P Domingo

Summary

Publications

  1. ncbi request reprint Disseminated cryptococcosis resembling milliary tuberculosis in an HIV-1-infected patient
    Virginia Pomar
    Infectious Diseases Unit, Internal Medicine Department, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, St Antoni Maria Claret 167, Barcelona 08025, Catalonia, Spain
    Lancet Infect Dis 5:189. 2005
  2. doi request reprint Effectiveness and safety of didanosine, lamivudine and efavirenz versus zidovudine, lamivudine and efavirenz for the initial treatment of HIV-infected patients from the Spanish VACH cohort
    Manuel Crespo
    Hospital Universitari Vall d Hebron, Barcelona, Spain
    J Antimicrob Chemother 63:189-96. 2009
  3. doi request reprint [Role of etravirine in combination antiretroviral therapy]
    Pere Domingo
    Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Espana
    Enferm Infecc Microbiol Clin 27:46-51. 2009
  4. doi request reprint Drug safety profile of integrase strand transfer inhibitors
    María del Mar Gutierrez
    Universitat Autonoma de Barcelona, Hospital de la Santa Creu i Sant Pau, Infectious Diseases Unit, Av Sant Antoni Ma Claret, 167, 08025 Barcelona, Spain 34935565624 34935565938
    Expert Opin Drug Saf 13:431-45. 2014
  5. pmc Association of thymidylate synthase polymorphisms with acute pancreatitis and/or peripheral neuropathy in HIV-infected patients on stavudine-based therapy
    Pere Domingo
    Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    PLoS ONE 8:e57347. 2013
  6. pmc The spectrum of acute bacterial meningitis in elderly patients
    Pere Domingo
    Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Av, Sant Antoni Mª Claret, 167, Barcelona 08025, Spain
    BMC Infect Dis 13:108. 2013
  7. doi request reprint The changing pattern of bacterial meningitis in adult patients at a large tertiary university hospital in Barcelona, Spain (1982-2010)
    Pere Domingo
    Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Av Sant Antoni M a Claret 167, 08025 Barcelona, Spain
    J Infect 66:147-54. 2013
  8. ncbi request reprint Fat redistribution syndromes associated with HIV-1 infection and combination antiretroviral therapy
    Pere Domingo
    Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    AIDS Rev 14:112-23. 2012
  9. doi request reprint Drug safety evaluation profile of stavudine plus lamivudine for HIV-1/AIDS infection
    Maria Gracia Mateo
    Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Univeristat Autònoma de Barcelona, Av Sant Antoni Mª Claret, 167, 08025 Barcelona, Spain
    Expert Opin Drug Saf 11:473-85. 2012
  10. pmc Effect of TNF-alpha genetic variants and CCR5 Delta 32 on the vulnerability to HIV-1 infection and disease progression in Caucasian Spaniards
    Sergi Veloso
    Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain
    BMC Med Genet 11:63. 2010

Detail Information

Publications76

  1. ncbi request reprint Disseminated cryptococcosis resembling milliary tuberculosis in an HIV-1-infected patient
    Virginia Pomar
    Infectious Diseases Unit, Internal Medicine Department, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, St Antoni Maria Claret 167, Barcelona 08025, Catalonia, Spain
    Lancet Infect Dis 5:189. 2005
  2. doi request reprint Effectiveness and safety of didanosine, lamivudine and efavirenz versus zidovudine, lamivudine and efavirenz for the initial treatment of HIV-infected patients from the Spanish VACH cohort
    Manuel Crespo
    Hospital Universitari Vall d Hebron, Barcelona, Spain
    J Antimicrob Chemother 63:189-96. 2009
    ..In an observational study, we analyse the efficacy and tolerability of didanosine plus lamivudine and efavirenz versus zidovudine plus lamivudine and efavirenz in a cohort of therapy naive patients...
  3. doi request reprint [Role of etravirine in combination antiretroviral therapy]
    Pere Domingo
    Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Espana
    Enferm Infecc Microbiol Clin 27:46-51. 2009
    ..However, the characteristics of this drug suggest that it may be useful in a series of potential indications, due to its antiviral potency, differential resistance profile, safety, tolerability and drug-drug interaction profile...
  4. doi request reprint Drug safety profile of integrase strand transfer inhibitors
    María del Mar Gutierrez
    Universitat Autonoma de Barcelona, Hospital de la Santa Creu i Sant Pau, Infectious Diseases Unit, Av Sant Antoni Ma Claret, 167, 08025 Barcelona, Spain 34935565624 34935565938
    Expert Opin Drug Saf 13:431-45. 2014
    ..INSTIs intrinsic potency, together with an outstanding safety profile, preludes an important role for these drugs to build up highly active antiretroviral treatment (HAART) in the near future. ..
