Charles A Dinarello

Summary

Publications

  1. pmc IL-37 is a fundamental inhibitor of innate immunity
    Marcel F Nold
    Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA
    Nat Immunol 11:1014-22. 2010
  2. pmc Membrane interleukin-18 revisits membrane IL-1α in T-helper type 1 responses
    Charles A Dinarello
    University of Colorado Denver, Division of Infectious Diseases, B168, 12700 East 19th Ave, Auroia, CO 80045, USA
    Eur J Immunol 42:1385-7. 2012
  3. doi request reprint A clinical perspective of IL-1β as the gatekeeper of inflammation
    Charles A Dinarello
    Department of Medicine, University of Colorado, Aurora, CO 80045, USA
    Eur J Immunol 41:1203-17. 2011
  4. pmc Anti-inflammatory Agents: Present and Future
    Charles A Dinarello
    Department of Medicine, University of Colorado, Aurora, 80045, USA
    Cell 140:935-50. 2010
  5. doi request reprint IL-1: discoveries, controversies and future directions
    Charles A Dinarello
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Eur J Immunol 40:599-606. 2010
  6. pmc Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
    Charles A Dinarello
    Department of Medicine, University of Colorado, Aurora, CO 80045, USA
    Blood 117:3720-32. 2011
  7. doi request reprint Immunological and inflammatory functions of the interleukin-1 family
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Denver, Aurora, Colorado 80045, USA
    Annu Rev Immunol 27:519-50. 2009
  8. pmc Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
    PLoS Med 3:e277. 2006
  9. doi request reprint IL-32 is a host protective cytokine against Mycobacterium tuberculosis in differentiated THP-1 human macrophages
    Xiyuan Bai
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver at Anschutz Medical Center, Denver, CO 80045, USA
    J Immunol 184:3830-40. 2010
  10. ncbi request reprint Regulation of Staphylococcus epidermidis-induced IFN-gamma in whole human blood: the role of endogenous IL-18, IL-12, IL-1, and TNF
    Rogier J L Stuyt
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Cytokine 21:65-73. 2003

Collaborators

Detail Information

Publications79

  1. pmc IL-37 is a fundamental inhibitor of innate immunity
    Marcel F Nold
    Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA
    Nat Immunol 11:1014-22. 2010
    ..IL-37 thus emerges as a natural suppressor of innate inflammatory and immune responses...
  2. pmc Membrane interleukin-18 revisits membrane IL-1α in T-helper type 1 responses
    Charles A Dinarello
    University of Colorado Denver, Division of Infectious Diseases, B168, 12700 East 19th Ave, Auroia, CO 80045, USA
    Eur J Immunol 42:1385-7. 2012
    ..The immunological and inflammatory implications for this finding are considerable because of the role of IL-18 as the primary IFN-γ inducing cytokine in promoting Th1 responses...
  3. doi request reprint A clinical perspective of IL-1β as the gatekeeper of inflammation
    Charles A Dinarello
    Department of Medicine, University of Colorado, Aurora, CO 80045, USA
    Eur J Immunol 41:1203-17. 2011
    ..Evidence for the involvement of IL-1β and the clinical results of reducing IL-1β activity in this broad spectrum of inflammatory diseases are the focus of this review...
  4. pmc Anti-inflammatory Agents: Present and Future
    Charles A Dinarello
    Department of Medicine, University of Colorado, Aurora, 80045, USA
    Cell 140:935-50. 2010
    ..This Review discusses the current status of anti-inflammatory drug research and the development of new anti-inflammatory therapeutics...
  5. doi request reprint IL-1: discoveries, controversies and future directions
    Charles A Dinarello
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Eur J Immunol 40:599-606. 2010
    ....
  6. pmc Interleukin-1 in the pathogenesis and treatment of inflammatory diseases
    Charles A Dinarello
    Department of Medicine, University of Colorado, Aurora, CO 80045, USA
    Blood 117:3720-32. 2011
    ..This review summarizes acute and chronic inflammatory diseases that are treated by reducing IL-1β activity and proposes that disease severity is affected by the anti-inflammatory members of the IL-1 family of ligands and receptors...
