C A Dinarello

Summary

Publications

  1. ncbi request reprint The paradox of pro-inflammatory cytokines in cancer
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, 4200 East Ninth Ave, B168, Denver, CO 80262, USA
    Cancer Metastasis Rev 25:307-13. 2006
  2. doi request reprint Interleukin-37
    Charles A Dinarello
    Department of Medicine, University of Colorado Denver, Aurora, CO, USA Department of Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands Electronic address
    Semin Immunol 25:466-8. 2013
  3. doi request reprint Overview of the interleukin-1 family of ligands and receptors
    Charles A Dinarello
    Department of Medicine, University of Colorado Denver, Aurora, CO, United States Department of Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands Electronic address
    Semin Immunol 25:389-93. 2013
  4. pmc Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
    Charles A Dinarello
    Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    Nat Rev Drug Discov 11:633-52. 2012
  5. pmc Why not treat human cancer with interleukin-1 blockade?
    Charles A Dinarello
    Department of Medicine, University of Colorado, 12700 East 19th Ave, B168, Aurora, CO 80045, USA
    Cancer Metastasis Rev 29:317-29. 2010
  6. ncbi request reprint A signal for the caspase-1 inflammasome free of TLR
    Charles A Dinarello
    Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue B168, Denver, CO 80262, USA
    Immunity 26:383-5. 2007
  7. pmc Histone deacetylase inhibitors for treating a spectrum of diseases not related to cancer
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Denver, Aurora, Colorado 80045, USA
    Mol Med 17:333-52. 2011
  8. pmc Blocking interleukin-1β in acute and chronic autoinflammatory diseases
    C A Dinarello
    Department of Medicine, University of Colorado, Aurora, CO, USA
    J Intern Med 269:16-28. 2011
  9. ncbi request reprint Hyperosmolar sodium chloride, p38 mitogen activated protein and cytokine-mediated inflammation
    Charles A Dinarello
    Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Semin Dial 22:256-9. 2009
  10. pmc Historical insights into cytokines
    Charles A Dinarello
    University of Colorado Health Sciences Center, 4200 East Ninth Ave, B168, Denver, CO 80262, USA
    Eur J Immunol 37:S34-45. 2007

Collaborators

Detail Information

Publications133 found, 100 shown here

  1. ncbi request reprint The paradox of pro-inflammatory cytokines in cancer
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, 4200 East Ninth Ave, B168, Denver, CO 80262, USA
    Cancer Metastasis Rev 25:307-13. 2006
    ..However, blocking cytokines will not kill tumor cells nor prevent carcinogenesis. Blocking cytokines is best as an adjunct therapy together with tumorocidal drugs...
  2. doi request reprint Interleukin-37
    Charles A Dinarello
    Department of Medicine, University of Colorado Denver, Aurora, CO, USA Department of Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands Electronic address
    Semin Immunol 25:466-8. 2013
    ..Indeed, in mice expressing human IL-37, inflammation is reduced in models of LPS shock, chemical colitis, cardiac ischemia and contact dermatitis. ..
  3. doi request reprint Overview of the interleukin-1 family of ligands and receptors
    Charles A Dinarello
    Department of Medicine, University of Colorado Denver, Aurora, CO, United States Department of Medicine, University Medical Center Nijmegen, Nijmegen, The Netherlands Electronic address
    Semin Immunol 25:389-93. 2013
    ....
  4. pmc Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases
    Charles A Dinarello
    Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    Nat Rev Drug Discov 11:633-52. 2012
    ..In addition, a monoclonal antibody directed against the IL-1 receptor and a neutralizing anti-IL-1α antibody are in clinical trials...
  5. pmc Why not treat human cancer with interleukin-1 blockade?
    Charles A Dinarello
    Department of Medicine, University of Colorado, 12700 East 19th Ave, B168, Aurora, CO 80045, USA
    Cancer Metastasis Rev 29:317-29. 2010
    ....
  6. ncbi request reprint A signal for the caspase-1 inflammasome free of TLR
    Charles A Dinarello
    Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue B168, Denver, CO 80262, USA
    Immunity 26:383-5. 2007
    ..However, Kanneganti et al. (2007) find that bacteria can use pore-forming mechanisms to activate caspase-1 for the production of IL-1beta precursor independently of TLRs...
  7. pmc Histone deacetylase inhibitors for treating a spectrum of diseases not related to cancer
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Denver, Aurora, Colorado 80045, USA
    Mol Med 17:333-52. 2011
    ..The data suggest the use of HDACi's in treating autoimmune as well as chronic inflammatory diseases...
