Hans H Wandall

Summary

Country: Denmark

Publications

  1. pmc Lectin domains of polypeptide GalNAc transferases exhibit glycopeptide binding specificity
    Johannes W Pedersen
    Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen, USA
    J Biol Chem 286:32684-96. 2011
  2. pmc Cancer associated aberrant protein O-glycosylation can modify antigen processing and immune response
    Caroline B Madsen
    Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e50139. 2012
  3. pmc The origin and function of platelet glycosyltransferases
    Hans H Wandall
    Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen N, Denmark
    Blood 120:626-35. 2012
  4. doi request reprint Cancer biomarkers defined by autoantibody signatures to aberrant O-glycopeptide epitopes
    Hans H Wandall
    Center for Glycomics, Departments of Cellular and Molecular Medicine and Oral Diagnostics, University of Copenhagen, Blegdamsvej 3, Copenhagen 2200 N, Denmark
    Cancer Res 70:1306-13. 2010
  5. ncbi request reprint Egghead and brainiac are essential for glycosphingolipid biosynthesis in vivo
    Hans H Wandall
    Faculty of Health Sciences, University of Copenhagen, Nørre Allé 20, 2200 Copenhagen N, Denmark
    J Biol Chem 280:4858-63. 2005
  6. doi request reprint Seromic profiling of colorectal cancer patients with novel glycopeptide microarray
    Johannes W Pedersen
    Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen N, Denmark
    Int J Cancer 128:1860-71. 2011
  7. pmc Glycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing
    Caroline B Madsen
    Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Department of International health, Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e72413. 2013
  8. doi request reprint Carbon anhydrase IX specific immune responses in patients with metastatic renal cell carcinoma potentially cured by interleukin-2 based immunotherapy
    Susanne Rasmussen
    Department of International Health, Immunology and Microbiology, The Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
    Immunopharmacol Immunotoxicol 35:487-96. 2013
  9. ncbi request reprint The lectin domains of polypeptide GalNAc-transferases exhibit carbohydrate-binding specificity for GalNAc: lectin binding to GalNAc-glycopeptide substrates is required for high density GalNAc-O-glycosylation
    Hans H Wandall
    Department of Medical Biochemistry and Genetics, Dental School, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Glycobiology 17:374-87. 2007
  10. pmc A high-throughput O-glycopeptide discovery platform for seromic profiling
    Ola Blixt
    Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3b, Copenhagen, Denmark
    J Proteome Res 9:5250-61. 2010

