact of MiR-155 in non-small cell lung cancer evaluated by in situ hybridization
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso, Norway
    J Transl Med 9:6. 2011
  7. doi Prognostic impact of angiogenic markers in non-small-cell lung cancer is related to tumor size
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso
    Clin Lung Cancer 12:106-15. 2011
  8. doi Prognostic impact of fibroblast growth factor 2 in non-small cell lung cancer: coexpression with VEGFR-3 and PDGF-B predicts poor survival
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, Norway
    J Thorac Oncol 4:578-85. 2009
  9. doi Co-expression of PDGF-B and VEGFR-3 strongly correlates with lymph node metastasis and poor survival in non-small-cell lung cancer
    T Donnem
    Department of Oncology, Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    Ann Oncol 21:223-31. 2010
  10. doi Independent and tissue-specific prognostic impact of miR-126 in nonsmall cell lung cancer: coexpression with vascular endothelial growth factor-A predicts poor survival
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso, Norway
    Cancer 117:3193-200. 2011

Detail Information

Publications31

  1. doi Diverging prognostic impacts of hypoxic markers according to NSCLC histology
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Norway
    Lung Cancer 72:294-302. 2011
    ....
  2. pmc Prognostic impacts of angiopoietins in NSCLC tumor cells and stroma: VEGF-A impact is strongly associated with Ang-2
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    PLoS ONE 6:e19773. 2011
    ..This study evaluates the prognostic impact of all known human angiopoietins (Ang-1, Ang-2 and Ang-4) and their receptor Tie-2, as well as their relation to the prognostic expression of VEGF-A...
  3. pmc The prognostic impact of Akt isoforms, PI3K and PTEN related to female steroid hormone receptors in soft tissue sarcomas
    Andrej Valkov
    Dept of Clinical Pathology, University Hospital of Northern Norway, Tromsø, Norway
    J Transl Med 9:200. 2011
    ....
  4. doi Bridging the distance: a prospective tele-oncology study in Northern Norway
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso, Norway
    Support Care Cancer 20:2097-103. 2012
    ..In this study, we aimed to evaluate the feasibility of these VCs...
  5. pmc MicroRNA signatures in tumor tissue related to angiogenesis in non-small cell lung cancer
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromsφ, Norway
    PLoS ONE 7:e29671. 2012
    ..MicroRNAs (miRs) are small non-coding, endogenous, single stranded RNAs that regulate gene expression. In this study we aimed to identify significantly altered miRs related to angiogenesis in NSCLC...
  6. pmc Prognostic impact of MiR-155 in non-small cell lung cancer evaluated by in situ hybridization
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso, Norway
    J Transl Med 9:6. 2011
    ..MiR-155 is one of the miRNAs most consistently involved in various neoplastic diseases. We aimed to investigate the prognostic impact of the multifunctional miR-155 in non-small cell lung cancer (NSCLC) patients...
  7. doi Prognostic impact of angiogenic markers in non-small-cell lung cancer is related to tumor size
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso
    Clin Lung Cancer 12:106-15. 2011
    ....
  8. doi Prognostic impact of fibroblast growth factor 2 in non-small cell lung cancer: coexpression with VEGFR-3 and PDGF-B predicts poor survival
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, Norway
    J Thorac Oncol 4:578-85. 2009
    ..This study investigates the prognostic impact of FGF2 and FGFR-1 in tumor cells and tumor stroma of resected non-small cell lung carcinomas (NSCLC) and explores the importance of their coexpression with VEGFR-3 or PDGF-B...
  9. doi Co-expression of PDGF-B and VEGFR-3 strongly correlates with lymph node metastasis and poor survival in non-small-cell lung cancer
    T Donnem
    Department of Oncology, Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    Ann Oncol 21:223-31. 2010
    ..We aimed to study the PDGFs/PDGFRs and correlations with lymph node metastasis (LNM) and investigate the prognostic impact of the co-expression of PDGF-B and VEGFR-3 and its correlation with LNM...
  10. doi Independent and tissue-specific prognostic impact of miR-126 in nonsmall cell lung cancer: coexpression with vascular endothelial growth factor-A predicts poor survival
    Tom Donnem
    Department of Oncology, University Hospital of North Norway, Tromso, Norway
    Cancer 117:3193-200. 2011
    ..miR-126 has been related to tumor angiogenesis and in the regulation of VEGF-A. The authors aimed to investigate the prognostic impact of miR-126 and its co-expression with VEGF-A in nonsmall cell lung cancer (NSCLC) patients...