  8. pmc Blocking interleukin-1β in acute and chronic autoinflammatory diseases
    C A Dinarello
    Department of Medicine, University of Colorado, Aurora, CO, USA
    J Intern Med 269:16-28. 2011
    ..Flares of gout, type 2 diabetes, heart failure and smouldering multiple myeloma are examples of seemingly unrelated diseases, which are uniquely responsive to IL 1β neutralization...
  9. ncbi request reprint Hyperosmolar sodium chloride, p38 mitogen activated protein and cytokine-mediated inflammation
    Charles A Dinarello
    Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Semin Dial 22:256-9. 2009
    ..Hence a possible link of high salt intake, inflammation, and atherogenesis may be one molecular mechanism for the association of high salt intake and cardiovascular events...
  10. pmc Historical insights into cytokines
    Charles A Dinarello
    University of Colorado Health Sciences Center, 4200 East Ninth Ave, B168, Denver, CO 80262, USA
    Eur J Immunol 37:S34-45. 2007
    ..A recent advance in the field has been that of differential cytokine production, which can be used to classify human disease as being "autoimmune" or "autoinflammatory" thus impacting on therapeutic interventions...
  11. ncbi request reprint Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Endotoxin Res 10:201-22. 2004
    ..Thus, fever is the result of either cytokine receptor or TLR triggering; in autoimmune diseases, fever is mostly cytokine mediated whereas both cytokine and TLR account for fever during infection...
  12. pmc IL-32, a novel cytokine with a possible role in disease
    C A Dinarello
    University of Colorado, Health Science Center, 4200 East Ninth Avenue, 80262 Denver, CO, USA
    Ann Rheum Dis 65:iii61-4. 2006
    ..Thus, IL-32 exhibits many properties of proinflammatory cytokines and associations with disease severity...
  13. doi request reprint Role of IL-1beta in type 2 diabetes
    Charles A Dinarello
    Department of Medicine, University of Colorado, Aurora, Colorado 80045, USA
    Curr Opin Endocrinol Diabetes Obes 17:314-21. 2010
    ..To understand the role of inflammation as the fundamental cause of type 2 diabetes and specifically to examine the contribution of IL-1beta...
  14. ncbi request reprint Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Clin Nutr 83:447S-455S. 2006
    ..From human and animal studies, one may conclude that IL-1beta and IL-18 participate in fundamental inflammatory processes that increase during the aging process...
  15. pmc Blocking IL-1 in systemic inflammation
    Charles A Dinarello
    Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Exp Med 201:1355-9. 2005
    ..Loss of control of the secretion of IL-1beta might be a common mechanism explaining the aberrant activity of IL-1 in these diseases...
  16. ncbi request reprint Therapeutic strategies to reduce IL-1 activity in treating local and systemic inflammation
    Charles A Dinarello
    University of Colorado Health Sciences Center, Division of Infectious Diseases, B168, 4200 East Ninth Ave, Denver, Colorado 80262, USA
    Curr Opin Pharmacol 4:378-85. 2004
    ....
  17. ncbi request reprint Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production
    B Siegmund
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80206, USA
    Am J Physiol Regul Integr Comp Physiol 281:R1264-73. 2001
    ..The stimulation of lamina propria mononuclear cells by IL-18 and IL-12 resulted in a synergistic increase in IFN-gamma synthesis. These findings suggest that IL-18 is a pivotal mediator in experimental colitis...
  18. pmc IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-gamma
    L L Reznikov
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 97:2174-9. 2000
    ..These studies demonstrate that IL-18BP decreases endogenous IL-18 activity by reducing IFN-gamma-mediated responses...
  19. ncbi request reprint Interleukin-18 regulation of interferon gamma production and cell proliferation as shown in interleukin-1beta-converting enzyme (caspase-1)-deficient mice
    G Fantuzzi
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Blood 91:2118-25. 1998
    ..Our results show that IL-18 is an IL-12-independent regulator of IFNgamma production and of cell proliferation induced by microbial stimuli. However, ICE-dependent processing of IL-18 is not needed for response to mitogens or antigens...
  20. pmc Site-specific mutations in the mature form of human IL-18 with enhanced biological activity and decreased neutralization by IL-18 binding protein
    S H Kim
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 98:3304-9. 2001
    ..The identification of E42 and K89 in the mature IL-18 peptide is consistent with previous modeling studies of IL-18 binding to IL-18BP and explains the unusually high affinity of IL-18BP for IL-18...
  21. pmc Differential roles of interleukin-18 (IL-18) and IL12 for induction of gamma interferon by staphylococcal cell wall components and superantigens
    R J Stuyt
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Infect Immun 69:5025-30. 2001
    ..In contrast to its role in the interactions between staphylococci and host cells, IL-18 does not appear to play a major role in superantigen-induced IFN-gamma...
