Ivo Mueller

Summary

Affiliation: Disaster Mental Health Institute

Publications

  1. ncbi Vaccines against malaria: perspectives from Papua New Guinea
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
    Hum Vaccin 6:17-20. 2010
  2. pmc Intermittent preventive treatment for malaria in Papua New Guinean infants exposed to Plasmodium falciparum and P. vivax: a randomized controlled trial
    Nicolas Senn
    Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
    PLoS Med 9:e1001195. 2012
  3. pmc Differential patterns of infection and disease with P. falciparum and P. vivax in young Papua New Guinean children
    Enmoore Lin
    PNG Institute of Medical Research, Madang, Papua New Guinea
    PLoS ONE 5:e9047. 2010
  4. pmc Reduced risk of Plasmodium vivax malaria in Papua New Guinean children with Southeast Asian ovalocytosis in two cohorts and a case-control study
    Anna Rosanas-Urgell
    PNG Institute of Medical Research, Madang, Papua New Guinea
    PLoS Med 9:e1001305. 2012
  5. pmc Estimating the burden of malaria: the need for improved surveillance
    Ivo Mueller
    Barcelona Centre for International Health Research CRESIB, Barcelona, Spain
    PLoS Med 8:e1001144. 2011
  6. pmc A histopathologic study of fatal paediatric cerebral malaria caused by mixed Plasmodium falciparum/Plasmodium vivax infections
    Laurens Manning
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, PO Box 480, Fremantle 6959, Western Australia, Australia
    Malar J 11:107. 2012
  7. pmc Population genetic analysis of the Plasmodium falciparum 6-cys protein Pf38 in Papua New Guinea reveals domain-specific balancing selection
    John C Reeder
    Burnet Institute, Melbourne, Australia
    Malar J 10:126. 2011
  8. pmc Multilocus haplotypes reveal variable levels of diversity and population structure of Plasmodium falciparum in Papua New Guinea, a region of intense perennial transmission
    Lee Schultz
    Centre for Population Health, Burnet Institute, Melbourne, Australia
    Malar J 9:336. 2010
  9. pmc Plasmodium falciparum resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular monitoring of resistance
    Jutta Marfurt
    Swiss Tropical Institute, Department of Medical Parasitology and Infection Biology, and Department of Public Health and Epidemiology, Socinstrasse 57, PO Box, CH 4002 Basel, Switzerland
    Malar J 9:8. 2010
  10. pmc High sensitivity detection of Plasmodium species reveals positive correlations between infections of different species, shifts in age distribution and reduced local variation in Papua New Guinea
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
    Malar J 8:41. 2009

Collaborators

Detail Information

Publications77

  1. ncbi Vaccines against malaria: perspectives from Papua New Guinea
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
    Hum Vaccin 6:17-20. 2010
    ..vivax vaccine candidates and future combined P. falciparum / P. vivax vaccines and also offers unique opportunities for P. falciparum vaccine research. PNG is thus ready to contribute significantly in the global malaria vaccine endeavor...
  2. pmc Intermittent preventive treatment for malaria in Papua New Guinean infants exposed to Plasmodium falciparum and P. vivax: a randomized controlled trial
    Nicolas Senn
    Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
    PLoS Med 9:e1001195. 2012
    ..It remains unclear whether IPTi is an appropriate prevention strategy in non-African settings or those co-endemic for P. vivax (Pv)...
  3. pmc Differential patterns of infection and disease with P. falciparum and P. vivax in young Papua New Guinean children
    Enmoore Lin
    PNG Institute of Medical Research, Madang, Papua New Guinea
    PLoS ONE 5:e9047. 2010
    ..vivax than to P. falciparum challenge. There is however little prospective data on the comparative risk of infection and disease from both species in young children living in co-endemic areas...
  4. pmc Reduced risk of Plasmodium vivax malaria in Papua New Guinean children with Southeast Asian ovalocytosis in two cohorts and a case-control study
    Anna Rosanas-Urgell
    PNG Institute of Medical Research, Madang, Papua New Guinea
    PLoS Med 9:e1001305. 2012
    ..vivax infection and disease...