  5. pmc Association of thymidylate synthase polymorphisms with acute pancreatitis and/or peripheral neuropathy in HIV-infected patients on stavudine-based therapy
    Pere Domingo
    Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    PLoS ONE 8:e57347. 2013
    ..The use of d4T has been associated with acute pancreatitis and peripheral neuropathy. However, no relationship has ever been proved between TS polymorphisms and pancreatitis and/or peripheral neuropathy...
  6. pmc The spectrum of acute bacterial meningitis in elderly patients
    Pere Domingo
    Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Av, Sant Antoni Mª Claret, 167, Barcelona 08025, Spain
    BMC Infect Dis 13:108. 2013
    ..We conducted a prospective, observational study in Barcelona to determine the epidemiology, clinical features, and outcome of elderly patients with acute bacterial meningitis (ABM) compared with younger adults...
  7. doi request reprint The changing pattern of bacterial meningitis in adult patients at a large tertiary university hospital in Barcelona, Spain (1982-2010)
    Pere Domingo
    Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Av Sant Antoni M a Claret 167, 08025 Barcelona, Spain
    J Infect 66:147-54. 2013
    ..We conducted a prospective, observational study in Barcelona (Spain) to determine changes in the spectrum of adult patients with bacterial meningitis (BM) over a 29-year period...
  8. ncbi request reprint Fat redistribution syndromes associated with HIV-1 infection and combination antiretroviral therapy
    Pere Domingo
    Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    AIDS Rev 14:112-23. 2012
    ..In the context of HIV-1-infected patients under long-term antiretroviral therapy, fat toxicity is still the dark side of the rainbow...
  9. doi request reprint Drug safety evaluation profile of stavudine plus lamivudine for HIV-1/AIDS infection
    Maria Gracia Mateo
    Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Univeristat Autònoma de Barcelona, Av Sant Antoni Mª Claret, 167, 08025 Barcelona, Spain
    Expert Opin Drug Saf 11:473-85. 2012
    ..This review is intended to assess the benefits and risks in terms of safety of d4T + 3TC-based combination antiretroviral therapy (ART) for the treatment of HIV-1 infection...
  10. pmc Effect of TNF-alpha genetic variants and CCR5 Delta 32 on the vulnerability to HIV-1 infection and disease progression in Caucasian Spaniards
    Sergi Veloso
    Hospital Universitari de Tarragona Joan XXIII, Tarragona, Spain
    BMC Med Genet 11:63. 2010
    ..Tumor necrosis factor alpha (TNF-alpha) is thought to be involved in the various immunogenetic events that influence HIV-1 infection...
  11. doi request reprint [Management of antiretroviral drug toxicity]
    Pere Domingo
    Unidad de Enfermedades Infecciosas, Hospital de la Santa Creu i Sant Pau, Barcelona, Espana
    Enferm Infecc Microbiol Clin 29:535-44. 2011
    ....
  12. pmc Uridine metabolism in HIV-1-infected patients: effect of infection, of antiretroviral therapy and of HIV-1/ART-associated lipodystrophy syndrome
    Pere Domingo
    Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    PLoS ONE 5:e13896. 2010
    ..Uridine has been advocated for the treatment of HIV-1/HAART-associated lipodystrophy (HALS), although its metabolism in HIV-1-infected patients is poorly understood...
  13. ncbi request reprint Combination antiretroviral therapy
    Pere Domingo
    Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Av Sant Antoni Ma Claret 167, 08025 Barcelona, Spain 34 935 565 624 34 935 565 938
    Expert Opin Pharmacother 12:995-8. 2011
    ..Currently, the greatest challenge is to make cART available to everybody who needs it with the future prospects of HIV-1 eradication...
  14. doi request reprint Relationship between HIV/Highly active antiretroviral therapy (HAART)-associated lipodystrophy syndrome and stavudine-triphosphate intracellular levels in patients with stavudine-based antiretroviral regimens
    Pere Domingo
    Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain
    Clin Infect Dis 50:1033-40. 2010
    ..However, to our knowledge, no relationship has been proven between intracellular levels of stavudine (d4T) and HALS...
  15. doi request reprint [Assessment and management of kidney disease in the HIV-1-infected patient. A practical review]
    Pere Domingo
    Unidad de Enfermedades Infecciosas, Hospital de la Santa Creu i Sant Pau, Barcelona, Espana
    Enferm Infecc Microbiol Clin 28:185-98. 2010
    ..As a practical contribution to the management of HIV-1-associated renal dysfunction, guidelines are proposed for assessing the most common kidney-related problems and their management in daily practice...
