Eske Willerslev

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. pmc The use of coded PCR primers enables high-throughput sequencing of multiple homolog amplification products by 454 parallel sequencing
    Jonas Binladen
    Center for Ancient Genetics, Institute of Biology, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 2:e197. 2007
  2. pmc Barking up the wrong tree: modern northern European dogs fail to explain their origin
    Helena Malmström
    Department of Evolutionary Biology, Uppsala University, SE 752 36 Uppsala, Sweden
    BMC Evol Biol 8:71. 2008
  3. ncbi request reprint Evolution. The origin of insects
    Henrik Glenner
    Centre for Ancient Genetics, Department of Evolutionary Biology, Biological Institute, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Science 314:1883-4. 2006
  4. pmc Ancient biomolecules from deep ice cores reveal a forested southern Greenland
    Eske Willerslev
    Centre for Ancient Genetics, University of Copenhagen, Denmark
    Science 317:111-4. 2007
  5. pmc Analysis of complete mitochondrial genomes from extinct and extant rhinoceroses reveals lack of phylogenetic resolution
    Eske Willerslev
    Centre for Ancient Genetics, University of Copenhagen, Universitetsparken 15, DK 2100, Denmark
    BMC Evol Biol 9:95. 2009
  6. pmc Ancient human genome sequence of an extinct Palaeo-Eskimo
    Morten Rasmussen
    Centre for GeoGenetics, Natural History Museum of Denmark and Department of Biology, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Nature 463:757-62. 2010
  7. doi request reprint Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse
    Ludovic Orlando
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5 7, 1350 Copenhagen K, Denmark
    Nature 499:74-8. 2013
  8. pmc Detection of a diverse marine fish fauna using environmental DNA from seawater samples
    Philip Francis Thomsen
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade, Copenhagen, Denmark
    PLoS ONE 7:e41732. 2012
  9. ncbi request reprint Diverse plant and animal genetic records from Holocene and Pleistocene sediments
    Eske Willerslev
    Department of Evolutionary Biology, Zoological Institute, University of Copenhagen, Universitetsparken 15, Denmark DK 2100 Ø
    Science 300:791-5. 2003
  10. doi request reprint The effect of ancient DNA damage on inferences of demographic histories
    Erik Axelsson
    Department of Biology, Evolutionary Biology, Copenhagen University, Copenhagen, Denmark
    Mol Biol Evol 25:2181-7. 2008

Collaborators

Detail Information

Publications78

  1. pmc The use of coded PCR primers enables high-throughput sequencing of multiple homolog amplification products by 454 parallel sequencing
    Jonas Binladen
    Center for Ancient Genetics, Institute of Biology, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 2:e197. 2007
    ....
  2. pmc Barking up the wrong tree: modern northern European dogs fail to explain their origin
    Helena Malmström
    Department of Evolutionary Biology, Uppsala University, SE 752 36 Uppsala, Sweden
    BMC Evol Biol 8:71. 2008
    ..This has been suggested to indicate a possible origin of the haplogroup (perhaps even a separate domestication) in central or northern Europe...
  3. ncbi request reprint Evolution. The origin of insects
    Henrik Glenner
    Centre for Ancient Genetics, Department of Evolutionary Biology, Biological Institute, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Science 314:1883-4. 2006
  4. pmc Ancient biomolecules from deep ice cores reveal a forested southern Greenland
    Eske Willerslev
    Centre for Ancient Genetics, University of Copenhagen, Denmark
    Science 317:111-4. 2007
    ..The results provide direct evidence in support of a forested southern Greenland and suggest that many deep ice cores may contain genetic records of paleoenvironments in their basal sections...
  5. pmc Analysis of complete mitochondrial genomes from extinct and extant rhinoceroses reveals lack of phylogenetic resolution
    Eske Willerslev
    Centre for Ancient Genetics, University of Copenhagen, Universitetsparken 15, DK 2100, Denmark
    BMC Evol Biol 9:95. 2009
    ..One notable example concerns the rhinoceroses, a group for which several contradictory phylogenies were proposed on the basis of morphology, then apparently resolved using mitochondrial DNA fragments...
  6. pmc Ancient human genome sequence of an extinct Palaeo-Eskimo
    Morten Rasmussen
    Centre for GeoGenetics, Natural History Museum of Denmark and Department of Biology, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Nature 463:757-62. 2010
    ..This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit...
