Mario D Bachi

Summary

Affiliation: Weizmann Institute of Science
Country: Israel

Publications

  1. ncbi request reprint A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic beta-sulfonyl-endoperoxides
    Mario D Bachi
    Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Med Chem 46:2516-33. 2003
  2. ncbi request reprint Total syntheses of Yingzhaosu A and of its C(14)-epimer including the first evaluation of their antimalarial and cytotoxic activities
    Alex M Szpilman
    Department of Organic Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel
    J Org Chem 70:3618-32. 2005
  3. ncbi request reprint Diels-Alder/thiol-olefin co-oxygenation approach to antimalarials incorporating the 2,3-dioxabicyclo[3.3.1]nonane pharmacophore
    Paul M O'Neill
    Department of Chemistry, University of Liverpool, PO Box 147, Liverpool L69 3BX, UK
    Bioorg Med Chem Lett 16:2991-5. 2006
  4. ncbi request reprint Design and synthesis of endoperoxide antimalarial prodrug models
    Paul M O'Neill
    Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool L69 7ZD, UK
    Angew Chem Int Ed Engl 43:4193-7. 2004
  5. ncbi request reprint Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore
    Paul M O'Neill
    Department of Chemistry, University of Liverpool, P O Box 147, Liverpool L69 3BX, UK
    Org Lett 6:3035-8. 2004

Collaborators

Detail Information

Publications5

  1. ncbi request reprint A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic beta-sulfonyl-endoperoxides
    Mario D Bachi
    Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Med Chem 46:2516-33. 2003
    ..NS. In view of the nontoxicity of beta-sulfonyl peroxides 39a, 46a, and 46b in mice, at high dosing, these compounds are regarded as promising antimalarial drug candidates...
  2. ncbi request reprint Total syntheses of Yingzhaosu A and of its C(14)-epimer including the first evaluation of their antimalarial and cytotoxic activities
    Alex M Szpilman
    Department of Organic Chemistry, The Weizmann Institute of Science, 76100 Rehovot, Israel
    J Org Chem 70:3618-32. 2005
    ..The C(14)-epiyingzhaosu A (40) exhibits potent cytotoxic activity against the KB nasal-pharyngeal cancer cell line in vitro...
  3. ncbi request reprint Diels-Alder/thiol-olefin co-oxygenation approach to antimalarials incorporating the 2,3-dioxabicyclo[3.3.1]nonane pharmacophore
    Paul M O'Neill
    Department of Chemistry, University of Liverpool, PO Box 147, Liverpool L69 3BX, UK
    Bioorg Med Chem Lett 16:2991-5. 2006
    ..Reactive C-radical intermediates of this type may be involved in the expression of the antimalarial effect of these bicyclic endoperoxides...
  4. ncbi request reprint Design and synthesis of endoperoxide antimalarial prodrug models
    Paul M O'Neill
    Department of Chemistry, The Robert Robinson Laboratories, University of Liverpool, Liverpool L69 7ZD, UK
    Angew Chem Int Ed Engl 43:4193-7. 2004
  5. ncbi request reprint Application of thiol-olefin co-oxygenation methodology to a new synthesis of the 1,2,4-trioxane pharmacophore
    Paul M O'Neill
    Department of Chemistry, University of Liverpool, P O Box 147, Liverpool L69 3BX, UK
    Org Lett 6:3035-8. 2004
    ..Manipulation of the phenylsulfenyl group in 4a allows for convenient modification to the spiro-trioxane substituents, and we describe, for the first time, the preparation of a new class of antimalarial prodrug...