  22. ncbi request reprint Endotoxemic renal failure in mice: Role of tumor necrosis factor independent of inducible nitric oxide synthase
    M Knotek
    Department of Medicine, Division of Renal Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Kidney Int 59:2243-9. 2001
    ..The present study tested the hypothesis that the role of TNF in endotoxic renal failure is mediated by iNOS-derived NO...
  23. ncbi request reprint Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain
    S H Kim
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 166:148-54. 2001
    ..The synergism of IL-18 plus IL-12 for IFN-gamma production is, in part, due to IL-12 up-regulation of both IL-18R alpha and IL-18R beta chains, although postreceptor events likely contribute to IFN-gamma production...
  24. ncbi request reprint Liposomal delivery of purified inhibitory-kappaBalpha inhibits tumor necrosis factor-alpha-induced human vascular smooth muscle proliferation
    C H Selzman
    Department of Surgery, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
    Circ Res 84:867-75. 1999
    ..Furthermore, liposomal delivery of endogenous inhibitory proteins may represent a novel, therapeutically accessible method for selective transcriptional suppression in the response to vascular injury...
  25. ncbi request reprint Neutralization of IL-18 reduces neutrophil tissue accumulation and protects mice against lethal Escherichia coli and Salmonella typhimurium endotoxemia
    M G Netea
    Departments ofMedicine and Surgery, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 164:2644-9. 2000
    ..coli LPS) or TNF (S. typhimurium LPS) synthesis by anti-IL-18 treatment may also be involved...
  26. ncbi request reprint Response to local inflammation of IL-1 beta-converting enzyme- deficient mice
    G Fantuzzi
    Department of Medicine, Tufts University School of Medicine and New England Medical Center, Boston, MA 02111, USA
    J Immunol 158:1818-24. 1997
    ..Our results demonstrate that in turpentine-induced tissue necrosis, precursor IL-1 beta is processed by non-ICE proteases, but in complement-mediated inflammation, ICE participates in the processing of the IL-1 beta precursor...
  27. ncbi request reprint Physiological and cytokine responses in IL-1 beta-deficient mice after zymosan-induced inflammation
    G Fantuzzi
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver 80262, USA
    Am J Physiol 273:R400-6. 1997
    ..Our results demonstrate that IL-1 beta plays a significant, although not exclusive, role in the physiological and cytokine responses to zymosan-mediated inflammation...
  28. ncbi request reprint Utilization of endoscopic inoculation in a mouse model of intrauterine infection-induced preterm birth: role of interleukin 1beta
    L L Reznikov
    Division of Infectious Diseases, University of Colorado Health SciencesCenter, Denver 80262, USA
    Biol Reprod 60:1231-8. 1999
    ..This model using direct intracervical bacterial or LPS inoculation is useful for studying preterm pregnancy loss in genetically altered mice in order to develop novel interventions for infection-associated preterm labor...
  29. pmc IL-1 beta -converting enzyme (caspase-1) in intestinal inflammation
    B Siegmund
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 98:13249-54. 2001
    ..We conclude that inhibition of ICE represents a novel anti-inflammatory strategy for intestinal inflammation...
  30. pmc Novel targets for interleukin 18 binding protein
    C A Dinarello
    Department of Medicine, University Colorado Health Sciences Centre, Denver 80262, USA
    Ann Rheum Dis 60:iii18-24. 2001
    ..IL18BP binds IL18 with a high affinity (Kd of 400 pM) and, at equimolar ratios, inhibits 50-70% of IL18; at twofold molar excess, IL18BP neutralises nearly all IL18 activity...
  31. pmc Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure
    V Y Melnikov
    Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Clin Invest 107:1145-52. 2001
    ..Finally, we confirmed histologically that caspase-1(-/-) mice show decreased neutrophil infiltration, indicating that the deleterious role of IL-18 in ischemic ARF may be due to increased neutrophil infiltration...
  32. ncbi request reprint TNF receptor I is required for induction of macrophage heat shock protein 70
    J K Heimbach
    Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado, 80262, USA
    Am J Physiol Cell Physiol 281:C241-7. 2001
    ..These studies demonstrate that TNFR-I is required for the synthesis of HSP70 in stressed Mphi by a TNF-independent mechanism and support an intracellular role for TNFR-I...
  33. ncbi request reprint The IL-1 family and inflammatory diseases
    C A Dinarello
    Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Ave, B168, Denver, CO 80262, USA
    Clin Exp Rheumatol 20:S1-13. 2002
    ..This property, of IL-1 is not observed in the responses to TNFalpha. Furthermore, in animal models of destructive rheumatoid arthritis, IL-1 is necessary but TNFalpha is not...