  7. doi request reprint Recalibrating Equus evolution using the genome sequence of an early Middle Pleistocene horse
    Ludovic Orlando
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5 7, 1350 Copenhagen K, Denmark
    Nature 499:74-8. 2013
    ..Such regions could correspond to loci selected early during domestication...
  8. pmc Detection of a diverse marine fish fauna using environmental DNA from seawater samples
    Philip Francis Thomsen
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade, Copenhagen, Denmark
    PLoS ONE 7:e41732. 2012
    ..Although further studies are needed to validate the eDNA approach in varying environmental conditions, our findings provide a strong proof-of-concept with great perspectives for future monitoring of marine biodiversity and resources...
  9. ncbi request reprint Diverse plant and animal genetic records from Holocene and Pleistocene sediments
    Eske Willerslev
    Department of Evolutionary Biology, Zoological Institute, University of Copenhagen, Universitetsparken 15, Denmark DK 2100 Ø
    Science 300:791-5. 2003
    ..Therefore, many sedimentary deposits may contain unique, and widespread, genetic records of paleoenvironments...
  10. doi request reprint The effect of ancient DNA damage on inferences of demographic histories
    Erik Axelsson
    Department of Biology, Evolutionary Biology, Copenhagen University, Copenhagen, Denmark
    Mol Biol Evol 25:2181-7. 2008
    ..Our results suggest that population genetic analyses of aDNA sequences, which do not accurately account for damage, should be interpreted with great caution...
  11. pmc Species-specific responses of Late Quaternary megafauna to climate and humans
    Eline D Lorenzen
    Centre for GeoGenetics, University of Copenhagen, Øster Voldgade 5 7, DK 1350 Copenhagen K, Denmark
    Nature 479:359-64. 2011
    ....
  12. pmc Ancient DNA analyses exclude humans as the driving force behind late Pleistocene musk ox (Ovibos moschatus) population dynamics
    Paula F Campos
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, DK 1350 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 107:5675-80. 2010
    ....
  13. ncbi request reprint A comparative study of ancient sedimentary DNA, pollen and macrofossils from permafrost sediments of northern Siberia reveals long-term vegetational stability
    Tina Jørgensen
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark
    Mol Ecol 21:1989-2003. 2012
    ....
  14. doi request reprint Paleo-Eskimo mtDNA genome reveals matrilineal discontinuity in Greenland
    M Thomas P Gilbert
    Center for Ancient Genetics, Department of Biology, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Science 320:1787-9. 2008
    ..This result suggests that the earliest migrants into the New World's northern extremes derived from populations in the Bering Sea area and were not directly related to Native Americans or the later Neo-Eskimos that replaced them...
  15. doi request reprint Ancient DNA sequences point to a large loss of mitochondrial genetic diversity in the saiga antelope (Saiga tatarica) since the Pleistocene
    Paula F Campos
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5 7, 1350 Copenhagen, Denmark
    Mol Ecol 19:4863-75. 2010
    ..66-77%) following either a demographic bottleneck in the course of the Holocene or late Pleistocene, or a geographic fragmentation (followed by local extinction of one subpopulation) at the Holocene/Pleistocene transition...
  16. doi request reprint DNA from keratinous tissue. Part I: hair and nail
    Camilla Friis Bengtsson
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Denmark
    Ann Anat 194:17-25. 2012
    ....
  17. pmc Intraspecific phylogenetic analysis of Siberian woolly mammoths using complete mitochondrial genomes
    M Thomas P Gilbert
    Centre for Ancient Genetics, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Proc Natl Acad Sci U S A 105:8327-32. 2008
    ..Modeling of protein structures failed to indicate any important functional difference between genomes belonging to the two clades, suggesting that the loss of clade II more likely is due to genetic drift than a selective sweep...
  18. pmc Non-destructive sampling of ancient insect DNA
    Philip Francis Thomsen
    Centre for Ancient Genetics and Environments, Natural History Museum and Institute of Biology, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 4:e5048. 2009
    ..Finally, we test the possibility of obtaining ancient insect DNA directly from non-frozen sediments deposited 3280-1800 years ago -- an alternative approach that also does not involve destruction of valuable material...
