Antiangiogenic strategies in medulloblastoma: reality or mysteryFabio Grizzi
Laboratories of Quantitative Medicine, Istituto Clinico Humanitas IRCCS, 20089 Rozzano, Milan, Italy
Pediatr Res 63:584-90. 2008
..We here review the state-of-the-art concerning antiangiogenic targets for medulloblastoma treatment, and discuss the complexity of the vascular system that intrinsically limits the efficacy of current strategies...
- Lumbar arachnoiditis and thecaloscopy: brief review and proposed treatment algorithm
A Di Ieva
Istituto Clinico Humanitas, Neurosurgery, Milan, Italy
Cent Eur Neurosurg 71:207-12. 2010
..We here review the most modern techniques for the treatment of this disease such as thecaloscopy and neurostimulation...
- Correlation of microvascular fractal dimension with positron emission tomography [(11)C]-methionine uptake in glioblastoma multiforme: preliminary findings
Antonio Di Ieva
Center for Anatomy and Cell Biology, Institute of Systematic Anatomy, Medical University of Vienna, Austria
Microvasc Res 80:267-73. 2010
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- Three-dimensional susceptibility-weighted imaging at 7 T using fractal-based quantitative analysis to grade gliomas
Antonio Di Ieva
Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Vienna, Austria
Neuroradiology 55:35-40. 2013
..Here, we test whether objective quantification of intratumoral SWI patterns by applying fractal analysis can offer reliable indexes capable of differentiating glial tumor grades...
Fractal analysis of microvascular networks in malignant brain tumorsAntonio Di Ieva
Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Austria
Clin Neuropathol 31:342-51. 2012
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- Fractal analysis of the susceptibility weighted imaging patterns in malignant brain tumors during antiangiogenic treatment: technical report on four cases serially imaged by 7 T magnetic resonance during a period of four weeks
Antonio Di Ieva
Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Vienna, Austria
World Neurosurg 77:785.e11-21. 2012
..The image analysis involved the application of susceptibility weighted imaging (SWI) to evaluate vascular structures...
Computer-assisted and fractal-based morphometric assessment of microvascularity in histological specimens of gliomasAntonio Di Ieva
Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Vienna, Austria
Sci Rep 2:429. 2012
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- Endoscopic telovelar approach to the fourth ventricle: anatomic study
Antonio Di Ieva
Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Waehringerstrasse 13, 1090, Vienna, Austria
Neurosurg Rev 35:341-8; discussion 348-9. 2012
..In conclusion, we showed that the endoscope is a valid tool to gain an anatomic understanding of the fourth ventricle reached by means of the telovelar approach...
- The subdiaphragmatic cistern: historic and radioanatomic findings
Antonio Di Ieva
Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Austria
Acta Neurochir (Wien) 154:667-74; discussion 674. 2012
..The aim of this study was to evaluate the anatomical characteristics of the subdiaphragmatic cistern of the pituitary gland...
- Magnetic resonance elastography: a general overview of its current and future applications in brain imaging
Antonio Di Ieva
Department of Neurosurgery, Istituto Clinico Humanitas, Via Manzoni, 56, 20089, Rozzano, Milan, Italy
Neurosurg Rev 33:137-45; discussion 145. 2010
..The aim of this article is to review the current state-of-the-art of MRE imaging and discuss its possible future diagnostic applications in neuroscience...
- Angioarchitectural morphometrics of brain tumors: are there any potential histopathological biomarkers?
Antonio Di Ieva
Center for Anatomy and Cell Biology, Department of Systematic Anatomy and Department of Neurosurgery, Medical University of Vienna, Waehringerstrasse 13, Vienna, Austria
Microvasc Res 80:522-33. 2010
..An empirical algorithm for assessing the microangioarchitecture of brain tumors is also provided...
- Berengario da Carpi: a pioneer in neurotraumatology
Antonio Di Ieva
Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Austria
J Neurosurg 114:1461-70. 2011
..This was a systematic treatise covering the mechanisms, classification, and medical and surgical treatment of head traumas, and can be considered a milestone in the history of neurotraumatology...
