P Dey

..Well-differentiated liposarcoma is difficult to diagnose on fine needle aspiration cytology (FNAC) smears and may create considerable diagnostic problems...

..Thus, our study highlighted the morphological manifestations of secretory activity in MTC and the nature of secretory material as calcitonin, supported by immunocytochemical staining and serum calcitonin level...

..Hence, immunostaining is an efficient method of detecting increased numbers of megakaryocytes and micromegakaryocytes that would ordinarily be missed by using routine hematoxylin-eosin staining...

..CONCLUSION: Cells in Indian file in serous effusions are strongly suggestive of metastatic carcinoma. They are not specific to any particular site of the primary adenocarcinoma...

..A suitably designed ANN may be able to diagnose the lobular carcinoma of breast on FNAC material. ANN is an efficient software program with immense potential...

..In future, MN scoring could be used as biomonitoring of DNA damage and in early detection of high risk cases of carcinoma of breast...

..To use a commercially available artificial neural network (ANN) software program to distinguish prognostically good and bad cases of chronic myeloid leukemia (CML)...

..In this mini review the role of epigenetic changes of tumor microenvironment in carcinogenesis has been discussed...

....

..Herein, the salient visual and subvisual morphological changes of cancer nuclei and their possible etiology and significance have been reviewed...

..This article reviews a general overview of chromatin remodeling proteins, their role in carcinogenesis and the future potential of the histone deacetylase inhibitors in cancer chemotherapy...

..In the near future, FNAC combined with ancillary techniques may play a major role in diagnosis, subclassification and management of lymphomas...

..Biologic model formation is possible with fractal geometry. In the future, fractal geometry may help with the diagnosis, understanding of pathogenesis and management of lesions. It may also provide new insights into disease processes...

..In conclusion, clinical history along with the certain cytological features such as the presence of CCs, cells with eccentric nuclei, and intranuclear inclusions are helpful to diagnose metastatic TCC on FNAC material...

..It is not impossible that the chromatin pattern alteration may be just a secondary change due to the interaction of fixative with chromatin and nonchromatinic substances in the nucleus...

..In this brief review, the various aspects of aneuploidy with special emphasis on its mechanism of development and impact on progression of cancer are discussed...

..To explore the role of fractal dimension (FD) in distinguishing normal and different grades of cervical intraepithelial lesions...

..To measure the multifractal dimension in histopathology sections of chorionic villi to study its role to distinguish between normal chorionic villi and hydatidiform mole...

..In future, this promising variable can be incorporated along with other image morphometric features for accurate classification of dysplastic cells in cervical smear...

..Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc...

..In this review, the probable causes and impact of nuclear margin irregularities are discussed...

..Further ancillary studies, e.g., electron microscopy, image analysis, and other molecular investigations, are required to further categorize these tumors more precisely for better clinical management of these cases...

..It was possible to differentiate WT and NHL with ICM. Nuclear ICM was not significantly different in the NB, PNET and ES groups, and probably ICM would not be very helpful to differentiate these groups of MRCT...

....

..In Sertoli cell-only cases, there were only 2N populations of cells. With the help of DNA FCM, a rapid and objective assessment of spermatogenesis is possible from FNAC of the testis...

..S.A.) and conventional preparation (CP) specimens from fine needle aspiration cytology (FNAC) material by a semiquantitative scoring system...

..We also compared MN scores among different cytological grades of breast carcinoma...

..To assess the diagnostic value of fine needle aspiration cytology (FNAC) in ovarian lesions...

..FNAC was thus helpful in the early diagnosis, proper staging, and management. Importantly, it obviated a lymph node biopsy in the majority of cases...

..CONCLUSION: FCI technique is sensitive, more objective and quantitative in comparison with manual absorbance-based microscopic detection of enzyme immunohistochemistry products. FCI may determine divergent differentiation in SRCTs...

..To correlate visual cytologic grade with automated nuclear morphometry of carcinoma of the breast...

..Behaviour and management guidelines of dysgenetic gonads with XY mosaicism have also been discussed...

..CONCLUSION: FNAB is a relatively inexpensive initial investigative technique in the diagnosis and management of HIV-positive patients. It can obviate the need for surgical excision and enable immediate treatment of specific infections...

..It is useful not only in detecting primary and metastatic lesions, but also in follow-up of tumor recurrence...

..3%, respectively. We conclude that both bladder wash cytology and DNA FCM techniques should be done in all the cases of suspected TCC to detect more number of positive cases...

..To assess the role of glomerular morphometry in biopsy evaluation in renal disorders in addition to conventional diagnostic procedures...

..Cytological features of this tumour have only rarely been reported in the literature. We describe the cytomorphological features of SFT with an emphasis on diagnostic pitfalls...