  19. pmc Assessing the fidelity of ancient DNA sequences amplified from nuclear genes
    Jonas Binladen
    Ancient DNA and Evolution Group, Centre for Ancient Genetics, Niels Bohr Institute, University of Copenhagen, Denmark
    Genetics 172:733-41. 2006
    ....
  20. pmc 800,000 year old mammoth DNA, modern elephant DNA or PCR artefact?
    Jonas Binladen
    Centre for Ancient Genetics, Niels Bohr Institute and Biological Institute, University of Copenhagen, Juliane Maries Vej 30, 2100 Copenhagen, Denmark
    Biol Lett 3:55-6; discussion 60-3. 2007
    ..Finally, we demonstrate using a simple BLAST search in GenBank that the claimed 'uniquely derived character state' for mammoths is in fact also found within modern elephants...
  21. doi request reprint Monitoring endangered freshwater biodiversity using environmental DNA
    Philip Francis Thomsen
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5 7, DK 1350 Copenhagen, Denmark
    Mol Ecol 21:2565-73. 2012
    ..Our findings underpin the ubiquitous nature of DNA traces in the environment and establish environmental DNA as a tool for monitoring rare and threatened species across a wide range of taxonomic groups...
  22. doi request reprint Meta-barcoding of 'dirt' DNA from soil reflects vertebrate biodiversity
    Kenneth Andersen
    Centre for GeoGenetics, University of Copenhagen, Copenhagen, Denmark
    Mol Ecol 21:1966-79. 2012
    ....
  23. doi request reprint Islands in the ice: detecting past vegetation on Greenlandic nunataks using historical records and sedimentary ancient DNA meta-barcoding
    Tina Jørgensen
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark
    Mol Ecol 21:1980-8. 2012
    ..This suggests that even the flora of fairly small and isolated ice-free areas reacts quickly to a changing climate...
  24. ncbi request reprint The last Viking King: a royal maternity case solved by ancient DNA analysis
    Jørgen Dissing
    Research Laboratory, Institute of Forensic Medicine, University of Copenhagen, Frederik V Vej 11, DK 2100 Copenhagen, Denmark
    Forensic Sci Int 166:21-7. 2007
    ..Although the entombed woman cannot be the Estrid, she may well be one of Sven's two daughters-in-law who were also called Estrid and who both became queens...
  25. doi request reprint DNA in ancient bone - where is it located and how should we extract it?
    Paula F Campos
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Denmark
    Ann Anat 194:7-16. 2012
    ..In doing so we offer hypotheses relevant to the DNA degradation process itself, and to where and how the DNA is actually preserved in ancient bone...
  26. ncbi request reprint Evaluating Neanderthal genetics and phylogeny
    Martin B Hebsgaard
    Centre for Ancient Genetics, Niels Bohr Institute and Biological Institute, University of Copenhagen, Juliane Maries Vej 30, Copenhagen DK 2100, Denmark
    J Mol Evol 64:50-60. 2007
    ....
  27. pmc Reconstructing genome evolution in historic samples of the Irish potato famine pathogen
    Michael D Martin
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5 7, 1350 Copenhagen K, Denmark
    Nat Commun 4:2172. 2013
    ..At least one of these genotypes encodes a virulent phenotype in modern strains, which helps explain the 20th century's episodic replacements of European P. infestans lineages...
  28. ncbi request reprint Whole-genome shotgun sequencing of mitochondria from ancient hair shafts
    M Thomas P Gilbert
    Centre for Ancient Genetics, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Science 317:1927-30. 2007
    ..The method therefore sets the stage for molecular-genetic analysis of museum collections...
  29. pmc Out of the Pacific and back again: insights into the matrilineal history of Pacific killer whale ecotypes
    Andrew D Foote
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 6:e24980. 2011
    ....
  30. doi request reprint DNA from pre-Clovis human coprolites in Oregon, North America
    M Thomas P Gilbert
    Centre for Ancient Genetics, University of Copenhagen, Universitetsparken 15, 2100 Copenhagen, Denmark
    Science 320:786-9. 2008
    ..The mtDNA corresponds to Native American founding haplogroups A2 and B2. The dates of the coprolites are >1000 14C years earlier than currently accepted dates for the Clovis complex...
  31. pmc Ancient DNA reveals late survival of mammoth and horse in interior Alaska
    James Haile
    Centre for GeoGenetics, University of Copenhagen, Copenhagen 2100, Denmark
    Proc Natl Acad Sci U S A 106:22352-7. 2009
    ....
