Ole D Wolthers

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Growth suppression caused by corticosteroid eye drops
    Ole D Wolthers
    Children s Clinic Randers, Randers, Denmark
    J Pediatr Endocrinol Metab 24:393-4. 2011
  2. pmc Serum Fructosamine, Total Cholesterol, and High-Density Lipoprotein in Children with Asthma during Glucocorticoid Treatment
    A J Schou
    Children s Clinic Randers, Dytmaersken 9, 8900 Randers C, Denmark
    ISRN Allergy 2011:295124. 2011
  3. pmc A five-year followup of human seminal plasma allergy in an 18-year-old woman
    Ole D Wolthers
    Asthma and Allergy Clinic, Children s Clinic Randers, 8900 Randers, Denmark
    Case Report Med 2012:257246. 2012
  4. pmc Bilastine: a new nonsedating oral H1 antihistamine for treatment of allergic rhinoconjunctivitis and urticaria
    Ole D Wolthers
    Asthma and Allergy Clinic, Children s Clinic Randers, Dytmærsken 9, 8900 Randers, Denmark
    Biomed Res Int 2013:626837. 2013
  5. ncbi request reprint New patents of fixed combinations of nasal antihistamines and corticosteroids in allergic rhinitis
    Ole D Wolthers
    Asthma and Allergy Clinic, Children s Clinic Randers, Dytmærsken 9, 8900 Randers, Denmark
    Recent Pat Inflamm Allergy Drug Discov 7:223-8. 2013
  6. ncbi request reprint The usefulness of the multiple allergen simultaneous test-chemiluminescent as compared to the Phadia Immunocap IgE test panel system in children and adolescents
    Ole D Wolthers
    Asthma and Allergy Clinic, Children s Clinic Randers, Dytmaersken 9, DK 8900 Randers, Denmark
    Recent Pat Inflamm Allergy Drug Discov 7:96-9. 2013
  7. ncbi request reprint [Sublingual immunotherapy in children with grass pollen induced allergic rhinoconjunctivitis]
    Ole D Wolthers
    Børne og Allergi Klinikken, Dytmærsken 9, 8900 Randers, Denmark
    Ugeskr Laeger 174:1989-92. 2012
  8. doi request reprint Systemic activity of inhaled beclomethasone dipropionate: a double-blind comparison of volume spacers
    Ole D Wolthers
    Children s Clinic Randers, Denmark
    Acta Paediatr 101:159-63. 2012
  9. ncbi request reprint Short-term growth after withdrawal of exogenous glucocorticoids
    Ole D Wolthers
    Children s Clinic Randers, Randers, Denmark
    Horm Res 64:116-8. 2005
  10. ncbi request reprint Age and gender related differences in children's evaluation of procedures experienced during participation in clinical research
    Ole D Wolthers
    Children s Clinic Randers, Dytmaersken 9, 8900 Randers, Denmark
    Eur J Pediatr 164:50-1. 2005

Detail Information

Publications46

  1. ncbi request reprint Growth suppression caused by corticosteroid eye drops
    Ole D Wolthers
    Children s Clinic Randers, Randers, Denmark
    J Pediatr Endocrinol Metab 24:393-4. 2011
    ..Two weeks treatment with fluorometholone eye drops in a case series of five children caused growth suppression detected by knemometry. The suppression had no impact on height growth during the following year...
  2. pmc Serum Fructosamine, Total Cholesterol, and High-Density Lipoprotein in Children with Asthma during Glucocorticoid Treatment
    A J Schou
    Children s Clinic Randers, Dytmaersken 9, 8900 Randers C, Denmark
    ISRN Allergy 2011:295124. 2011
    ..Conclusion. Short-term treatment with oral prednisolone and inhaled budesonide may adversely affect mean blood glucose concentration. Possible long-term consequences require further investigations...
  3. pmc A five-year followup of human seminal plasma allergy in an 18-year-old woman
    Ole D Wolthers
    Asthma and Allergy Clinic, Children s Clinic Randers, 8900 Randers, Denmark
    Case Report Med 2012:257246. 2012
    ..Due to intimacy concerns and the low prevalence of the condition robust long term data on the natural course of the condition are difficult to obtain. The present case suggests that in some patients the condition may improve over time...