  5. pmc Estimating the burden of malaria: the need for improved surveillance
    Ivo Mueller
    Barcelona Centre for International Health Research CRESIB, Barcelona, Spain
    PLoS Med 8:e1001144. 2011
    b>Ivo Mueller, Laurence Slutsker, and Marcel Tanner highlight the importance of using complementary methods to estimate the burden of malaria and call for a renewed focus on efficient malaria surveillance.
  6. pmc A histopathologic study of fatal paediatric cerebral malaria caused by mixed Plasmodium falciparum/Plasmodium vivax infections
    Laurens Manning
    School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, PO Box 480, Fremantle 6959, Western Australia, Australia
    Malar J 11:107. 2012
    ..No P. vivax DNA was detected. These findings do not support the hypothesis that P. vivax sequestration occurs in human brain...
  7. pmc Population genetic analysis of the Plasmodium falciparum 6-cys protein Pf38 in Papua New Guinea reveals domain-specific balancing selection
    John C Reeder
    Burnet Institute, Melbourne, Australia
    Malar J 10:126. 2011
    ..This study explores the population genetics of Pf38 in Papua New Guinea, to determine the extent and geographic distribution of diversity and to measure selective pressure along the length of the gene...
  8. pmc Multilocus haplotypes reveal variable levels of diversity and population structure of Plasmodium falciparum in Papua New Guinea, a region of intense perennial transmission
    Lee Schultz
    Centre for Population Health, Burnet Institute, Melbourne, Australia
    Malar J 9:336. 2010
    ..falciparum in the region. This study describes the population genetics of P. falciparum in thirteen villages spread over four distinct catchment areas of Papua New Guinea...
  9. pmc Plasmodium falciparum resistance to anti-malarial drugs in Papua New Guinea: evaluation of a community-based approach for the molecular monitoring of resistance
    Jutta Marfurt
    Swiss Tropical Institute, Department of Medical Parasitology and Infection Biology, and Department of Public Health and Epidemiology, Socinstrasse 57, PO Box, CH 4002 Basel, Switzerland
    Malar J 9:8. 2010
    ....
  10. pmc High sensitivity detection of Plasmodium species reveals positive correlations between infections of different species, shifts in age distribution and reduced local variation in Papua New Guinea
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
    Malar J 8:41. 2009
    ....
  11. doi Key gaps in the knowledge of Plasmodium vivax, a neglected human malaria parasite
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
    Lancet Infect Dis 9:555-66. 2009
    ..This Review critically examines what is known about P vivax, focusing on identifying the crucial gaps that create obstacles to the elimination of this parasite in human populations...
  12. pmc Guidance on the evaluation of Plasmodium vivax vaccines in populations exposed to natural infection
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Goroka, EHP 441, Papua, New Guinea
    Vaccine 27:5633-43. 2009
    ..In this paper we discuss the rationale and background to trials of P. vivax vaccines, requirements for Phase IIb and Phase III field trials, implementation of clinical trials, methods of measurement and analysis, and ethical aspects...
  13. pmc Three different Plasmodium species show similar patterns of clinical tolerance of malaria infection
    Ivo Muller
    Department of Public Health and Epidemiology, Swiss Tropical Institute, Basel, Switzerland
    Malar J 8:158. 2009
    ..There is little data on the age dependence of tolerance in other species of human malaria...
  14. ncbi Low efficacy of amodiaquine or chloroquine plus sulfadoxine-pyrimethamine against Plasmodium falciparum and P. vivax malaria in Papua New Guinea
    Jutta Marfurt
    Department of Medical Parasitology and Infection Biology, Swiss Tropical Institute, Basel, Switzerland
    Am J Trop Med Hyg 77:947-54. 2007
    ..According to the new WHO guidelines for the treatment of malaria, a rate of parasitological resistance greater than 10% in the two dominant malaria species in the country justifies a change in treatment policy...