  11. doi Combination of low vascular endothelial growth factor A (VEGF-A)/VEGF receptor 2 expression and high lymphocyte infiltration is a strong and independent favorable prognostic factor in patients with nonsmall cell lung cancer
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    Cancer 116:4318-25. 2010
    ..The authors of this report investigated the prognostic role of angiogenic markers in coexpression with immune system markers in patients with nonsmall cell lung cancer (NSCLC)...
  12. doi Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer: coexpression of Notch-1 and vascular endothelial growth factor-A predicts poor survival
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    Cancer 116:5676-85. 2010
    ..The authors aimed to study the prognostic role of the angiogenesis-related Notch ligands and receptors and investigate the prognostic impact of the coexpression of vascular endothelial growth factor-A (VEGF-A) and Notch signaling...
  13. doi Prognostic impact of platelet-derived growth factors in non-small cell lung cancer tumor and stromal cells
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, Norway
    J Thorac Oncol 3:963-70. 2008
    ..This study investigates the prognostic impact of these molecular markers in tumor cells and tumor stroma of resected non-small cell lung cancer (NSCLC) tumors...
  14. doi VEGF-A and VEGFR-3 correlate with nodal status in operable non-small cell lung cancer: inverse correlation between expression in tumor and stromal cells
    Tom Donnem
    Department of Oncology, Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    Lung Cancer 63:277-83. 2009
    ..We aimed to explore the correlations between nodal metastasis and the expression of VEGFs and VEGFRs in tumor cells and in tumor-related stroma...
  15. pmc Fibroblast growth factor 2 orchestrates angiogenic networking in non-GIST STS patients
    Thomas K Kilvaer
    Institute of Medical Biology, University of Tromso, PB 9037, Tromso, Norway
    J Transl Med 9:104. 2011
    ..This study investigates the prognostic impact of FGF2 and FGFR-1 and explores the impact of their co-expression with PDGF-B and VEGFR-3 in widely resected tumors from non-GIST STS patients...
  16. ncbi Correlation and coexpression of HIFs and NOTCH markers in NSCLC
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Norway
    Anticancer Res 31:1603-6. 2011
    ..NOTCH and hypoxia pathways are both known to be highly involved in cancer. Because of the close interplay between both of these pathways, we investigated correlation and co-expression of molecules in these pathways...
  17. doi Angiogenic markers show high prognostic impact on survival in marginally operable non-small cell lung cancer patients treated with adjuvant radiotherapy
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    J Thorac Oncol 4:463-71. 2009
    ..Both expression and its prognostic impact may be associated with patient selection. Data addressing the prognostic relevance of angiogenic marker expression in NSCLC patients treated with postoperative radiotherapy (PORT) is warranted...
  18. doi Clinical significance of epidermal growth factor receptors in non-small cell lung cancer and a prognostic role for HER2 gene copy number in female patients
    Samer Al-Saad
    Institute of Medical Biology, Faculty of Health Sciences, University of Tromso, Norway
    J Thorac Oncol 5:1536-43. 2010
    ....
  19. ncbi In NSCLC, VEGF-A response to hypoxia may differ between squamous cell and adenocarcinoma histology
    Marte Eilertsen
    Department of Clinical Medicine, University of Tromso, Norway
    Anticancer Res 32:4729-36. 2012
    ..To investigate if hypoxia induces vascular endothelial growth factor (VEGF)-A and VEGF-C secretion in non-small cell lung cancer (NSCLC) cells and if the secretion is cell type-dependent...
  20. pmc Prognostic impact of Jab1, p16, p21, p62, Ki67 and Skp2 in soft tissue sarcomas
    Sveinung W Sorbye
    Department of Clinical Pathology, University Hospital of North Norway, Tromso, Norway
    PLoS ONE 7:e47068. 2012
    ..Optimised treatment of STS requires better identification of high risk patients who will benefit from adjuvant therapy. The prognostic significance of Jab1, p16, p21, p62, Ki67 and Skp2 in STS has not been sufficiently investigated...
  21. doi Overexpression of matrix metalloproteinase-7 and -9 in NSCLC tumor and stromal cells: correlation with a favorable clinical outcome
    Helge Stenvold
    Institute of Clinical Medicine, University of Tromso, Norway
    Lung Cancer 75:235-41. 2012
    ..As both malignant cells and cells of the surrounding stroma contribute to tumor growth, we have explored the impact of MMP-2, -7 and -9 expression in both the tumor and stromal compartment of non-small-cell lung cancers (NSCLC)...
