Jørgen F P Wojtaszewski
Affiliation: University of Copenhagen
Wojtaszewski J, Lynge J, Jakobsen A, Goodyear L, Richter E. Differential regulation of MAP kinase by contraction and insulin in skeletal muscle: metabolic implications. Am J Physiol. 1999;277:E724-32 pubmed publisher
Wojtaszewski J, Hansen B, Gade -, Kiens B, Markuns J, Goodyear L, et al
. Insulin signaling and insulin sensitivity after exercise in human skeletal muscle. Diabetes. 2000;49:325-31 pubmed
..Diabetes 46:1775-1781, 1997]); and 3) prior exercise increases insulin stimulation of both glucose uptake and glycogen synthase activity in the absence of an upregulation of signaling events in human skeletal muscle. ..
Wojtaszewski J, Nielsen P, Kiens B, Richter E, Wojtazsewski J. Regulation of glycogen synthase kinase-3 in human skeletal muscle: effects of food intake and bicycle exercise. Diabetes. 2001;50:265-9 pubmed
..However, in contrast to findings in muscle from rats, exercise does not deactivate GSK3 in humans, suggesting a GSK3-independent mechanism in the regulation of GS activity in muscle during physical activity. ..
Wojtaszewski J, Nielsen J, Jørgensen S, Frøsig C, Birk J, Richter E. Transgenic models--a scientific tool to understand exercise-induced metabolism: the regulatory role of AMPK (5'-AMP-activated protein kinase) in glucose transport and glycogen synthase activity in skeletal muscle. Biochem Soc Trans. 2003;31:1290-4 pubmed
Wojtaszewski J, MacDonald C, Nielsen J, Hellsten Y, Hardie D, Kemp B, et al
. Regulation of 5'AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle. Am J Physiol Endocrinol Metab. 2003;284:E813-22 pubmed
..It is concluded that muscle AMPK activity and ACCbeta Ser(221) phosphorylation at rest and during exercise are sensitive to the fuel status of the muscle. During exercise, this dependence may in part be mediated by humoral factors. ..
Wojtaszewski J, Mourtzakis M, Hillig T, Saltin B, Pilegaard H. Dissociation of AMPK activity and ACCbeta phosphorylation in human muscle during prolonged exercise. Biochem Biophys Res Commun. 2002;298:309-16 pubmed