  32. pmc Recharacterization of ancient DNA miscoding lesions: insights in the era of sequencing-by-synthesis
    M Thomas P Gilbert
    Center for Ancient Genetics, Niels Bohr Institute and Biological Institutes, The University of Copenhagen, Juliane Maries Vej 30, DK 2100 Copenhagen Ø, Denmark
    Nucleic Acids Res 35:1-10. 2007
    ..How widespread these implications are for aDNA will become apparent as future studies analyse data recovered from a wider range of substrates...
  33. doi request reprint Statistical guidelines for detecting past population shifts using ancient DNA
    Tobias Mourier
    Centre for GeoGenetics, Natural History Museum, University of Copenhagen, Copenhagen, Denmark
    Mol Biol Evol 29:2241-51. 2012
    ..In addition, our results suggest that many ancient DNA studies may face power issues in detecting moderate demographic collapses and/or highly dynamic demographic shifts when based solely on mitochondrial information...
  34. pmc Improving ancient DNA read mapping against modern reference genomes
    Mikkel Schubert
    Centre for GeoGenetics Natural History Museum of Denmark, University of Copenhagen, 5 7 Øster Voldgade, 1350, Kobenhavns K, Denmark
    BMC Genomics 13:178. 2012
    ....
  35. doi request reprint Next-generation sequencing offers new insights into DNA degradation
    Søren Overballe-Petersen
    Centre for GeoGenetics, University of Copenhagen, Øster Voldgade 5 7, 1350 Copenhagen K, Denmark
    Trends Biotechnol 30:364-8. 2012
    ..In this review, we argue that the latter results from an electron resonance structure unique to guanosine rather than adenosine having an extra resonance structure over guanosine as previously suggested...
  36. doi request reprint DNA from keratinous tissue. Part II: feather
    Maia E Olsen
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Denmark
    Ann Anat 194:31-5. 2012
    ..However, PCR-free genetic analyses that can exploit much smaller DNA fragments may promise to be a powerful tool for future exploitation...
  37. ncbi request reprint Bayesian inference of the metazoan phylogeny; a combined molecular and morphological approach
    Henrik Glenner
    Department of Evolutionary Biology, Biological Institute, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Curr Biol 14:1644-9. 2004
    ..Parsimony, on the contrary, shows conflicting results, with morphology being congruent to the Bayesian results and the molecular data set producing peculiarities that are largely reflected in the combined analysis...
  38. doi request reprint High-throughput sequencing of core STR loci for forensic genetic investigations using the Roche Genome Sequencer FLX platform
    Sarah L Fordyce
    Centre for GeoGenetics, Natural History Museum of Denmark, Copenhagen, Denmark
    Biotechniques 51:127-33. 2011
    ..Furthermore, we found DNA base substitutions and repeat sequence variations that would not have been identified using conventional STR typing...
  39. ncbi request reprint Authenticity in ancient DNA studies
    M Thomas P Gilbert
    Center for Ancient Genetics, Niels Bohr and Biological Institutes, University of Copenhagen
    Med Secoli 18:701-23. 2006
    ..In this paper we outline first the problems associated with aDNA studies, and secondly present potential guidelines designed so as to enable non-specialist readers the opportunity to critically assess the quality of aDNA publications...
  40. ncbi request reprint 5'-tailed sequencing primers improve sequencing quality of PCR products
    Jonas Binladen
    University of Copenhagen, Denmark
    Biotechniques 42:174, 176. 2007
  41. doi request reprint Ancient DNA reveals that bowhead whale lineages survived Late Pleistocene climate change and habitat shifts
    Andrew D Foote
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5 7, DK 1350 Copenhagen K, Denmark
    Nat Commun 4:1677. 2013
    ..We estimate that the core suitable habitat of bowhead whales will be almost halved by the end of this century, potentially influencing future population dynamics...
  42. doi request reprint Proteomic analysis of a pleistocene mammoth femur reveals more than one hundred ancient bone proteins
    Enrico Cappellini
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5 7, 1350, Copenhagen, Denmark
    J Proteome Res 11:917-26. 2012
    ..This approach therefore represents a further step into the ongoing integration of different high-throughput technologies for identification of ancient biomolecules, unleashing the field of paleoproteomics...