  15. ncbi The epidemiology of malaria in the Papua New Guinea highlands: 4. Enga Province
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Goroka and Malaria Surveillance and Control Unit, Goroka, Papua New Guinea
    P N G Med J 49:115-25. 2006
    ....
  16. pmc Treatment with coartem (artemether-lumefantrine) in Papua New Guinea
    Sonja Schoepflin
    Swiss Tropical Institute, Basel, Switzerland
    Am J Trop Med Hyg 82:529-34. 2010
    ..In contrast to the situation in classic drug trials with ideal treatment conditions, our field survey highlights potential problems with unsupervised usage of Coartem in routine clinical practice and under program conditions...
  17. pmc Comparison of Plasmodium falciparum allelic frequency distribution in different endemic settings by high-resolution genotyping
    Sonja Schoepflin
    Swiss Tropical Institute, Basel, Switzerland
    Malar J 8:250. 2009
    ..These previous reports relied on low resolution genotyping techniques...
  18. pmc Heterogeneous distribution of Plasmodium falciparum drug resistance haplotypes in subsets of the host population
    Sonja Schoepflin
    Swiss Tropical Institute, Department of Medical Parasitology and Infection Biology, Socinstr 57, 4002 Basel, Switzerland
    Malar J 7:78. 2008
    ..In particular newly acquired haplotypes after radical cure were characterized and compared to haplotypes from persistent infections...
  19. ncbi The epidemiology of malaria in the Papua New Guinea highlands: 3. Simbu Province
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Goroka
    P N G Med J 47:159-73. 2004
    ..Epidemic prevention, surveillance and response in the north, and bednet distribution and strengthening of curative services in the south, are therefore the priorities for malaria control in Simbu Province...
  20. pmc Tolerability and safety of primaquine in Papua New Guinean children 1 to 10 years of age
    Inoni Betuela
    PNG Institute of Medical Research, Goroka, Papua New Guinea
    Antimicrob Agents Chemother 56:2146-9. 2012
    ..5 mg/kg of body weight) showed that both treatments are well tolerated, do not lead to reductions in hemoglobin levels, and can thus safely be used in children 1 to 10 years of age...
  21. pmc How much remains undetected? Probability of molecular detection of human Plasmodia in the field
    Cristian Koepfli
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 6:e19010. 2011
    ..falciparum and P. vivax parasite clones in consecutive samples of the same patient and at investigating the impact of sampling strategies on basic epidemiological measures such as multiplicity of infection (MOI)...
  22. ncbi The epidemiology of malaria in the Papua New Guinea highlands: 6. Simbai and Bundi, Madang Province
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Goroka
    P N G Med J 50:123-33. 2007
    ..6, CI95 [3.6-8.6], p < 0.001). Based on the survey results, areas of different malaria epidemiology are delineated and options for control in each area are discussed...
  23. doi Evaluation of Plasmodium vivax genotyping markers for molecular monitoring in clinical trials
    Cristian Koepfli
    Swiss Tropical Institute, Basel, Switzerland
    J Infect Dis 199:1074-80. 2009
    ..The method was tested with samples from an in vivo drug efficacy study...
  24. pmc Population hemoglobin mean and anemia prevalence in Papua New Guinea: new metrics for defining malaria endemicity?
    Nicolas Senn
    Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
    PLoS ONE 5:e9375. 2010
    ....
  25. pmc The risk of malarial infections and disease in Papua New Guinean children
    Pascal Michon
    Papua New Guinea Institute of Medical Research, PO Box 378, Madang, MAD 511, Papua New Guinea
    Am J Trop Med Hyg 76:997-1008. 2007
    ..falciparum malaria remained incomplete. These observations suggest that different mechanisms of immunity may be important for protection from these malaria species...
  26. ncbi The epidemiology of malaria in the Papua New Guinea highlands: 5. Aseki, Menyamya and Wau-Bulolo, Morobe Province
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Goroka
    P N G Med J 50:111-22. 2007
    ..As a consequence all villages below 1500-1600 m in Morobe Province should be included in malaria control activities...