  7. doi request reprint Immunological and inflammatory functions of the interleukin-1 family
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Denver, Aurora, Colorado 80045, USA
    Annu Rev Immunol 27:519-50. 2009
    ....
  8. pmc Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
    PLoS Med 3:e277. 2006
    ..Interleukin (IL)-32 is a newly described proinflammatory cytokine that seems likely to play a role in inflammation and host defense. Little is known about the regulation of IL-32 production by primary cells of the immune system...
  9. doi request reprint IL-32 is a host protective cytokine against Mycobacterium tuberculosis in differentiated THP-1 human macrophages
    Xiyuan Bai
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver at Anschutz Medical Center, Denver, CO 80045, USA
    J Immunol 184:3830-40. 2010
    ..tuberculosis bacteria, which was modestly but significantly abrogated with a caspase-3 inhibitor. We conclude that IL-32 plays a host defense role against M. tuberculosis in differentiated THP-1 human macrophages...
  10. ncbi request reprint Regulation of Staphylococcus epidermidis-induced IFN-gamma in whole human blood: the role of endogenous IL-18, IL-12, IL-1, and TNF
    Rogier J L Stuyt
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Cytokine 21:65-73. 2003
    ..In conclusion, S. epidermidis stimulates IFN-gamma which is IL-18, IL-12 and TNF-dependent, but IL-1 independent...
  11. pmc Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
    Blood 113:2324-35. 2009
    ..We conclude that IL-1beta production is differentially regulated in monocytes and macrophages, and this reflects their separate functions in host defense and inflammation...
  12. pmc Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury
    Zhibin He
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Physiol Renal Physiol 295:F1414-21. 2008
    ..In conclusion, protection against ischemic AKI in IL-18BP Tg mice is associated with less macrophage infiltration and less production of CXCL1 in the kidney...
  13. pmc IL-32-dependent effects of IL-1beta on endothelial cell functions
    Claudia A Nold-Petry
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 106:3883-8. 2009
    ..This study introduces IL-32 as a critical regulator of endothelial function, expanding the properties of this cytokine relevant to coagulation, endothelial inflammation, and atherosclerosis...
  14. ncbi request reprint Endogenous IL-32 controls cytokine and HIV-1 production
    Marcel F Nold
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 181:557-65. 2008
    ..In summary, depletion of endogenous IL-32 reduced the levels of Th1 and proinflammatory cytokines but paradoxically increased p24, proposing IL-32 as a natural inhibitor of HIV-1...
  15. pmc Interleukin-32 induces the differentiation of monocytes into macrophage-like cells
    Mihai G Netea
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 105:3515-20. 2008
    ..Thus, IL-32 not only contributes to host responses through the induction of proinflammatory cytokines but also directly affects specific immunity by differentiating monocytes into macrophage-like cells...
  16. ncbi request reprint Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice
    Wei Wang
    Department of Medicine, Division of Renal Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Renal Physiol 288:F997-1004. 2005
    ..Neutralization of IL-1beta and IL-18 is not functionally protective. The role of the intracellular proinflammatory cytokine IL-1alpha in endotoxemic ARF merits further study...
  17. ncbi request reprint Frontline: interferon regulatory factor-1 as a protective gene in intestinal inflammation: role of TCR gamma delta T cells and interleukin-18-binding protein
    Britta Siegmund
    Department of Medicine, University of Colorado Health Sciences Center, Denver, USA
    Eur J Immunol 34:2356-64. 2004
    ..IL-18BP and TCR gamma delta cells appear to be critical factors in the anti-inflammatory effects of IRF-1...
  18. ncbi request reprint Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin
    Joseph A Sennello
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Endocrinology 146:2157-64. 2005
    ..In conclusion, although leptin increases susceptibility to hepatotoxicity by regulating cytokine production and T cell activation, adiponectin protects hepatocytes from TNF alpha-induced death...
  19. ncbi request reprint Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis
    Xianzhong Meng
    Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Physiol Cell Physiol 294:C29-35. 2008
    ..These results suggest that TLR2 and TLR4 may play a role in aortic valve inflammation and stenosis...
