Dr. Charles J. DiComo

Summary

Affiliation: Eurofins
Location: Chantilly, VA, USA
URL: https://www.researchgate.net/profile/Charles_Di_Como/
Summary:
Dr. Charles J. DiComo is currently the Vice President and Global Head of Laboratory Operations for Eurofins Medinet Global Central Laboratory with strategically located harmonized facilities in the U.S., Europe, and Asia that can accommodate clinical trials of any nature, size, foot print or complexity.

Prior to joining Eurofins, he was the Chief Compliance Officer for Aureon Biosciences where he ensured the appropriate licensing, marketing and legal compliance of medical products, combining his knowledge of scientific, legal and business issues to ensure product safety.

Prior to joining Aureon, he was a Research Associate and Leukemia & Lymphoma Society Special Fellow at Memorial Sloan-Kettering Cancer Center and a Damon Runyon-Walter Winchell Post-Doctoral Fellow at Columbia University.

He is highly active in economic development serving on numerous boards, and is the Scientific Adviser to the NY BIOHUD VALLEY. He holds a Ph.D. in Genetics from State University of New York at Stony Brook and an M.S. in Molecular & Cellular Biology from LIU.

Specialties: Corporate Compliance; Commercial Operations; Regulatory and Quality Systems; Laboratory Design, Permitting and Construction; Contract Negotiation; Intellectual Property; Research and Discovery in Signal Transduction, Tumor Suppressor Pathways, Oncogenes, Multiplexing, Biomarkers; Grant and Publication Writing, Public Speaking.

Publications

  1. ncbi request reprint p63 expression profiles in human normal and tumor tissues
    Charles J Di Como
    Division of Molecular Pathology, Department of Pathology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Cancer Res 8:494-501. 2002
  2. ncbi request reprint Regulation of the cell integrity pathway by rapamycin-sensitive TOR function in budding yeast
    Jordi Torres
    Departament de Ciencies Mediques Basiques, Universitat de Lleida, Lleida 25198, Spain
    J Biol Chem 277:43495-504. 2002
  3. pmc Loss of p63 expression is associated with tumor progression in bladder cancer
    Marshall J Urist
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Am J Pathol 161:1199-206. 2002
  4. ncbi request reprint Comparative study of p63 and p53 expression in tissue microarrays of malignant melanomas
    Ulrich Brinck
    Department of Gastroenteropathology, University of Gottingen, 37075 Gottingen, Germany
    Int J Mol Med 10:707-11. 2002
  5. ncbi request reprint p73 Expression in human normal and tumor tissues: loss of p73alpha expression is associated with tumor progression in bladder cancer
    Pere Puig
    Division of Molecular Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 9:5642-51. 2003
  6. pmc Ubiquitin-dependent degradation of p73 is inhibited by PML
    Francesca Bernassola
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Exp Med 199:1545-57. 2004
  7. ncbi request reprint Expression of p63 in diffuse large B-cell lymphoma
    Cyrus V Hedvat
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Appl Immunohistochem Mol Morphol 13:237-42. 2005
  8. ncbi request reprint The association of Tap42 phosphatase complexes with TORC1: another level of regulation in Tor signaling
    Charles J Di Como
    Aureon Laboratories, Inc, Yonkers, New York, USA
    Cell Cycle 5:2729-32. 2006
  9. ncbi request reprint High Ki-67 proliferative index predicts disease specific survival in patients with high-risk soft tissue sarcomas
    A Hoos
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Cancer 92:869-74. 2001
  10. ncbi request reprint Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
    M Ollmann
    Exelixis, Inc, South San Francisco, California 94080, USA
    Cell 101:91-101. 2000