  27. doi Effectiveness of artemether/lumefantrine for the treatment of uncomplicated Plasmodium vivax and P. falciparum malaria in young children in Papua New Guinea
    Nicolas Senn
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    Clin Infect Dis 56:1413-20. 2013
    ..A common treatment for both vivax and falciparum malaria would be welcome...
  28. pmc Estimating the numbers of malaria infections in blood samples using high-resolution genotyping data
    Amanda Ross
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS ONE 7:e42496. 2012
    ..In contrast, the second method by Li et al estimates both the numbers of infections and the true allele frequencies simultaneously and produced accurate estimates of the mean number of infections...
  29. pmc Multiplicity and diversity of Plasmodium vivax infections in a highly endemic region in Papua New Guinea
    Cristian Koepfli
    Swiss Tropical and Public Health Institute, Basel, Switzerland
    PLoS Negl Trop Dis 5:e1424. 2011
    ..02), with the strongest increase in very young children. Intensified efforts to control malaria can benefit from knowledge of the diversity and MOI both for assessing the endemic situation and monitoring the effects of interventions...
  30. pmc The sensitivity of the OptiMAL rapid diagnostic test to the presence of Plasmodium falciparum gametocytes compromises its ability to monitor treatment outcomes in an area of Papua New Guinea in which malaria is endemic
    Ivo Mueller
    PNG Institute of Medical Research, P O Box 378, Madang 511, Papua New Guinea
    J Clin Microbiol 45:627-30. 2007
    ..falciparum gametocytes. This high sensitivity limits the use of pLDH-based tests in the monitoring of treatment outcomes in circumstances where gametocytemia is common...
  31. ncbi The epidemiology of malaria in the Papua New Guinea highlands: 7. Southern Highlands Province
    Seri Maraga
    Papua New Guinea Institute of Medical Research, PO Box 60, Goroka, Eastern Highlands Province 441, Papua New Guinea
    P N G Med J 54:35-47. 2011
    ..79, p < 0.001). Based on the survey results, areas of different malaria epidemiology are delineated and options for control in each area are discussed...
  32. doi Lack of associations of α(+)-thalassemia with the risk of Plasmodium falciparum and Plasmodium vivax infection and disease in a cohort of children aged 3-21 months from Papua New Guinea
    Anna Rosanas-Urgell
    Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
    Int J Parasitol 42:1107-13. 2012
    ..falciparum and challenges the hypothesis of immunological cross-protection between P. falciparum and P. vivax as a mechanism underlying α(+)-thalassemia protection against severe P. falciparum disease in Melanesian children...
  33. doi Relapses contribute significantly to the risk of Plasmodium vivax infection and disease in Papua New Guinean children 1-5 years of age
    Inoni Betuela
    Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
    J Infect Dis 206:1771-80. 2012
    ..Plasmodium vivax forms long-lasting hypnozoites in the liver. How much they contribute to the burden of P. vivax malaria in children living in highly endemic areas is unknown...
  34. pmc A high force of plasmodium vivax blood-stage infection drives the rapid acquisition of immunity in papua new guinean children
    Cristian Koepfli
    Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland Walter and Eliza Hall Institute, Parkville, Victoria, Australia
    PLoS Negl Trop Dis 7:e2403. 2013
    ..vivax ((mol)FOB, i.e. the number of genetically distinct blood-stage infections over time), and compared it to previously reported values for P. falciparum...
  35. ncbi The epidemiology of malaria in the Papua New Guinea highlands: 2. Eastern Highlands Province
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, P O Box 60, Goroka, EHP 441, Papua New Guinea
    P N G Med J 46:166-79. 2003
    ..Epidemic prevention, surveillance and response therefore are priorities in malaria control in EHP...
  36. pmc Strategies for detection of Plasmodium species gametocytes
    Rahel Wampfler
    Swiss Tropical and Public Health Institute, Basel, Switzerland University of Basel, Basel, Switzerland
    PLoS ONE 8:e76316. 2013
    ....