  20. pmc Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling
    Claudia A Nold-Petry
    Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Biol Chem 284:25900-11. 2009
    ....
  21. pmc IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist
    Frank L van de Veerdonk
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 109:3001-5. 2012
    ..These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra, and that IL-38 and IL-36Ra have similar biological effects on immune cells by engaging the IL-36 receptor...
  22. doi request reprint Alpha-1-antitrypsin therapy ameliorates acute colitis and chronic murine ileitis
    Colm B Collins
    Mucosal Inflammation Program, Division of Gastroenterology, University of Colorado School of Medicine, Aurora, Colorado, USA
    Inflamm Bowel Dis 19:1964-73. 2013
    ....
  23. ncbi request reprint Generation and characterization of mice transgenic for human IL-18-binding protein isoform a
    Giamila Fantuzzi
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Leukoc Biol 74:889-96. 2003
    ..These results indicate that high endogenous levels of IL-18BP in trangenic mice effectively neutralize IL-18 and are protective in response to different inflammatory stimuli...
  24. ncbi request reprint Interleukin-32: a cytokine and inducer of TNFalpha
    Soo Hyun Kim
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Immunity 22:131-42. 2005
    ....
  25. pmc Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide
    Philip Bufler
    Division of Infectious Diseases, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Denver, CO 80262, USA
    Biochem J 381:503-10. 2004
    ..These results indicate that both IL-1F7b and IL-18 mRNA contain functional instability determinants within their coding region, which influence mRNA decay as a novel mechanism to regulate the expression of IL-1 family members...
  26. pmc Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice
    Eli C Lewis
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 102:12153-8. 2005
    ..In light of the established safety record and the nondiabetogenic potential of AAT, these data suggest that AAT may be beneficial as adjunctive therapy in patients undergoing islet transplantation...
  27. ncbi request reprint Interleukin 18 and interleukin 18 binding protein: possible role in immunosuppression of chronic renal failure
    Charles A Dinarello
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
    Blood Purif 21:258-70. 2003
    ..Because of the importance of IL-18 and IFN-gamma in the Th1 response, the biology of IL-18 and IL-18BP is reviewed here in the context of the immunosuppression of chronic renal failure...
  28. pmc Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor
    Eli C Lewis
    Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 103:16852-7. 2006
    ..Importantly, discrepancies between IL-18- and IL-18R-deficient cells suggest that IL-18Ralpha chain is used by an inflammation-suppressing signal...
  29. ncbi request reprint Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Endotoxin Res 10:201-22. 2004
    ..Thus, fever is the result of either cytokine receptor or TLR triggering; in autoimmune diseases, fever is mostly cytokine mediated whereas both cytokine and TLR account for fever during infection...
  30. pmc The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet β cells in vivo and in vitro
    Eli C Lewis
    Department of Medicine, University of Colorado Denver, Aurora, Colorado, USA
    Mol Med 17:369-77. 2011
    ..01). Thus at clinically relevant doses, the orally active HDAC inhibitor ITF2357 favors β-cell survival during inflammatory conditions...
  31. ncbi request reprint The combination of soluble IL-18Ralpha and IL-18Rbeta chains inhibits IL-18-induced IFN-gamma
    Leonid L Reznikov
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Interferon Cytokine Res 22:593-601. 2002
    ..These studies reveal that the combination of the ligand-binding and the nonligand-binding extracellular domains of IL-18R is needed to inhibit IL-18, whereas IL-18BP neutralizes at equimolar concentration...
  32. pmc Cytokines link Toll-like receptor 4 signaling to cardiac dysfunction after global myocardial ischemia
    John Cha
    Department of Surgery, University of Colorado Denver, Denver, Colorado 80262, USA
    Ann Thorac Surg 85:1678-85. 2008
    ..This study examined whether TLR4 regulates TNF-alpha and interleukin (IL)-1beta peptide production during global ischemia/reperfusion and whether TLR4 signaling influences postischemic cardiac function through TNF-alpha and IL-1beta...
