Research Topics
| Allan S WiikSummaryAffiliation: University of Copenhagen Country: Denmark Publications
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Detail Information
Publications
Clinical and pathophysiological significance of anti-neutrophil cytoplasmic autoantibodies in vasculitis syndromesAllan Wiik
Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark
Mod Rheumatol 19:590-9. 2009..The review concludes that the presence of ANCA is likely to become an important criterion for diagnosing idiopathic small vessel vasculitis...- Autoantibodies in ANCA-associated vasculitisAllan S Wiik
Department of Autoimmunology, Statens Serum Institut, DK 2300 Copenhagen S, Denmark
Rheum Dis Clin North Am 36:479-89. 2010..These autoantibodies are assumed to play a role in the initiation and propagation of chronic inflammation. ANCAs are valuable for clinical diagnosis, follow-up, and guidance in therapy... - All you wanted to know about anti-CCP but were afraid to askAllan S Wiik
Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark
Autoimmun Rev 10:90-3. 2010..Still, larger and strictly stratified studies are highly warranted to substantiate this conclusion... 
The use of citrullinated peptides and proteins for the diagnosis of rheumatoid arthritisGer Jm Pruijn
Department of Biomolecular Chemistry 271, Nijmegen Center for Molecular Life Sciences, Institute for Molecules and Materials, Radboud University Nijmegen, PO Box 9101, NL 6500 HB Nijmegen, The Netherlands
Arthritis Res Ther 12:203. 2010..Finally, the levels of anti-CCP2 and anti-CCP3 (and possibly anti-mutated citrullinated vimentin) in rheumatoid arthritis patients are not significantly influenced by TNFalpha blocking agents...- Antinuclear antibodies: a contemporary nomenclature using HEp-2 cellsAllan S Wiik
Department of Clinical Biochemistry and Immunology, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark
J Autoimmun 35:276-90. 2010..All results from this project were reported to the European Commission but have not previously been published in scientific literature. This communication presents the final results of agreed image classifications... - Drug-induced vasculitisAllan Wiik
Department of Autoimmunology, Statens Serum Institut, Copenhagen, Denmark
Curr Opin Rheumatol 20:35-9. 2008..The clinical phenotypes vary from single tissue or organ involvement to severe systemic inflammatory disease dominated by vasculitis and sometimes organ failure... - Clinical and laboratory characteristics of drug-induced vasculitic syndromesAllan Wiik
Department of Autoimmunology, Statens Serum Institut, Copenhagen, Denmark
Arthritis Res Ther 7:191-2. 2005..Clinically, skin vasculitis and arthralgias predominated and renal vasculitis was rare... 
Tissue transglutaminase and endomysial autoantibodies measured in an historical cohort of children and young adults in whom coeliac disease was suspectedBirgitte Weile
Department of Autoimmunology, Statens Serum Institut, Copenhagen, Denmark
Eur J Gastroenterol Hepatol 14:71-6. 2002..To evaluate whether anti-endomysial and anti-transglutaminase antibodies are relevant important markers of coeliac disease in an historical group of patient sera...- [Forty four pregnancies with idiopathic thrombocytopenic purpura]Tine Boe Mortensen
H S Rigshospitalet, Obstetrisk Klinik, Juliane Marie Centret
Ugeskr Laeger 164:3968-72. 2002..The aim of this project was to describe the course of pregnancy with idiopathic thrombocytopenic purpura (ITP) and to estimate risk factors and indications for treatment... - Anti-neutrophil cytoplasmic autoantibody (ANCA) profiles in propylthiouracil-induced lupus-like manifestations in monozygotic triplets with hyperthyroidismTroels Herlin
Department of Pediatrics, Skejby Sygehus, Aarhus University Hospital, Denmark
Scand J Rheumatol 31:46-9. 2002..Triplet A and B, but not C, both developed a strongly positive elastase-ANCA. Our results confirm the importance of a genetic factor influencing the susceptibility to drug-induced LE... - Autoantibodies in vasculitisAllan Wiik