  37. doi Rapid diagnostic test-based management of malaria: an effectiveness study in Papua New Guinean infants with Plasmodium falciparum and Plasmodium vivax malaria
    Nicolas Senn
    Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
    Clin Infect Dis 54:644-51. 2012
    ..We evaluated the safety of withholding antimalarial drugs from young Papua New Guinean children with negative RDT results in areas with high levels of both Plasmodium falciparum and P. vivax infections...
  38. pmc Characterization of treatment failure in efficacy trials of drugs against Plasmodium vivax by genotyping neutral and drug resistance-associated markers
    Céline Barnadas
    Vector Borne Diseases Unit, PNG Institute of Medical Research, Goroka, Papua New Guinea
    Antimicrob Agents Chemother 55:4479-81. 2011
    ..The PCR-corrected adequate clinical and parasitologic response may constitute an informative secondary endpoint in future P. vivax drug trials...
  39. pmc Rosetting in Plasmodium vivax: a cytoadhesion phenotype associated with anaemia
    Alejandro Marín-Menéndez
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    PLoS Negl Trop Dis 7:e2155. 2013
    ..vivax sequestration and organ injury although its physiological impact is still unknown. Here, we aimed to describe clinically-relevant cytoadhesive phenotypes of P. vivax isolates...
  40. ncbi Molecular analysis of Plasmodium falciparum from drug treatment failure patients in Papua New Guinea
    Gerard J Casey
    Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
    Am J Trop Med Hyg 70:251-5. 2004
    ..The study period encompasses a change in standard malaria treatment policy. These findings stress the need for regular monitoring of the effects of standard drug treatment of uncomplicated malaria in Papua New Guinea...
  41. pmc Minimal association of common red blood cell polymorphisms with Plasmodium falciparum infection and uncomplicated malaria in Papua New Guinean school children
    Enmoore Lin
    Papua New Guinea Institute of Medical Research, Papua, New Guinea
    Am J Trop Med Hyg 83:828-33. 2010
    ..2). This suggests that these polymorphisms are not associated with significant protection against P. falciparum blood-stage infection or uncomplicated malaria in school-aged children...
  42. pmc Force of infection is key to understanding the epidemiology of Plasmodium falciparum malaria in Papua New Guinean children
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Goroka, Eastern Highland Province 441, Papua New Guinea
    Proc Natl Acad Sci U S A 109:10030-5. 2012
    ....
  43. pmc Predictors of acute bacterial meningitis in children from a malaria-endemic area of Papua New Guinea
    Moses Laman
    Papua New Guinea Institute of Medical Research, Madang and Goroka, Papua New Guinea
    Am J Trop Med Hyg 86:240-5. 2012
    ..04). In young children, a bulging fontanel added to the model (P < 0.001). Simple clinical features predict ABM in children in Papua New Guinea but malaria microscopy augments diagnostic precision...
  44. ncbi The epidemiology of malaria in the Papua New Guinea highlands: 1. Western Highlands Province
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
    P N G Med J 46:16-31. 2003
    ..Based on the survey results, areas of different malaria epidemiology are delineated and options for control in each area are discussed...
  45. pmc Plasmodium malariae and Plasmodium ovale--the "bashful" malaria parasites
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Madang MAD511, Papua New Guinea
    Trends Parasitol 23:278-83. 2007
    ....
  46. pmc Naturally-acquired humoral immune responses against the N- and C-termini of the Plasmodium vivax MSP1 protein in endemic regions of Brazil and Papua New Guinea using a multiplex assay
    Carmen Fernandez-Becerra
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic IDIBAPS, Universitat de Barcelona, Rosello 132, 08036 Barcelona, Spain
    Malar J 9:29. 2010
    ....
  47. pmc A new high-throughput method for simultaneous detection of drug resistance associated mutations in Plasmodium vivax dhfr, dhps and mdr1 genes
    Céline Barnadas
    Vector Borne Diseases Unit, Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
    Malar J 10:282. 2011
    ..A new high-throughput assay for detecting the most relevant markers related to P. vivax drug resistance was developed and assessed on Papua New Guinea (PNG) patient isolates...
