Paul Di Cesare

Summary

Publications

  1. ncbi request reprint Serum interleukin-6 as a marker of periprosthetic infection following total hip and knee arthroplasty
    Paul E Di Cesare
    Musculoskeletal Research Center, Room 1500, NYU Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA
    J Bone Joint Surg Am 87:1921-7. 2005
  2. ncbi request reprint Failure of a constrained acetabular liner without reinforcement ring disruption
    Jeffrey A Arthur
    University of California Davis Medical Center, Sacramento, CA
    Am J Orthop (Belle Mead NJ) 42:566-8. 2013
  3. ncbi request reprint The Application of Minimally Invasive Surgical Techniques. Part II: Total Knee Arthroplasty
    Derek F Amanatullah
    Resident, Department of Orthopaedic Surgery, University of California Davis Health System, Sacramento, California
    Am J Orthop (Belle Mead NJ) 41:E140-4. 2012
  4. ncbi request reprint The application of minimally invasive surgical techniques. Part I: total hip arthroplasty
    Derek F Amanatullah
    Resident, Department of Orthopaedic Surgery, University of California Davis Health System, Sacramento, California
    Am J Orthop (Belle Mead NJ) 41:E134-9. 2012
  5. ncbi request reprint Regional gene therapy for full-thickness articular cartilage lesions using naked DNA with a collagen matrix
    Paul E Di Cesare
    Musculoskeletal Research Laboratory, New York University Hospital for Joint Diseases, Department of Orthopaedic Surgery, 301 East 17th Street, Suite 1500, New York 10003, USA
    J Orthop Res 24:1118-27. 2006
  6. ncbi request reprint Expression of cartilage oligomeric matrix protein by human synovium
    P E Di Cesare
    Musculoskeletal Research Center, Hospital for Joint Diseases Orthopaedic Institute, New York, NY 10003, USA
    FEBS Lett 412:249-52. 1997
  7. ncbi request reprint Up-regulation of inducible nitric oxide synthase and production of nitric oxide by the Swarm rat and human chondrosarcoma
    P E Di Cesare
    Department of Orthopaedic Surgery, Musculoskeletal Research Center, New York University Medical Center, Hospital for Joint Diseases Orthopaedic Institute, New York 10003, USA
    J Orthop Res 16:667-74. 1998
  8. ncbi request reprint Localization and expression of cartilage oligomeric matrix protein by human rheumatoid and osteoarthritic synovium and cartilage
    P E Di Cesare
    Musculoskeletal Research Center, Department of Orthopaedic Surgery, New York University Medical Center Hospital for Joint Diseases, New York 10003, USA
    J Orthop Res 17:437-45. 1999
  9. ncbi request reprint Expression of cartilage oligomeric matrix protein (COMP) by embryonic and adult osteoblasts
    P E Di Cesare
    Musculoskeletal Research Center, Hospital for Joint Diseases Orthopaedic Institute, New York, New York 10003, USA
    J Orthop Res 18:713-20. 2000
  10. ncbi request reprint Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin
    Paul E Di Cesare
    Musculoskeletal Research Center, NYU Hospital for Joint Diseases Department of Orthopedic Surgery, 301 East 17th Street, New York, NY 10030, USA
    Matrix Biol 21:461-70. 2002

Research Grants

Collaborators

  • Cathy S Carlson
  • M Attur
  • S B Abramson
  • G Steiner
  • Chuan Ju Liu
  • Jian Q Feng
  • Helmut Friess
  • Zongbing You
  • Yan Huang
  • Yi Zhang
  • S R Frenkel
  • Derek F Amanatullah
  • Ke Xu
  • Jeffrey A Arthur
  • Matthew T Burrus
  • Brett Levine
  • Sathappan S Sathappan
  • Andrew L Chen
  • Yi Luan
  • Eric Fulkerson
  • Charles F Preston
  • Paul S Issack
  • Steven S Shin
  • Yi Xiao
  • Derrick G Hickey
  • Thomas N Joseph
  • Gannon D Kennedy
  • Kirill Ilalov
  • Bo Ding
  • Peter Lengyel
  • Ning Yang
  • Jin Yu
  • Xiu Ping Yu
  • Craig J Della Valle
  • Michael Walsh
  • Brent Wise
  • Charles Preston
  • Eric W Fulkerson
  • Robert Meislin
  • Carrie Fang
  • Markus W Buchler
  • Michael P Leslie
  • Eric Y Chang
  • Quan Liao
  • Junchao Guo
  • Amiq Gazdhar
  • Lisa Prazak
  • Jorg Kleeff
  • Eric Chang