  16. ncbi request reprint Switching to nevirapine decreases insulin levels but does not improve subcutaneous adipocyte apoptosis in patients with highly active antiretroviral therapy-associated lipodystrophy
    P Domingo
    Department of Internal Medicine, Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Avgda Sant Antoni M Claret, 167, 08025 Barcelona, Spain
    J Infect Dis 184:1197-201. 2001
    ....
  17. ncbi request reprint Prognostic factors in meningococcal disease. Development of a bedside predictive model and scoring system. Barcelona Meningococcal Disease Surveillance Group
    N Barquet
    CAP Gràcia, Institut Catala de la Salut, Barcelona, Spain
    JAMA 278:491-6. 1997
    ..Meningococcal disease is associated with significant morbidity and mortality. Development of a prognostic model based on clinical findings may be useful for identification and management of patients with meningococcal infection...
  18. ncbi request reprint Subcutaneous adipocyte apoptosis in HIV-1 protease inhibitor-associated lipodystrophy
    P Domingo
    Department of Internal Medicine, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Spain
    AIDS 13:2261-7. 1999
    ..The pathogenic mechanisms underlying HIV-1 protease inhibitor-associated lipodystrophy are still largely unknown...
  19. doi request reprint Lipid profiles for nevirapine vs. atazanavir/ritonavir, both combined with tenofovir disoproxil fumarate and emtricitabine over 48 weeks, in treatment-naïve HIV-1-infected patients (the ARTEN study)
    Daniel Podzamczer
    Infectious Disease Service, Hospital Universitario de Bellvitge, Barcelona, Spain
    HIV Med 12:374-82. 2011
    ..Lipid profiles and CR from baseline to week 48 are reported...
  20. doi request reprint Improvement of mitochondrial toxicity in patients receiving a nucleoside reverse-transcriptase inhibitor-sparing strategy: results from the Multicenter Study with Nevirapine and Kaletra (MULTINEKA)
    Eugenia Negredo
    Lluita contra la SIDA Foundation, Barcelona, Spain
    Clin Infect Dis 49:892-900. 2009
    ..This study aimed to evaluate in vivo the effects of NRTI withdrawal on mitochondrial parameters and body fat distribution...
  21. doi request reprint Targeting only reverse transcriptase with zidovudine/lamivudine/abacavir plus tenofovir in HIV-1-infected patients with multidrug-resistant virus: a multicentre pilot study
    J M Llibre
    Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain Departament de Medicina, Universitat Autonoma de Barcelona, Barcelona, Spain corrected
    HIV Med 9:508-13. 2008
    ..To evaluate the safety, immunological outcome and HIV-1 evolution in the reverse transcriptase (RT) in patients with multidrug resistance receiving zidovudine/lamivudine/abacavir (TZV) plus tenofovir (TDF)...
  22. doi request reprint Impact of antiretroviral therapy interruption on plasma biomarkers of cardiovascular risk and lipids: 144-week final data from the STOPAR study
    M Olmo
    Infectious Disease Service, Bellvitge University Hospital, Bellvitge Biomedical Research Institute IDIBELL, Hospitalet de Llobregat, Barcelona, Spain
    HIV Med 13:488-98. 2012
    ..The aim of the study was to investigate changes in plasma biomarkers of cardiovascular risk and lipids in a CD4-guided antiretroviral therapy interruption study...
  23. ncbi request reprint Fat distribution and metabolic abnormalities in HIV-infected patients on first combination antiretroviral therapy including stavudine or zidovudine: role of physical activity as a protective factor
    Pere Domingo
    Department of Internal Medicine Infectious Diseases Unit Biochemistry and Endocrinology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    Antivir Ther 8:223-31. 2003
    ....
  24. doi request reprint Prevalence of HLA-B*5701 in HIV-infected patients in Spain (results of the EPI Study)
    J Arrizabalaga
    Infectious Diseases Unit, H Donostia, San Sebastian, Spain
    HIV Clin Trials 10:48-51. 2009
    ..6% in HIV-infected population. However the prevalence of this allele in HIV-infected patients in Spain has not been established yet...
  25. ncbi request reprint Thrice-weekly sulfadiazine-pyrimethamine for maintenance therapy of toxoplasmic encephalitis in HIV-infected patients. Spanish Toxoplasmosis Study Group
    D Podzamczer
    Infectious Disease Service, Ciutat Sanitaria de Bellvitge, c Feixa Llarga s n L Hospitalet, Barcelona, Spain
    Eur J Clin Microbiol Infect Dis 19:89-95. 2000
    ..Administration of antiretroviral therapy was the only factor associated with a lower incidence of relapse...
