Dai J, Qiao W, Shi J, Liu C, Hu X, Dong N. Modifying decellularized aortic valve scaffolds with stromal cell-derived factor-1α loaded proteolytically degradable hydrogel for recellularization and remodeling. Acta Biomater. 2019;88:280-292 pubmed publisher
..This suggests that the extracellular matrix-based valve scaffolds have potential for clinical applications. ..
Su W, Wang R, Lohano M, Wang L, Zhu P, Luo Y, et al
. Identification of Two Mutations in PCDHGA4 and SLFN14 Genes in an Atrial Septal Defect Family. Curr Med Sci. 2018;38:989-996 pubmed publisher
..In conclusion, the mutations of c.1187delT of PCDHGA4 and c.2557insC of SLFN14 may be pathogenic factors contributing to the development of ASD. ..
Nie X, Fan J, Li H, Yin Z, Zhao Y, Dai B, et al
. miR-217 Promotes Cardiac Hypertrophy and Dysfunction by Targeting PTEN. Mol Ther Nucleic Acids. 2018;12:254-266 pubmed publisher
..All of these findings show that miR-217 participates in cardiac hypertrophy and cardiac fibrosis processes through regulating PTEN, which suggests a promising therapeutic target for CHF. ..
Bai P, Wang Y, Chen S, Liu J, Dong N, Liu J. Application of Endoscopic Vein Harvesting in Obese Patients Undergoing Coronary Artery Bypass Grafting. Curr Med Sci. 2018;38:691-696 pubmed publisher
..EVH can reduce the risk of wound complications, whereas does not influence short- and medium-term outcomes in obese patients. It can be considered a reliable procedure of harvesting vessel conduits for obese patients undergoing CABG. ..
Deng C, Dong N, Shi J, Chen S, Xu L, Shi F, et al
. Application of decellularized scaffold combined with loaded nanoparticles for heart valve tissue engineering in vitro. J Huazhong Univ Sci Technolog Med Sci. 2011;31:88-93 pubmed publisher
..Altogether this study proved that it was feasible to fabricate the hybrid scaffold and effective to improve extracellular matrix microenvironment, which is beneficial for an application in heart valve tissue engineering. ..
Xu K, Al Ani M, Wang C, Qiu X, Chi Q, Zhu P, et al
. Emodin as a selective proliferative inhibitor of vascular smooth muscle cells versus endothelial cells suppress arterial intima formation. Life Sci. 2018;207:9-14 pubmed publisher
..It is concluded that emodin will provide a promising approach for efficient prevention of blood vessel restenosis. ..
Liu F, Chu C, Wei Q, Shi J, Li H, Dong N. Metformin ameliorates TGF-?1-induced osteoblastic differentiation of human aortic valve interstitial cells by inhibiting ?-catenin signaling. Biochem Biophys Res Commun. 2018;500:710-716 pubmed publisher
..In conclusion, our results suggest a beneficial effect of metformin based on the prevention of osteoblastic differentiation of human AVICs via inhibition of ?-catenin, which indicates the therapeutic potential of metformin for CAVD. ..
Wang Y, Shi J, Li F, Wang Y, Dong N. Aortic valve replacement for severe aortic regurgitation in asymptomatic patients with normal ejection fraction and severe left ventricular dilatation. Interact Cardiovasc Thorac Surg. 2016;22:425-30 pubmed publisher
..It is observed that 50% â‰¤ LVEF < 55% or LVEDD â‰¥ 81 mm are associated with poorer prognosis in patients undergoing AVR. ..
Wang B, Li F, Zhang C, Wei G, Liao P, Dong N. High-mobility group box-1 protein induces osteogenic phenotype changes in aortic valve interstitial cells. J Thorac Cardiovasc Surg. 2016;151:255-62 pubmed publisher
..The HMGB1 protein may promote osteoblastic differentiation and calcification of VICs, through the TLR4-JNK-NF-ÎºB signaling pathway. ..