D P Woldbye

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi Antiepileptic effects of NPY on pentylenetetrazole seizures
    D P Woldbye
    Department of Pharmacology, University of Copenhagen, Copenhagen N, Denmark
    Regul Pept 75:279-82. 1998
  2. ncbi Neuropeptide Y inhibits in vitro epileptiform activity in the entorhinal cortex of mice
    D P D Woldbye
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A 11, University Hospital, S 221 84, Lund, Sweden
    Neurosci Lett 333:127-30. 2002
  3. ncbi Neuropeptide Y and seizures: effects of exogenously applied ligands
    D P D Woldbye
    Laboratory of Neuropsychiatry, Rigshospitalet University Hospital and Department of Pharmacology, University of Copenhagen, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Neuropeptides 38:253-60. 2004
  4. ncbi Repeated inhibitory effects of NPY on hippocampal CA3 seizures and wet dog shakes
    K Klemp
    Laboratory of Neuropsychiatry, Department of Pharmacology, University of Copenhagen, Copenhagen, Denmark
    Peptides 22:523-7. 2001
  5. ncbi GABAA receptor antisense epilepsy: histological changes following infusion of antisense oligodeoxynucleotide to GABAA receptor gamma 2 subunit into rat hippocampus
    J Karle
    Department of Psychiatry, Rigshospitalet, National Hospital, DK 2100 Copenhagen, Denmark
    Neurol Res 23:39-46. 2001
  6. ncbi Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors
    D P Woldbye
    Department of Pharmacology, University of Copenhagen, Denmark
    Nat Med 3:761-4. 1997
  7. ncbi Inhibitory effect of neuropeptide Y on morphine withdrawal is accompanied by reduced c-fos expression in specific brain regions
    T R Clausen
    Laboratory of Neuropsychiatry, Department of Pharmacology, University of Copenhagen, Copenhagen, Denmark
    J Neurosci Res 64:410-7. 2001

Detail Information

Publications7

  1. ncbi Antiepileptic effects of NPY on pentylenetetrazole seizures
    D P Woldbye
    Department of Pharmacology, University of Copenhagen, Copenhagen N, Denmark
    Regul Pept 75:279-82. 1998
    ..Specifically, antiepileptic effects in the PTZ model suggest that NPYergic agonists might also prove active against human myoclonic seizures...
  2. ncbi Neuropeptide Y inhibits in vitro epileptiform activity in the entorhinal cortex of mice
    D P D Woldbye
    Section of Restorative Neurology, Wallenberg Neuroscience Center, BMC A 11, University Hospital, S 221 84, Lund, Sweden
    Neurosci Lett 333:127-30. 2002
    ..Therefore our data further strengthen the concept of NPY and its receptors as widespread regulators of epileptiform activity and as a potential future target for antiepileptic therapy...
  3. ncbi Neuropeptide Y and seizures: effects of exogenously applied ligands
    D P D Woldbye
    Laboratory of Neuropsychiatry, Rigshospitalet University Hospital and Department of Pharmacology, University of Copenhagen, 9 Blegdamsvej, DK 2100 Copenhagen, Denmark
    Neuropeptides 38:253-60. 2004
    ..This may lead to the development of future antiepileptic drug treatments targeting the NPY system...
  4. ncbi Repeated inhibitory effects of NPY on hippocampal CA3 seizures and wet dog shakes
    K Klemp
    Laboratory of Neuropsychiatry, Department of Pharmacology, University of Copenhagen, Copenhagen, Denmark
    Peptides 22:523-7. 2001
    ..Tolerance being a problem with several current antiepileptic drugs, this further strengthens the concept of NPY receptors as a potential future antiepileptic target...
  5. ncbi GABAA receptor antisense epilepsy: histological changes following infusion of antisense oligodeoxynucleotide to GABAA receptor gamma 2 subunit into rat hippocampus
    J Karle
    Department of Psychiatry, Rigshospitalet, National Hospital, DK 2100 Copenhagen, Denmark
    Neurol Res 23:39-46. 2001
    ..e., coincident with the development of neurodegeneration, in the ipsilateral hippocampus. At this time GFAP-immunoreactivity was also evident in the contralateral hippocampus, indicating contralateral spread of seizure activity...
  6. ncbi Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors
    D P Woldbye
    Department of Pharmacology, University of Copenhagen, Denmark
    Nat Med 3:761-4. 1997
    ..This is consistent with the concept that NPY is an endogenous anticonvulsant and suggests that agonists acting at Y5-like receptors may constitute a novel group of drugs in antiepileptic therapy...
  7. ncbi Inhibitory effect of neuropeptide Y on morphine withdrawal is accompanied by reduced c-fos expression in specific brain regions
    T R Clausen
    Laboratory of Neuropsychiatry, Department of Pharmacology, University of Copenhagen, Copenhagen, Denmark
    J Neurosci Res 64:410-7. 2001
    ..Our data suggest that neo- and allo-cortical areas as well as specific brainstem nuclei are involved in the anti-withdrawal effects of NPY...