  34. pmc Inhibition of caspase 1 reduces human myocardial ischemic dysfunction via inhibition of IL-18 and IL-1beta
    B J Pomerantz
    Department of Surgery, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 98:2871-6. 2001
    ....
  35. ncbi request reprint Inflammatory markers and the risk of Alzheimer disease: the Framingham Study
    Z S Tan
    Department of Medicine, Institute for Aging Research, Hebrew Senior Life, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02131, USA
    Neurology 68:1902-8. 2007
    ..To examine whether serum cytokines and spontaneous production of peripheral blood mononuclear cell (PBMC) cytokines are associated with the risk of incident Alzheimer disease (AD)...
  36. ncbi request reprint Interleukin-1beta deficiency results in reduced NF-kappaB levels in pregnant mice
    L L Reznikov
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Regul Integr Comp Physiol 278:R263-70. 2000
    ..This suppression was 25% greater in IL-1beta(-/-) than in IL-1beta(+/+) mice. These data suggest that constitutive NF-kappaB p65 protein synthesis is regulated by IL-1beta, particularly during pregnancy...
  37. pmc IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor
    G Fantuzzi
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Clin Invest 104:761-7. 1999
    ..Furthermore, administration of IL-12 significantly increased liver-associated IL-18 levels. These data demonstrate that endogenous, ICE-cleaved IL-18 significantly contributes to induction of IFN-gamma by IL-12...
  38. pmc Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis
    C Plater-Zyberk
    Serono Pharmaceutical Research Institute, Geneva, Switzerland. Rheumatology Research Laboratory, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Clin Invest 108:1825-32. 2001
    ..IL-18 neutralizing antibody or rhIL-18BP could therefore represent new disease-modifying anti-rheumatic drugs that warrant testing in clinical trials in patients with rheumatoid arthritis...
  39. ncbi request reprint Acellular components of Chlamydia pneumoniae stimulate cytokine production in human blood mononuclear cells
    M G Netea
    Department of Medicine, University Hospital Nijmegen, Nijmegen, The Netherlands
    Eur J Immunol 30:541-9. 2000
    ..In conclusion, acellular components of C. pneumoniae are a potent stimulus for cytokine production, and this mechanism may have an important role in the inflammatory aspects of atherogenesis...
  40. ncbi request reprint Role of interferon regulatory factor-1 in the regulation of IL-18 production and activity
    G Fantuzzi
    Department of Medicine, University of Colorado Health Sciences Center, Denver, USA
    Eur J Immunol 31:369-75. 2001
    ..In conclusion, IRF-1 regulates IL-18 production and activity mostly by modulating expression of caspase-1 and IL-18BP. In addition, IRF-1 participates in the induction of IFN-gamma by IL-18...
  41. ncbi request reprint Effect of advanced glycation end products on endotoxin-induced TNF-alpha, IL-1beta and IL-8 in human peripheral blood mononuclear cells
    L L Reznikov
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Clin Nephrol 61:324-36. 2004
    ..In patients receiving hemodialysis, AGE are thought to contribute to the inflammatory components of the therapy, particularly in diabetic patients...
  42. pmc Modulation of muramyl dipeptide stimulation of cytokine production by blood components
    J H M van der Meer
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80602, USA
    Clin Exp Immunol 156:428-33. 2009
    ..The inhibition of MDP stimulation was dependent upon cellular components, with erythrocyte-derived haemoglobin and neutrophils collaborating in the inhibition of MDP effects in whole blood...
  43. pmc Targeting interleukin 18 with interleukin 18 binding protein
    C A Dinarello
    University of Colorado Health Sciences Center, Division Infectious Diseases, B168, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Ann Rheum Dis 59:i17-20. 2000
    ..It is likely that preferential secretion of high affinity functional and non-functional isoforms of IL18BP affect the immune response and the outcome of disease...
  44. pmc Differences in signaling pathways by IL-1beta and IL-18
    Jae Kwon Lee
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 101:8815-20. 2004
    ..We conclude that in epithelial cells, IL-18 signal transduction is primarily via the MAPK p38 pathway rather than NF-kappaB, which may explain the absence of COX-2 and the failure of IL-18 to cause fever...
  45. pmc Differential expression of interleukin-32 in chronic rhinosinusitis with and without nasal polyps
    A Keswani
    Division of Allergy Immunology, Northwestern University Feinberg School of Medicine, 240 E Huron, Chicago, IL 60611, USA
    Allergy 67:25-32. 2012
    ..However, the mechanism of inflammation in CRS has still not been fully elucidated. The aim of the study was to investigate the role of interleukin-32 (IL-32), a recently discovered proinflammatory cytokine, in CRS...