  43. ncbi request reprint Screening mammal biodiversity using DNA from leeches
    Ida Bærholm Schnell
    Copenhagen Zoo, Frederiksberg, 2000, Denmark Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, 1350, Denmark
    Curr Biol 22:R262-3. 2012
    ..We propose that DNA from leeches represents a quick, cost-effective and standardised way to obtain basic data on mammalian biodiversity and species occupancy, facilitating efficient use of limited conservation resources...
  44. pmc Positive selection on the killer whale mitogenome
    Andrew D Foote
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Volgade 5 7, 1350 Copenhagen, Denmark
    Biol Lett 7:116-8. 2011
    ..Both substitutions were associated with changes in local polarity, increased steric constraints and α-helical tendencies that could influence overall metabolic performance, suggesting a functional change...
  45. pmc Mitogenomic phylogenetic analyses of the Delphinidae with an emphasis on the Globicephalinae
    Julia T Vilstrup
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5 7, 1350 Copenhagen, Denmark
    BMC Evol Biol 11:65. 2011
    ..Further ad hoc tests were then conducted to estimate the support for alternative topologies...
  46. pmc Large-scale transcriptome data reveals transcriptional activity of fission yeast LTR retrotransposons
    Tobias Mourier
    Ancient DNA and Evolution Group, Natural History Museum of Denmark, University of Copenhagen, Øster Voldgade 5 7, DK 1350 Copenhagen, Denmark
    BMC Genomics 11:167. 2010
    ..pombe exist as solitary LTRs, i.e. as single terminal repeat sequences not flanking a retrotransposon. Transcriptional activity was analysed for both full-length LTR retrotransposons and solitary LTRs...
  47. pmc Deep sequencing of RNA from ancient maize kernels
    Sarah L Fordyce
    Centre for GeoGenetics, Natural History Museum of Denmark, Copenhagen, Denmark
    PLoS ONE 8:e50961. 2013
    ..The results suggest that ancient seed transcriptomics may offer a powerful new tool with which to study plant domestication...
  48. pmc Molecular diet analysis of two african free-tailed bats (molossidae) using high throughput sequencing
    Kristine Bohmann
    Centre for GeoGenetics, Natural History Museum of Denmark, Copenhagen, Denmark
    PLoS ONE 6:e21441. 2011
    ..condylurus and C. pumilus in the Simunye region of Swaziland at the time of year when the samples were collected, although as more complete databases against which to compare the sequences are generated this may have to be re-evaluated...
  49. pmc Bacterial natural transformation by highly fragmented and damaged DNA
    Søren Overballe-Petersen
    Centre for GeoGenetics and Nordic Center for Earth Evolution, University of Copenhagen, 1350 Copenhagen K, Denmark
    Proc Natl Acad Sci U S A 110:19860-5. 2013
    ..Our findings open for the possibility that natural genetic exchange can occur with DNA up to several hundreds of thousands years old...
  50. pmc One hundred twenty years of koala retrovirus evolution determined from museum skins
    Maria C Avila-Arcos
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark
    Mol Biol Evol 30:299-304. 2013
    ..Given that museum and modern koalas share nearly identical KoRV sequences, it is likely that koala populations, for more than a century, have experienced increased susceptibility to diseases caused by viral pathogenesis...
  51. pmc Ligation bias in illumina next-generation DNA libraries: implications for sequencing ancient genomes
    Andaine Seguin-Orlando
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e78575. 2013
    ..Consequently, we show that models adequate for estimating post-mortem DNA damage levels must be robust to the molecular tools used for building ancient DNA libraries. ..
  52. ncbi request reprint Retrotransposons and non-protein coding RNAs
    Tobias Mourier
    Natural History Museum of Denmark, University of Copenhagen, Universitetsparken 15, DK 2100 Copenhagen, Denmark
    Brief Funct Genomic Proteomic 8:493-501. 2009
    ..Finally, we review the emerging understanding of how retrotransposons themselves are regulated by small RNAs...
  53. ncbi request reprint mtDNA analysis of human remains from an early Danish Christian cemetery
    Lars Rudbeck
    Research Laboratory, Institute of Forensic Medicine, University of Copenhagen, 2100 Copenhagen, Denmark
    Am J Phys Anthropol 128:424-9. 2005
    ....