  33. pmc Alpha-1-antitrypsin is an endogenous inhibitor of proinflammatory cytokine production in whole blood
    Gregory B Pott
    Denver Veterans Affairs Medical Center, Department of Medicine, Division of Infectious Diseases, University of Colorado Denver, 12700 E 19th Ave, Aurora, CO 80045, USA
    J Leukoc Biol 85:886-95. 2009
    ..These ex vivo and in vitro observations suggest that endogenous AAT in blood contributes to the suppression of proinflammatory cytokine synthesis...
  34. ncbi request reprint Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors
    Mihai G Netea
    Division of Infectious Diseases, B168 University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Leukoc Biol 80:1454-61. 2006
    ..This latter finding supports the concept that TREM-1 provides optimal amplification of cytokine-induced inflammation during the initiation of host defense...
  35. pmc Dual role of apoptosis-associated speck-like protein containing a CARD (ASC) in tumorigenesis of human melanoma
    Weimin Liu
    Department of Dermatology, University of Colorado Denver, School of Medicine, Aurora, Colorado, USA
    J Invest Dermatol 133:518-27. 2013
    ..In metastatic melanoma, on the other hand, this inhibitory effect is diminished, and ASC induces tumorigenic pathways through enhanced NF-κB activity and inflammasome-mediated IL-1β secretion...
  36. ncbi request reprint Interleukin-18 and the pathogenesis of inflammatory diseases
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO, USA
    Semin Nephrol 27:98-114. 2007
    ..Other options for reducing IL-18 activities are inhibitors of caspase-1, human monoclonal antibodies to IL-18, soluble IL-18 receptors, and anti-IL-18 receptor monoclonal antibodies...
  37. pmc Interleukin 37 expression protects mice from colitis
    Eoin N McNamee
    Department of Medicine, Section of Pediatric Gastroenterology, Digestive Health Institute, Children s Hospital Colorado, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 108:16711-6. 2011
    ..Thus, IL-37 emerges as key modulator of intestinal inflammation...
  38. ncbi request reprint The paradox of pro-inflammatory cytokines in cancer
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, 4200 East Ninth Ave, B168, Denver, CO 80262, USA
    Cancer Metastasis Rev 25:307-13. 2006
    ..However, blocking cytokines will not kill tumor cells nor prevent carcinogenesis. Blocking cytokines is best as an adjunct therapy together with tumorocidal drugs...
  39. pmc Differences in signaling pathways by IL-1beta and IL-18
    Jae Kwon Lee
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 101:8815-20. 2004
    ..We conclude that in epithelial cells, IL-18 signal transduction is primarily via the MAPK p38 pathway rather than NF-kappaB, which may explain the absence of COX-2 and the failure of IL-18 to cause fever...
  40. pmc Why not treat human cancer with interleukin-1 blockade?
    Charles A Dinarello
    Department of Medicine, University of Colorado, 12700 East 19th Ave, B168, Aurora, CO 80045, USA
    Cancer Metastasis Rev 29:317-29. 2010
    ....
  41. pmc alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice
    Eli C Lewis
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 105:16236-41. 2008
    ..Because AAT treatment in humans is safe, its use during human islet transplantation may be considered...
  42. doi request reprint Protection from RNA and DNA viruses by IL-32
    Jarod A Zepp
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    J Immunol 186:4110-8. 2011
    ..In conclusion, these data suggest a central role for IL-32 in the immune response to RNA and DNA viruses, which may be exploitable for clinical use in the future...
  43. pmc Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta
    Miyako Okamoto
    Department of Dermatology, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Biol Chem 285:6477-88. 2010
    ....
  44. pmc Abrogation of anti-inflammatory transcription factor LKLF in neutrophil-dominated airways
    Milene T Saavedra
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
    Am J Respir Cell Mol Biol 38:679-88. 2008
    ....
  45. pmc IL-32 expression in the airway epithelial cells of patients with Mycobacterium avium complex lung disease
    Xiyuan Bai
    Department of Medicine, Denver Veterans Affairs Medical Center, Denver, CO 80220, USA
    Int Immunol 23:679-91. 2011
    ..These findings indicate that IL-32 facilitates host defense against MAC organisms but may also contribute to the airway inflammation associated with MAC pulmonary disease...