  4. pmc Bilastine: a new nonsedating oral H1 antihistamine for treatment of allergic rhinoconjunctivitis and urticaria
    Ole D Wolthers
    Asthma and Allergy Clinic, Children s Clinic Randers, Dytmærsken 9, 8900 Randers, Denmark
    Biomed Res Int 2013:626837. 2013
    ....
  5. ncbi request reprint New patents of fixed combinations of nasal antihistamines and corticosteroids in allergic rhinitis
    Ole D Wolthers
    Asthma and Allergy Clinic, Children s Clinic Randers, Dytmærsken 9, 8900 Randers, Denmark
    Recent Pat Inflamm Allergy Drug Discov 7:223-8. 2013
    ..Fixed combination treatment of azelastine and fluticasone propionate may offer additional benefit to selected populations of adolescents and adults with moderate-to-severe symptoms...
  6. ncbi request reprint The usefulness of the multiple allergen simultaneous test-chemiluminescent as compared to the Phadia Immunocap IgE test panel system in children and adolescents
    Ole D Wolthers
    Asthma and Allergy Clinic, Children s Clinic Randers, Dytmaersken 9, DK 8900 Randers, Denmark
    Recent Pat Inflamm Allergy Drug Discov 7:96-9. 2013
    ..The sensitizations gave clinically useful information in 7 patients (6.6%). As compared to the Phadia CAP the MAST CLA screening test panel adds little to the diagnostic work-up of IgE mediated disease in children and adolescents...
  7. ncbi request reprint [Sublingual immunotherapy in children with grass pollen induced allergic rhinoconjunctivitis]
    Ole D Wolthers
    Børne og Allergi Klinikken, Dytmærsken 9, 8900 Randers, Denmark
    Ugeskr Laeger 174:1989-92. 2012
    ....
  8. doi request reprint Systemic activity of inhaled beclomethasone dipropionate: a double-blind comparison of volume spacers
    Ole D Wolthers
    Children s Clinic Randers, Denmark
    Acta Paediatr 101:159-63. 2012
    ..To which extent volume spacers may influence systemic activity of inhaled beclomethasone dipropionate (BDP) has not been evaluated...
  9. ncbi request reprint Short-term growth after withdrawal of exogenous glucocorticoids
    Ole D Wolthers
    Children s Clinic Randers, Randers, Denmark
    Horm Res 64:116-8. 2005
    ..The growth-suppressive effect of systemic glucocorticoids in children is well established, however, recovery of growth after withdrawal of short-term treatment in school-age children has not been evaluated...
  10. ncbi request reprint Age and gender related differences in children's evaluation of procedures experienced during participation in clinical research
    Ole D Wolthers
    Children s Clinic Randers, Dytmaersken 9, 8900 Randers, Denmark
    Eur J Pediatr 164:50-1. 2005
  11. ncbi request reprint Short-term growth and adrenal function in children with asthma treated with inhaled beclomethasone dipropionate hydrofluoroalkane-134a
    O D Wolthers
    Children s Clinic Randers, Randers, Denmark
    Pediatr Allergy Immunol 17:613-9. 2006
    ..Though non-inferiority between BDP HFA and CFC 100 microg twice daily in terms of effects on LLGR was not found, equivalence was suggested by comparisons of LLGR during run-in and active treatments and by HPA function measures...
  12. doi request reprint Methodology and implications of knemometry in growth assessment of inhaled glucocorticoids
    O D Wolthers
    Asthma and Allergy Clinic, Children s Clinic Randers, Randers, Denmark
    Pediatr Allergy Immunol 21:e190-8. 2010
    ..Short-term knemometry should be performed as an integral part of the safety assessments of new inhaled glucocorticoids and inhalation devices in children with asthma, before intermediate-term height growth evaluations are initiated...
  13. pmc A questionnaire on factors influencing children's assent and dissent to non-therapeutic research
    O D Wolthers
    Children s Clinic Randers, Dytmaersken 9, DK 8900 Randers, Denmark
    J Med Ethics 32:292-7. 2006
    ..Knowledge about assent or dissent of children to non-therapeutic research is poor...
  14. ncbi request reprint Short-term growth in children with eczema during treatment with topical mometasone furoate and tacrolimus
    Josefine Gradman
    Children s Clinic Randers, Randers, Denmark
    Acta Paediatr 96:1233-7. 2007
    ..Treatment with topical glucocorticoids in children with atopic eczema may be associated with systemic adverse effects, such as suppression of growth...