- Angioarchitectural heterogeneity in human glioblastoma multiforme: a fractal-based histopathological assessment
Antonio Di Ieva
Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Vienna, Austria
Microvasc Res 81:222-30. 2011
..The present study shows that angioarchitectural subtypes can be identified by mvFD, making this parameter a potential tool for quantifying different neoplastic microvascular patterns...
- The microvascular network of the pituitary gland: a model for the application of fractal geometry to the analysis of angioarchitecture and angiogenesis of brain tumors
A Di Ieva
Department of Neurosurgery, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
J Neurosurg Sci 54:49-54. 2010
..We propose extending the application of this model to the analysis of the angiogenesis and angioarchitecture of brain tumors...
- Liquor cotunnii: the history of cerebrospinal fluid in Domenico Cotugno's work
Antonio Di Ieva
Department of Neurosurgery, Istituto Clinico Humanitas, Rozzano, Milan, Italy
Neurosurgery 63:352-8; discussion 358. 2008
..quot;..
- The veins of the nucleus dentatus: anatomical and radiological findings
Antonio Di Ieva
Centre for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Vienna, Austria
Neuroimage 54:74-9. 2011
..An anatomical and radiological description of the veins of the dentate nucleus is provided, with some remarks on the future clinical applications that these findings could provide...
- Oligodendroglial gliomatosis cerebri. Case report
A Di Ieva
Department of Neurosurgery, Istituto Clinico Humanitas, Milan, Italy
J Neurosurg Sci 50:123-5. 2006
..We give a short focus about the diagnosis and the therapy of this neoplastic disease...
- Focal extra-axial hemorrahagic mass with subdural hemorrhage secondare to extramedullary hematopoiesis in idiopathic myelodysplastic sindrome
A Di Ieva
Department of Neurosurgery, Istituto Clinico Humanitas IRCCS, Rozzano Milan, Italy
J Neurosurg Sci 51:29-32. 2007
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- Fractal dimension as a quantitator of the microvasculature of normal and adenomatous pituitary tissue
Antonio Di Ieva
Department of Neurosurgery, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
J Anat 211:673-80. 2007
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- The neuroanatomical plates of Guido da Vigevano
Antonio Di Ieva
Department of Neurosurgery, Istituto Clinico Humanitas IRCCS, Milan, Italy
Neurosurg Focus 23:E15. 2007
..Ventricles are also described and shown. This book constituted the first attempt in the history of neuroscience to illustrate an anatomical description with schematic pictures to achieve a better understanding of such complex structures...
- Euclidean and fractal geometry of microvascular networks in normal and neoplastic pituitary tissue
Antonio Di Ieva
Department of Neurosurgery, Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy
Neurosurg Rev 31:271-81. 2008
..We also discuss the limitations of Euclidean quantitative analyses of vascularity and the helpfulness of a fractal geometry-based approach as a better means of quantifying normal and neoplastic pituitary microvasculature...
- Spinal decompression and vertebroplasty in Paget's disease of the spine
Flavio Tancioni
Department of Neurosurgery, Istituto Clinico Humanitas, 20089 Milan, Italy
Surg Neurol 66:189-91; discussion 191. 2006
..To our knowledge, this is the first case report in which these procedures have been performed together in the same operation to treat spinal pathologies due to Paget's disease...
- Vertebroplasty for pain relief and spinal stabilization in multiple myeloma
Flavio Tancioni
Department of Neurosurgery, Instituto Clinico Humanitas, Milan, Italy
Neurol Sci 31:151-7. 2010
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- Lancisi's nerves and the seat of the soul
Antonio Di Ieva
Department of Neurosurgery, Istituto Clinico Humanitas, Milan, Italy
Neurosurgery 60:563-8; discussion 568. 2007
..This essay offers an account of this eminent physician, his era, and his philosophical background, as well as a description of the anatomic structures that bear his name...