  46. pmc Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat)
    Antonio Furlan
    Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    Mol Med 17:353-62. 2011
    ..We conclude that dosing of 50 or 100 mg ITF2357 is safe in healthy humans and transiently but repeatedly reduces the production of proinflammatory cytokines without affecting production of antiinflammatory cytokines...
  47. ncbi request reprint Unraveling the NALP-3/IL-1beta inflammasome: a big lesson from a small mutation
    Charles A Dinarello
    University Colorado Health Sciences Center, Division of Infectious Diseases, B168, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Immunity 20:243-4. 2004
    ..Blocking IL-1 receptors arrests inflammation in humans with the mutation...
  48. pmc Innate immune response of human alveolar macrophages during influenza A infection
    Jieru Wang
    Department of Medicine, National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 7:e29879. 2012
    ..Targeting local components of innate immune response might provide a strategy for controlling influenza A infection-induced proinflammatory response in vivo...
  49. pmc The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4(+) T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro
    Shay Matalon
    Department of Medicine, University of Colorado Denver, 12700 E 19th Avenue B 168, Aurora, CO 80045, USA
    J Acquir Immune Defic Syndr 54:1-9. 2010
    ..Here we compared the efficacy of ITF2357, an orally active and safe HDAC inhibitor, with VPA for HIV-1 expression from latently infected cells in vitro. We also evaluated the effect of ITF2357 on the surface expression of CXCR4 and CCR5...
  50. pmc Blocking IL-1 in systemic inflammation
    Charles A Dinarello
    Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Exp Med 201:1355-9. 2005
    ..Loss of control of the secretion of IL-1beta might be a common mechanism explaining the aberrant activity of IL-1 in these diseases...
  51. ncbi request reprint Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Clin Nutr 83:447S-455S. 2006
    ..From human and animal studies, one may conclude that IL-1beta and IL-18 participate in fundamental inflammatory processes that increase during the aging process...
  52. ncbi request reprint α1-Antitrypsin Therapy Downregulates Toll-Like Receptor-Induced IL-1β Responses in Monocytes and Myeloid Dendritic Cells and May Improve Islet Function in Recently Diagnosed Patients With Type 1 Diabetes
    Peter A Gottlieb
    Barbara Davis Center for Childhood Diabetes P A G, A K A, A W M, D Z and Division of Infectious Diseases C A D, University of Colorado Denver, Aurora, Colorado 80045 Department of Clinical Biochemistry and Pharmacology E C L, Faculty of Health Sciences, Ben Gurion University of the Negev, 84105 Beer Sheva, Israel and Department of Medicine L S, Division of Infectious Diseases, Veterans Affairs Medical Center and University of Colorado Denver, Denver, Colorado 80202
    J Clin Endocrinol Metab 99:E1418-26. 2014
    ..Recent studies have implicated proinflammatory responses in the mechanism of type 1 diabetes (T1D)...
  53. pmc Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
    Charles A Dinarello
    Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    Nat Rev Drug Discov 11:633-52. 2012
    ..In addition, a monoclonal antibody directed against the IL-1 receptor and a neutralizing anti-IL-1α antibody are in clinical trials...
  54. ncbi request reprint Differences between anti-tumor necrosis factor-alpha monoclonal antibodies and soluble TNF receptors in host defense impairment
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Rheumatol Suppl 74:40-7. 2005
    ....
  55. pmc Histone deacetylase inhibitors for treating a spectrum of diseases not related to cancer
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Denver, Aurora, Colorado 80045, USA
    Mol Med 17:333-52. 2011
    ..The data suggest the use of HDACi's in treating autoimmune as well as chronic inflammatory diseases...
  56. ncbi request reprint The role of endogenous interleukin (IL)-18, IL-12, IL-1beta, and tumor necrosis factor-alpha in the production of interferon-gamma induced by Candida albicans in human whole-blood cultures
    Mihai G Netea
    Department of Medicine and Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Infect Dis 185:963-70. 2002
    ..Blocking the biologic activities of IL-18, IL-12, and IL-1beta in patients (e.g., for treatment of autoimmune diseases) may result in increased susceptibility to C. albicans infection...
