David A Dichek
Bi L, Wacker B, Dichek D. A Rabbit Model of Durable Transgene Expression in Jugular Vein to Common Carotid Artery Interposition Grafts. J Vis Exp. 2018;: pubmed publisher
..Compared to rodent vein graft models, rabbits have larger and easier-to-manipulate blood vessels that provide abundant tissue for analysis. ..
Hu J, Touch P, Zhang J, Wei H, Liu S, Lund I, et al
. Reduction of mouse atherosclerosis by urokinase inhibition or with a limited-spectrum matrix metalloproteinase inhibitor. Cardiovasc Res. 2015;105:372-82 pubmed publisher
..distal aortic atherosclerosis suggest prevention of atherosclerosis progression vs. initiation. Systemic inhibition of uPA or a subset of MMPs shows promise for treating atherosclerosis. ..
Wacker B, Bi L, Dichek D. In Vivo Gene Transfer to the Rabbit Common Carotid Artery Endothelium. J Vis Exp. 2018;: pubmed publisher
Hu J, Wei H, Jaffe M, Airhart N, Du L, Angelov S, et al
. Postnatal Deletion of the Type II Transforming Growth Factor-Î² Receptor in Smooth Muscle Cells Causes Severe Aortopathy in Mice. Arterioscler Thromb Vasc Biol. 2015;35:2647-56 pubmed publisher
..These results suggest that pharmacological blockade of TGF-Î² signaling in humans could cause aortic disease rather than prevent it. ..
Wacker B, Dronadula N, Zhang J, Dichek D. Local Vascular Gene Therapy With Apolipoprotein A-I to Promote Regression of Atherosclerosis. Arterioscler Thromb Vasc Biol. 2017;37:316-327 pubmed publisher
..Even when administered on a background of aggressive lowering of plasma cholesterol, local HDAdApoAI vascular gene therapy may promote rapid regression of small-to-moderate-sized atherosclerotic lesions. ..
Wei H, Hu J, Angelov S, Fox K, Yan J, Enstrom R, et al
. Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor ? Signaling. J Am Heart Assoc. 2017;6: pubmed publisher
..Loss of physiologic SMC TGF-? signaling exacerbates MFS-associated aortopathy. Our data support a protective role for SMC TGF-? signaling during early development of MFS-associated aortopathy. ..
Angelov S, Hu J, Wei H, Airhart N, Shi M, Dichek D. TGF-β (Transforming Growth Factor-β) Signaling Protects the Thoracic and Abdominal Aorta From Angiotensin II-Induced Pathology by Distinct Mechanisms. Arterioscler Thromb Vasc Biol. 2017;37:2102-2113 pubmed publisher
..Smooth muscle extrinsic signaling protects the abdominal aorta and smooth muscle intrinsic signaling protects the thoracic aorta. ..
Wacker B, Dronadula N, Bi L, Stamatikos A, Dichek D. Apo A-I (Apolipoprotein A-I) Vascular Gene Therapy Provides Durable Protection Against Atherosclerosis in Hyperlipidemic Rabbits. Arterioscler Thromb Vasc Biol. 2018;38:206-217 pubmed publisher