Antonio Di Ieva

Summary

Publications

  1. doi request reprint Antiangiogenic strategies in medulloblastoma: reality or mystery
    Fabio Grizzi
    Laboratories of Quantitative Medicine, Istituto Clinico Humanitas IRCCS, 20089 Rozzano, Milan, Italy
    Pediatr Res 63:584-90. 2008
  2. ncbi request reprint Lumbar arachnoiditis and thecaloscopy: brief review and proposed treatment algorithm
    A Di Ieva
    Istituto Clinico Humanitas, Neurosurgery, Milan, Italy
    Cent Eur Neurosurg 71:207-12. 2010
  3. doi request reprint Correlation of microvascular fractal dimension with positron emission tomography [(11)C]-methionine uptake in glioblastoma multiforme: preliminary findings
    Antonio Di Ieva
    Center for Anatomy and Cell Biology, Institute of Systematic Anatomy, Medical University of Vienna, Austria
    Microvasc Res 80:267-73. 2010
  4. ncbi request reprint Skull base embryology: a multidisciplinary review
    Antonio Di Ieva
    Division of Neurosurgery, Department of Surgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, ON, Canada, M5B 1W8
    Childs Nerv Syst 30:991-1000. 2014
  5. doi request reprint Microvascular morphometrics of the hypophysis and pituitary tumors: from bench to operating theatre
    Antonio Di Ieva
    Division of Neurosurgery, Department of Surgery, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Microvasc Res 89:7-14. 2013
  6. doi request reprint Cranial sutures: a multidisciplinary review
    Antonio Di Ieva
    Division of Neurosurgery, St Michael s Hospital, 30 Bond Street, Toronto, ON, Canada
    Childs Nerv Syst 29:893-905. 2013
  7. doi request reprint Three-dimensional susceptibility-weighted imaging at 7 T using fractal-based quantitative analysis to grade gliomas
    Antonio Di Ieva
    Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Vienna, Austria
    Neuroradiology 55:35-40. 2013
  8. ncbi request reprint Fractal analysis of microvascular networks in malignant brain tumors
    Antonio Di Ieva
    Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Austria
    Clin Neuropathol 31:342-51. 2012
  9. doi request reprint Fractal analysis of the susceptibility weighted imaging patterns in malignant brain tumors during antiangiogenic treatment: technical report on four cases serially imaged by 7 T magnetic resonance during a period of four weeks
    Antonio Di Ieva
    Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Vienna, Austria
    World Neurosurg 77:785.e11-21. 2012
  10. pmc Computer-assisted and fractal-based morphometric assessment of microvascularity in histological specimens of gliomas
    Antonio Di Ieva
    Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Vienna, Austria
    Sci Rep 2:429. 2012

Collaborators

Detail Information

Publications47

  1. doi request reprint Antiangiogenic strategies in medulloblastoma: reality or mystery
    Fabio Grizzi
    Laboratories of Quantitative Medicine, Istituto Clinico Humanitas IRCCS, 20089 Rozzano, Milan, Italy
    Pediatr Res 63:584-90. 2008
    ..We here review the state-of-the-art concerning antiangiogenic targets for medulloblastoma treatment, and discuss the complexity of the vascular system that intrinsically limits the efficacy of current strategies...
  2. ncbi request reprint Lumbar arachnoiditis and thecaloscopy: brief review and proposed treatment algorithm
    A Di Ieva
    Istituto Clinico Humanitas, Neurosurgery, Milan, Italy
    Cent Eur Neurosurg 71:207-12. 2010
    ..We here review the most modern techniques for the treatment of this disease such as thecaloscopy and neurostimulation...
  3. doi request reprint Correlation of microvascular fractal dimension with positron emission tomography [(11)C]-methionine uptake in glioblastoma multiforme: preliminary findings
    Antonio Di Ieva
    Center for Anatomy and Cell Biology, Institute of Systematic Anatomy, Medical University of Vienna, Austria
    Microvasc Res 80:267-73. 2010
    ....
  4. ncbi request reprint Skull base embryology: a multidisciplinary review
    Antonio Di Ieva
    Division of Neurosurgery, Department of Surgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, ON, Canada, M5B 1W8
    Childs Nerv Syst 30:991-1000. 2014
    ..Embryology of the cranial base is of great interest due to its pronounced impact on the development of adjacent regions including the brain, neck, and craniofacial skeleton...
