Philippe Djian

Summary

Publications

  1. Hoffner G, Djian P. Polyglutamine Aggregation in Huntington Disease: Does Structure Determine Toxicity?. Mol Neurobiol. 2015;52:1297-1314 pubmed publisher
    ..When defined, the toxic structures could then specifically be targeted by prophylactic or therapeutic drugs aimed at inhibiting polyglutamine aggregation. ..
  2. Vanhoutteghem A, Delhomme B, Hervé F, Nondier I, Petit J, Araki M, et al. The importance of basonuclin 2 in adult mice and its relation to basonuclin 1. Mech Dev. 2016;140:53-73 pubmed publisher
    ..The function of the basonuclins in the secondary hair germ is of particular interest. ..
  3. André W, Nondier I, Valensi M, Guillonneau F, Federici C, Hoffner G, et al. Identification of brain substrates of transglutaminase by functional proteomics supports its role in neurodegenerative diseases. Neurobiol Dis. 2017;101:40-58 pubmed publisher
    ..These results strongly support the idea that the crosslinking activity of brain transglutaminase participates in the formation of the protein aggregates found in diseases of the central nervous system. ..
  4. Vanhoutteghem A, Messiaen S, Hervé F, Delhomme B, Moison D, Petit J, et al. The zinc-finger protein basonuclin 2 is required for proper mitotic arrest, prevention of premature meiotic initiation and meiotic progression in mouse male germ cells. Development. 2014;141:4298-310 pubmed publisher
    ..In view of the extreme evolutionary conservation of BNC2, the findings described here are likely to apply to many species. ..