John P DeVincenzo

Summary

Publications

  1. doi The promise, pitfalls and progress of RNA-interference-based antiviral therapy for respiratory viruses
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee Health Sciences Center, University of Tennessee, Memphis, TN, USA
    Antivir Ther 17:213-25. 2012
  2. pmc Assessing Modeled CO(2) Retention and Rebreathing of a Facemask Designed for Efficient Delivery of Aerosols to Infants
    Christian Mundt
    Faculty of Aeronautics and Astronautics, Institute for Thermodynamics, University of Bundeswehr Munich, 85579 Neubiberg, Germany
    ISRN Pediatr 2012:721295. 2012
  3. pmc Viral load drives disease in humans experimentally infected with respiratory syncytial virus
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee College of Medicine, Memphis, USA
    Am J Respir Crit Care Med 182:1305-14. 2010
  4. pmc Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children
    Chadi M El Saleeby
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Harvard Medical School, Massachusetts General Hospital for Children, Boston, USA
    J Infect Dis 204:996-1002. 2011
  5. doi Surfactant protein A2 polymorphisms and disease severity in a respiratory syncytial virus-infected population
    Chadi M El Saleeby
    Department of Pediatrics, Harvard Medical School, Massachusetts General Hospital for Children, Boston, MA 02114, USA
    J Pediatr 156:409-14. 2010
  6. ncbi Natural infection of infants with respiratory syncytial virus subgroups A and B: a study of frequency, disease severity, and viral load
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee, LeBonheur Children s Medical Center, Memphis, TN 38103, USA
    Pediatr Res 56:914-7. 2004
  7. ncbi Respiratory syncytial virus load predicts disease severity in previously healthy infants
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee School of Medicine, Memphis, Tennessee, USA
    J Infect Dis 191:1861-8. 2005
  8. doi Harnessing RNA interference to develop neonatal therapies: from Nobel Prize winning discovery to proof of concept clinical trials
    John P DeVincenzo
    University of Tennessee School of Medicine, Department of Pediatrics, LeBonheur Children s Medical Center, Room 433, 50N Dunlap Street, Memphis, TN 38103, USA
    Early Hum Dev 85:S31-5. 2009
  9. doi RNA interference strategies as therapy for respiratory viral infections
    John P DeVincenzo
    Department of Pediatrics and Molecular Sciences, University of Tennessee, The Children s Foundation Research Center, and LeBonheur Children s Medical Center, Memphis, TN 38103, USA
    Pediatr Infect Dis J 27:S118-22. 2008
  10. ncbi Surveillance of clinical isolates of respiratory syncytial virus for palivizumab (Synagis)-resistant mutants
    John P DeVincenzo
    University of Tennessee, LeBonheur Children s Medical Center, Memphis 38103, USA
    J Infect Dis 190:975-8. 2004