  5. doi request reprint Microvascular morphometrics of the hypophysis and pituitary tumors: from bench to operating theatre
    Antonio Di Ieva
    Division of Neurosurgery, Department of Surgery, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Microvasc Res 89:7-14. 2013
    ....
  6. doi request reprint Cranial sutures: a multidisciplinary review
    Antonio Di Ieva
    Division of Neurosurgery, St Michael s Hospital, 30 Bond Street, Toronto, ON, Canada
    Childs Nerv Syst 29:893-905. 2013
    ..Improving our holistic view helps further guide clinicians who treat cranial sutural abnormalities as well as researchers who study them...
  7. doi request reprint Three-dimensional susceptibility-weighted imaging at 7 T using fractal-based quantitative analysis to grade gliomas
    Antonio Di Ieva
    Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Vienna, Austria
    Neuroradiology 55:35-40. 2013
    ..Here, we test whether objective quantification of intratumoral SWI patterns by applying fractal analysis can offer reliable indexes capable of differentiating glial tumor grades...
  8. ncbi request reprint Fractal analysis of microvascular networks in malignant brain tumors
    Antonio Di Ieva
    Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Austria
    Clin Neuropathol 31:342-51. 2012
    ....
  9. doi request reprint Fractal analysis of the susceptibility weighted imaging patterns in malignant brain tumors during antiangiogenic treatment: technical report on four cases serially imaged by 7 T magnetic resonance during a period of four weeks
    Antonio Di Ieva
    Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Vienna, Austria
    World Neurosurg 77:785.e11-21. 2012
    ..The image analysis involved the application of susceptibility weighted imaging (SWI) to evaluate vascular structures...
  10. pmc Computer-assisted and fractal-based morphometric assessment of microvascularity in histological specimens of gliomas
    Antonio Di Ieva
    Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Vienna, Austria
    Sci Rep 2:429. 2012
    ....
  11. doi request reprint Endoscopic telovelar approach to the fourth ventricle: anatomic study
    Antonio Di Ieva
    Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Waehringerstrasse 13, 1090, Vienna, Austria
    Neurosurg Rev 35:341-8; discussion 348-9. 2012
    ..In conclusion, we showed that the endoscope is a valid tool to gain an anatomic understanding of the fourth ventricle reached by means of the telovelar approach...
  12. doi request reprint The subdiaphragmatic cistern: historic and radioanatomic findings
    Antonio Di Ieva
    Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Austria
    Acta Neurochir (Wien) 154:667-74; discussion 674. 2012
    ..The aim of this study was to evaluate the anatomical characteristics of the subdiaphragmatic cistern of the pituitary gland...
  13. ncbi request reprint The microvascular network of the pituitary gland: a model for the application of fractal geometry to the analysis of angioarchitecture and angiogenesis of brain tumors
    A Di Ieva
    Department of Neurosurgery, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    J Neurosurg Sci 54:49-54. 2010
    ..We propose extending the application of this model to the analysis of the angiogenesis and angioarchitecture of brain tumors...
  14. doi request reprint Angioarchitectural heterogeneity in human glioblastoma multiforme: a fractal-based histopathological assessment
    Antonio Di Ieva
    Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Vienna, Austria
    Microvasc Res 81:222-30. 2011
    ..The present study shows that angioarchitectural subtypes can be identified by mvFD, making this parameter a potential tool for quantifying different neoplastic microvascular patterns...
  15. doi request reprint Berengario da Carpi: a pioneer in neurotraumatology
    Antonio Di Ieva
    Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Austria
    J Neurosurg 114:1461-70. 2011
    ..This was a systematic treatise covering the mechanisms, classification, and medical and surgical treatment of head traumas, and can be considered a milestone in the history of neurotraumatology...
  16. ncbi request reprint Angioarchitectural morphometrics of brain tumors: are there any potential histopathological biomarkers?
    Antonio Di Ieva
    Center for Anatomy and Cell Biology, Department of Systematic Anatomy and Department of Neurosurgery, Medical University of Vienna, Waehringerstrasse 13, Vienna, Austria
    Microvasc Res 80:522-33. 2010
    ..An empirical algorithm for assessing the microangioarchitecture of brain tumors is also provided...