  22. pmc Overexpression of the HIF hydroxylases PHD1, PHD2, PHD3 and FIH are individually and collectively unfavorable prognosticators for NSCLC survival
    Sigve Andersen
    Institute of Clinical Medicine, University of Tromso, Tromso, Norway
    PLoS ONE 6:e23847. 2011
    ..HIFs are regulated by four hydroxylases; Prolyl hydroxylase (PHD)-1,-2,-3 and factor inhibiting HIF (FIH). We aimed to investigate the prognostic impact of these oxygen sensors in NSCLC...
  23. ncbi Diverse prognostic roles of Akt isoforms, PTEN and PI3K in tumor epithelial cells and stromal compartment in non-small cell lung cancer
    Samer Al-Saad
    Institute of Medical Biology, University of Tromso, Norway
    Anticancer Res 29:4175-83. 2009
    ..By tissue microarray methodology, the expression of altered Akt isoforms, PTEN and PI3K and their prognostic significance in 335 non-small cell lung cancer (NSCLC) tumors were investigated...
  24. pmc Prognostic impact of lymphocytes in soft tissue sarcomas
    Sveinung W Sorbye
    Department of Clinical Pathology, University Hospital of North Norway, Tromso, Norway
    PLoS ONE 6:e14611. 2011
    ..The immune status at the time of resection may be important, but the prognostic significance of tumor infiltrating lymphocytes is controversial as the immune system has conflicting roles during cancer development...
  25. doi The role of tumor-infiltrating immune cells and chronic inflammation at the tumor site on cancer development, progression, and prognosis: emphasis on non-small cell lung cancer
    Roy M Bremnes
    Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway
    J Thorac Oncol 6:824-33. 2011
    ..This review reports on the tumor stroma and in particular tumor-suppressing and -promoting roles of the immune system. Furthermore, it presents recent literature on relevant immune cell-related research in NSCLC...
  26. pmc Prognostic impact of CD57, CD68, M-CSF, CSF-1R, Ki67 and TGF-beta in soft tissue sarcomas
    Sveinung W Sorbye
    Dept of Clinical Pathology, University Hospital of North Norway, Tromso, 9038, Norway
    BMC Clin Pathol 12:7. 2012
    ..abstract:..
  27. pmc Prognostic impact of Skp2, ER and PGR in male and female patients with soft tissue sarcomas
    Sveinung W Sorbye
    Department of Clinical Pathology, University Hospital of North Norway, Tromso, Norway
    BMC Clin Pathol 13:9. 2013
    ..Optimized treatment of STS requires better identification of high-risk patients who will benefit from adjuvant therapy. The prognostic significance of Skp2 related to ER and PGR in STS has not been sufficiently investigated...
  28. pmc Prognostic impact of peritumoral lymphocyte infiltration in soft tissue sarcomas
    Sveinung W Sorbye
    Dept of Clinical Pathology, University Hospital of North Norway, 9038 Tromso, Norway
    BMC Clin Pathol 12:5. 2012
    ..abstract:..
  29. pmc Prognostic impacts of hypoxic markers in soft tissue sarcoma
    Eivind Smeland
    Institute of Clinical Medicine, University of Tromso, 9037 Tromso, Norway
    Sarcoma 2012:541650. 2012
    ..7, CI 95% 1.1-2.7, P = 0.021) was a significant independent prognostic indicator of poor DSS. Conclusion. GLUT-1 is a significant independent negative prognostic factor in non-GIST STS...
  30. ncbi Inverse prognostic impact of angiogenic marker expression in tumor cells versus stromal cells in non small cell lung cancer
    Tom Donnem
    Institute of Clinical Medicine, University of Tromso, University Hospital of Northern Norway, Tromso, Norway
    Clin Cancer Res 13:6649-57. 2007
    ..This study elucidates the prognostic significance of these molecular markers in tumor cells as well as in the tumor stroma of resected non-small cell lung cancer tumors...
  31. pmc Profiling of VEGFs and VEGFRs as prognostic factors in soft tissue sarcoma: VEGFR-3 is an independent predictor of poor prognosis
    Thomas K Kilvaer
    Institute of Medical Biology, University of Tromso, and Department of Clinical Pathology, University Hospital of North Norway, Tromso, Norway
    PLoS ONE 5:e15368. 2010
    ..This study investigates the prognostic impact of VEGFs and VEGFRs in non-GIST STS with wide and non-wide resection margins...