  26. ncbi request reprint Drug resistance in patients experiencing early virological failure under a triple combination including indinavir
    O Gallego
    Service of Infectious Diseases, Instituto de Salud Carlos III, Barcelona, Spain
    AIDS 15:1701-6. 2001
    ..Therefore, treatment intensification in those patients without resistance, or a selective substitution of nucleosides in those with resistance limited to these compounds, might be justified...
  27. ncbi request reprint The toxicogenetics of antiretroviral therapy: the evil inside
    Maria del M Gutierrez
    Infectious Diseases Unit, Red de Investigación en SIDA, Hospital de Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Curr Med Chem 18:209-19. 2011
    ..The ultimate goal of pharmacogenetics is to customize antiretroviral therapy by identifying the genes that can maximize efficacy whilst helping avoid known side effects of antiretroviral drugs...
  28. doi request reprint Viral response in stable patients switching to fosamprenavir/ritonavir monotherapy (the FONT Study)
    M Saumoy
    Infectious Disease Service, Bellvitge University Hospital, Sant Pau Hospital and Autonomous University, Barcelona, Spain
    HIV Med 12:438-41. 2011
    ..The aim of the study was to evaluate the efficacy of fosamprenavir/ritonavir (FPV/r) monotherapy in plasma and reservoirs in virologically suppressed patients...
  29. doi request reprint Immune reconstitution in severely immunosuppressed antiretroviral-naive HIV type 1-infected patients using a nonnucleoside reverse transcriptase inhibitor-based or a boosted protease inhibitor-based antiretroviral regimen: three-year results (The Advanz T
    Jose M Miro
    Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    AIDS Res Hum Retroviruses 26:747-57. 2010
    ..At 1 and 3 years, the immune reconstitution induced by an efavirenz-based regimen in very immunosuppressed patients was at least as potent as that induced by a ritonavir-boosted protease inhibitor-based antiretroviral regimen...
  30. doi request reprint Pneumocystis jirovecii pneumonia in Spanish HIV-infected patients in the combined antiretroviral therapy era: prevalence of dihydropteroate synthase mutations and prognostic factors of mortality
    Miriam J Alvarez-Martinez
    Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Diagn Microbiol Infect Dis 62:34-43. 2008
    ..03 and P < 0.001, respectively). The prevalence of DHPS mutants in Spain is low and is not associated with a worse outcome. Severe respiratory failure at admission is the strongest predictor of PCP outcome...
  31. doi request reprint Differences between HIV-infected and uninfected adults in the contributions of smoking, diabetes and hypertension to acute coronary syndrome: two parallel case-control studies
    M Calvo-Sánchez
    Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    HIV Med 14:40-8. 2013
    ..The aim of the study was to assess the separate contributions of smoking, diabetes and hypertension to acute coronary syndrome (ACS) in HIV-infected adults relative to uninfected adults...
  32. ncbi request reprint Herpes zoster as an immune reconstitution disease after initiation of combination antiretroviral therapy in patients with human immunodeficiency virus type-1 infection
    P Domingo
    Department of Internal Medicine, Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, , Barcelona, Spain
    Am J Med 110:605-9. 2001
    ..0002). CONCLUSION: The initiation of combination antiretroviral therapy in HIV-1-infected patients was often associated with the development of herpes zoster, especially in those in whom the number of CD8 cells increased after therapy...
  33. ncbi request reprint Lipodystrophy in HIV 1-infected patients: lessons for obesity research
    F Villarroya
    Department of Biochemistry and Molecular Biology, University of Barcelona and CIBER Fisiopatologia de la Obesidad y Nutrición, Instituto de Salud Carlos III, Barcelona, Spain
    Int J Obes (Lond) 31:1763-76. 2007
    ..However, this also potentially provides an explanation for the existence of systemic alterations common to lipodystrophy and obese patients and reminiscent of the metabolic syndrome...
  34. ncbi request reprint Failure of a short-term prednisone regimen to prevent nevirapine-associated rash: a double-blind placebo-controlled trial: the GESIDA 09/99 study
    H Knobel
    Department of Internal Medicine Infectious Diseases, Hospital del Mar, Barcelona, Spain
    J Acquir Immune Defic Syndr 28:14-8. 2001
    ..The use of prednisone has been controversial in this setting. A double-blind placebo-controlled study was performed to evaluate its efficacy in nevirapine-induced rash prevention...