  17. doi request reprint The veins of the nucleus dentatus: anatomical and radiological findings
    Antonio Di Ieva
    Centre for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Vienna, Austria
    Neuroimage 54:74-9. 2011
    ..An anatomical and radiological description of the veins of the dentate nucleus is provided, with some remarks on the future clinical applications that these findings could provide...
  18. doi request reprint Magnetic resonance elastography: a general overview of its current and future applications in brain imaging
    Antonio Di Ieva
    Department of Neurosurgery, Istituto Clinico Humanitas, Via Manzoni, 56, 20089, Rozzano, Milan, Italy
    Neurosurg Rev 33:137-45; discussion 145. 2010
    ..The aim of this article is to review the current state-of-the-art of MRE imaging and discuss its possible future diagnostic applications in neuroscience...
  19. doi request reprint Euclidean and fractal geometry of microvascular networks in normal and neoplastic pituitary tissue
    Antonio Di Ieva
    Department of Neurosurgery, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    Neurosurg Rev 31:271-81. 2008
    ..We also discuss the limitations of Euclidean quantitative analyses of vascularity and the helpfulness of a fractal geometry-based approach as a better means of quantifying normal and neoplastic pituitary microvasculature...
  20. ncbi request reprint Oligodendroglial gliomatosis cerebri. Case report
    A Di Ieva
    Department of Neurosurgery, Istituto Clinico Humanitas, Milan, Italy
    J Neurosurg Sci 50:123-5. 2006
    ..We give a short focus about the diagnosis and the therapy of this neoplastic disease...
  21. ncbi request reprint Focal extra-axial hemorrahagic mass with subdural hemorrhage secondare to extramedullary hematopoiesis in idiopathic myelodysplastic sindrome
    A Di Ieva
    Department of Neurosurgery, Istituto Clinico Humanitas IRCCS, Rozzano Milan, Italy
    J Neurosurg Sci 51:29-32. 2007
    ....
  22. pmc Fractal dimension as a quantitator of the microvasculature of normal and adenomatous pituitary tissue
    Antonio Di Ieva
    Department of Neurosurgery, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
    J Anat 211:673-80. 2007
    ....
  23. ncbi request reprint The neuroanatomical plates of Guido da Vigevano
    Antonio Di Ieva
    Department of Neurosurgery, Istituto Clinico Humanitas IRCCS, Milan, Italy
    Neurosurg Focus 23:E15. 2007
    ..Ventricles are also described and shown. This book constituted the first attempt in the history of neuroscience to illustrate an anatomical description with schematic pictures to achieve a better understanding of such complex structures...
  24. doi request reprint Liquor cotunnii: the history of cerebrospinal fluid in Domenico Cotugno's work
    Antonio Di Ieva
    Department of Neurosurgery, Istituto Clinico Humanitas, Rozzano, Milan, Italy
    Neurosurgery 63:352-8; discussion 358. 2008
    ....
  25. doi request reprint Practical guidelines for setting up an endoscopic/skull base cadaver laboratory
    Manfred Tschabitscher
    Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Vienna, Austria
    World Neurosurg 79:S16.e1-7. 2013
    ..We describe the basic principles of the philosophy of anatomic dissection and the equipment necessary to set up an endoscopic cadaver laboratory...
  26. ncbi request reprint Spinal decompression and vertebroplasty in Paget's disease of the spine
    Flavio Tancioni
    Department of Neurosurgery, Istituto Clinico Humanitas, 20089 Milan, Italy
    Surg Neurol 66:189-91; discussion 191. 2006
    ..To our knowledge, this is the first case report in which these procedures have been performed together in the same operation to treat spinal pathologies due to Paget's disease...
  27. doi request reprint Endoscopic extradural subtemporal approach to lateral and central skull base: a cadaveric study
    Fuminari Komatsu
    Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Vienna, Austria Electronic address
    World Neurosurg 80:591-7. 2013
    ....
  28. doi request reprint Endoscopic far-lateral approach to the posterolateral craniovertebral junction: an anatomical study
    Fuminari Komatsu
    Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Waehringer Strasse 13, 1090 Vienna, Austria
    Neurosurg Rev 36:239-47; discussion 247. 2013
    ..Endoscopic soft tissue dissection is key to creating the surgical corridor. This approach could offer an alternative to the conventional far-lateral approach in selected cases...