Collaborators

Detail Information

Publications22

  1. doi The promise, pitfalls and progress of RNA-interference-based antiviral therapy for respiratory viruses
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee Health Sciences Center, University of Tennessee, Memphis, TN, USA
    Antivir Ther 17:213-25. 2012
    ..This review discusses the science behind RNAi and the potential practical issues in applying this technology to various respiratory viral diseases...
  2. pmc Assessing Modeled CO(2) Retention and Rebreathing of a Facemask Designed for Efficient Delivery of Aerosols to Infants
    Christian Mundt
    Faculty of Aeronautics and Astronautics, Institute for Thermodynamics, University of Bundeswehr Munich, 85579 Neubiberg, Germany
    ISRN Pediatr 2012:721295. 2012
    ..Conclusion. The mask is predicted to cause minimal CO(2) retention and rebreathing. Infants with normal and distressed breathing should tolerate the mask intermittently delivering aerosols over brief time frames...
  3. pmc Viral load drives disease in humans experimentally infected with respiratory syncytial virus
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee College of Medicine, Memphis, USA
    Am J Respir Crit Care Med 182:1305-14. 2010
    ..Two major challenges have stalled antiviral development: ethical difficulties in performing pediatric proof-of-concept studies and the prevailing concept that the disease is immune-mediated rather than being driven by viral load...
  4. pmc Respiratory syncytial virus load, viral dynamics, and disease severity in previously healthy naturally infected children
    Chadi M El Saleeby
    Division of Pediatric Infectious Diseases, Department of Pediatrics, Harvard Medical School, Massachusetts General Hospital for Children, Boston, USA
    J Infect Dis 204:996-1002. 2011
    ..The relationships between RSV load, viral clearance dynamics, and disease severity have not been carefully evaluated...
  5. doi Surfactant protein A2 polymorphisms and disease severity in a respiratory syncytial virus-infected population
    Chadi M El Saleeby
    Department of Pediatrics, Harvard Medical School, Massachusetts General Hospital for Children, Boston, MA 02114, USA
    J Pediatr 156:409-14. 2010
    ..To examine whether genetic variations within the surfactant protein A2 (SP-A2) gene are associated with respiratory syncytial virus (RSV) disease severity in infected children...
  6. ncbi Natural infection of infants with respiratory syncytial virus subgroups A and B: a study of frequency, disease severity, and viral load
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee, LeBonheur Children s Medical Center, Memphis, TN 38103, USA
    Pediatr Res 56:914-7. 2004
    ..Disease severity risk factors were similar between subgroups. RSV loads were similar between A and B subgroups (4.77 versus 4.68 log PFU/mL). Measures of disease severity were also similar between subgroups...
  7. ncbi Respiratory syncytial virus load predicts disease severity in previously healthy infants
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee School of Medicine, Memphis, Tennessee, USA
    J Infect Dis 191:1861-8. 2005
    ..Elucidating the relationship between viral load and respiratory syncytial virus (RSV) disease severity is critical to understanding pathogenesis and predicting the utility of antivirals...
  8. doi Harnessing RNA interference to develop neonatal therapies: from Nobel Prize winning discovery to proof of concept clinical trials
    John P DeVincenzo
    University of Tennessee School of Medicine, Department of Pediatrics, LeBonheur Children s Medical Center, Room 433, 50N Dunlap Street, Memphis, TN 38103, USA
    Early Hum Dev 85:S31-5. 2009
    ..RNAi may offer new strategies for the treatment of a variety of orphan diseases including neonatal diseases, RSV infections, and other respiratory viruses...
  9. doi RNA interference strategies as therapy for respiratory viral infections
    John P DeVincenzo
    Department of Pediatrics and Molecular Sciences, University of Tennessee, The Children s Foundation Research Center, and LeBonheur Children s Medical Center, Memphis, TN 38103, USA
    Pediatr Infect Dis J 27:S118-22. 2008
    ..RNAi may offer new strategies for the treatment of respiratory syncytial virus and other respiratory viruses...
  10. ncbi Surveillance of clinical isolates of respiratory syncytial virus for palivizumab (Synagis)-resistant mutants
    John P DeVincenzo
    University of Tennessee, LeBonheur Children s Medical Center, Memphis 38103, USA
    J Infect Dis 190:975-8. 2004
    ..Palivizumab bound to all 371 RSV isolates able to be evaluated, including 25 from active-palivizumab recipients. The palivizumab epitope appears to be highly conserved, even in infants receiving prophylaxis with palivizumab...
  11. ncbi Respiratory syncytial virus (RSV) loads in premature infants with and without prophylactic RSV fusion protein monoclonal antibody
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee, LeBonheur Children s Medical Center, and the Children s Foundation Research Center, Memphis, Tennessee 38103, USA
    J Pediatr 143:123-6. 2003