Collaborators

Detail Information

Publications20

  1. ncbi request reprint p63 expression profiles in human normal and tumor tissues
    Charles J Di Como
    Division of Molecular Pathology, Department of Pathology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Cancer Res 8:494-501. 2002
    ..The p63 gene, located on chromosome 3q27-28, is a member of the p53 gene family. The product encoded by the p63 gene has been reported to be essential for normal development...
  2. ncbi request reprint Regulation of the cell integrity pathway by rapamycin-sensitive TOR function in budding yeast
    Jordi Torres
    Departament de Ciencies Mediques Basiques, Universitat de Lleida, Lleida 25198, Spain
    J Biol Chem 277:43495-504. 2002
    ....
  3. pmc Loss of p63 expression is associated with tumor progression in bladder cancer
    Marshall J Urist
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Am J Pathol 161:1199-206. 2002
    ..These data indicate that in contrast to the skin and prostate, p63 is not required for formation of a bladder epithelium but is indispensable for the specific differentiation of a transitional urothelium...
  4. ncbi request reprint Comparative study of p63 and p53 expression in tissue microarrays of malignant melanomas
    Ulrich Brinck
    Department of Gastroenteropathology, University of Gottingen, 37075 Gottingen, Germany
    Int J Mol Med 10:707-11. 2002
    ..Multivariate analysis confirmed the prognostically independent role of p53. This study also confirmed that tissue microarrays can be used effectively for evaluation of the expression of certain tumour markers...
  5. ncbi request reprint p73 Expression in human normal and tumor tissues: loss of p73alpha expression is associated with tumor progression in bladder cancer
    Pere Puig
    Division of Molecular Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 9:5642-51. 2003
    ..To characterize the expression profile of p73 in human normal tissues by immunohistochemistry (IHC) and to analyze the correlation between p73 expression and bladder cancer progression...
  6. pmc Ubiquitin-dependent degradation of p73 is inhibited by PML
    Francesca Bernassola
    Molecular Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
    J Exp Med 199:1545-57. 2004
    ..Our findings demonstrate that PML plays a crucial role in modulating p73 function, thus providing further insights on the molecular network for tumor suppression...
  7. ncbi request reprint Expression of p63 in diffuse large B-cell lymphoma
    Cyrus V Hedvat
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Appl Immunohistochem Mol Morphol 13:237-42. 2005
    ..Even though in univariate analysis p63 expression did not correlate with overall survival, the association of p63 with increased proliferative index suggests its involvement in DLBCL tumor progression...
  8. ncbi request reprint The association of Tap42 phosphatase complexes with TORC1: another level of regulation in Tor signaling
    Charles J Di Como
    Aureon Laboratories, Inc, Yonkers, New York, USA
    Cell Cycle 5:2729-32. 2006
    ..This association adds another level of regulation in Tor signaling, and explains why rapamycin or nutrient availability is able to initiate a rapid and robust response in the cell...
  9. ncbi request reprint High Ki-67 proliferative index predicts disease specific survival in patients with high-risk soft tissue sarcomas
    A Hoos
    Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
    Cancer 92:869-74. 2001
    ....
  10. ncbi request reprint Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
    M Ollmann
    Exelixis, Inc, South San Francisco, California 94080, USA
    Cell 101:91-101. 2000
    ..These data reveal an ancestral proapoptotic function for p53 and identify Drosophila as an ideal model system for elucidating the p53 apoptotic pathway(s) induced by DNA damage...
  11. pmc Overexpression of SIS2, which contains an extremely acidic region, increases the expression of SWI4, CLN1 and CLN2 in sit4 mutants
    C J Di Como
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724 2212
    Genetics 139:95-107. 1995
    ....
  12. pmc Activation of CLN1 and CLN2 G1 cyclin gene expression by BCK2
    C J Di Como
    Cold Spring Harbor Laboratory, New York 11724 2212
    Mol Cell Biol 15:1835-46. 1995
    ..Moreover, overexpression of BCK2 induces very high levels of CLN1, CLN2, and HCS26 RNAs. The results suggest that BCK2 and CLN3 provide parallel activation pathways for the expression of CLN1 and CLN2 during late G1...
  13. pmc The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase
    M M Luke
    Cold Spring Harbor Laboratory, New York 11724 2212, USA
    Mol Cell Biol 16:2744-55. 1996
    ..Overexpression of a SAP from one group does not suppress the defects due to the loss of the other group. These findings and others indicate that the SAPs have distinct functions...
  14. ncbi request reprint Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases
    C J Di Como
    Cold Spring Harbor Laboratory, New York 11724, USA
    Genes Dev 10:1904-16. 1996
    ..These findings, combined with the defect in translation of the tap42-11 mutant at the nonpermissive temperature, suggest that Tap42, Sit4, and PP2A are components of the Tor signaling pathway...
  15. pmc p73 function is inhibited by tumor-derived p53 mutants in mammalian cells
    C J Di Como
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Mol Cell Biol 19:1438-49. 1999
    ..Our data suggest the possibility that in some tumor cells, an outcome of the expression of mutant p53 protein may be to interfere with the endogenous p73 protein...
  16. pmc The TOR signaling cascade regulates gene expression in response to nutrients
    M E Cardenas
    Departments of Genetics, Duke University Medical Center, Durham, North Carolina 27710 USA
    Genes Dev 13:3271-9. 1999
    ....
  17. ncbi request reprint Effects of ethidium bromide and SYBR Green I on different polymerase chain reaction systems
    K Nath
    Long Island University, Department of Biology, Brookville, New York, NY 11548 1300, USA
    J Biochem Biophys Methods 42:15-29. 2000
    ....
  18. doi request reprint Nucleofection is a highly effective gene transfer technique for human melanoma cell lines
    Sandra Y Han
    Department of Dermatology, New York Harbor Healthcare System, New York University School of Medicine, New York, NY 10016, USA
    Exp Dermatol 17:405-11. 2008
    ..In conclusion, nucleofection is highly effective for the transfer of nucleic acid substrates, singly or in combination, into human melanoma cell lines...