  29. ncbi request reprint Lancisi's nerves and the seat of the soul
    Antonio Di Ieva
    Department of Neurosurgery, Istituto Clinico Humanitas, Milan, Italy
    Neurosurgery 60:563-8; discussion 568. 2007
    ..This essay offers an account of this eminent physician, his era, and his philosophical background, as well as a description of the anatomic structures that bear his name...
  30. doi request reprint Vertebroplasty for pain relief and spinal stabilization in multiple myeloma
    Flavio Tancioni
    Department of Neurosurgery, Instituto Clinico Humanitas, Milan, Italy
    Neurol Sci 31:151-7. 2010
    ....
  31. pmc Cancer initiation and progression: an unsimplifiable complexity
    Fabio Grizzi
    Laboratories of Quantitative Medicine, Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
    Theor Biol Med Model 3:37. 2006
    ....
  32. doi request reprint A management algorithm for cerebrospinal fluid leak associated with anterior skull base fractures: detailed clinical and radiological follow-up
    Camillo Sherif
    Department of Neurosurgery, Medical University Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
    Neurosurg Rev 35:227-37; discussion 237-8. 2012
    ..Large randomized controlled trials are needed to better define the role of prophylactic antibiotics and to better characterize the optimal timing and approach of surgical repair...
  33. ncbi request reprint Functional disability after instrumented stabilization in lumbar degenerative spondylolisthesis: a follow-up study
    Paolo Gaetani
    Department of Neurosurgery, Istituto Clinico Humanitas, Milan, Italy
    Funct Neurol 21:31-7. 2006
    ..Instrumental pedicle screw fixation and arthorodesis seem to be very effective in improving quality of life, as shown by the reduced disability scores at follow up...
  34. doi request reprint Endoscopic approaches to the trigeminal nerve and clinical consideration for trigeminal schwannomas: a cadaveric study
    Fuminari Komatsu
    Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Vienna, Austria
    J Neurosurg 117:690-6. 2012
    ..The aims of this study were to become familiar with the endoscopic anatomy of the trigeminal nerve and to develop a minimally invasive surgical strategy for the treatment of trigeminal schwannomas...
  35. doi request reprint Endoscopic reconstruction of the middle cranial fossa through a subtemporal keyhole using a pedicled deep temporal fascial flap: a cadaveric study
    Mika Komatsu
    Department of Neurosurgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    Neurosurgery 70:157-61; discussion 162. 2012
    ..Reconstruction of the skull base is essential to prevent postoperative leakage of cerebrospinal fluid (CSF). However, a reliable method of reconstructing the middle cranial fossa via a subtemporal keyhole is not available...
  36. pmc Sperm protein 17 is expressed in human nervous system tumours
    Fabio Grizzi
    Istituto Clinico Humanitas, IRCCS, 20089 Rozzano, Milan, Italy
    BMC Cancer 6:23. 2006
    ..We investigated its immunolocalisation in specimens of nervous system (NS) malignancies, in order to establish its usefulness as a target for tumour-vaccine strategies...
  37. doi request reprint Strong 5-aminolevulinic acid-induced fluorescence is a novel intraoperative marker for representative tissue samples in stereotactic brain tumor biopsies
    Georg Widhalm
    Department of Neurosurgery, Medical University Vienna, Vienna, Austria
    Neurosurg Rev 35:381-91; discussion 391. 2012
    ..Thereby, the application of 5-ALA in stereotactic brain tumor biopsies may in future reduce costs for operating room and neuropathology and may decrease procedure-related morbidity...
  38. ncbi request reprint MicroRNAs as Biomarkers in Pituitary Tumors
    Antonio Di Ieva
    Division of Neurosurgery, Department of Surgery, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada Department of Laboratory Medicine, Division of Pathology, and the Keenan Research Centre for Biomedical Science at the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Canada Division of Cardiology, Magna Graecia University, Catanzaro, Italy Department of Pathology, Acibadem University, School of Medicine, Maltepe, Istanbul, Turkey
    Neurosurgery 75:181-9. 2014
    ..Here we review the biological significance of miRNAs in pituitary tumors and the potential value of circulating miRNAs as biomarkers...
