James DiNicolantonio



  1. Dinicolantonio J. Aspirin 50 versus 100 mg: a case of wrong dosing. Am J Cardiol. 2011;108:1840 pubmed publisher
  2. Dinicolantonio J, Hackam D. Carvedilol: a third-generation ?-blocker should be a first-choice ?-blocker. Expert Rev Cardiovasc Ther. 2012;10:13-25 pubmed publisher
    ..We will provide compelling evidence of why carvedilol should be a first-line ?-blocker and why it offers many advantages over the ?1-selective ?-blockers...
  3. Dinicolantonio J. Azithromycin for prevention of exacerbations of COPD. N Engl J Med. 2011;365:2235; author reply 2236 pubmed publisher
  4. Dinicolantonio J, Lucan S, O Keefe J. The Evidence for Saturated Fat and for Sugar Related to Coronary Heart Disease. Prog Cardiovasc Dis. 2016;58:464-72 pubmed publisher
  5. Dinicolantonio J, Chatterjee S, O Keefe J. Dietary Salt Restriction in Heart Failure: Where Is the Evidence?. Prog Cardiovasc Dis. 2016;58:401-6 pubmed publisher
    ..To evaluate the strength of current evidences to recommend dietary salt restriction among HF patients, we performed a comprehensive literature review and explored the safety and efficacy of such recommendations. ..
  6. Dinicolantonio J, O Keefe J. Hypertension Due to Toxic White Crystals in the Diet: Should We Blame Salt or Sugar?. Prog Cardiovasc Dis. 2016;59:219-225 pubmed publisher
    ..Based on our review of the scientific literature, guidelines should focus more on reducing sugar rather than salt for the prevention and treatment of HTN and its consequences. ..
  7. McCarty M, DiNicolantonio J. Suppression of NADPH Oxidase Activity May Slow the Expansion of Osteolytic Bone Metastases. Healthcare (Basel). 2016;4: pubmed publisher
    ..Ingestion of omega-3-rich flaxseed or fish oil may also have potential for controlling osteolysis in cancer patients. ..
  8. Dinicolantonio J, Liu J, O Keefe J. Thiamine and Cardiovascular Disease: A Literature Review. Prog Cardiovasc Dis. 2018;: pubmed publisher
  9. Dinicolantonio J, Lavie C, Fares H, Menezes A, O Keefe J. Meta-analysis of carvedilol versus beta 1 selective beta-blockers (atenolol, bisoprolol, metoprolol, and nebivolol). Am J Cardiol. 2013;111:765-9 pubmed publisher
    ..Additionally, carvedilol significantly reduced all-cause mortality compared with ?(1)-selective BBs in AMI patients using the fixed-effects model but not using the random-effects model...

Detail Information


  1. Dinicolantonio J, Tomek A. Misrepresentation of vital status follow-up: challenging the integrity of the PLATO trial and the claimed mortality benefit of ticagrelor versus clopidogrel. Int J Cardiol. 2013;169:145-6 pubmed publisher
    ..The fact that significantly more patients on ticagrelor had incomplete vital status follow-up versus clopidogrel challenges the claimed mortality benefit of ticagrelor and the approval of the PLATO trial. ..
  2. Dinicolantonio J, Mehta V, O Keefe J. Is Salt a Culprit or an Innocent Bystander in Hypertension? A Hypothesis Challenging the Ancient Paradigm. Am J Med. 2017;130:893-899 pubmed publisher
  3. McCarty M, O Keefe J, Dinicolantonio J. Interleukin-1beta may act on hepatocytes to boost plasma homocysteine - The increased cardiovascular risk associated with elevated homocysteine may be mediated by this cytokine. Med Hypotheses. 2017;102:78-81 pubmed publisher
  4. Dinicolantonio J, O Keefe J. The History of the Salt Wars. Am J Med. 2017;130:1011-1014 pubmed publisher
    ..The overall evidence in the first half of the 1900s suggests that a low-salt diet was not a reasonable strategy for treating hypertension. ..
  5. Dinicolantonio J, Mehta V, Onkaramurthy N, O Keefe J. Fructose-induced inflammation and increased cortisol: A new mechanism for how sugar induces visceral adiposity. Prog Cardiovasc Dis. 2017;: pubmed publisher
    ..This review paper will discuss in detail the hypothesis that fructose-induced inflammation and cortisol activation causes visceral adiposity. ..