Detail Information

Publications27

  1. ncbi request reprint Serum interleukin-6 as a marker of periprosthetic infection following total hip and knee arthroplasty
    Paul E Di Cesare
    Musculoskeletal Research Center, Room 1500, NYU Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA
    J Bone Joint Surg Am 87:1921-7. 2005
    ....
  2. ncbi request reprint Failure of a constrained acetabular liner without reinforcement ring disruption
    Jeffrey A Arthur
    University of California Davis Medical Center, Sacramento, CA
    Am J Orthop (Belle Mead NJ) 42:566-8. 2013
    ..Dislocation without disruption of containment ring has not been described for the Pinnacle Acetabular Cup with the Enhanced Stability Constrained Liner (DePuy Orthopaedics, Warsaw, Indiana). ..
  3. ncbi request reprint The Application of Minimally Invasive Surgical Techniques. Part II: Total Knee Arthroplasty
    Derek F Amanatullah
    Resident, Department of Orthopaedic Surgery, University of California Davis Health System, Sacramento, California
    Am J Orthop (Belle Mead NJ) 41:E140-4. 2012
    ..Skeptics claim that there is no advantage in using MIS over time-tested approaches and are concerned that MIS approaches are being implemented before being properly subjected to peer review...
  4. ncbi request reprint The application of minimally invasive surgical techniques. Part I: total hip arthroplasty
    Derek F Amanatullah
    Resident, Department of Orthopaedic Surgery, University of California Davis Health System, Sacramento, California
    Am J Orthop (Belle Mead NJ) 41:E134-9. 2012
    ..Skeptics claim that there is no advantage in using MIS over time-tested approaches and are concerned that MIS approaches are being implemented before being properly subjected to peer review...
  5. ncbi request reprint Regional gene therapy for full-thickness articular cartilage lesions using naked DNA with a collagen matrix
    Paul E Di Cesare
    Musculoskeletal Research Laboratory, New York University Hospital for Joint Diseases, Department of Orthopaedic Surgery, 301 East 17th Street, Suite 1500, New York 10003, USA
    J Orthop Res 24:1118-27. 2006
    ..Naked plasmid DNA as a vehicle for transferring therapeutic genes has been shown to be effective in a therapeutic model within rabbit articular cartilage and appears to be safe and cost effective...
  6. ncbi request reprint Expression of cartilage oligomeric matrix protein by human synovium
    P E Di Cesare
    Musculoskeletal Research Center, Hospital for Joint Diseases Orthopaedic Institute, New York, NY 10003, USA
    FEBS Lett 412:249-52. 1997
    ..Human synovium should be considered as a potential tissue source of COMP in any investigation of biological markers of cartilage metabolism...
  7. ncbi request reprint Up-regulation of inducible nitric oxide synthase and production of nitric oxide by the Swarm rat and human chondrosarcoma
    P E Di Cesare
    Department of Orthopaedic Surgery, Musculoskeletal Research Center, New York University Medical Center, Hospital for Joint Diseases Orthopaedic Institute, New York 10003, USA
    J Orthop Res 16:667-74. 1998
    ..Because the chondrosarcoma of the Swarm rat is a well differentiated solid tumor that rarely metastasizes, nitric oxide may be produced by the tumor to promote local growth by effects on vascular supply...
  8. ncbi request reprint Localization and expression of cartilage oligomeric matrix protein by human rheumatoid and osteoarthritic synovium and cartilage
    P E Di Cesare
    Musculoskeletal Research Center, Department of Orthopaedic Surgery, New York University Medical Center Hospital for Joint Diseases, New York 10003, USA
    J Orthop Res 17:437-45. 1999
    ..The upregulated expression of cartilage oligomeric matrix protein in inflammatory tissues suggests its in vivo regulation by cytokines...
  9. ncbi request reprint Expression of cartilage oligomeric matrix protein (COMP) by embryonic and adult osteoblasts
    P E Di Cesare
    Musculoskeletal Research Center, Hospital for Joint Diseases Orthopaedic Institute, New York, New York 10003, USA
    J Orthop Res 18:713-20. 2000
    ....
  10. ncbi request reprint Matrix-matrix interaction of cartilage oligomeric matrix protein and fibronectin
    Paul E Di Cesare
