Research Topics

Genomes and Genes


Mev Dominguez Valentin



  1. Dominguez Valentin M, Therkildsen C, Veerla S, Jönsson M, Bernstein I, Borg A, et al. Distinct gene expression signatures in lynch syndrome and familial colorectal cancer type x. PLoS ONE. 2013;8:e71755 pubmed publisher
  2. Dominguez Valentin M, Nakken S, Tubeuf H, Vodák D, Ekstrøm P, Nissen A, et al. Identification of genetic variants for clinical management of familial colorectal tumors. BMC Med Genet. 2018;19:26 pubmed publisher
    ..Our study suggests that the analysis of genes currently excluded from routine molecular diagnostic screens may confer cancer susceptibility. ..
  3. request reprint
    da Silva F, Wernhoff P, Dominguez Barrera C, Dominguez Valentin M. Update on Hereditary Colorectal Cancer. Anticancer Res. 2016;36:4399-405 pubmed
    ..The review is intended to present and discuss the molecular nature of various conditions related to MMR deficiency and discusses the tools and strategies that have been used in detecting these conditions. ..
  4. Valentin M, da Silva F, dos Santos E, Lisboa B, de Oliveira L, Ferreira F, et al. Characterization of germline mutations of MLH1 and MSH2 in unrelated south American suspected Lynch syndrome individuals. Fam Cancer. 2011;10:641-7 pubmed publisher
    ..The high rate of novel mutations demonstrates the importance of defining MLH1 and MSH2 mutations in distinct LS populations. ..
  5. Dominguez Valentin M, Nakken S, Tubeuf H, Vodák D, Ekstrøm P, Nissen A, et al. Potentially pathogenic germline CHEK2 c.319+2T>A among multiple early-onset cancer families. Fam Cancer. 2018;17:141-153 pubmed publisher