  35. ncbi request reprint Tumour necrosis factor alpha in fat redistribution syndromes associated with combination antiretroviral therapy in HIV-1-infected patients: potential role in subcutaneous adipocyte apoptosis
    P Domingo
    Department of Internal Medicine Infectious Diseases Unit, Autonomous University of Barcelona, Barcelona, Spain
    Eur J Clin Invest 35:771-80. 2005
    ..A dysregulation of the tumour necrosis factor alpha (TNF-alpha) system occurs in HIV-infected patients with FRS...
  36. doi request reprint Induction therapy with trizivir plus efavirenz or lopinavir/ritonavir followed by trizivir alone in naive HIV-1-infected adults
    Josep Mallolas
    Infectious Diseases Service, Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    AIDS 22:377-84. 2008
    ..Induction-maintenance strategies were associated with a low response rate. We compared the virological response with two different induction regimens with trizivir plus efavirenz or lopinavir/ritonavir...
  37. ncbi request reprint Sustained improvement of dyslipidaemia in HAART-treated patients replacing stavudine with tenofovir
    Josep M Llibre
    Internal Medicine Department, Hospital de Calella, Barcelona, Spain
    AIDS 20:1407-14. 2006
    ..To describe the 12-month evolution of lipid profile in HIV-infected virologically suppressed patients substituting tenofovir for stavudine...
  38. doi request reprint Polyradiculoneuropathy associated to human herpesvirus 2 in an HIV-1-infected patient (Elsberg syndrome): case report and literature review
    Marc Suárez-Calvet
    Neuromuscular Diseases Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Sex Transm Dis 37:123-5. 2010
    ..We describe an HIV-1-infected patient who developed lumbosacral poliradiculoneuropathy caused by Human herpesvirus 2 and review the literature about this uncommon condition...
  39. ncbi request reprint Three-year follow-up of protease inhibitor-based regimen simplification in HIV-infected patients
    Esteban Martinez
    Hospital Clinic, Barcelona, Spain
    AIDS 21:367-9. 2007
    ..In contrast, abacavir showed a lower incidence of adverse effects leading to drug discontinuation...
  40. ncbi request reprint Substitution of nevirapine, efavirenz, or abacavir for protease inhibitors in patients with human immunodeficiency virus infection
    Esteban Martinez
    Infectious Diseases Unit, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    N Engl J Med 349:1036-46. 2003
    ..We assessed the strategy of substituting nevirapine, efavirenz, or abacavir for a protease inhibitor in patients infected with human immunodeficiency virus type 1 (HIV-1) in whom virologic suppression had been achieved...
  41. ncbi request reprint Meningococcal disease in a large urban population (Barcelona, 1987-1992): predictors of dismal prognosis. Barcelona Meningococcal Disease Surveillance Group
    N Barquet
    CAP Gràcia, Institut Catala de la Salut, Barcelona, Spain
    Arch Intern Med 159:2329-40. 1999
    ..Studies on meningococcal disease in large urban communities have rarely been performed and are usually based on passive epidemiologic surveillance. Active surveillance may provide new insights...
  42. doi request reprint Effectiveness and tolerability of abacavir-lamivudine-nevirapine (ABC/3TC/NVP) in a multicenter cohort of HIV-infected ARV-experienced patients
    D Podzamczer
    Hospital Univeristari de Bellvitge, Barcelona, Spain
    J Int AIDS Soc 15:18343. 2012
    ..A favourable lipid profile was observed after 96 weeks of follow up...
  43. doi request reprint Prevalence of metabolic syndrome among human immunodeficiency virus-infected subjects is widely influenced by the diagnostic criteria
    J M Cubero
    Department of Endocrinology, Hospital de la Santa Creu i Sant Pau, UAB, Barcelona, Spain
    Metab Syndr Relat Disord 9:345-51. 2011
    ....
  44. ncbi request reprint Morbidity associated with long-term use of totally implantable ports in patients with AIDS
    P Domingo
    Department of Internal Medicine, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain
    Clin Infect Dis 29:346-51. 1999
    ..05; 95% CI, 0.0-0.59; P = .008). This technique may be useful to treat PAC infection in patients with AIDS, for whom the risk of PAC-related complications is very high...
  45. doi request reprint Substitution of raltegravir for ritonavir-boosted protease inhibitors in HIV-infected patients: the SPIRAL study
    Esteban Martinez
    Infectious Diseases Unit, Hospital Clínic Institut d Investigaciones Biomèdiques August Pi i Sunyer IDIBAPS, University of Barcelona, Barcelona, Spain
    AIDS 24:1697-707. 2010
    ..Switching to raltegravir in selected patients treated with ritonavir-boosted protease inhibitors may result in similar efficacy and lower plasma lipids...