- A management algorithm for cerebrospinal fluid leak associated with anterior skull base fractures: detailed clinical and radiological follow-up
Camillo Sherif
Department of Neurosurgery, Medical University Vienna, Waehringer Guertel 18 20, 1090 Vienna, Austria
Neurosurg Rev 35:227-37; discussion 237-8. 2012
..Large randomized controlled trials are needed to better define the role of prophylactic antibiotics and to better characterize the optimal timing and approach of surgical repair...
- Functional disability after instrumented stabilization in lumbar degenerative spondylolisthesis: a follow-up study
Paolo Gaetani
Department of Neurosurgery, Istituto Clinico Humanitas, Milan, Italy
Funct Neurol 21:31-7. 2006
..Instrumental pedicle screw fixation and arthorodesis seem to be very effective in improving quality of life, as shown by the reduced disability scores at follow up...
- Endoscopic approaches to the trigeminal nerve and clinical consideration for trigeminal schwannomas: a cadaveric study
Fuminari Komatsu
Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Vienna, Austria
J Neurosurg 117:690-6. 2012
..The aims of this study were to become familiar with the endoscopic anatomy of the trigeminal nerve and to develop a minimally invasive surgical strategy for the treatment of trigeminal schwannomas...
- Endoscopic reconstruction of the middle cranial fossa through a subtemporal keyhole using a pedicled deep temporal fascial flap: a cadaveric study
Mika Komatsu
Department of Neurosurgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
Neurosurgery 70:157-61; discussion 162. 2012
..Reconstruction of the skull base is essential to prevent postoperative leakage of cerebrospinal fluid (CSF). However, a reliable method of reconstructing the middle cranial fossa via a subtemporal keyhole is not available...
- Cancer initiation and progression: an unsimplifiable complexity
Fabio Grizzi
Laboratories of Quantitative Medicine, Istituto Clinico Humanitas IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
Theor Biol Med Model 3:37. 2006
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- Sperm protein 17 is expressed in human nervous system tumours
Fabio Grizzi
Istituto Clinico Humanitas, IRCCS, 20089 Rozzano, Milan, Italy
BMC Cancer 6:23. 2006
..We investigated its immunolocalisation in specimens of nervous system (NS) malignancies, in order to establish its usefulness as a target for tumour-vaccine strategies...
- Strong 5-aminolevulinic acid-induced fluorescence is a novel intraoperative marker for representative tissue samples in stereotactic brain tumor biopsies
Georg Widhalm
Department of Neurosurgery, Medical University Vienna, Vienna, Austria
Neurosurg Rev 35:381-91; discussion 391. 2012
..Thereby, the application of 5-ALA in stereotactic brain tumor biopsies may in future reduce costs for operating room and neuropathology and may decrease procedure-related morbidity...
- Calvarial metastases as clinical presentation of renal cell carcinoma: report of two cases and review of the literature
Paolo Gaetani
Department of Neurosurgery, Istituto Clinico Humanitas, Via Manzoni 56, I 20089 Rozzano, Milan, Italy
Clin Neurol Neurosurg 107:329-33. 2005
..We also briefly review the literature...
- Endoscopic far-lateral approach to the posterolateral craniovertebral junction: an anatomical study
Fuminari Komatsu
Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Waehringer Strasse 13, 1090 Vienna, Austria
Neurosurg Rev 36:239-47; discussion 247. 2013
..Endoscopic soft tissue dissection is key to creating the surgical corridor. This approach could offer an alternative to the conventional far-lateral approach in selected cases...
- Practical Guidelines for Setting up an Endoscopic/Skull Base Cadaver Laboratory
Manfred Tschabitscher
Center for Anatomy and Cell Biology, Department of Systematic Anatomy, Medical University of Vienna, Vienna, Austria Electronic address
World Neurosurg 79:S16.e1-7. 2013
..We describe the basic principles of the philosophy of anatomic dissection and the equipment necessary to set up an endoscopic cadaver laboratory...