  46. ncbi request reprint Effect of endotoxin in IL-1 beta-deficient mice
    G Fantuzzi
    Department of Medicine, Tufts University School of Medicine, Boston, MA 02111, USA
    J Immunol 157:291-6. 1996
    ..In summary, our results suggest that either IL-1 beta is not essential for the in vivo systemic response to LPS or that its role can be fulfilled by other cytokines with overlapping activities...
  47. pmc Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18
    S H Kim
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 97:1190-5. 2000
    ..It is likely that preferential secretion of functional and nonfunctional isoforms of IL-18BP affect the immune response...
  48. ncbi request reprint Macrophage inflammatory protein-1 alpha production in lipopolysaccharide-stimulated human adherent blood mononuclear cells is inhibited by the nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine
    H Muhl
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver 80262, USA
    J Immunol 159:5063-9. 1997
    ....
  49. ncbi request reprint Measurement of soluble and membrane-bound interleukin 1 using a fibroblast bioassay
    C A Dinarello
    University of Colorado Health Sciences Center, Denver, Colorado, USA
    Curr Protoc Immunol . 2001
    ..Also listed are sources of commercially available kits (ELISAs, immunoassays) to measure IL-1, and antibodies useful in setting up these assays...
  50. ncbi request reprint Elevated circulating levels of soluble interleukin-1 receptor type II during interleukin-2 immunotherapy
    E Vannier
    Department of Medicine, Division of Geographic Medicine and Infectious Diseases, New England Medical Center and Tufts University School of Medicine, Boston, MA, USA
    Eur Cytokine Netw 10:37-42. 1999
    ..IL-1sRI levels did not increase during immunotherapy with IL-2 or IL-6. Our results indicate that IL-1sRII, unlike IL-1Ra, remains a modest, natural, anti-inflammatory mechanism triggered by immunotherapy with IL-2, but not with IL-6...
  51. pmc Defective localization of the NADPH phagocyte oxidase to Salmonella-containing phagosomes in tumor necrosis factor p55 receptor-deficient macrophages
    A Vazquez-Torres
    Department of Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 98:2561-5. 2001
    ..TNFalpha-TNFRp55 signaling plays a critical role in the immediate innate immune response to an intracellular pathogen by optimizing the delivery of toxic reactive oxygen species to the phagosome...
  52. pmc Mycobacterium tuberculosis induces interleukin-32 production through a caspase- 1/IL-18/interferon-gamma-dependent mechanism
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
    PLoS Med 3:e277. 2006
    ..Interleukin (IL)-32 is a newly described proinflammatory cytokine that seems likely to play a role in inflammation and host defense. Little is known about the regulation of IL-32 production by primary cells of the immune system...
  53. ncbi request reprint Interleukin-18 and the treatment of rheumatoid arthritis
    Charles A Dinarello
    Division of Infectious Diseases, Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, B168, Denver, CO 80262, USA
    Rheum Dis Clin North Am 30:417-34, ix. 2004
    ....
  54. ncbi request reprint Inhibition of early airway neutrophilia does not affect development of airway hyperresponsiveness
    Christian Taube
    Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 30:837-43. 2004
    ..The effects of inhibiting p38 MAPK in decreasing AHR indicate activities independent of its prevention of neutrophil accumulation...
  55. ncbi request reprint The inflammatory response in interleukin-1 beta-deficient mice: comparison with other cytokine-related knock-out mice
    G Fantuzzi
    Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, USA
    J Leukoc Biol 59:489-93. 1996
    ....
  56. ncbi request reprint Proinflammatory cytokines in heart disease
    C A Dinarello
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Blood Purif 19:314-21. 2001
    ..Two orally effective agents, the IL-1beta-converting enzyme inhibitor and the mitogen-activating protein kinase p38 inhibitor, are currently being investigated in clinical trials...
  57. ncbi request reprint Interleukin-18 inhibits human immunodeficiency virus type 1 production in peripheral blood mononuclear cells
    H J Choi
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Infect Dis 184:560-8. 2001
    ..Furthermore, inhibition was present during the early stages of viral infection and was associated with reduced HIV-1 receptor expression...
  58. ncbi request reprint Regulation of Staphylococcus epidermidis-induced IFN-gamma in whole human blood: the role of endogenous IL-18, IL-12, IL-1, and TNF
    Rogier J L Stuyt
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Cytokine 21:65-73. 2003
    ..In conclusion, S. epidermidis stimulates IFN-gamma which is IL-18, IL-12 and TNF-dependent, but IL-1 independent...
  59. ncbi request reprint Physiological levels of interleukin-18 stimulate multiple neutrophil functions through p38 MAP kinase activation
    Travis H Wyman
    Bonfils Blood Center, Denver, CO 80230, USA
    J Leukoc Biol 72:401-9. 2002
    ..We conclude that IL-18, at physiologic concentrations, is an effective PMN priming agent that requires p38 MAP kinase activity...
