Risk factors for prediction of inadequate response to antiresorptivesAdolfo Diez-Perez
Hospital del Mar IMIM UAB, Department of Internal Medicine, Barcelona, Spain
J Bone Miner Res 27:817-24. 2012
..More potent regimes should be developed and adequate supplementation implemented to solve this problem...
- Regional differences in treatment for osteoporosis. The Global Longitudinal Study of Osteoporosis in Women (GLOW)
Adolfo Diez-Perez
Hospital del Mar IMIM, Autonomous University of Barcelona and RETICEF, Instituto Carlos III, Barcelona, Spain
Bone 49:493-8. 2011
..To determine if important geographic differences exist in treatment rates for osteoporosis and whether this variation can be explained by regional variation in risk factors...
- Analysis of three functional polymorphisms in relation to osteoporosis phenotypes: replication in a Spanish cohort
Lidia Agueda
Department of Genetics, Faculty of Biology, University of Barcelona, Barcelona, Spain
Calcif Tissue Int 87:14-24. 2010
..038, adjusted by age). In conclusion, no significant association was observed between the studied polymorphisms and LS BMD or FN BMD in postmenopausal Spanish women, and only MTHFR Ala222Val was associated with vertebral fractures...
- Functional relevance of the BMD-associated polymorphism rs312009: novel involvement of RUNX2 in LRP5 transcriptional regulation
Lidia Agueda
Department of Genetics, Faculty of Biology, University of Barcelona, IBUB, CIBERER, Barcelona, Spain
J Bone Miner Res 26:1133-44. 2011
..This adds evidence to previously described links between two important bone-regulating systems: the RUNX2 transcription-factor cascade and the Wnt signaling pathway...
- COL1A1 haplotypes and hip fracture
Roser Urreizti
Departament de Genetica, Universitat de Barcelona, IBUB, Centro de Investigación Biomédica en Red de Enfermedades Raras, ISCIII, Barcelona, Spain
J Bone Miner Res 27:950-3. 2012
..However, we observed a small but significant (p = 0.03) association with another rare haplotype, G-insT-T, which was slightly overrepresented in the patient group...
Promoter 2 -1025 T/C polymorphism in the RUNX2 gene is associated with femoral neck bmd in Spanish postmenopausal womenMariona Bustamante
Department of Genetics, University of Barcelona, Av Diagonal, 645, E 08028, Barcelona, Spain
Calcif Tissue Int 81:327-32. 2007
..001). In particular, individuals carrying the TC genotype had higher mean adjusted FN BMD values than those bearing the TT genotype. Our results highlight the importance of this RUNX2 promoter 2 polymorphism in FN BMD determination...
- Vitamin D threshold to prevent aromatase inhibitor-induced arthralgia: a prospective cohort study
Daniel Prieto-Alhambra
Department of Internal Medicine, URFOA IMIM Hospital del Mar, Parc de Salut Mar, Autonomous University of Barcelona, Barcelona, Spain
Breast Cancer Res Treat 125:869-78. 2011
..12 ** [0.03 to 0.40]). A target concentration of 40 ng/ml 25OHD may prevent development of AI arthralgia but higher loading doses are required to attain this level in women with deficiency at baseline...
- Vitamin D threshold to prevent aromatase inhibitor-related bone loss: the B-ABLE prospective cohort study
Daniel Prieto-Alhambra
URFOA IMIM, Parc de Salut Mar, Parc de Recerca Biomedica de Barcelona, c Dr Aiguader, 88, 2nd Floor, 08003 Barcelona, Spain
Breast Cancer Res Treat 133:1159-67. 2012
..For this population, the current Institute of Medicine target recommendation of 20 ng/ml might be too low to ensure good bone health...
- Effect of IL-1beta, PGE(2), and TGF-beta1 on the expression of OPG and RANKL in normal and osteoporotic primary human osteoblasts
Susana Jurado
Internal Medicine, URFOA, IMIM, RETICEF, Hospital del Mar, Autonomous University of Barcelona, Barcelona, Spain
J Cell Biochem 110:304-10. 2010
..In conclusion, osteoporotic hOB cells showed an anomalous response under cytokine stimulation, consistent with an enhanced osteoclastogenesis resulting in high levels of bone resorption...
- Comparison of the effects of ossein-hydroxyapatite complex and calcium carbonate on bone metabolism in women with senile osteoporosis: a randomized, open-label, parallel-group, controlled, prospective study
Manel Ciria-Recasens
Rheumatology Unit, Hospitales Universitarios del Mar y de la Esperana, Barcelona, Spain
Clin Drug Investig 31:817-24. 2011
..The objective of this study was to compare the effects of OHC and calcium carbonate on bone metabolism in women with senile osteoporosis...
