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Genomes and Genes | Hans H WandallSummaryCountry: Denmark Publications
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Publications
The origin and function of platelet glycosyltransferasesHans H Wandall
Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen N, Denmark
Blood 120:626-35. 2012..This platelet-glycosylation machinery offers a pathway to a simple glycoengineering strategy improving storage of platelets and may serve hitherto unknown biologic functions...
Cancer biomarkers defined by autoantibody signatures to aberrant O-glycopeptide epitopesHans H Wandall
Center for Glycomics, Departments of Cellular and Molecular Medicine and Oral Diagnostics, University of Copenhagen, Blegdamsvej 3, Copenhagen 2200 N, Denmark
Cancer Res 70:1306-13. 2010..The methods we have developed for chemoenzymatic synthesis of O-glycopeptides on microarrays may allow for broader mining of the entire cancer O-glycopeptidome...
Egghead and brainiac are essential for glycosphingolipid biosynthesis in vivoHans H Wandall
Faculty of Health Sciences, University of Copenhagen, Nørre Allé 20, 2200 Copenhagen N, Denmark
J Biol Chem 280:4858-63. 2005..The study demonstrates that glycosphingolipids are essential for development of complex organisms and suggests that the function of the Drosophila glycosphingolipids in development does not depend on the core structure...- Lectin domains of polypeptide GalNAc transferases exhibit glycopeptide binding specificityJohannes W Pedersen
Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen, USA
J Biol Chem 286:32684-96. 2011..The lectin domains of GalNAc-T1, -T2, -T3, and -T4 bound different subsets of small glycopeptides. These results indicate an additional level of complexity in the initiation step of O-glycosylation by GalNAc-Ts... - Drosophila egghead encodes a beta 1,4-mannosyltransferase predicted to form the immediate precursor glycosphingolipid substrate for brainiacHans H Wandall
School of Dentistry, University of Copenhagen, Nørre Allé 20, 2200 Copenhagen N, Denmark
J Biol Chem 278:1411-4. 2003.... - Seromic profiling of colorectal cancer patients with novel glycopeptide microarrayJohannes W Pedersen
Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen N, Denmark
Int J Cancer 128:1860-71. 2011..Our study provides evidence for the value of glycopeptides and other PTM-peptide arrays in diagnostic measures... - A high-throughput O-glycopeptide discovery platform for seromic profilingOla Blixt
Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3b, Copenhagen, Denmark
J Proteome Res 9:5250-61. 2010..As proof-of-concept, we have demonstrated that MUC1 glycopeptides could be assembled and used to detect autoantibodies in vaccine-induced disease-free breast cancer patients and in patients with confirmed disease at time of diagnosis... - The lectin domains of polypeptide GalNAc-transferases exhibit carbohydrate-binding specificity for GalNAc: lectin binding to GalNAc-glycopeptide substrates is required for high density GalNAc-O-glycosylationHans H Wandall
Department of Medical Biochemistry and Genetics, Dental School, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
Glycobiology 17:374-87. 2007..The results suggest that GalNAc-transferase lectins serve to modulate the kinetic properties of the enzymes in the late stages of the initiation process of O-glycosylation to accomplish dense or complete O-glycan occupancy... - Influences of tumor stroma on the malignant phenotypeJørgen Dau Nielsen
Department of Oral Diagnostics, Dental School, Faculty of Health Sciences, Copenhagen University, Copenhagen, Denmark
J Oral Pathol Med 37:412-6. 2008..The purpose of the present study was to investigate how cellular and mechanical properties of the three-dimensional collagen matrix may influence cell proliferation and invasion of oral carcinoma cell lines... - Wildtype p53-specific antibody and T-cell responses in cancer patientsAnders Elm Pedersen
Department of International Health, Immunology and Microbiology, The Panum Institute, University of Copenhagen, Denmark
J Immunother 34:629-40. 2011..However, none of the wt p53 reactivity observed justified use of 15-mer or was related to survival in this rare patient population... - Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytesAnne Louise Sørensen
Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark
Blood 114:1645-54. 2009..Moreover, we report data that establish the importance of sialylation of the von Willebrand factor in its function... - Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCellsKatrine T B G Schjoldager
Copenhagen Center for Glycomics, Department of Cellular Medicine and School of Dentistry, Faculty of Health Sciences, University of Copenhagen, DK 2200 Copenhagen N, Denmark
Proc Natl Acad Sci U S A 109:9893-8. 2012..The presented glycoengineering strategy opens the way for proteome-wide discovery of functions of GalNAc-T isoforms and their role in congenital diseases and disorders... - Aberrantly glycosylated MUC1 is expressed on the surface of breast cancer cells and a target for antibody-dependent cell-mediated cytotoxicityKirstine Lavrsen
Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen N, Denmark
Glycoconj J 30:227-36. 2013.... - Carbohydrate clearance receptors in transfusion medicineAnne Louise Tølbøll Sørensen
Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark
Biochim Biophys Acta 1820:1797-808. 2012.... - Serum galectin-2, -4, and -8 are greatly increased in colon and breast cancer patients and promote cancer cell adhesion to blood vascular endotheliumHannah Barrow
Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
Clin Cancer Res 17:7035-46. 2011..This study determined the levels of galectin-1, -2, -3, -4, -8, and -9 in the sera of healthy people and patients with colon and breast cancer and assessed the influence of these galectins on cancer-endothelium adhesion... - Neurofibromatosis-like phenotype in Drosophila caused by lack of glucosylceramide extensionKatja Dahlgaard
Copenhagen Center for Glycomics, Faculty of Health Sciences, University of Copenhagen, DK 2200 Copenhagen N, Denmark
Proc Natl Acad Sci U S A 109:6987-92. 2012..These results show that loss of the glycosyltransferase Egh affects membrane signaling and activation of PI3K signaling in glia of the peripheral nervous system, and suggest that glycosyltransferases may suppress proliferation... - Glycans and glycosylation of platelets: current concepts and implications for transfusionAnne Louise Sørensen
Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
Curr Opin Hematol 15:606-11. 2008..The present review addresses the current knowledge of platelet glycans and the potential of glycosylation for improving platelet storage... - Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancerNeeley Remmers
Authors Affiliations Departments of Biochemistry and Molecular Biology and Pathology and Microbiology Eppley Institute for Research in Cancer and Allied Diseases Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine and School of Dentistry, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
Clin Cancer Res 19:1981-93. 2013.... - Cancer associated aberrant protein O-glycosylation can modify antigen processing and immune responseCaroline B Madsen
Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
PLoS ONE 7:e50139. 2012..GalNAc glycosylation of MUC1 antigen therefore facilitates uptake, MHC class II presentation, and antibody response but might block the antigen presentation to CD8+ T cells... - Molecular basis for the presence of glycosylated onco-foetal fibronectin in oral carcinomas: the production of glycosylated onco-foetal fibronectin by carcinoma cellsHans H Wandall
Department of Oral Diagnostics, The Faculty of Health Sciences, University of Copenhagen, Nørre Allé 20, DK 2200 Copenhagen N, Denmark
Oral Oncol 43:301-9. 2007..RT-PCR analysis of RNA isolated from carcinoma cells provided further support for this conclusion by demonstrating in-splicing of the alternative spliced IIICS domain in GOF... - The Drosophila gene brainiac encodes a glycosyltransferase putatively involved in glycosphingolipid synthesisTilo Schwientek
School of Dentistry, University of Copenhagen, Nørre Allé 20, 2200 Copenhagen N, Denmark
J Biol Chem 277:32421-9. 2002..We suggest that brainiac exerts its biological functions by regulating biosynthesis of glycosphingolipids...