  48. pmc Malaria--a major health problem within an oil palm plantation around Popondetta, Papua New Guinea
    Bianca Pluess
    Swiss Tropical Institute, Basel, Switzerland
    Malar J 8:56. 2009
    ..This study provides an overview of the malaria epidemiology within an oil palm plantation in Popondetta, south-eastern Papua New Guinea, its implication for the company with its employees and their families and the potential for control...
  49. ncbi γδ T cells and CD14+ Monocytes Are Predominant Cellular Sources of Cytokines and Chemokines Associated With Severe Malaria
    Danielle I Stanisic
    Division of Infection and Immunity, Walter and Eliza Hall Institute, Parkville, Victoria, Australia Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
    J Infect Dis 210:295-305. 2014
    ..Severe malaria (SM) is associated with high levels of cytokines such as tumor necrosis factor (TNF), interleukin 1 (IL-1), and interleukin 6 (IL-6). The role of chemokines is less clear, as is their cellular source...
  50. ncbi Epidemic malaria in the highlands of Papua New Guinea
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Goroka, Eastern Highlands Province, Papua New Guinea
    Am J Trop Med Hyg 72:554-60. 2005
    ..0-3.3% to 3.8-18.4%. These massive increases in morbidity have devastating impact on the affected communities and highlight that malaria epidemics are a serious and increasing public health problem in the highlands of Papua New Guinea...
  51. ncbi Malaria control in Papua New Guinea results in complex epidemiological changes
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Goroka, Swiss Tropical Institute, Basel, Switzerland
    P N G Med J 48:151-7. 2005
    ..The example of Karimui indicates that unsustained control can lead to changes in malaria patterns that may leave a population worse off...
  52. ncbi Molecular evidence for the localization of Plasmodium falciparum immature gametocytes in bone marrow
    Ruth Aguilar
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic de Barcelona, University of Barcelona, Barcelona, Spain
    Blood 123:959-66. 2014
    ..Our results highlight the high prevalence and abundance of early sexual stages in bone marrow, as well as the relationship between hematological disturbances and gametocyte development in this tissue. ..
  53. pmc Naturally acquired immune responses to P. vivax merozoite surface protein 3α and merozoite surface protein 9 are associated with reduced risk of P. vivax malaria in young Papua New Guinean children
    Danielle I Stanisic
    Walter and Eliza Hall Institute, Parkville, Australia Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
    PLoS Negl Trop Dis 7:e2498. 2013
    ..Although numerous P. vivax merozoite antigens are targets of naturally acquired antibodies, the role of many of these antibodies in protective immunity is yet unknown...
  54. doi Lumbar puncture in children from an area of malaria endemicity who present with a febrile seizure
    Moses Laman
    Papua New Guinea Institute of Medical Research, Modilon General Hospital, Madang, Papua New Guinea
    Clin Infect Dis 51:534-40. 2010
    ..Our primary hypothesis was that children who present with a single seizure but with no clinical signs of meningism or coma do not require LP as part of initial diagnostic assessment...
  55. pmc Community response to intermittent preventive treatment of malaria in infants (IPTi) in Papua New Guinea
    Christopher Pell
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic IDIBAPS, Universitat de Barcelona, Spain
    Malar J 9:369. 2010
    ..Building on previous acceptability research undertaken in sub-Saharan Africa this article aims to investigate the acceptability of intermittent preventive treatment of malaria in infants (IPTi) in Papua New Guinea (PNG)...
  56. pmc Geographical structure of diversity and differences between symptomatic and asymptomatic infections for Plasmodium falciparum vaccine candidate AMA1
    Alfred Cortes
    Papua New Guinea Institute of Medical Research, MP511, Madang, Papua New Guinea
    Infect Immun 71:1416-26. 2003
    ..The information yielded by this study has implications for the design and assessment of AMA1-based vaccines and provides additional data supporting the importance of AMA1 as a malaria vaccine candidate...