Microindentation for in vivo measurement of bone tissue mechanical properties in humansAdolfo Diez-Perez
Hospital del Mar IMIM Universitat Autónoma, Barcelona, Spain
J Bone Miner Res 25:1877-85. 2010
..It discriminates precisely between patients with and without fragility fracture and may provide clinicians and researchers with a direct in vivo measurement of bone tissue resistance to fracture...
- Vitamin D deficiency and bone mineral density in postmenopausal women receiving aromatase inhibitors for early breast cancer
Xavier Nogues
Internal Medicine Department, URFOA IMIM, RETICEF, Hospital del Mar, Autonomous University of Barcelona, Barcelona, Spain
Maturitas 66:291-7. 2010
....
- The association between fracture and obesity is site-dependent: a population-based study in postmenopausal women
Daniel Prieto-Alhambra
IDIAP Jordi Gol, Primary Health Care Research Institute, Barcelona, Spain
J Bone Miner Res 27:294-300. 2012
..The reasons for these site-specific variations are unknown but may be related to different patterns of falls and attenuation of their impact by adipose tissue...
- Bone metabolism and histomorphometric changes in rheumatoid arthritis
Luis Pérez-Edo
Service of Rheumatology, Hospital de la Esperanga and Hospital del Mar, Barcelona, Spain
Scand J Rheumatol 31:285-90. 2002
..We studied bone metabolism and histomorphometry in 66 patients with rheumatoid arthritis...
- The ECOS-16 questionnaire for the evaluation of health related quality of life in post-menopausal women with osteoporosis
Xavier Badia
Health Outcomes Research HOR Europe, Barcelona, Spain
Health Qual Life Outcomes 2:41. 2004
..The aim of this study is to validate the questionnaire ECOS-16 (Assessment of health related quality of life in osteoporosis) for the evaluation of health related quality of life (HRQoL) in post-menopausal women with osteoporosis...
- Microindentation for in vivo measurement of bone tissue material properties in atypical femoral fracture patients and controls
Roberto C Güerri-Fernández
Hospital del Mar IMIM Universitat Autònoma de Barcelona, Barcelona, Spain
J Bone Miner Res 28:162-8. 2013
..The LTB group shows levels that are in between controls and both type of fractures, although not statistically different. These results suggest that bisphosphonate therapy probably does not put the majority of patients at risk for AFF...
- Probability of fractures predicted by FRAX® and observed incidence in the Spanish ECOSAP Study cohort
Jesus Gonzalez-Macias
Department of Internal Medicine, Hospital Marques de Valdecilla, University of Cantabria, Santander, Spain
Bone 50:373-7. 2012
..To assess the ability of the Spanish version of the WHO fracture risk assessment tool (FRAX®) to predict the observed incident fractures in the ECOSAP Study cohort...
- "Burden of osteoporotic fractures in primary health care in Catalonia (Spain): a population-based study"
Aina Pagès-Castellà
Institut Catala de la Salut, Barcelona, Spain
BMC Musculoskelet Disord 13:79. 2012
..Using computerized primary care records from the SIDIAP database, we derived age and sex-specific fracture incidence rates for the region of Catalonia during the year 2009...
- Simvastatin and atorvastatin enhance gene expression of collagen type 1 and osteocalcin in primary human osteoblasts and MG-63 cultures
Silvia Ruiz-Gaspa
URFOA, IMIM, Hospital del Mar, Barcelona, Spain
J Cell Biochem 101:1430-8. 2007
..These findings support the bone-forming effect of statins, probably through the BMP2 pathway...
- Evaluation of calcaneal quantitative ultrasound in a primary care setting as a screening tool for osteoporosis in postmenopausal women
Adolfo Diez-Perez
Unidad de Investigación de Fisiopatología sea y Articular, Hospital Universitario del Mar, Universitat Autonoma, Barcelona, Spain
J Clin Densitom 6:237-45. 2003
..1% of cases. In conclusion, in postmenopausal women, QUS screening conclusively confirms or rules out osteoporosis in approximately one-fifth of cases, thereby avoiding the need for a DXA measurement...
- Selective estrogen receptor modulators (SERMS)
Adolfo Diez-Perez
Department of Internal Medicine, Autonomous University of Barcelona, Hospital del Mar URFOA IMIM, Barcelona, Spain
Arq Bras Endocrinol Metabol 50:720-34. 2006
..Their development has permitted a targeted efficacy profile avoiding some of the side effects of the hormone therapy. Their clinical utility relies today mostly on the effects on breast cancer and bone...
- A haplotype-based analysis of the LRP5 gene in relation to osteoporosis phenotypes in Spanish postmenopausal women
Lidia Agueda
Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
J Bone Miner Res 23:1954-63. 2008
..029, one copy of the haplotype versus none). In silico analyses showed that SNP 1 (rs312009) lies in a putative RUNX2 binding site. Electro-mobility shift assays confirmed RUNX2 binding to this site...