  46. ncbi request reprint Once-daily regimen of saquinavir, ritonavir, didanosine, and lamivudine in HIV-infected patients with standard tuberculosis therapy (TBQD Study)
    Esteban Ribera
    Infectious Diseases Service, Hospital Universitari Vall d Hebron, Barcelona, Spain
    J Acquir Immune Defic Syndr 40:317-23. 2005
    ....
  47. ncbi request reprint HIV-1 infection alters gene expression in adipose tissue, which contributes to HIV- 1/HAART-associated lipodystrophy
    Marta Giralt
    Department de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Antivir Ther 11:729-40. 2006
    ....
  48. ncbi request reprint Effects of metformin or gemfibrozil on the lipodystrophy of HIV-infected patients receiving protease inhibitors
    Esteban Martinez
    Hospital Clinic IDIBAPS, Barcelona, Spain
    Antivir Ther 8:403-10. 2003
    ..Whether a therapeutic approach addressed to those metabolic abnormalities may have any impact on body fat is not clear...
  49. doi request reprint Efficacy and safety of switching from boosted lopinavir to boosted atazanavir in patients with virological suppression receiving a LPV/r-containing HAART: the ATAZIP study
    Josep Mallolas
    Hospital Clinic Universitari IDIBAPS, University of Barcelona, Barcelona, Spain
    J Acquir Immune Defic Syndr 51:29-36. 2009
    ..To evaluate the efficacy and safety of switching from boosted lopinavir (LPV/r) to boosted atazanavir (ATV/r) in virologically suppressed HIV-1-infected patients versus continuing LPV/r...
  50. doi request reprint Influence of HAART on the clinical course of HIV-1-infected patients with progressive multifocal leukoencephalopathy: results of an observational multicenter study
    Vicenc Falco
    Infectious Disease Department, Hospital Universitario Vall d Hebron, Barcelona, Spain
    J Acquir Immune Defic Syndr 49:26-31. 2008
    ....
  51. ncbi request reprint Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients
    Jordi P Guallar
    Department of Biochemistry and Molecular Biology, University of Barcelona and Institut de Biomedicina de la Universitat de Barcelona, Barcelona, Spain
    Antivir Ther 12:853-63. 2007
    ..Nucleoside transporter proteins (NTs) encoded by members of the SLC28 and SLC29 gene families contribute to nucleoside and nucleobase recycling but also modulate extracellular adenosine levels and thus adenosine-regulated metabolic targets...
  52. ncbi request reprint Pharmacokinetic interaction between rifampicin and the once-daily combination of saquinavir and low-dose ritonavir in HIV-infected patients with tuberculosis
    Esteban Ribera
    Infectious Diseases Department, Hospital Universitari Vall d Hebron, Barcelona, Spain
    J Antimicrob Chemother 59:690-7. 2007
    ..To assess plasma steady-state pharmacokinetics (PK) of rifampicin, isoniazid, saquinavir and ritonavir in HIV and tuberculosis (TB) co-infected patients, and investigate potential interactions between TB drugs and protease inhibitors (PIs)...
  53. ncbi request reprint Long-distance interactive expert advice in highly treatment-experienced HIV-infected patients
    Josep M Llibre
    Lluita contra la SIDA Foundation, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain
    J Antimicrob Chemother 61:206-9. 2008
    ..To determine the feasibility and outcomes of long-distance interactive expert advice for treatment-experienced patients...
  54. ncbi request reprint Acute Q fever in adult patients: report on 63 sporadic cases in an urban area
    P Domingo
    Department of Internal Medicine, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Spain
    Clin Infect Dis 29:874-9. 1999
    ..Hepatic Q fever presented with more pronounced increases in liver function test values than did pneumonic Q fever. Treatment with doxycycline caused a significant reduction in the duration of fever...
  55. doi request reprint Switching to an etravirine regimen in virologically suppressed patients with previous virological failures and presence of resistance mutations
    J Blanco
    Hospital Clinic, Barcelona, Spain
    J Int AIDS Soc 15:18379. 2012
    ..Conclusions: Our results suggest that ETV plus 2NRTI could be a good strategy for simplification in virologically suppressed patients despite previous episodes of VF if the GSS to the new regimen is ≥1.5 and ETV remains active...