  57. ncbi Progress in mosquito net coverage in Papua New Guinea
    Manuel W Hetzel
    Papua New Guinea Institute of Medical Research, PO Box 60, EHP 441 Goroka, Papua New Guinea
    Malar J 13:242. 2014
    ..5% of the population used a LLIN, mainly due to an insufficient number of nets available. This study investigated changes in mosquito net ownership and use following the continued free distribution of LLINs across PNG...
  58. ncbi Factors affecting attendance at and timing of formal antenatal care: results from a qualitative study in Madang, Papua New Guinea
    Erin V W Andrew
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 9:e93025. 2014
    ..Drawing on qualitative research, this paper explores the influences on ANC attendance and timing of first visit in the Madang region of Papua New Guinea...
  59. doi Placental infection with Plasmodium vivax: a histopathological and molecular study
    Alfredo Mayor
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    J Infect Dis 206:1904-10. 2012
    ..Evidence of the presence of Plasmodium vivax in the placenta is scarce and inconclusive. This information is relevant to understanding whether P. vivax affects placental function and how it may contribute to poor pregnancy outcomes...
  60. pmc Malaria case management in Papua New Guinea prior to the introduction of a revised treatment protocol
    Justin Pulford
    Papua New Guinea Institute of Medical Research, PO Box 60, Goroka, EHP 441, Papua New Guinea
    Malar J 11:157. 2012
    ..Findings presented in this paper primarily focus on diagnostic, prescription and treatment counselling practices...
  61. doi Indifferent to disease: a qualitative investigation of the reasons why some Papua New Guineans who own mosquito nets choose not to use them
    Justin Pulford
    Papua New Guinea Institute of Medical Research PNGIMR, Goroka, Papua New Guinea
    Soc Sci Med 75:2283-90. 2012
    ....
  62. ncbi Mapping the prevalence of malaria in rural Papua New Guinea using a geographic information system
    Elias Namosha
    Papua New Guinea Institute of Medical Research, Maprik, East Sepik Province, Papua New Guinea
    P N G Med J 53:5-14. 2010
    ..The optimized implementation of GIS can be of tremendous benefit in the fight against malaria and other public health challenges in PNG...
  63. pmc Artemisinin-naphthoquine combination therapy for uncomplicated pediatric malaria: a tolerability, safety, and preliminary efficacy study
    John Benjamin
    Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
    Antimicrob Agents Chemother 56:2465-71. 2012
    ..The lower single ART-NQ dose was associated with relatively frequent recurrence of parasitemia, but the prolonged gametocytemia in all three groups has implications for the transmission of malaria...
  64. ncbi The population structure of Plasmodium falciparum and Plasmodium vivax during an epidemic of malaria in the Eastern Highlands of Papua New Guinea
    Ivo Mueller
    PNG Institute of Medical Research, Goroka, Papua New Guinea
    Am J Trop Med Hyg 67:459-64. 2002
    ..This striking difference in genetic diversity suggests endemic, low-level local transmission for P. vivax but an outside introduction of P. falciparum as the most likely source of the epidemic...
  65. doi Malaria case management in Papua New Guinea following the introduction of a revised treatment protocol
    Justin Pulford
    Papua New Guinea Institute of Medical Research PNGIMR, Goroka, EHP 441, Papua New Guinea
    Malar J 12:433. 2013
    ..Health worker adherence to the new NMTP is also examined and comparisons made with previously reported pre-implementation findings...
  66. pmc Ownership and usage of mosquito nets after four years of large-scale free distribution in Papua New Guinea
    Manuel W Hetzel
    Papua New Guinea Institute of Medical Research, PO Box 60, Goroka, EHP 441, Papua New Guinea
    Malar J 11:192. 2012
    ..With the aim of achieving 80% ownership and usage, a country-wide campaign distributed two million free long-lasting insecticide-treated nets (LLINs)...