    Musculoskeletal Research Center, NYU Hospital for Joint Diseases Department of Orthopedic Surgery, 301 East 17th Street, New York, NY 10030, USA
    Matrix Biol 21:461-70. 2002
    ....
  11. ncbi request reprint The interferon-inducible p204 protein acts as a transcriptional coactivator of Cbfa1 and enhances osteoblast differentiation
    Chuan Ju Liu
    Musculoskeletal Research Center and Department of Orthopaedic Surgery, New York University, Hospital for Joint Diseases, New York, New York 10003, USA
    J Biol Chem 280:2788-96. 2005
    ..p204, which is the first interferon-inducible protein found to associate with Cbfa1, functions as a novel regulator of osteoblast differentiation...
  12. ncbi request reprint Doublecortin is expressed in articular chondrocytes
    Yi Zhang
    Lawrence Ellison Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, School of Medicine, University of California Davis, 4635 Second Avenue, Room 2000, Sacramento, CA 95817, USA
    Biochem Biophys Res Commun 363:694-700. 2007
    ....
  13. ncbi request reprint Cartilage oligomeric matrix protein associates with granulin-epithelin precursor (GEP) and potentiates GEP-stimulated chondrocyte proliferation
    Ke Xu
    Department of Orthopaedic Surgery, New York University Hospital for Joint Diseases, New York, New York 10003, USA
    J Biol Chem 282:11347-55. 2007
    ..These findings provide the first evidence linking the association of COMP and GEP and identifying a previously unrecognized growth factor (i.e. GEP) in cartilage...
  14. pmc ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein
    Chuan Ju Liu
    Musculoskeletal Research Center, New York University Hospital for Joint Diseases Department of Orthopaedic Surgery, School of Medicine, 301 East 17th St, New York, New York 10003, USA
    FASEB J 20:988-90. 2006
    ..ADAMTS-7 is the first metalloproteinase found to bind directly to and degrade COMP...
  15. ncbi request reprint Expression of bone morphogenetic proteins, receptors, and tissue inhibitors in human fetal, adult, and osteoarthritic articular cartilage
    Andrew L Chen
    Department of Orthopaedic Surgery, Musculoskeletal Research Center, NYU Hospital for Joint Diseases Orthopaedic Institute, 301 East 17th Street, New York, NY 1003, USA
    J Orthop Res 22:1188-92. 2004
    ..Similarly, Western blotting demonstrated BMPs 7 and 8 to be present in fetal but not in adult samples. BMP-3 protein was present in fetal and adult normal samples, to a lesser extent, but absent in osteoarthritic cartilage...
  16. ncbi request reprint A silencer element in the cartilage oligomeric matrix protein gene regulates chondrocyte-specific expression
    Paul S Issack
    Department of Orthopaedic Surgery, Musculoskeletal Research Center, Hospital for Joint Diseases, NYU, 301 East 17th Street, New York, NY, USA
    J Orthop Res 22:751-8. 2004
    ..These results suggest that negative regulation of transcription is an important mechanism for chondrocyte-specific expression of the COMP gene...
  17. ncbi request reprint Clinical applications of growth factors for articular cartilage repair
    Derrick G Hickey
    Department of Orthopaedic Surgery, New York University Medical Center Hospital for Joint Diseases, New York, New York, USA
    Am J Orthop (Belle Mead NJ) 32:70-6. 2003
    ..Orthopedic surgeons need to be familiar with the properties of these growth factors, as they hold great therapeutic promise. In-progress clinical studies are examining how growth factors may have applications in treatments of bone...
  18. ncbi request reprint Cartilage oligomeric matrix protein expression in hepatocellular carcinoma and the cirrhotic liver
    Yi Xiao
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    J Gastroenterol Hepatol 19:296-302. 2004
    ..In the present study the expression of COMP was investigated in normal liver (n=19), liver cirrhosis (n=14) and hepatocellular carcinoma (HCC; n=16) tissues, both at the mRNA and protein level...
  19. ncbi request reprint Scaffolds for articular cartilage repair
    Sally R Frenkel
    NYU Hospital for Joint Diseases, Musculoskeletal Research Center, Department of Orthopaedic Surgery, New York, NY 10003, USA
    Ann Biomed Eng 32:26-34. 2004
    ..This review will discuss various promising scaffolds for cartilage tissue engineering applications...