  39. ncbi request reprint Aggressive pituitary adenomas--diagnosis and emerging treatments
    Antonio Di Ieva
    Department of Surgery, Division of Neurosurgery, St Michael s Hospital, University of Toronto, 30 Bond Street, Toronto, ON M5B 1W8, Canada
    Nat Rev Endocrinol 10:423-35. 2014
    ..New drugs, such as temozolomide, have potential use in the management of these patients; anti-VEGF therapy, mTOR and tyrosine kinase inhibitors are also potentially useful in managing selected patients. ..
  40. doi request reprint Autophagy in the endocrine glands
    Andrea Weckman
    Division of Neurosurgery, Department of Surgery, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada Division of Pathology, Department of Laboratory Medicine, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada Department of Neurosurgery, Hospital Pablo Tobon Uribe and Clinica Medellin, Medellin, Colombia Division of Neurooncology, Instituto de Cancerologia, Clinic Las Americas, Medellin, Colombia
    J Mol Endocrinol 52:R151-63. 2014
    ..This review aims to clarify the known roles of autophagy in the physiology of the endocrine system, as well as in various endocrine diseases. ..
  41. doi request reprint Canula-assisted endoscopy in bi-portal transphenoidal cranial base surgery: technical note
    Michael D Cusimano
    Division of Neurosurgery, St Michael s Hospital, 30 Bond Street, M5B 1W8, Toronto, Ontario, Canada
    Acta Neurochir (Wien) 155:909-11. 2013
    ..This technique is very simple and is particularly helpful for novice neuroendoscopists who are trying to navigate the confines of a narrow nasal cavity, especially when they are assisting more experienced colleagues...
  42. ncbi request reprint Calvarial metastases as clinical presentation of renal cell carcinoma: report of two cases and review of the literature
    Paolo Gaetani
    Department of Neurosurgery, Istituto Clinico Humanitas, Via Manzoni 56, I 20089 Rozzano, Milan, Italy
    Clin Neurol Neurosurg 107:329-33. 2005
    ..We also briefly review the literature...
  43. doi request reprint Evaluation of cerebral aneurysm wall thickness in experimental aneurysms: comparison of 3T-MR imaging with direct microscopic measurements
    Camillo Sherif
    Department of Neurosurgery and Cerebrovascular Research Group, Krankenanstalt Rudolfstiftung, Juchgasse 25, A 1030, Vienna, Austria
    Acta Neurochir (Wien) 156:27-34. 2014
    ..This analysis should help to define the clinical potential of MRI estimates of AWT...
  44. ncbi request reprint Computational fractal-based analysis of brain arteriovenous malformation angioarchitecture
    Antonio Di Ieva
    Division of Neurosurgery, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada University of Toronto, Toronto, Ontario, Canada Division of Neuroradiology, Toronto Western Hospital, Toronto, Ontario, Canada Department of Radiation Oncology, Odette Cancer Centre, Toronto, Ontario, Canada Department of Radiation Oncology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada Division of Neurosurgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
    Neurosurgery 75:72-9. 2014
    ..The fractal dimension (FD), which is a mathematical parameter able to quantify the space-filling properties and roughness of natural objects, may be useful in quantifying the geometrical complexity of bAVMs nidus...
  45. ncbi request reprint Watertight dural closure in brain surgery: a simple model for training
    Christian Matula
    Department of Neurosurgery, Medical University of Vienna, Vienna, Austria
    J Neurol Surg A Cent Eur Neurosurg 75:241-5. 2014
    ..Several techniques for duraplasty and different material for watertight closure have been described...
  46. ncbi request reprint Analysis of intracranial pressure: past, present, and future
    Antonio Di Ieva
    1Department of Surgery, Division of Neurosurgery, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    Neuroscientist 19:592-603. 2013
    ....
  47. ncbi request reprint Distinguishing Alzheimer's disease from normal pressure hydrocephalus: a search for MRI biomarkers
    Antonio Di Ieva
    Division of Neurosurgery, Department of Surgery, St Michael s Hospital, University of Toronto, Toronto, ON, Canada Injury Prevention Research Office, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    J Alzheimers Dis 38:331-50. 2014
    ..We conclude that the combination of different neuroimaging sequences as well as quantitative and qualitative parameters could provide new insight for better diagnosis and treatment of these two different diseases. ..