  60. doi request reprint Immunological and inflammatory functions of the interleukin-1 family
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Denver, Aurora, Colorado 80045, USA
    Annu Rev Immunol 27:519-50. 2009
    ....
  61. ncbi request reprint The role of endogenous interleukin (IL)-18, IL-12, IL-1beta, and tumor necrosis factor-alpha in the production of interferon-gamma induced by Candida albicans in human whole-blood cultures
    Mihai G Netea
    Department of Medicine and Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado, USA
    J Infect Dis 185:963-70. 2002
    ..Blocking the biologic activities of IL-18, IL-12, and IL-1beta in patients (e.g., for treatment of autoimmune diseases) may result in increased susceptibility to C. albicans infection...
  62. pmc Interleukin-1 homologues IL-1F7b and IL-18 contain functional mRNA instability elements within the coding region responsive to lipopolysaccharide
    Philip Bufler
    Division of Infectious Diseases, University of Colorado Health Sciences Center, 4200 East Ninth Ave, Denver, CO 80262, USA
    Biochem J 381:503-10. 2004
    ..These results indicate that both IL-1F7b and IL-18 mRNA contain functional instability determinants within their coding region, which influence mRNA decay as a novel mechanism to regulate the expression of IL-1 family members...
  63. ncbi request reprint Unraveling the NALP-3/IL-1beta inflammasome: a big lesson from a small mutation
    Charles A Dinarello
    University Colorado Health Sciences Center, Division of Infectious Diseases, B168, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Immunity 20:243-4. 2004
    ..Blocking IL-1 receptors arrests inflammation in humans with the mutation...
  64. ncbi request reprint Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice
    Wei Wang
    Department of Medicine, Division of Renal Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Am J Physiol Renal Physiol 288:F997-1004. 2005
    ..Neutralization of IL-1beta and IL-18 is not functionally protective. The role of the intracellular proinflammatory cytokine IL-1alpha in endotoxemic ARF merits further study...
  65. ncbi request reprint Interleukin-1 receptor antagonist attenuates airway hyperresponsiveness following exposure to ozone
    Jung Won Park
    Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 30:830-6. 2004
    ..In summary, acute exposure to O(3) induces AHR, neutrophilic inflammation, epithelial damage, and IL-1. An IL-1Ra effectively prevents the development of altered airway function, inflammation, and structural damage...
  66. ncbi request reprint Interleukin-32: a cytokine and inducer of TNFalpha
    Soo Hyun Kim
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Immunity 22:131-42. 2005
    ....
  67. ncbi request reprint Neutralization of IL-18 attenuates lipopolysaccharide-induced myocardial dysfunction
    Christopher D Raeburn
    Department of Surgery, University of Colorado Health Sciences Center, 4200 E Ninth Avenue, Box C 320, Denver, CO 80262, USA
    Am J Physiol Heart Circ Physiol 283:H650-7. 2002
    ..In conclusion, neutralization of IL-18 protects against LPS-induced myocardial dysfunction. IL-18 may mediate endotoxemic myocardial dysfunction through induction of and/or synergy with IL-1beta, ICAM-1, and VCAM-1...
  68. ncbi request reprint Anti-cytokine therapies in response to systemic infection
    C A Dinarello
    Department of Medicine, Division Infectious Diseases, University of Colorado Health Sciences Center, Denver 80262, USA
    J Investig Dermatol Symp Proc 6:244-50. 2001
    ..It appears that systemic inflammation of sepsis requires more than anticytokine monotherapy to significantly reduce mortality...
  69. ncbi request reprint Interleukin-1beta
    Charles A Dinarello
    University of Colorado Health Sciences Center, Denver, CO, USA
    Crit Care Med 33:S460-2. 2005
  70. ncbi request reprint Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney
    Sarah Faubel
    Division of Renal Diseases and Hypertension, University of Colorado School of Medicine, Box C281, 4200 E 9th Ave, Denver, CO 80262, USA
    J Pharmacol Exp Ther 322:8-15. 2007
    ..However, inhibition of IL-1beta, IL-18, and IL-6 or neutrophil infiltration in the kidney is not sufficient to prevent cisplatin-induced ARF...
  71. ncbi request reprint Mechanisms of inhibition of collagen-induced arthritis by murine IL-18 binding protein
    Nirmal K Banda
    Division of Rheumatology, Health Sciences Center, University of Colorado School of Medicine, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Immunol 170:2100-5. 2003
    ..The mechanisms of mIL-18BP inhibition of CIA include reductions in cell-mediated and humoral immunity to collagen as well as decreases in production of proinflammatory cytokines in the spleen and joints...