Collaborators

Detail Information

Publications28

  1. pmc Lectin domains of polypeptide GalNAc transferases exhibit glycopeptide binding specificity
    Johannes W Pedersen
    Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen, USA
    J Biol Chem 286:32684-96. 2011
    ..The lectin domains of GalNAc-T1, -T2, -T3, and -T4 bound different subsets of small glycopeptides. These results indicate an additional level of complexity in the initiation step of O-glycosylation by GalNAc-Ts...
  2. pmc Cancer associated aberrant protein O-glycosylation can modify antigen processing and immune response
    Caroline B Madsen
    Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e50139. 2012
    ..GalNAc glycosylation of MUC1 antigen therefore facilitates uptake, MHC class II presentation, and antibody response but might block the antigen presentation to CD8+ T cells...
  3. pmc The origin and function of platelet glycosyltransferases
    Hans H Wandall
    Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen N, Denmark
    Blood 120:626-35. 2012
    ..This platelet-glycosylation machinery offers a pathway to a simple glycoengineering strategy improving storage of platelets and may serve hitherto unknown biologic functions...
  4. doi request reprint Cancer biomarkers defined by autoantibody signatures to aberrant O-glycopeptide epitopes
    Hans H Wandall
    Center for Glycomics, Departments of Cellular and Molecular Medicine and Oral Diagnostics, University of Copenhagen, Blegdamsvej 3, Copenhagen 2200 N, Denmark
    Cancer Res 70:1306-13. 2010
    ..The methods we have developed for chemoenzymatic synthesis of O-glycopeptides on microarrays may allow for broader mining of the entire cancer O-glycopeptidome...
  5. ncbi request reprint Egghead and brainiac are essential for glycosphingolipid biosynthesis in vivo
    Hans H Wandall
    Faculty of Health Sciences, University of Copenhagen, Nørre Allé 20, 2200 Copenhagen N, Denmark
    J Biol Chem 280:4858-63. 2005
    ..The study demonstrates that glycosphingolipids are essential for development of complex organisms and suggests that the function of the Drosophila glycosphingolipids in development does not depend on the core structure...
  6. doi request reprint Seromic profiling of colorectal cancer patients with novel glycopeptide microarray
    Johannes W Pedersen
    Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen N, Denmark
    Int J Cancer 128:1860-71. 2011
    ..Our study provides evidence for the value of glycopeptides and other PTM-peptide arrays in diagnostic measures...
  7. pmc Glycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing
    Caroline B Madsen
    Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark Department of International health, Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e72413. 2013
    ....
  8. doi request reprint Carbon anhydrase IX specific immune responses in patients with metastatic renal cell carcinoma potentially cured by interleukin-2 based immunotherapy
    Susanne Rasmussen
    Department of International Health, Immunology and Microbiology, The Faculty of Health and Medical Sciences, University of Copenhagen, Denmark
    Immunopharmacol Immunotoxicol 35:487-96. 2013
    ..This may have interest in future cancer vaccines, but more studies are needed to elucidate the immunological mechanisms of action in potentially cured patients treated with an immunotherapeutic agent...
  9. ncbi request reprint The lectin domains of polypeptide GalNAc-transferases exhibit carbohydrate-binding specificity for GalNAc: lectin binding to GalNAc-glycopeptide substrates is required for high density GalNAc-O-glycosylation
    Hans H Wandall
    Department of Medical Biochemistry and Genetics, Dental School, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Glycobiology 17:374-87. 2007
    ..The results suggest that GalNAc-transferase lectins serve to modulate the kinetic properties of the enzymes in the late stages of the initiation process of O-glycosylation to accomplish dense or complete O-glycan occupancy...
  10. pmc A high-throughput O-glycopeptide discovery platform for seromic profiling
    Ola Blixt
    Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Blegdamsvej 3b, Copenhagen, Denmark
    J Proteome Res 9:5250-61. 2010
    ..As proof-of-concept, we have demonstrated that MUC1 glycopeptides could be assembled and used to detect autoantibodies in vaccine-induced disease-free breast cancer patients and in patients with confirmed disease at time of diagnosis...
  11. ncbi request reprint Drosophila egghead encodes a beta 1,4-mannosyltransferase predicted to form the immediate precursor glycosphingolipid substrate for brainiac
    Hans H Wandall
    School of Dentistry, University of Copenhagen, Nørre Allé 20, 2200 Copenhagen N, Denmark
    J Biol Chem 278:1411-4. 2003
    ....
  12. doi request reprint Wildtype p53-specific antibody and T-cell responses in cancer patients
    Anders Elm Pedersen
    Department of International Health, Immunology and Microbiology, The Panum Institute, University of Copenhagen, Denmark
    J Immunother 34:629-40. 2011
    ..However, none of the wt p53 reactivity observed justified use of 15-mer or was related to survival in this rare patient population...
  13. doi request reprint Aberrantly glycosylated MUC1 is expressed on the surface of breast cancer cells and a target for antibody-dependent cell-mediated cytotoxicity
    Kirstine Lavrsen
    Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Blegdamsvej 3, Copenhagen N, Denmark
    Glycoconj J 30:227-36. 2013
    ....
  14. pmc Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology
    Catharina Steentoft
    Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine and School of Dentistry, University of Copenhagen, Copenhagen N, Denmark
    EMBO J 32:1478-88. 2013
    ..The greatly expanded view of the O-glycoproteome should facilitate the exploration of how site-specific O-glycosylation regulates protein function...
  15. doi request reprint Influences of tumor stroma on the malignant phenotype
    Jørgen Dau Nielsen
    Department of Oral Diagnostics, Dental School, Faculty of Health Sciences, Copenhagen University, Copenhagen, Denmark
    J Oral Pathol Med 37:412-6. 2008
    ..The purpose of the present study was to investigate how cellular and mechanical properties of the three-dimensional collagen matrix may influence cell proliferation and invasion of oral carcinoma cell lines...
  16. pmc Neurofibromatosis-like phenotype in Drosophila caused by lack of glucosylceramide extension
    Katja Dahlgaard
    Copenhagen Center for Glycomics, Faculty of Health Sciences, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    Proc Natl Acad Sci U S A 109:6987-92. 2012
    ..These results show that loss of the glycosyltransferase Egh affects membrane signaling and activation of PI3K signaling in glia of the peripheral nervous system, and suggest that glycosyltransferases may suppress proliferation...
  17. pmc Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes
    Anne Louise Sørensen
    Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark
    Blood 114:1645-54. 2009
    ..Moreover, we report data that establish the importance of sialylation of the von Willebrand factor in its function...
  18. pmc Probing isoform-specific functions of polypeptide GalNAc-transferases using zinc finger nuclease glycoengineered SimpleCells
    Katrine T B G Schjoldager
    Copenhagen Center for Glycomics, Department of Cellular Medicine and School of Dentistry, Faculty of Health Sciences, University of Copenhagen, DK 2200 Copenhagen N, Denmark
    Proc Natl Acad Sci U S A 109:9893-8. 2012
    ..The presented glycoengineering strategy opens the way for proteome-wide discovery of functions of GalNAc-T isoforms and their role in congenital diseases and disorders...
  19. ncbi request reprint Precision genome editing: A small revolution for glycobiology
    Catharina Steentoft
    Copenhagen Center for Glycomics, Departments of Cellular and Molecular Medicine and Odontology, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Glycobiology 24:663-80. 2014
    ....
  20. ncbi request reprint Carbohydrate clearance receptors in transfusion medicine
    Anne Louise Tølbøll Sørensen
    Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark
    Biochim Biophys Acta 1820:1797-808. 2012
    ....
  21. ncbi request reprint The Drosophila gene brainiac encodes a glycosyltransferase putatively involved in glycosphingolipid synthesis
    Tilo Schwientek
    School of Dentistry, University of Copenhagen, Nørre Allé 20, 2200 Copenhagen N, Denmark
    J Biol Chem 277:32421-9. 2002
    ..We suggest that brainiac exerts its biological functions by regulating biosynthesis of glycosphingolipids...
  22. doi request reprint Serum galectin-2, -4, and -8 are greatly increased in colon and breast cancer patients and promote cancer cell adhesion to blood vascular endothelium
    Hannah Barrow
    Department of Gastroenterology, Institute of Translational Medicine, University of Liverpool, Liverpool, UK
    Clin Cancer Res 17:7035-46. 2011
    ..This study determined the levels of galectin-1, -2, -3, -4, -8, and -9 in the sera of healthy people and patients with colon and breast cancer and assessed the influence of these galectins on cancer-endothelium adhesion...
  23. doi request reprint Glycans and glycosylation of platelets: current concepts and implications for transfusion
    Anne Louise Sørensen
    Department of Cellular and Molecular Medicine, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Curr Opin Hematol 15:606-11. 2008
    ..The present review addresses the current knowledge of platelet glycans and the potential of glycosylation for improving platelet storage...
  24. doi request reprint Chemo-enzymatic production of O-glycopeptides for the detection of serum glycopeptide antibodies
    Alexander Nøstdal
    Department of Cellular and Molecular Medicine, University of Copenhagen, København, Denmark
    Methods Mol Biol 1061:167-79. 2013
    ..In this protocol we present a detailed method for enzymatic generation of disease-specific O-glycopeptides and how to monitor the antibody response to these in serum using microarray technology. ..
  25. pmc Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer
    Neeley Remmers
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Clin Cancer Res 19:1981-93. 2013
    ....
  26. ncbi request reprint Molecular basis for the presence of glycosylated onco-foetal fibronectin in oral carcinomas: the production of glycosylated onco-foetal fibronectin by carcinoma cells
    Hans H Wandall
    Department of Oral Diagnostics, The Faculty of Health Sciences, University of Copenhagen, Nørre Allé 20, DK 2200 Copenhagen N, Denmark
    Oral Oncol 43:301-9. 2007
    ..RT-PCR analysis of RNA isolated from carcinoma cells provided further support for this conclusion by demonstrating in-splicing of the alternative spliced IIICS domain in GOF...
  27. pmc High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zinc finger nucleases or CRISPR/Cas9 nickase pairs
    Katarzyna Duda
    Biotech Research and Innovation Centre BRIC and Centre for Epigenetics, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark
    Nucleic Acids Res 42:e84. 2014
    ..The method was also applicable to the CRISPR/Cas9 system, including CRISPR/Cas9 mutant nickase pairs, which exhibit low off-target mutagenesis compared to wild-type Cas9. ..