  57. pmc Role of IL-18 in second-hand smoke-induced emphysema
    Adelheid Kratzer
    Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado at Denver, Aurora, CO 80045, USA
    Am J Respir Cell Mol Biol 48:725-32. 2013
    ..Our findings suggest that IL-18-mediated endothelial cell death may contribute to vascular destruction and disappearance in SHS-induced COPD. Moreover, IL-18 and IL-18BP are potential new targets for therapeutics...
  58. ncbi request reprint Anti-cytokine therapeutics and infections
    Charles A Dinarello
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Vaccine 21:S24-34. 2003
    ....
  59. ncbi request reprint High cytokine levels at admission are associated with fatal outcome in patients with necrotizing fasciitis
    Kathrin Lungstras-Bufler
    University of Colorado, Health Sciences Center, Denver, CO 80262, USA
    Eur Cytokine Netw 15:135-8. 2004
    ..The measurement of proinflammatory cytokines and IL-1Ra may help to establish early diagnosis of life-threatening necrotizing fasciitis and thus to initiate aggressive treatment...
  60. ncbi request reprint Interleukin-18 and the treatment of rheumatoid arthritis
    Charles A Dinarello
    Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, B168, Denver, CO 80262, USA
    Rheum Dis Clin North Am 30:417-34, ix. 2004
    ....
  61. ncbi request reprint Interleukin-18 and host defense against infection
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Infect Dis 187:S370-84. 2003
    ..Thus, blockade of IL-18 appears to be a viable clinical target to combat the pathologic consequences of sepsis via IFN-gamma mechanisms...
  62. ncbi request reprint Therapeutic strategies to reduce IL-1 activity in treating local and systemic inflammation
    Charles A Dinarello
    University of Colorado Health Sciences Center, Division of Infectious Diseases, B168, 4200 East Ninth Ave, Denver, Colorado 80262, USA
    Curr Opin Pharmacol 4:378-85. 2004
    ....
  63. pmc Histone deacetylase inhibitors for purging HIV-1 from the latent reservoir
    Shay Matalon
    Department of Medicine, Division of Infectious Diseases, University of Colorado Denver, Aurora, Colorado 80045, USA
    Mol Med 17:466-72. 2011
    ..An additional benefit is the antiinflammatory properties of HDAC inhibitors, including downregulation of HIV-1 coreceptor expression...
  64. ncbi request reprint Caspase-1-deficient mice are protected against cisplatin-induced apoptosis and acute tubular necrosis
    Sarah Faubel
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Kidney Int 66:2202-13. 2004
    ..Although well studied in vitro, caspases have not been previously studied in cisplatin-induced acute renal failure (ARF) in vivo...
  65. doi request reprint Role of IL-1beta in type 2 diabetes
    Charles A Dinarello
    Department of Medicine, University of Colorado, Aurora, Colorado 80045, USA
    Curr Opin Endocrinol Diabetes Obes 17:314-21. 2010
    ..To understand the role of inflammation as the fundamental cause of type 2 diabetes and specifically to examine the contribution of IL-1beta...
  66. ncbi request reprint Hyperosmolar sodium chloride, p38 mitogen activated protein and cytokine-mediated inflammation
    Charles A Dinarello
    Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Semin Dial 22:256-9. 2009
    ..Hence a possible link of high salt intake, inflammation, and atherogenesis may be one molecular mechanism for the association of high salt intake and cardiovascular events...
  67. pmc Ozone exposure of macrophages induces an alveolar epithelial chemokine response through IL-1alpha
    Rizwan Manzer
    Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 38:318-23. 2008
    ..These observations indicate that secretion of IL-1alpha from macrophages stimulates alveolar epithelial cells to secrete chemokines that can elicit an inflammatory response...