  72. ncbi request reprint Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors
    Mihai G Netea
    Division of Infectious Diseases, B168 University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    J Leukoc Biol 80:1454-61. 2006
    ..This latter finding supports the concept that TREM-1 provides optimal amplification of cytokine-induced inflammation during the initiation of host defense...
  73. ncbi request reprint Interleukin-18 and the pathogenesis of inflammatory diseases
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO, USA
    Semin Nephrol 27:98-114. 2007
    ..Other options for reducing IL-18 activities are inhibitors of caspase-1, human monoclonal antibodies to IL-18, soluble IL-18 receptors, and anti-IL-18 receptor monoclonal antibodies...
  74. ncbi request reprint Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin
    Joseph A Sennello
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Endocrinology 146:2157-64. 2005
    ..In conclusion, although leptin increases susceptibility to hepatotoxicity by regulating cytokine production and T cell activation, adiponectin protects hepatocytes from TNF alpha-induced death...
  75. ncbi request reprint Proximal tubules from caspase-1-deficient mice are protected against hypoxia-induced membrane injury
    Charles L Edelstein
    University of Colorado Health Science Center, Department of Internal Medicine, Denver, CO 80262, USA, and Division of Pulmonary and Critical Care Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Taiwan
    Nephrol Dial Transplant 22:1052-61. 2007
    ..The role of caspase-1 in hypoxia-induced membrane injury of proximal tubules (PT) in vitro is unknown...
  76. pmc Tumor necrosis factor-alpha causes release of cytosolic interleukin-18 from human neutrophils
    Christopher C Silliman
    Research Dept, Bonfils Blood Center, 717 Yosemite St, Denver, CO 80230, USA
    Am J Physiol Cell Physiol 298:C714-24. 2010
    ..Extracellular IL-18 participates in TNF-alpha priming of the PMN oxidase as demonstrated by inhibition with the IL-18 binding protein...
  77. ncbi request reprint IL-1 regulates in vivo C-X-C chemokine induction and neutrophil sequestration following endotoxemia
    Casey M Calkins
    Department of Surgery, University of Colorado Health Sciences Center and Veterans Affairs Hospital, 4200 East 9th Avenue, Box C 313, Denver, CO 80262, USA
    J Endotoxin Res 8:59-67. 2002
    ..These data suggest that IL-1 regulates tissue chemokine expression and neutrophil accumulation after LPS...
  78. pmc Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages
    Mihai G Netea
    Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, USA
    Blood 113:2324-35. 2009
    ..We conclude that IL-1beta production is differentially regulated in monocytes and macrophages, and this reflects their separate functions in host defense and inflammation...
  79. ncbi request reprint Generation and characterization of mice transgenic for human IL-18-binding protein isoform a
    Giamila Fantuzzi
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Leukoc Biol 74:889-96. 2003
    ..These results indicate that high endogenous levels of IL-18BP in trangenic mice effectively neutralize IL-18 and are protective in response to different inflammatory stimuli...
  80. doi request reprint IL-1: discoveries, controversies and future directions
    Charles A Dinarello
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Eur J Immunol 40:599-606. 2010
    ....
  81. pmc Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta
    Miyako Okamoto
    Department of Dermatology, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Biol Chem 285:6477-88. 2010
    ....
  82. pmc Anti-inflammatory Agents: Present and Future
    Charles A Dinarello
    Department of Medicine, University of Colorado, Aurora, 80045, USA
    Cell 140:935-50. 2010
    ..This Review discusses the current status of anti-inflammatory drug research and the development of new anti-inflammatory therapeutics...
  83. pmc Pulmonary inflammation induced by Pseudomonas aeruginosa lipopolysaccharide, phospholipase C, and exotoxin A: role of interferon regulatory factor 1
    Catharina W Wieland
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Infect Immun 70:1352-8. 2002
    ..These data indicate that different virulence factors from P. aeruginosa induce pulmonary inflammation in vivo and that IRF-1 is involved in some of the cytokine responses to LPS and ETA...
  84. ncbi request reprint Effect of a four-week course of interleukin-10 on cytokine production in a placebo-controlled study of HIV-1-infected subjects
    Gregory B Pott
    Department of Medicine, Division of Infectious Diseases, University of Colorado at Denver and Health Sciences Center, 4200 E 9th Ave Box B168, Denver, CO 80262, USA
    Eur Cytokine Netw 18:49-58. 2007
    ....
  85. pmc IL-32-dependent effects of IL-1beta on endothelial cell functions
    Claudia A Nold-Petry
    Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 106:3883-8. 2009
    ..This study introduces IL-32 as a critical regulator of endothelial function, expanding the properties of this cytokine relevant to coagulation, endothelial inflammation, and atherosclerosis...