Department of Autoimmunology, Statens Serum Institut, Copenhagen, Denmark
Arthritis Res Ther 5:147-52. 2003..Although autoantibodies to endothelial cells may be important players in the pathogenesis of several vasculitic conditions, they have not gained clinical popularity because of lack of standardized detection methods... - [Laboratory diagnostics in rheumatology]Allan Wiik
Autoimmunafdelingen, Statens Serum Institut, bygning 81, rum 544, Artillerivej 5, DK 2300 København S
Ugeskr Laeger 164:610-4. 2002..A clinically important use of serodiagnostics can only be implemented by a close collaboration between clinicians and laboratory specialists. A tentative diagnosis is the best basis for ordering and interpreting laboratory results... - The immune response to citrullinated proteins in patients with rheumatoid arthritis: genetic, clinical, technical, and epidemiological aspectsAllan S Wiik
Department of Autoimmunology, Statens Serum Institut, Copenhagen S, Denmark
Clin Rev Allergy Immunol 32:13-22. 2007..The antibody can sometimes be found several years before the onset of clinical symptoms of RA, which may represent an open window for preventive measures to be taken... - Cutting edge diagnostics in rheumatology: the role of patients, clinicians, and laboratory scientists in optimizing the use of autoimmune serologyAllan S Wiik
Statens Serum Institut, Copenhagen, Denmark
Arthritis Rheum 51:291-8. 2004 - Untreated silicone breast implant ruptureLisbet R Hölmich
Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
Plast Reconstr Surg 114:204-14; discussion 215-6. 2004..Because implant ruptures often occur asymptomatically, any woman with silicone implants, regardless of rupture status, should be evaluated at regular intervals... - Neutrophil-specific autoantibodies in chronic inflammatory bowel diseasesAllan Wiik
Department of Autoimmunology, Statens Serum Institut, Artillerivej 5, 2300 Copenhagen S, Denmark
Autoimmun Rev 1:67-72. 2002..Laboratory reports on NSA-positivity must be clearly distinguishable from reports on ANCA to help avoid clinical misinterpretation... - IgG and IgM isotypes of anti-cardiolipin and anti-beta2-glycoprotein i antibodies reflect different forms of recent thrombo-embolic eventsHenning Locht
Department of Autoimmunology, Statens Serum Institut, 2300, Copenhagen S, Denmark
Clin Rheumatol 25:246-50. 2006.... - Appropriateness of autoantibody testing in clinical medicineAllan S Wiik
Department of Autoimmunology, Statens Serum Institut, Bldg 81, 5th Floor, Room 544, Artillerivej 5, DK 2300 Copenhagen S, Denmark
Clin Chim Acta 333:177-80. 2003..Pathologically expressed autoantibodies reflect ongoing immune-mediated inflammation in patients and may even be regarded as surrogate markers of disease prognosis and clinical outcome in certain clinical settings... - P53 autoantibodies in sera from Danish ovarian cancer patients and their correlation with clinical data and prognosisEstrid V S Høgdall
Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
APMIS 110:545-53. 2002..The presence of increased serum p53 AAb in patients with diagnosed OC could not be correlated with any clinical data and preoperative serum p53 AAb status had no evident value... - Prevalence of antibodies against oxidised LDL in a cohort of 163 patients with positive anti-phospholipid antibodies and recent thrombosisHenning Locht
Department of Autoimmunology, Building 81, 5th Floor, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen S, Denmark
Rheumatol Int 26:416-21. 2006..However, a-oxLDL antibodies appear to define a subset of patients, who were older, had more arterial vascular disease, and with no apparent association to the presence of IgG aCL... - The influence of pregnancy on the development of autoimmunity in chronic lymphocytic leukemiaViggo Jønsson
Department of Hematology, Rigshospital, School of Medicine, University of Copenhagen, Copenhagen, Denmark