  54. pmc Does selection against transcriptional interference shape retroelement-free regions in mammalian genomes?
    Tobias Mourier
    Ancient DNA and Evolution Group, Department of Biology, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 3:e3760. 2008
    ..We speculate that such retroelement transcription, or transcriptional interference, is a contributing factor in generating and maintaining retroelement-free regions in the human genome...
  55. ncbi request reprint Characterization of ancient and modern genomes by SNP detection and phylogenomic and metagenomic analysis using PALEOMIX
    Mikkel Schubert
    Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen, Copenhagen, Denmark
    Nat Protoc 9:1056-82. 2014
    ..Applying the PALEOMIX pipeline to the three ancient and seven modern Phytophthora infestans genomes as described here takes 5 d using a 16-core server. ..
  56. doi request reprint Aerial photographs reveal late-20th-century dynamic ice loss in northwestern Greenland
    Kurt H Kjær
    Centre for GeoGenetics, Natural History Museum, University of Copenhagen, Copenhagen, Denmark
    Science 337:569-73. 2012
    ..This finding challenges predictions about the future response of the Greenland Ice Sheet to increasing global temperatures...
  57. pmc Distribution patterns of postmortem damage in human mitochondrial DNA
    M Thomas P Gilbert
    Henry Wellcome Ancient Biomolecules Centre, Department of Zoology, Oxford University, Oxford, United Kingdom
    Am J Hum Genet 72:32-47. 2003
    ..Finally, a simple method for the identification of incorrect archaeological haplogroup designations is introduced, on the basis of the observed spectrum of postmortem damage...
  58. ncbi request reprint Extreme reversed sexual size dimorphism in the extinct New Zealand moa Dinornis
    Michael Bunce
    Henry Wellcome Ancient Biomolecules Centre, Department of Zoology, University of Oxford, Oxford OX1 3PS, UK
    Nature 425:172-5. 2003
    ..The combination of molecular and palaeontological data highlights the difficulties of analysing extinct groups, even those with detailed fossil records...
  59. ncbi request reprint Rise and fall of the Beringian steppe bison
    Beth Shapiro
    Henry Wellcome Ancient Biomolecules Centre, Oxford University, South Parks Road, Oxford OX13PS, UK
    Science 306:1561-5. 2004
    ....
  60. ncbi request reprint Worldwide phylogeography of wild boar reveals multiple centers of pig domestication
    Greger Larson
    Henry Wellcome Ancient Biomolecules Centre, University of Oxford, Department of Zoology, South Parks Road OX1 3PS, UK
    Science 307:1618-21. 2005
    ..In contrast, new genetic data reveal multiple centers of domestication across Eurasia and that European, rather than Near Eastern, wild boar are the principal source of modern European domestic pigs...
  61. pmc The genetic origins of the Andaman Islanders
    Phillip Endicott
    Henry Wellcome Ancient Biomolecules Centre, Department of Zoology, University of Oxford, Oxford, OX1 3PS England
    Am J Hum Genet 72:178-84. 2003
    ..The results demonstrate that Victorian anthropological collections can be used to study extinct, or seriously admixed populations, to provide new data about early human origins...
  62. pmc Ancient DNA
    Eske Willerslev
    Henry Wellcome Ancient Biomolecules Centre, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Proc Biol Sci 272:3-16. 2005
    ....
  63. pmc Evolution, systematics, and phylogeography of pleistocene horses in the new world: a molecular perspective
    Jaco Weinstock
    Ancient Biomolecules Centre, Department of Zoology, University of Oxford, United Kingdom
    PLoS Biol 3:e241. 2005
    ..Both caballine and stilt-legged lineages may each have comprised a single, wide-ranging species...
  64. ncbi request reprint Profile: Eske Willerslev. Ancient DNA's intrepid explorer
    Andrew Curry
    Science 317:36-7. 2007
  65. ncbi request reprint Ancient DNA chronology within sediment deposits: are paleobiological reconstructions possible and is DNA leaching a factor?
    James Haile
    Henry Wellcome Ancient Biomolecules Centre, Department of Zoology, University of Oxford, South Parks Road, Oxford, United Kingdom
    Mol Biol Evol 24:982-9. 2007
    ..Our study indicates that DNA from sediments can still offer a rich source of information on past environments, provided that the risk from vertical migration can be controlled for...