    ..Mean (SEM) RSV loads in the MAb and non-MAb groups were 3.36 (0.59) versus 4.89 (0.27) logPFU/ml (P=.01). Prophylactic palivizumab reduces nasal RSV in premature hospitalized infants...
  12. ncbi Factors predicting childhood respiratory syncytial virus severity: what they indicate about pathogenesis
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee School of Medicine, Memphis, TN, USA
    Pediatr Infect Dis J 24:S177-83, discussion S182. 2005
    ..Reviewing and interpreting the clinical risk factors to gain an insight into RSV pathogenesis is important, especially considering the relative lack of parallel between many animal models of RSV infection and observed human disease...
  13. doi Risk factors for severe respiratory syncytial virus disease in children with cancer: the importance of lymphopenia and young age
    Chadi M El Saleeby
    Department of Infectious Diseases, St Jude Children s Research Hospital, 332 N Lauderdale St, Memphis, TN 38105, USA
    Pediatrics 121:235-43. 2008
    ..We sought to determine the epidemiologic features of respiratory syncytial virus infection in immunocompromised pediatric patients and to identify the risk factors for severe disease...
  14. pmc Comparison of a real-time reverse transcriptase PCR assay and a culture technique for quantitative assessment of viral load in children naturally infected with respiratory syncytial virus
    Stephanie M Perkins
    Unversity of Tennessee School of Medicine, Memphis, TN, USA
    J Clin Microbiol 43:2356-62. 2005
    ..The utility of the RTrtPCR quantification technique for clinical studies would be solidified after its correlation with RSV disease severity is established...
  15. pmc Human genetic factors and respiratory syncytial virus disease severity
    Isao Miyairi
    Department of Pediatrics, University of Tennessee, Memphis, Tennessee 38103, USA
    Clin Microbiol Rev 21:686-703. 2008
    ..Such problems highlight the limitation of the candidate gene approach and the need for an unbiased large-scale genome-wide association study to evaluate this important disease...
  16. doi 2007 International Congress on Respiratory Viruses. Introduction
    John P DeVincenzo
    Department of Pediatrics and Molecular Sciences, University of Tennessee, The Children s Foundation Research Center, and LeBonheur Children s Medical Center, Memphis, TN 38103, USA
    Pediatr Infect Dis J 27:S53. 2008
  17. ncbi A randomized, double-blind, placebo-controlled trial of dexamethasone in severe respiratory syncytial virus (RSV) infection: effects on RSV quantity and clinical outcome
    Steven C Buckingham
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA
    J Infect Dis 185:1222-8. 2002
    ....
  18. ncbi Opportunities for early therapy of respiratory syncytial virus (RSV) infection: what happens before hospitalization
    John P DeVincenzo
    Department of Pediatrics, University of Tennessee and the Children s Foundation Research Center, 4th floor CFRC, LBCMC, 50 North Dunlap St, Memphis, TN 38103, USA
    Antiviral Res 62:47-51. 2004
    ..6 +/- 1.8 days. RSV-hospitalized infants routinely have contact with health care professionals at significantly early time points in their illness. These contacts are potential opportunities for initiation of early anti-RSV therapy...
  19. doi Comparing influenza and RSV viral and disease dynamics in experimentally infected adults predicts clinical effectiveness of RSV antivirals
    Bindiya Bagga
    Department of Pediatrics, University of Tennessee Health Sciences Center, Memphis, TN, USA
    Antivir Ther 18:785-91. 2013
    ..Whether experimental antivirals that reduce respiratory syncytial virus (RSV) load would also reduce disease is unknown. This study compares viral and disease dynamics in humans experimentally infected with influenza or RSV...
  20. ncbi Group B streptococcal ventriculitis: a report of three cases and literature review
    Isao Miyairi
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Pediatr Neurol 34:395-9. 2006
    ..One child died, and six of nine survivors were left with significant neurologic deficits. Physicians should be aware of this indolent but serious manifestation of group B streptococcal infection...
  21. pmc Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner
    Vasanthi Avadhanula
    Department of Infectious Diseases, St Jude Children s Research Hospital, Mailstop 320, 332 N Lauderdale St, Memphis, TN 38105, USA
    J Virol 80:1629-36. 2006
    ..These studies highlight the distinct responses of different cell types to viral infection and the need to consider this variation when interpreting studies of the interactions between respiratory cells and viral pathogens...
  22. ncbi Antibodies reactive to Rickettsia rickettsii among children living in the southeast and south central regions of the United States
    Gary S Marshall
    Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY40202, USA
    Arch Pediatr Adolesc Med 157:443-8. 2003
    ..This study estimated the prevalence of antibodies reactive to R rickettsii among children living in the southeastern and south central United States...