  20. ncbi request reprint Transcriptional activation of cartilage oligomeric matrix protein by Sox9, Sox5, and Sox6 transcription factors and CBP/p300 coactivators
    Chuan Ju Liu
    Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, NY 10003, USA
    Front Biosci 12:3899-910. 2007
    ..This study provides the first evidence that Sox9 directly associates with COMP gene promoter and that mediation of COMP gene activation by Sox9 involves Sox5, Sox6, CBP, and p300 coactivators...
  21. ncbi request reprint The retinoblastoma protein is an essential mediator of osteogenesis that links the p204 protein to the Cbfa1 transcription factor thereby increasing its activity
    Yi Luan
    Department of Orthopedic Surgery, New York University Medical Center, New York, New York 10003, USA
    J Biol Chem 282:16860-70. 2007
    ..Furthermore, as revealed in reporter gene and in vitro osteogenesis assays p204 synergized with pRb in the stimulation of Cbfa1-dependent gene activation and osteoblast differentiation...
  22. ncbi request reprint Leukemia/lymphoma-related factor, a POZ domain-containing transcriptional repressor, interacts with histone deacetylase-1 and inhibits cartilage oligomeric matrix protein gene expression and chondrogenesis
    Chuan Ju Liu
    Musculoskeletal Research Center, New York University Hospital for Joint Diseases Department of Orthopedic Surgery, New York, New York 10003, USA
    J Biol Chem 279:47081-91. 2004
    ..LRF is the first transcription factor found to bind directly to the COMP gene promoter, to recruit HDAC1, and to regulate both COMP gene expression and chondrogenic differentiation...
  23. ncbi request reprint Antibiotic susceptibility of bacteria infecting total joint arthroplasty sites
    Eric Fulkerson
    Musculoskeletal Research Center, New York University Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA
    J Bone Joint Surg Am 88:1231-7. 2006
    ..Currently, there is no consensus regarding the principles of empiric antibiotic treatment of suspected periprosthetic infection following total knee and hip arthroplasties. This study was undertaken to attempt to establish such principles...
  24. pmc ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein
    Chuan Ju Liu
    Department of Orthopaedic Surgery, Musculoskeletal Research Center, New York University Hospital for Joint Diseases, New York, New York 10003, USA
    J Biol Chem 281:15800-8. 2006
    ..Together, these findings indicate that ADAMTS-12 is a new COMP-interacting and -degrading enzyme and thus may play an important role in the COMP degradation in the initiation and progression of arthritis...
  25. ncbi request reprint Expression of bone morphogenetic proteins by Dupuytren's fibroblasts
    Steven S Shin
    Musculoskeletal Research Center, Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, NY 10003, USA
    J Hand Surg Am 29:809-14. 2004
    ..We hypothesize that bone morphogenetic proteins (BMPs) play a role in the modulation of Dupuytren's fibroblasts...
  26. ncbi request reprint Osteotomy about the knee: applications, techniques, and results
    Charles F Preston
    Department of Orthopedic Surgery, NYU Hospital for Joint Diseases, New York, NY 10003, USA
    J Knee Surg 18:258-72. 2005
    ..Recent long-term follow-up studies have concluded osteotomy allows for improved function and pain relief in properly selected young patients...
  27. ncbi request reprint Use of antibiotic-impregnated cement in total joint arthroplasty
    Thomas N Joseph
    Department of Orthopaedic Surgery, Musculoskeletal Research Center, NYU Hospital for Joint Diseases, New York, NY, USA
    J Am Acad Orthop Surg 11:38-47. 2003
    ..Problems associated with antibiotic-impregnated cement in total joint arthroplasty include weakening of the cement and the generation of antibiotic-resistant bacteria in infected implant sites...

Research Grants3

  1. EFFECT OF COMP MUTATION ON MUSCULOSKELETAL DEVELOPMENT
    Paul Di Cesare; Fiscal Year: 2002
    ..Identifying the functions, synthesis, interactions, tissue distribution and expression of COMP is critical to understanding its influence on growth during endochondral ossification and articular cartilage structure and function. ..