  66. ncbi request reprint More on contamination: the use of asymmetric molecular behavior to identify authentic ancient human DNA
    Helena Malmström
    Evolutionary Biology, Uppsala University, Uppsala, Sweden
    Mol Biol Evol 24:998-1004. 2007
    ..This asymmetrical behavior of authentic and contaminant DNA can be used to identify authentic haplotypes in human aDNA studies...
  67. ncbi request reprint Can identification of a fourth domain of life be made from sequence data alone, and could it be done on Mars?
    Anthony M Poole
    Department of Molecular Biology and Functional Genomics, Stockholm University, Stockholm, Sweden
    Astrobiology 7:801-14. 2007
    ....
  68. pmc Characterization of genetic miscoding lesions caused by postmortem damage
    M Thomas P Gilbert
    Henry Wellcome Ancient Biomolecules Centre, Department of Zoology, Oxford University, Oxford, United Kingdom
    Am J Hum Genet 72:48-61. 2003
    ..Last, a significant correlation between archaeological site and sample-specific level of DNA damage was detected...
  69. ncbi request reprint Rescuing ancient DNA
    M Thomas P Gilbert
    Nat Biotechnol 25:872-4. 2007
  70. ncbi request reprint Ancient DNA: would the real Neandertal please stand up?
    Alan Cooper
    Henry Wellcome Ancient Biomolecules Centre and Department of Zoology, University of Oxford, Oxford OX1 3PS, UK
    Curr Biol 14:R431-3. 2004
    ..This indicates that, if Neandertals made any genetic contribution at all to modern humans, it must have been limited, though the extent of the contribution cannot be resolved at present...
  71. ncbi request reprint Ancient mitochondrial DNA from hair
    M Thomas P Gilbert
    Curr Biol 14:R463-4. 2004
  72. ncbi request reprint Damage and repair of ancient DNA
    David Mitchell
    The University of Texas MD Anderson Cancer Center, Department of Carcinogenesis, P O Box 389, Park Road 1C, Smithville, TX 78957, USA
    Mutat Res 571:265-76. 2005
    ..In addition, we will present some of our own preliminary and published data on mechanisms of DNA degradation and some speculative thoughts on strategies for repair and restoration of aDNA...
  73. ncbi request reprint A preliminary analysis of the DNA and diet of the extinct Beothuk: a systematic approach to ancient human DNA
    Melanie Kuch
    McMaster Ancient DNA Center, McMaster University, Hamilton, ON L8S 4L9, Canada
    Am J Phys Anthropol 132:594-604. 2007
    ....
  74. ncbi request reprint Geologically ancient DNA: fact or artefact?
    Martin B Hebsgaard
    Department of Zoology, University of Oxford, South Parks Road, Oxford, UK OX1 3PS
    Trends Microbiol 13:212-20. 2005
    ..To enhance the credibility of future studies and assist in discarding false-positive results, we propose a rigorous set of authentication criteria for work with geologically ancient DNA...
  75. pmc Power and limitations of the chloroplast trnL (UAA) intron for plant DNA barcoding
    Pierre Taberlet
    Laboratoire d Ecologie Alpine, CNRS UMR 5553, Universite Joseph Fourier, BP 53, 38041 Grenoble Cedex 9, France
    Nucleic Acids Res 35:e14. 2007
    ....
  76. ncbi request reprint Nuclear gene indicates coat-color polymorphism in mammoths
    Holger Römpler
    Molecular Biochemistry, Institute of Biochemistry, Medical Faculty, University of Leipzig, 04103 Leipzig, Germany
    Science 313:62. 2006
    ..This finding suggests that mammoths may have been polymorphic in coat color, with both dark- and light-haired individuals co-occurring...
  77. pmc Crosslinks rather than strand breaks determine access to ancient DNA sequences from frozen sediments
    Anders J Hansen
    Genetics 173:1175-9. 2006
    ..Additionally, a clear relationship was found between DNA damage and sample age, contradicting previously raised concerns about the possible leaching of free DNA molecules between permafrost layers...
  78. pmc Beringian paleoecology inferred from permafrost-preserved fungal DNA
    Magnus C Lydolph
    Microbial Discovery, Novozymes A S, Smørmosevej 25 1B1, DK 2880 Bagsvaerd, Denmark
    Appl Environ Microbiol 71:1012-7. 2005
    ....