Nianguo Dong



  1. Dai J, Qiao W, Shi J, Liu C, Hu X, Dong N. Modifying decellularized aortic valve scaffolds with stromal cell-derived factor-1α loaded proteolytically degradable hydrogel for recellularization and remodeling. Acta Biomater. 2019;88:280-292 pubmed publisher
    ..This suggests that the extracellular matrix-based valve scaffolds have potential for clinical applications. ..
  2. Su W, Wang R, Lohano M, Wang L, Zhu P, Luo Y, et al. Identification of Two Mutations in PCDHGA4 and SLFN14 Genes in an Atrial Septal Defect Family. Curr Med Sci. 2018;38:989-996 pubmed publisher
    ..In conclusion, the mutations of c.1187delT of PCDHGA4 and c.2557insC of SLFN14 may be pathogenic factors contributing to the development of ASD. ..
  3. Nie X, Fan J, Li H, Yin Z, Zhao Y, Dai B, et al. miR-217 Promotes Cardiac Hypertrophy and Dysfunction by Targeting PTEN. Mol Ther Nucleic Acids. 2018;12:254-266 pubmed publisher
    ..All of these findings show that miR-217 participates in cardiac hypertrophy and cardiac fibrosis processes through regulating PTEN, which suggests a promising therapeutic target for CHF. ..
  4. Bai P, Wang Y, Chen S, Liu J, Dong N, Liu J. Application of Endoscopic Vein Harvesting in Obese Patients Undergoing Coronary Artery Bypass Grafting. Curr Med Sci. 2018;38:691-696 pubmed publisher
    ..EVH can reduce the risk of wound complications, whereas does not influence short- and medium-term outcomes in obese patients. It can be considered a reliable procedure of harvesting vessel conduits for obese patients undergoing CABG. ..
  5. Deng C, Dong N, Shi J, Chen S, Xu L, Shi F, et al. Application of decellularized scaffold combined with loaded nanoparticles for heart valve tissue engineering in vitro. J Huazhong Univ Sci Technolog Med Sci. 2011;31:88-93 pubmed publisher
    ..Altogether this study proved that it was feasible to fabricate the hybrid scaffold and effective to improve extracellular matrix microenvironment, which is beneficial for an application in heart valve tissue engineering. ..
  6. Xu K, Al Ani M, Wang C, Qiu X, Chi Q, Zhu P, et al. Emodin as a selective proliferative inhibitor of vascular smooth muscle cells versus endothelial cells suppress arterial intima formation. Life Sci. 2018;207:9-14 pubmed publisher
    ..It is concluded that emodin will provide a promising approach for efficient prevention of blood vessel restenosis. ..
  7. Liu F, Chu C, Wei Q, Shi J, Li H, Dong N. Metformin ameliorates TGF-?1-induced osteoblastic differentiation of human aortic valve interstitial cells by inhibiting ?-catenin signaling. Biochem Biophys Res Commun. 2018;500:710-716 pubmed publisher
    ..In conclusion, our results suggest a beneficial effect of metformin based on the prevention of osteoblastic differentiation of human AVICs via inhibition of ?-catenin, which indicates the therapeutic potential of metformin for CAVD. ..
  8. Wang Y, Shi J, Li F, Wang Y, Dong N. Aortic valve replacement for severe aortic regurgitation in asymptomatic patients with normal ejection fraction and severe left ventricular dilatation. Interact Cardiovasc Thorac Surg. 2016;22:425-30 pubmed publisher
    ..It is observed that 50% ≤ LVEF < 55% or LVEDD ≥ 81 mm are associated with poorer prognosis in patients undergoing AVR. ..
  9. Wang B, Li F, Zhang C, Wei G, Liao P, Dong N. High-mobility group box-1 protein induces osteogenic phenotype changes in aortic valve interstitial cells. J Thorac Cardiovasc Surg. 2016;151:255-62 pubmed publisher
    ..The HMGB1 protein may promote osteoblastic differentiation and calcification of VICs, through the TLR4-JNK-NF-κB signaling pathway. ..

More Information


  1. Wang Y, Chen S, Shi J, Li G, Dong N. Mid- to long-term outcome comparison of the Medtronic Hancock II and bi-leaflet mechanical aortic valve replacement in patients younger than 60 years of age: a propensity-matched analysis. Interact Cardiovasc Thorac Surg. 2016;22:280-6 pubmed publisher
    ..These findings suggest that a bioprosthetic valve may be a reasonable choice for AVR in patients younger than 60 years of age. ..
  2. Sun F, Shi J, Chen S, Deng C, Hu X, Li H, et al. Lazaroid U-74389G inhibits the osteoblastic differentiation of IL-1β-indcued aortic valve interstitial cells through glucocorticoid receptor and inhibition of NF-κB pathway. J Steroid Biochem Mol Biol. 2015;152:114-23 pubmed publisher
  3. Wang B, Cai Z, Liu B, Liu Z, Zhou X, Dong N, et al. RAGE deficiency alleviates aortic valve calcification in ApoE-/- mice via the inhibition of endoplasmic reticulum stress. Biochim Biophys Acta Mol Basis Dis. 2017;1863:781-792 pubmed publisher
    ..HMGB1 induces AVIC osteoblastic differentiation and calcification through RAGE/ER stress/Sox9 pathway. ..
  4. Gu Z, Pan Y, Qiao A, Hu X, Dong N, Li X, et al. Numerical simulation of closure performance for neo-aortic valve for arterial switch operation. Biomed Eng Online. 2016;15:150 pubmed publisher
    ..It is evident that enlarging or narrowing the sinotubular junction within a range of 20% can increase or decrease the maximum stress and aortic valve cusps contact force of neo-aortic valve. ..
  5. Alshirbini M, Xie F, Dong N, Chen S, Borham E. Patients 60 years of age and older should have the same chance for heart transplantation or not?. J Huazhong Univ Sci Technolog Med Sci. 2017;37:57-62 pubmed publisher
    ..48). According to our experience among older heart transplant candidates who were 60 years and older, we believe that advanced age should not be an excluding criterion to cardiac transplantation. ..
  6. Li G, Qiao W, Zhang W, Li F, Shi J, Dong N. The shift of macrophages toward M1 phenotype promotes aortic valvular calcification. J Thorac Cardiovasc Surg. 2017;153:1318-1327.e1 pubmed publisher
    ..Both total numbers and polarization of macrophage influence the process of calcification in human aortic valve. The shift toward M1 phenotype might promote valve interstitial cell calcification. ..
  7. Shi H, Zhang C, Pasupuleti V, Hu X, Prosdocimo D, Wu W, et al. CCN3 Regulates Macrophage Foam Cell Formation and Atherosclerosis. Am J Pathol. 2017;187:1230-1237 pubmed publisher
    ..These results suggest that bone marrow-derived CCN3 is an essential regulator of atherosclerosis and point to a novel role of CCN3 in modulating lipid accumulation within macrophages. ..