..To study the significance of nuclear grooves in thyroid and extrathyroid benign and malignant lesions...

..FNAC is a very helpful and cost-effective modality in determining the nature of such lesions...

..CONCLUSION: Estimates of MNV on conventional histopathology sections may provide objective and useful criteria for relatively subjective histopathology grading and staging (FIGO stage I and II vs. IIIb)...

..Cytological features of different groups of ovarian tumors are to some extent characteristic. FNAB is a relatively safe and reliable diagnostic procedure...

..FNAC was very useful in distinguishing benign from malignant soft tissue tumours. However, it was not so effective in exact categorization of tumours...

..Sensitivity of urine cytology is relatively low. Ancillary techniques on urine sample may increase the sensitivity...

..The Mann-Whitney U test showed a significant difference in fractal dimension in these 2 groups (P < .02). CONCLUSION: Fractal dimension may be a helpful adjunctive technique to discriminate between benign and malignant cells...

..49 microm3, respectively (P = .984, Mann-Whitney test), indicating a poor relationship between MNV and 5-year DFS. CONCLUSION: Estimation of MNV alone in cases of invasive squamous cell carcinoma of the cervix is not predictive of DFS...

..The data were collected from a large number of research articles published in various medical journals. The role of these techniques to increase the diagnostic accuracy in serous effusions is emphasised...

..We hereby report a case of cervical tuberculosis which was diagnosed on cervical smear. We also carried out a brief literature review of the cases diagnosed previously on cervical smear...

....

....

..To study the correlation of histomorphometric data of bone marrow trephine biopsies at the time of initial diagnosis in chronic myeloid leukemia (CML) patients with the patient prognosis...

..0000, Student's t-test). The present study highlights the significance of cannibalism in malignant urine and effusion cytology. We suggest that cell cannibalism is a dependable cytological feature of malignancy...

..There was a single case of grade III sarcoma on histopathology which was correctly diagnosed and graded on FNAC.In majority of the STS it is possible to grade on FNAC. Grade I STS is relatively difficult to grade than grade II STS...

..To analyze the role of automated image morphometry (AIM) in distinguishing infiltrating lobular carcinoma (ILC) of the breast from benign, borderline and infiltrating ductal carcinoma (IDC)...

..To correlate three-dimensional nuclear size (mean nuclear volume) estimated by the stereologic intercept methodfor objective classification of cervical intraepithelial neoplasia (CIN) and carcinoma...

..To analyze the diagnostic efficacy of fine needle aspiration cytology (FNAC) in the initial evaluation of thyroid nodules, with special emphasis on discrepant cytologic diagnoses...

....

..CONCLUSION: Image morphometry may be helpful in differentiating blasts from lymphoid and myeloid leukemic subtypes...

....

..The measurement of fractal dimension may be helpful in discriminating malignant from benign cells. This may be another discriminating feature of malignant cells, along with classic image morphometry based on Euclidean geometry...

..Automated AgNOR counting is rapid and less cumbersome...

..We suggest that a differential diagnosis of FVPCT should be considered if the cytology smears show abundant cellularity, syncytial clusters and follicular arrangement along with thick colloid...

..Immunocytochemistry for bcl-2 expression may be of help in cases with clinical and cytological suspicion of lymphoma. Image morphometry has a small role in this regard...

..001). The scoring of MNC can be used as an additional biomarker and to discriminate between benign reactive mesothelial cells versus metastatic adenocarcinoma in effusion fluids in difficult situation...

..Because of morphologic similarities, it is difficult to differentiate HL from anaplastic large cell lymphoma and TCRBCL on FNAC. It is advisable to request a histopathologic examination in all cases of primary HL...

..This paper discusses the stepwise diagnostic algorithm for fine needle aspiration cytology diagnosis of mediastinal tumors...

..To compare cytomorphology preservation and immunohistochemistry results between conventional cell blocks (CCB) and cytoscrape cell blocks (SCB)...

..FNA cytology features along with proper clinical history, radiological findings, family history, and location of the lesion may be helpful to suggest the probable preoperative diagnosis of this lesion...

..The cytomorphologic features along with clinical correlation are necessary to increase the diagnostic accuracy of MPNST on aspiration cytology...

..FNAC of metastatic NPC in lymph node is a valuable diagnostic modality in suggesting the site of origin of the tumor. Furthermore, it is also helpful to exclude residual disease and recurrence in a treated patient with lymphadenopathy...

..In this review we discussed the various urinary markers and their role in detection of bladder cancer...

..In this brief review we have discussed the basic mechanism of artificial neural network along with its application in the field of pathology...

..However, this was only a pilot study, and a large number of cases are needed to establish the prognostic value of p53 overexpression in locally advanced head and neck squamous cell carcinoma...

....