  56. ncbi request reprint Beta 2-microglobulin and immunoglobulins are more useful markers of disease progression in HIV than neopterin and adenosine deaminase
    C Martínez-Brú
    Servei de Bioquimica, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Ann Clin Biochem 36:601-8. 1999
    ..In 48 patients, no increases greater than calculated reference change values were detected. The sensitivity obtained using the six analytes was 94.4% and the specificity was 62.3%...
  57. ncbi request reprint Management of complications associated with totally implantable ports in patients with AIDS
    P Domingo
    Department of Internal Medicine Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain
    AIDS Patient Care STDS 15:7-13. 2001
    ..When patients have chamber infection (the most frequent infectious complication) with or without secondary bacteremia, the antibiotic lock technique has proven useful for device sterilization...
  58. doi request reprint Differential gene expression indicates that 'buffalo hump' is a distinct adipose tissue disturbance in HIV-1-associated lipodystrophy
    Jordi P Guallar
    Department of Biochemistry and Molecular Biology and Institut de Biomedicina IBUB, University of Barcelona, and CIBER Fisiopatología de Obesidad y Nutrición, Instituto de Salud Carlos III, Barcelona, Spain
    AIDS 22:575-84. 2008
    ..To elucidate the molecular basis of the progressive enlargement of dorso-cervical adipose tissue, the so-called 'buffalo hump', that appears in a sub-set of patients with HIV-1/HAART-associated lipodystrophy...
  59. doi request reprint First-line antiretroviral therapy with efavirenz or lopinavir/ritonavir plus two nucleoside analogues: the SUSKA study, a non-randomized comparison from the VACH cohort
    Pere Domingo
    Hospital de la Santa Creu i Sant Pau, Mas Casanovas 90, 08025 Barcelona, Spain
    J Antimicrob Chemother 61:1348-58. 2008
    ..A retrospective longitudinal study from the VACH cohort comparing both regimens was performed...
  60. doi request reprint Bacterial meningitis in HIV-1-infected patients in the era of highly active antiretroviral therapy
    Pere Domingo
    Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    J Acquir Immune Defic Syndr 51:582-7. 2009
    ..The burden that spontaneous bacterial meningitis (SBM) currently represents among HIV-1-infected patients is poorly known...
  61. doi request reprint Efficacy and safety of switching from enfuvirtide to raltegravir in patients with virological suppression
    Jose R Santos
    Lluita contra la SIDA, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain Universitat Autònoma de Barcelona, Barcelona, Spain
    HIV Clin Trials 10:432-8. 2009
    ..To assess the Efficacy and safety of switching from HAART containing enfuvirtide to raltegravir as a simplification strategy in patients with viral suppression and intolerance to enfuvirtide...
  62. ncbi request reprint Nevirapine-containing regimens in HIV-infected naive patients with CD4 cell counts of 200 cells/microl or less
    Elena Ferrer
    Infectious Disease Services, Universitari de Bellvitge Hospital, Barcelona, Spain
    AIDS 18:1727-9. 2004
    ..More than 80% of patients who continued with nevirapine had viral loads < 50 copies/ml and CD4 cell counts > 200 cells/pl...
  63. ncbi request reprint Strategies in the treatment of HIV-1-associated adipose redistribution syndromes
    María del Mar Gutierrez
    Autonomous University of Barcelona, Infectious Diseases Unit, Hospital de la Sant Creu i Sant Pau, Barcelona, Spain
    Expert Opin Pharmacother 8:1871-84. 2007
    ..Only through this effort can the best chances for preventing or reverting established HALS be recognised...
  64. doi request reprint Drug-induced lipotoxicity: lipodystrophy associated with HIV-1 infection and antiretroviral treatment
    Francesc Villarroya
    Department of Biochemistry and Molecular Biology and Institute of Biomedicine of the University of Barcelona IBUB, and Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Biochim Biophys Acta 1801:392-9. 2010
    ....
  65. ncbi request reprint Discontinuation of primary and secondary Toxoplasma gondii prophylaxis is safe in HIV-infected patients after immunological restoration with highly active antiretroviral therapy: results of an open, randomized, multicenter clinical trial
    Jose M Miro
    Institut d Investigacions Biomediques August Pi Sunyer Hospital Clinic, University of Barcelona, Barcelona, Spain
    Clin Infect Dis 43:79-89. 2006
    ..To our knowledge, no randomized trials have evaluated whether prophylaxis against toxoplasmic encephalitis can be safely discontinued after the CD4+ T cell count increases in response to highly active antiretroviral therapy...