  67. pmc Seeking treatment for symptomatic malaria in Papua New Guinea
    Carol P Davy
    Papua New Guinea Institute of Medical Research, Goroka, Eastern Highland Province, Papua New Guinea
    Malar J 9:268. 2010
    ..This study aims to better understand what influences treatment-seeking behaviour for malaria in one such low-income country context, Papua New Guinea (PNG)...
  68. pmc Reported reasons for not using a mosquito net when one is available: a review of the published literature
    Justin Pulford
    Papua New Guinea Institute of Medical Research PNGIMR, PO Box 60, Goroka, EHP 441, Papua New Guinea
    Malar J 10:83. 2011
    ..It was anticipated that the review findings would potentially inform an intervention or range of interventions best suited to promoting greater net use amongst this group...
  69. ncbi A review of the current state of malaria among pregnant women in Papua New Guinea
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, PO Box 60, Goroka, Eastern Highlands Province 441, Papua New Guinea
    P N G Med J 51:12-6. 2008
    ....
  70. ncbi Complex patterns of malaria epidemiology in the highlands region of Papua New Guinea
    Ivo Mueller
    Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
    P N G Med J 45:200-5. 2002
    ..This diversity in both parasite and vector populations indicates that complex malaria patterns are found in Papua New Guinea even at the moderate transmission levels found in low-lying inter-montane valleys...
  71. pmc Evaluation of the antigenic diversity of placenta-binding Plasmodium falciparum variants and the antibody repertoire among pregnant women
    Mirja Hommel
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Infect Immun 78:1963-78. 2010
    ..Inclusion of a limited number of variants in a candidate vaccine may be sufficient for broad population coverage, but geographic considerations may also have to be included in vaccine design...
  72. ncbi Clinical immunity to malaria
    Louis Schofield
    The Walter and Eliza Hall Institute of Medical Research, 1G, Royal Parade, Parkville, Victoria 3050, Australia
    Curr Mol Med 6:205-21. 2006
    ..This review addresses the targets and determinants of clinical immunity, and considers the implications for vaccine development...
  73. pmc Cellular tumor necrosis factor, gamma interferon, and interleukin-6 responses as correlates of immunity and risk of clinical Plasmodium falciparum malaria in children from Papua New Guinea
    Leanne J Robinson
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, Australia
    Infect Immun 77:3033-43. 2009
    ..falciparum may therefore be important correlates of immunity and risk of symptomatic malaria episodes and thus warrant detailed investigation in relation to the development and implementation of effective vaccines...
  74. doi Association of early interferon-gamma production with immunity to clinical malaria: a longitudinal study among Papua New Guinean children
    Marthe C D'Ombrain
    Infection and Immunity Division, The Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Parkville, Victoria, Australia
    Clin Infect Dis 47:1380-7. 2008
    ..The question remains whether similar heterogeneity is observed in malaria-exposed individuals and whether high, medium, or low IFN-gamma responsiveness is differentially associated with protective immunity or morbidity...
  75. pmc Immunoglobulin G subclass-specific responses against Plasmodium falciparum merozoite antigens are associated with control of parasitemia and protection from symptomatic illness
    Danielle I Stanisic
    Infection and Immunity Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Australia
    Infect Immun 77:1165-74. 2009
    ..However, no antibody response was significantly associated with protection from parasitization per se. Our findings have major implications for understanding human immunity and for malaria vaccine development and evaluation...
  76. pmc Pyrethroid susceptibility in natural populations of the Anopheles punctulatus group (Diptera: Culicidae) in Papua New Guinea
    John B Keven
    Papua New Guinea Institute of Medical Research, Madang, Papua New Guinea
    Am J Trop Med Hyg 83:1259-61. 2010
    ..Our results show 100% susceptibility to pyrethroids in all populations surveyed and an absence of the kdr allele...
  77. doi Evidence that the erythrocyte invasion ligand PfRh2 is a target of protective immunity against Plasmodium falciparum malaria
    Linda Reiling
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 185:6157-67. 2010
    ..These findings provide evidence suggesting that PfRh2 is an important target of protective immunity in humans and that Abs act by controlling blood-stage parasitemia and support its potential for vaccine development...