Leuk Lymphoma 47:1481-7. 2006..The spectrum of autoimmunity suggests that pregnancy-related alloimmunization may be involved in the development of autoimmunity in CLL... - Induction of biologically active antineutrophil cytoplasmic antibodies by immunization with human apoptotic polymorphonuclear leukocytesLubica Rauova
Center for Autoimmune Diseases, Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel
Clin Immunol 103:69-78. 2002..These results support the hypothesis that neutrophil-specific antigens presented on the cell membranes of apoptotic PMN may induce ANCA in the proper conditions... - A critical evaluation of enzyme immunoassay kits for detection of antinuclear autoantibodies of defined specificities. II. Potential for quantitation of antibody contentEng M Tan
Autoantibody Standardization Committee in Rheumatic and Related Disorders of the International Union of Immunological Societies, The World Health Organization, The Arthritis Foundation, and Centers for Disease Control and Prevention
J Rheumatol 29:68-74. 2002..Improved EIA kits would lend themselves to reliable quantitation of antibody levels in human sera and help to determine whether serial measurement of antibody levels might be useful in monitoring disease activity... - AutoAbSC.Org -- Autoantibody Standardization Committee in 2006Edward K L Chan
Department of Oral Biology, University of Florida, Health Science Center, 1600 SW Archer Road, Gainesville, FL 32610 0424, USA
Autoimmun Rev 6:577-80. 2007..A web site has been developed under "AutoAbSC.Org" to communicate to the wider stakeholder community and to facilitate ongoing activities in continuing the mission in autoantibody standardization... - Autoantibody response to BPI predict disease severity and outcome in cystic fibrosisMalin Carlsson
Department of Laboratory Medicine, Section of Microbiology, Immunology and Glycobiology, Lund University, S 221 85 Lund, Sweden
J Cyst Fibros 6:228-33. 2007..In the present study, we investigated BPI-ANCA as a prognostic marker and its relation to P. aeruginosa colonization and lung function... - International multicenter evaluation of autoantibodies to ribosomal P proteinsMichael Mahler
Dr Fooke Laboratorien GmbH, Mainstr 85, 41469 Neuss, Germany
Clin Vaccine Immunol 13:77-83. 2006..We confirm previously reported associations of antiribosomal antibodies with clinical symptoms and serological findings. Remarkably, we found a lower occurrence of serositis in Rib-P-positive lupus patients... - [Congenital heart block and autoantibodies]Niels H H Heegaard
Statens Serum Institut, Autoimmunafdelingen
Ugeskr Laeger 167:3775-6. 2005..It may prove beneficial to screen all expectant mothers for anti-Ro52 autoantibodies. Decisions about this will require further studies of the diagnostic performance of the Ro52 autoantibody test... - Long-term health status of Danish women with silicone breast implantsVibeke B Breiting
Holte Clinic of Plastic Surgery, Denmark
Plast Reconstr Surg 114:217-26; discussion 227-8. 2004..The authors' finding of excess use of drugs for treatment of depression and anxiety among women with breast implants may warrant further investigation... - Addendum to the International Consensus Statement on testing and reporting of antineutrophil cytoplasmic antibodies. Quality control guidelines, comments, and recommendations for testing in other autoimmune diseasesJudy Savige
University of Melbourne, Department of Medicine, Austin and Repatriation Medical Centre, Heidelberg, VIC 3084, Australia
Am J Clin Pathol 120:312-8. 2003.... - The use and abuse of commercial kits used to detect autoantibodiesMarvin J Fritzler
Faculty of Medicine, University of Calgary, Alberta, Canada
Arthritis Res Ther 5:192-201. 2003..It is suggested that a higher level of commitment and partnership between all of the participants is required to achieve the goal of improving the quality of patient care through the use of autoantibody testing and analysis...