  66. ncbi request reprint Bilateral Bell palsy and acute HIV type 1 infection: report of 2 cases and review
    Pedro Serrano
    Department of Internal Medicine and Infectious Diseases Unit, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Clin Infect Dis 44:e57-61. 2007
    ..Bell palsy appeared a median of 15 days after the beginning of the clinical disease, and aseptic meningitis was an invariable concomitant of facial neuropathy. All but 1 patient (8.3%) recovered without sequelae...
  67. doi request reprint Zidovudine/lamivudine/abacavir plus tenofovir in HIV-infected naive patients: a 96-week prospective one-arm pilot study
    Elena Ferrer
    Infectious Disease and Hospital Universitari de Bellvitge, L Hospitalet, Barcelona, Spain
    AIDS Res Hum Retroviruses 24:931-4. 2008
    ..Larger trials comparing this option with standard initial antiretroviral regimens should be conducted...
  68. doi request reprint Incidence of tuberculosis in HIV-infected patients in Spain: the impact of treatment for LTBI
    I Martínez-Pino
    Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain CIBER de Epidemiología y Salud Pública, Institute of Health Carlos III, Madrid, Spain
    Int J Tuberc Lung Dis 17:1545-51. 2013
    ..Twenty hospitals in Spain...
  69. ncbi request reprint Hypertrichosis lanuginosa acquisita preceding extraskeletal Ewing's sarcoma
    E Perez-Losada
    Department of Dermatology, Hospital de la Santa Creu i Sant Pau Hospital del Mar, IMAS, Barcelona, Spain
    Clin Exp Dermatol 26:182-3. 2001
    ..Our observation expands the spectrum of malignancies associated with this uncommon paraneoplastic disorder...
  70. doi request reprint Safety of Switching Nevirapine Twice Daily to Nevirapine Once Daily in Virologically Suppressed Patients
    Daniel Podzamczer
    Hospital Universitari de Bellvitge, L Hospitalet, Barcelona, Spain
    J Acquir Immune Defic Syndr 50:390-6. 2009
    ..The strategy of switching nevirapine (NVP) twice daily to once daily was evaluated...
  71. ncbi request reprint Failure of cetirizine to prevent nevirapine-associated rash: a double-blind placebo-controlled trial for the GESIDA 26/01 Study
    Hernando Knobel
    Department of Internal Medicine, Infectious Diseases, Hospital del Mar, Barcelona, Spain
    J Acquir Immune Defic Syndr 37:1276-81. 2004
    ..The use of antihistamines remains unclear in this setting. A double-blind placebo-controlled study was performed to evaluate the efficacy of cetirizine in the prevention of nevirapine rash...
  72. ncbi request reprint Reverse transcriptase inhibitors alter uncoupling protein-1 and mitochondrial biogenesis in brown adipocytes
    M Luísa Rodriguez de la Concepción
    Department de Bioquimica i Biologia Molecular, Universitat de Barcelona, Barcelona, Spain
    Antivir Ther 10:515-26. 2005
    ..The aim of this study was to evaluate the effects of reverse transcriptase inhibitors (RTIs) on primary brown adipocytes differentiated in culture...
  73. ncbi request reprint Air-leak syndromes in hematopoietic stem cell transplant recipients with chronic GVHD: high-resolution CT findings
    Tomas Franquet
    Department of Radiology, Hospital de Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Thorac Imaging 22:335-40. 2007
    ....
  74. ncbi request reprint Advances in adjuvant therapy against acute bacterial meningitis
    Virginia Pomar
    Department of Internal Medicine, Hospital de la Santa Creu i Sant Pau, Av Sant Antoni M Claret, 167, 08025 Barcelona, Spain
    Curr Drug Targets Infect Disord 4:303-9. 2004
    ..We review the current state-of-art of bacterial meningitis adjuvant therapy, including caspase inhibitors, antioxidants, poly (ADP-ribose) polymerase inhibitors, inhibitors of lipid peroxidation and metalloproteinase inhibitors...
  75. ncbi request reprint Gynecomastia among HIV-infected patients is associated with hypogonadism: a case-control study
    Alejandra Biglia
    Infectious Diseases Unit, Hospital Clinic Institut d Investigaciones Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    Clin Infect Dis 39:1514-9. 2004
    ..The prevalence, risk factors, and potential hormonal abnormalities associated with gynecomastia in a cohort of HIV-infected men are poorly understood...
  76. ncbi request reprint [Spanish recommendations for proper use of enfuvirtide]
    Esteban Ribera
    Hospital Vall d Hebron, Barcelona, Espana
    Enferm Infecc Microbiol Clin 25:131-42. 2007
    ....