  15. ncbi request reprint Does vitamin D administered to children with asthma treated with inhaled glucocorticoids affect short-term growth or bone turnover?
    Anders J Schou
    Children s Clinic Randers, Randers, Denmark
    Pediatr Pulmonol 36:399-404. 2003
    ..In conclusion, administration of 25-OH-vitamin D does not affect short-term growth or markers of bone turnover in children with asthma treated with inhaled dry-powder budesonide 400 microg daily...
  16. doi request reprint Anti-inflammatory treatment of asthma: differentiation and trial-and-error
    Ole D Wolthers
    Asthma and Allergy Clinic, Children s Clinic Randers, 8900 Randers, Denmark
    Acta Paediatr 98:1237-41. 2009
    ..In toddlers with viral wheeze and in children with mild asthma oral leukotriene receptor antagonists or inhaled corticosteroids may be given on a trial-and-error basis...
  17. ncbi request reprint A 2-week, crossover study to investigate the effect of fluticasone furoate nasal spray on short-term growth in children with allergic rhinitis
    Josefine Gradman
    Asthma and Allergy Clinic, Children s Clinic Randers, Randers, Denmark
    Clin Ther 29:1738-47. 2007
    ..Fluticasone furoate is a recently approved, enhanced- affinity intranasal corticosteroid with low systemic bioavailability and proven efficacy in treating allergic rhinitis...
  18. doi request reprint Suppressive effects of topical mometasone furoate and tacrolimus on skin prick testing in children
    Josefine Gradman
    Children s Clinic Randers, Randers, Denmark
    Pediatr Dermatol 25:269-70. 2008
    ..Mometasone furoate reduced the histamine wheal size as well. Skin prick testing in children treated with topical glucocorticoids or tacrolimus is associated with a risk of false-negative test results...
  19. ncbi request reprint Differential effects of short-term prednisolone treatment on peripheral and abdominal subcutaneous thickness in children assessed by ultrasound
    Anders J Schou
    Children s Clinic Randers, Dytmaersken 9, 3, Dk 8900, Randers, Denmark
    Steroids 68:525-31. 2003
    ..Short-term treatment with 5mg prednisolone daily may cause differential effects in peripheral and abdominal subcutaneous thickness in children...
  20. doi request reprint Short-term lower leg growth in 5- to 11-year-old asthmatic children using beclomethasone dipropionate inhalers with chlorofluorocarbon or hydrofluoroalkane propellants: a 9-week, open-label, randomized, crossover, noninferiority study
    Ole D Wolthers
    Children s Clinic Randers, Randers, Denmark
    Clin Ther 33:1069-76. 2011
    ..Beclomethasone dipropionate-hydrofluoroalkane (BDP-HFA) is a non-chlorofluorocarbon (CFC)-propelled metered dose inhaler. Data is needed to support the registration of BDP-HFA in pediatric populations for countries in the European Union...
  21. doi request reprint A randomized trial of lower leg and height growth in children with asthma treated with inhaled budesonide from a new dry powder inhaler
    Josefine Gradman
    Children s Clinic Randers, Randers, Denmark
    Pediatr Allergy Immunol 21:e206-12. 2010
    ..Short-term knemometry should be performed as part of the safety assessments of new inhaled corticosteroids and inhalation devices in children with asthma before long-term height growth evaluations are initiated...
  22. ncbi request reprint Assessment of the relation between short and intermediate term growth in children with asthma treated with inhaled glucocorticoids
    O D Wolthers
    Children s Clinic Randers, Randers, Denmark
    Allergy 59:1193-7. 2004
    ..To assess the relation between short-term growth and intermediate term growth in children with asthma treated with inhaled glucocorticoids...
  23. ncbi request reprint Anti-neutrophil cytoplasmic autoantibody (ANCA) profiles in propylthiouracil-induced lupus-like manifestations in monozygotic triplets with hyperthyroidism
    Troels Herlin
    Department of Pediatrics, Skejby Sygehus, Aarhus University Hospital, Denmark
    Scand J Rheumatol 31:46-9. 2002
    ..Triplet A and B, but not C, both developed a strongly positive elastase-ANCA. Our results confirm the importance of a genetic factor influencing the susceptibility to drug-induced LE...