  68. pmc Historical insights into cytokines
    Charles A Dinarello
    University of Colorado Health Sciences Center, 4200 East Ninth Ave, B168, Denver, CO 80262, USA
    Eur J Immunol 37:S34-45. 2007
    ..A recent advance in the field has been that of differential cytokine production, which can be used to classify human disease as being "autoimmune" or "autoinflammatory" thus impacting on therapeutic interventions...
  69. ncbi request reprint Effect of a four-week course of interleukin-10 on cytokine production in a placebo-controlled study of HIV-1-infected subjects
    Gregory B Pott
    Department of Medicine, Division of Infectious Diseases, University of Colorado at Denver and Health Sciences Center, 4200 E 9th Ave Box B168, Denver, CO 80262, USA
    Eur Cytokine Netw 18:49-58. 2007
    ....
  70. ncbi request reprint A signal for the caspase-1 inflammasome free of TLR
    Charles A Dinarello
    Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue B168, Denver, CO 80262, USA
    Immunity 26:383-5. 2007
    ..However, Kanneganti et al. (2007) find that bacteria can use pore-forming mechanisms to activate caspase-1 for the production of IL-1beta precursor independently of TLRs...
  71. ncbi request reprint Interleukin-1beta
    Charles A Dinarello
    University of Colorado Health Sciences Center, Denver, CO, USA
    Crit Care Med 33:S460-2. 2005
  72. doi request reprint Bypassing pathogen-induced inflammasome activation for the regulation of interleukin-1beta production by the fungal pathogen Candida albicans
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Infect Dis 199:1087-96. 2009
    ..The aim of the present study was to investigate the pathways of IL-1beta production induced by Candida albicans in human monocytes...
  73. doi request reprint Intravitreal anakinra inhibits choroidal neovascular membrane growth in a rat model
    Jeffrey L Olson
    University of Colorado Denver, Denver, Colorado, USA
    Ocul Immunol Inflamm 17:195-200. 2009
    ..To determine the effect of intravitreal anakinra on choroidal neovascularization (CNV) in an animal model...
  74. pmc Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta
    Leo A B Joosten
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 60:3651-62. 2009
    ..This study was undertaken to establish the relative importance of caspase 1 and serine proteases in mouse models of acute and chronic inflammatory arthritis...
  75. pmc Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Center and Nijmegen Institute for Infection, Inflammation, and Immunity N4i, 6500 HB Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 107:3030-3. 2010
    ..The absence of ROS in CGD monocytes may explain the presence of an inflammatory phenotype characterized by granulomas and inflammatory bowel disease occurring in CGD patients...
  76. ncbi request reprint Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    Eur J Immunol 32:1188-95. 2002
    ..pneumoniae stimulates cytokine production in a serum-dependent manner, but independently of complement, MBL and LBP. C. pneumoniae induces the pro-inflammatory cytokines TNF and IL-1beta through TLR2, but not TLR4 and CD14...
  77. doi request reprint IL-32gamma and Streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2
    Bas Heinhuis
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500HB, Nijmegen, The Netherlands
    Ann Rheum Dis 69:1866-72. 2010
    ..To investigate the potential synergism between interleukin (IL) 32γ and Streptococcus pyogenes cell wall (SCW) fragments in the development of destructive arthritis...
  78. pmc Role of interleukin-18 in host defense against disseminated Candida albicans infection
    Rogier J L Stuyt
    Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    Infect Immun 70:3284-6. 2002
    ..There was no effect on the organ load with Candida when gamma interferon (IFN-gamma)-deficient mice were treated with anti-IL-18 antibodies, suggesting that the protective effect of IL-18 is mediated through endogenous IFN-gamma...
  79. ncbi request reprint Transcriptional and inflammasome-mediated pathways for the induction of IL-1beta production by Mycobacterium tuberculosis
    Johanneke Kleinnijenhuis
    Department of Medicine, Radboud University Nijmegen Medical Center, The Netherlands
    Eur J Immunol 39:1914-22. 2009
    ..In conclusion, we have dissected the molecular mechanisms responsible for IL-1beta production by M. tuberculosis, and that may contribute to a deeper knowledge of the mechanisms of cell activation by M. tuberculosis...