  86. ncbi request reprint Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis
    Xianzhong Meng
    Department of Surgery, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Physiol Cell Physiol 294:C29-35. 2008
    ..These results suggest that TLR2 and TLR4 may play a role in aortic valve inflammation and stenosis...
  87. ncbi request reprint The combination of soluble IL-18Ralpha and IL-18Rbeta chains inhibits IL-18-induced IFN-gamma
    Leonid L Reznikov
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Interferon Cytokine Res 22:593-601. 2002
    ..These studies reveal that the combination of the ligand-binding and the nonligand-binding extracellular domains of IL-18R is needed to inhibit IL-18, whereas IL-18BP neutralizes at equimolar concentration...
  88. pmc Abrogation of anti-inflammatory transcription factor LKLF in neutrophil-dominated airways
    Milene T Saavedra
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Denver, Colorado, USA
    Am J Respir Cell Mol Biol 38:679-88. 2008
    ....
  89. pmc Interleukin-32 induces the differentiation of monocytes into macrophage-like cells
    Mihai G Netea
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 105:3515-20. 2008
    ..Thus, IL-32 not only contributes to host responses through the induction of proinflammatory cytokines but also directly affects specific immunity by differentiating monocytes into macrophage-like cells...
  90. pmc Interleukin-18 binding protein transgenic mice are protected against ischemic acute kidney injury
    Zhibin He
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Am J Physiol Renal Physiol 295:F1414-21. 2008
    ..In conclusion, protection against ischemic AKI in IL-18BP Tg mice is associated with less macrophage infiltration and less production of CXCL1 in the kidney...
  91. pmc alpha1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice
    Eli C Lewis
    Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 105:16236-41. 2008
    ..Because AAT treatment in humans is safe, its use during human islet transplantation may be considered...
  92. pmc Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling
    Claudia A Nold-Petry
    Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Biol Chem 284:25900-11. 2009
    ....
  93. ncbi request reprint Interleukin-18 and host defense against infection
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Infect Dis 187:S370-84. 2003
    ..Thus, blockade of IL-18 appears to be a viable clinical target to combat the pathologic consequences of sepsis via IFN-gamma mechanisms...
  94. pmc Responses of IL-18- and IL-18 receptor-deficient pancreatic islets with convergence of positive and negative signals for the IL-18 receptor
    Eli C Lewis
    Department of Medicine, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 103:16852-7. 2006
    ..Importantly, discrepancies between IL-18- and IL-18R-deficient cells suggest that IL-18Ralpha chain is used by an inflammation-suppressing signal...
  95. pmc A complex of the IL-1 homologue IL-1F7b and IL-18-binding protein reduces IL-18 activity
    Philip Bufler
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 99:13723-8. 2002
    ..We propose that after binding to IL-18BP, IL-1F7b forms a complex with IL-18Rbeta, depriving the beta-chain of forming a functional receptor complex with IL-18Ralpha and thus inhibiting IL-18 activity...
  96. pmc IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism
    Mihai G Netea
    Divisions of Infectious Diseases and Pulmonary Science and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 102:16309-14. 2005
    ..The modulation of intracellular NOD2 pathways by IL-32, but not cell-surface TLRs, and the marked expression of IL-32 in colon mucosa suggest a role of IL-32 in the pathogenesis of Crohn's disease...
  97. ncbi request reprint Alveolar type II cells inhibit fibroblast proliferation: role of IL-1alpha
    Joshua Portnoy
    Dept of Medicine, National Jewish Medical and Research Center, and Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80206, USA
    Am J Physiol Lung Cell Mol Physiol 290:L307-16. 2006
    ..In addition, these studies demonstrate that KGF enhances ATII cell PGE2 production through an IL-1alpha-independent pathway...
  98. pmc Alpha1-antitrypsin monotherapy prolongs islet allograft survival in mice
    Eli C Lewis
    Department of Medicine, University of Colorado at Denver and Health Sciences Center, Denver, CO 80262, USA
    Proc Natl Acad Sci U S A 102:12153-8. 2005
    ..In light of the established safety record and the nondiabetogenic potential of AAT, these data suggest that AAT may be beneficial as adjunctive therapy in patients undergoing islet transplantation...
  99. ncbi request reprint Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex
    Tania Azam
    University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 171:6574-80. 2003
    ....
  100. ncbi request reprint Differences between anti-tumor necrosis factor-alpha monoclonal antibodies and soluble TNF receptors in host defense impairment
    Charles A Dinarello
    Department of Medicine, Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Rheumatol Suppl 74:40-7. 2005
    ....