  24. ncbi request reprint Circadian variations in serum eosinophil cationic protein, and serum and urine eosinophil protein X
    O D Wolthers
    Children s Clinic Randers, Randers, Department of Paediatrics, Denmark
    Pediatr Allergy Immunol 14:130-3. 2003
    ..To avoid confounding influence from circadian variations in ECP and EPX in clinical studies blood or urine should be sampled at consistent times...
  25. ncbi request reprint A randomized, controlled lower leg growth study of vitamin D supplementation to healthy children during the winter season
    A J Schou
    Children s Clinic Randers, Randers, Denmark
    Ann Hum Biol 30:214-9. 2003
    ..Due to worries about deleterious effects on bone of a relative insufficiency, vitamin D supplementation to healthy children has been suggested...
  26. ncbi request reprint Inhaled corticosteroids and growth
    O D Wolthers
    Children s Clinic Randers, Denmark
    J Pediatr Endocrinol Metab 14:1487-90. 2001
    ..In children with severe asthma, high doses of inhaled corticosteroids may be potentially lifesaving and thus outweigh the potential risk of mild growth suppression...
  27. ncbi request reprint Vitamin D supplementation to healthy children does not affect serum osteocalcin or markers of type I collagen turnover
    A J Schou
    Children s Clinic Randers, Randers, Denmark
    Acta Paediatr 92:797-801. 2003
    ..This study aimed to determine whether supplementation with vitamin D3 to healthy children during the winter affects bone turnover in healthy children measured by serum osteocalcin, PICP, PINP or ICTP...
  28. ncbi request reprint Eosinophil granule proteins in the assessment of airway inflammation in pediatric bronchial asthma
    O D Wolthers
    Children s Clinic Randers, Randers, Denmark
    Pediatr Allergy Immunol 14:248-54. 2003
    ..In the future, perhaps, a combination of products of inflammatory cells may give more clinically relevant information with respect to prediction, diagnosis, monitoring and outcome of childhood asthma...
  29. ncbi request reprint Ultrasound of skin in prednisolone-induced short-term growth suppression
    A J Schou
    Children s Clinic Randers, Denmark
    J Pediatr Endocrinol Metab 16:973-80. 2003
    ..To assess the thickness of the cutis and subcutis in children with prednisolone-induced knemometric growth suppression...
  30. ncbi request reprint Lower leg growth suppression caused by inhaled glucocorticoids is not accompanied by reduced thickness of the cutis or subcutis
    A J Schou
    Children s Clinic, Randers, Denmark
    Acta Paediatr 93:623-7. 2004
    ..Exogenous glucocorticoids suppress short-term lower leg growth in children as assessed by knemometry. The knemometric measurements, however, may be confounded by reductions in the thickness of the cutis and subcutis over the knee...
  31. ncbi request reprint Systemic activity versus systemic adverse effects of nasal glucocorticoids in the treatment of allergic rhinitis
    O D Wolthers
    Department of Paediatrics, Randers Hospital, Denmark
    Acta Paediatr 89:1158-61. 2000
    ..Children on long-term treatment with intranasal glucocorticoids should be followed with height measurements every 6 mo...
  32. ncbi request reprint Short-term lower leg growth in asthmatic children treated with inhaled beta2-agonists
    A M Plomgaard
    Children s Clinic Randers, Dytmaersken 9, 3, DK 8900 Randers, Denmark
    Ann Hum Biol 33:135-41. 2006
    ..Systemic beta2-agonists, however, have been found to suppress growth hormone secretion and this has caused concern about a possible confounding effect of inhaled beta2-agonists on results of growth studies of exogenous glucocorticoids...
  33. ncbi request reprint Growth-suppressive effect of intra-articular glucocorticoids detected by knemometry
    C Heuck
    Department of Paediatrics, Aarhus University Hospital, Aarhus, Denmark
    Horm Res 52:95-6. 1999
    ..After one intra-articular injection of 20 mg triamcinolone hexacetonide in the knee, the length of the contralateral lower leg was found to be reduced in 2 boys with juvenile rheumatoid arthritis...
  34. ncbi request reprint Measures of hypothalamic-pituitary-adrenal function in patients with asthma treated with inhaled glucocorticoids: clinical and research implications
    O D Wolthers
    Department of Paediatrics, Randers Hospital, Denmark
    J Asthma 36:477-86. 1999
    ..Measures of basal adrenal activity are useful in clinical trials that assess and compare systemic activity of specific drugs, application devices, and administration regimens, but have no place in the management of asthma...
  35. ncbi request reprint Methodological aspects of high-frequency ultrasound of skin in children
    A J Schou
    Children s Clinic Randers, Dytmaersken 9, 3 Randers, Denmark
    Skin Res Technol 10:200-6. 2004
    ....
  36. ncbi request reprint Relevance of pharmacokinetics and bioavailability of intranasal corticosteroids in allergic rhinitis
    Ole D Wolthers
    Asthma and Allergy Clinic, Children s Clinic Randers, Randers, Germany
    Recent Pat Inflamm Allergy Drug Discov 4:118-23. 2010
    ..Evidence for intranasal corticosteroids in pre-school children has not been provided. In this paper, a brief review of recent patents for the treatment of allergic rhinitis has also been presented...
  37. ncbi request reprint Allergic conjunctivitis in children with asthma, rhinitis and eczema in a secondary outpatient clinic
    Josefine Gradman
    Children s Clinic Randers, Randers, Denmark
    Pediatr Allergy Immunol 17:524-6. 2006
    ..Allergic conjunctivitis need to be included as an important co-morbidity in future guidelines on asthma, rhinitis and eczema management...
  38. ncbi request reprint Growth problems in children with asthma
    Ole D Wolthers
    Children s Clinic Randers, Randers, Denmark
    Horm Res 57:83-7. 2002
    ....
  39. ncbi request reprint Diurnal leptin rhythms in children treated with prednisolone once daily in the morning or in the evening
    Ole D Wolthers
    Children s Clinic Randers, Denmark
    J Pediatr Endocrinol Metab 15:313-8. 2002
    ..44, p = 0.53). Therefore, the timing of administration of exogenous glucocorticoids does not affect diurnal leptin rhythms in children...
  40. ncbi request reprint Short-term treatment with prednisolone has no lasting effect on serum leptin
    O D Wolthers
    Children s Clinic Randers, Randers, Denmark o d wolthers dadlnet dk
    Scand J Clin Lab Invest 62:321-4. 2002
    ..03) but no statistically significant variations between run in and run out data (p=0.88). In healthy adults the stimulating effects on serum leptin of short-term prednisolone seem to last only a few days after withdrawal of treatment...
  41. ncbi request reprint Inhaled corticosteroids, growth, and compliance
    Ole D Wolthers
    N Engl J Med 347:1210-1. 2002
  42. ncbi request reprint Placebo-controlled study of montelukast and budesonide on short-term growth in prepubertal asthmatic children
    Søren Pedersen
    University of Southern Denmark, Kolding Hospital, Kolding, Denmark
    Pediatr Pulmonol 42:838-43. 2007
    ..The aim of this study was to assess the influence of montelukast on short-term lower leg growth rate (LLGR) in prepubertal children with asthma...
  43. ncbi request reprint [Longitudinal growth in children with asthma treated with inhaled glucocorticoids]
    Josefine Gradman
    Randers, Speciallaegepraksis, BørneklinikkenRanders
    Ugeskr Laeger 168:885-9. 2006
    ..Children with asthma on continuous treatment with inhaled glucocorticoids should have their height measured at six-month intervals. In the case of growth deviation, they should be referred for evaluation...
  44. ncbi request reprint Gender differences of oligomers and total adiponectin during puberty: a cross-sectional study of 859 Danish school children
    Kristian Kjaer Andersen
    The Medical Research Laboratories, Clinical Institute, Medical Department M Diabetes and Endocrinology, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 92:1857-62. 2007
    ..Pubertal stages have been shown to influence total adiponectin (ADPN) levels. Furthermore, testosterone has been shown to alter the isomer distribution of ADPN...
  45. ncbi request reprint Normal growth spurt and final height despite low levels of all forms of circulating insulin-like growth factor-I in a patient with acid-labile subunit deficiency
    Horacio M Domene
    Endocrinology Research Center CEDIE, Division of Endocrinology, Ricardo Gutierrez Children s Hospital, Buenos Aires, Argentina
    Horm Res 67:243-9. 2007
    ..To further study the role of circulating versus locally produced IGF-I in skeletal growth in this patient, we now describe in detail growth changes and their relationship with several components of the circulating IGF system...