R E Weber

Summary

Affiliation: University of Aarhus
Country: Denmark

Publications

  1. ncbi Enthalpic partitioning of the reduced temperature sensitivity of O2 binding in bovine hemoglobin
    Roy E Weber
    Zoophysiology, Department of Bioscience, Aarhus University, DK 8000 Aarhus C, Denmark Electronic address
    Comp Biochem Physiol A Mol Integr Physiol 176:20-5. 2014
  2. ncbi Enthalpic consequences of reduced chloride binding in Andean frog (Telmatobius peruvianus) hemoglobin
    Roy E Weber
    Zoophysiology, Department of Bioscience, Aarhus University, Aarhus, Denmark
    J Comp Physiol B 184:613-21. 2014
  3. pmc Lack of conventional oxygen-linked proton and anion binding sites does not impair allosteric regulation of oxygen binding in dwarf caiman hemoglobin
    Roy E Weber
    Zoophysiology, Department of Bioscience, Aarhus University, Aarhus, Denmark
    Am J Physiol Regul Integr Comp Physiol 305:R300-12. 2013
  4. pmc Molecular basis of a novel adaptation to hypoxic-hypercapnia in a strictly fossorial mole
    Kevin L Campbell
    Department of Biological Sciences, University of Manitoba, Winnipeg, Canada
    BMC Evol Biol 10:214. 2010
  5. pmc Globin-like proteins in Caenorhabditis elegans: in vivo localization, ligand binding and structural properties
    Eva Geuens
    Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    BMC Biochem 11:17. 2010
  6. ncbi Lacking deoxygenation-linked interaction between cytoplasmic domain of band 3 and HbF from fetal red blood cells
    R E Weber
    Zoophysiology, Institute of Biological Sciences, University of Aarhus, Universitetsparken, Aarhus C, Denmark
    Acta Physiol (Oxf) 191:247-52. 2007
  7. ncbi Isohemoglobin differentiation in the bimodal-breathing amazon catfish Hoplosternum littorale
    R E Weber
    Department of Zoophysiology, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Biol Chem 275:17297-305. 2000
  8. ncbi Functional adaptation and its molecular basis in vertebrate hemoglobins, neuroglobins and cytoglobins
    Roy E Weber
    Department of Zoophysiology, Institute of Biological Sciences, University of Aarhus, C F Møllers Alle 131, DK 8000 Aarhus C, Denmark
    Respir Physiol Neurobiol 144:141-59. 2004
  9. ncbi High-altitude adaptations in vertebrate hemoglobins
    Roy E Weber
    Zoophysiology, Institute of Biological Sciences, Building 1131, University of Aarhus, DK 8000 Aarhus, Denmark
    Respir Physiol Neurobiol 158:132-42. 2007
  10. ncbi 'Novel' factors that regulate oxygen binding in vertebrate hemoglobins
    Roy E Weber
    Zoophysiology Department, University of Aarhus, DK 8000 Aarhus C, Denmark
    Micron 35:45-6. 2004

Collaborators

Detail Information

Publications45

  1. ncbi Enthalpic partitioning of the reduced temperature sensitivity of O2 binding in bovine hemoglobin
    Roy E Weber
    Zoophysiology, Department of Bioscience, Aarhus University, DK 8000 Aarhus C, Denmark Electronic address
    Comp Biochem Physiol A Mol Integr Physiol 176:20-5. 2014
    ....
  2. ncbi Enthalpic consequences of reduced chloride binding in Andean frog (Telmatobius peruvianus) hemoglobin
    Roy E Weber
    Zoophysiology, Department of Bioscience, Aarhus University, Aarhus, Denmark
    J Comp Physiol B 184:613-21. 2014
    ..The high temperature sensitivity associated with decreased chloride binding and low phosphate sensitivity of Telmatobius Hb likely promotes cutaneous O2 uptake in cold, high-altitude ponds and streams...
  3. pmc Lack of conventional oxygen-linked proton and anion binding sites does not impair allosteric regulation of oxygen binding in dwarf caiman hemoglobin
    Roy E Weber
    Zoophysiology, Department of Bioscience, Aarhus University, Aarhus, Denmark
    Am J Physiol Regul Integr Comp Physiol 305:R300-12. 2013
    ..palpebrosus Hb provides a unique opportunity for studies on structure-function coupling and the evolution of compensatory mechanisms for maintaining tissue O2 delivery in Hbs that lack conventional effector-binding residues. ..
  4. pmc Molecular basis of a novel adaptation to hypoxic-hypercapnia in a strictly fossorial mole
    Kevin L Campbell
    Department of Biological Sciences, University of Manitoba, Winnipeg, Canada
    BMC Evol Biol 10:214. 2010
    ..g., 2,3-diphosphoglycerate; DPG), or by suppressing the sensitivity of Hb to these physiological cofactors...
  5. pmc Globin-like proteins in Caenorhabditis elegans: in vivo localization, ligand binding and structural properties
    Eva Geuens
    Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B 2610 Antwerp, Belgium
    BMC Biochem 11:17. 2010
    ..No information is available on the physicochemical properties and the in vivo expression...
  6. ncbi Lacking deoxygenation-linked interaction between cytoplasmic domain of band 3 and HbF from fetal red blood cells
    R E Weber
    Zoophysiology, Institute of Biological Sciences, University of Aarhus, Universitetsparken, Aarhus C, Denmark
    Acta Physiol (Oxf) 191:247-52. 2007
    ..g. via the major red cell membrane organising centre, band 3) between the individual oxygenation-linked reactions encountered in red cells...
  7. ncbi Isohemoglobin differentiation in the bimodal-breathing amazon catfish Hoplosternum littorale
    R E Weber
    Department of Zoophysiology, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Biol Chem 275:17297-305. 2000
    ....
  8. ncbi Functional adaptation and its molecular basis in vertebrate hemoglobins, neuroglobins and cytoglobins
    Roy E Weber
    Department of Zoophysiology, Institute of Biological Sciences, University of Aarhus, C F Møllers Alle 131, DK 8000 Aarhus C, Denmark
    Respir Physiol Neurobiol 144:141-59. 2004
    ..This review deals with the functional adaptations and the underlying molecular mechanisms in globins and presents case examples of molecular adaptations encountered in vertebrates and agnathans...
  9. ncbi High-altitude adaptations in vertebrate hemoglobins
    Roy E Weber
    Zoophysiology, Institute of Biological Sciences, Building 1131, University of Aarhus, DK 8000 Aarhus, Denmark
    Respir Physiol Neurobiol 158:132-42. 2007
    ..This treatise reviews the molecular and cellular mechanisms that adapt haemoglobin-oxygen affinities in mammals, birds and ectothermic vertebrates at high altitude...
  10. ncbi 'Novel' factors that regulate oxygen binding in vertebrate hemoglobins
    Roy E Weber
    Zoophysiology Department, University of Aarhus, DK 8000 Aarhus C, Denmark
    Micron 35:45-6. 2004
  11. ncbi Modulation of red cell glycolysis: interactions between vertebrate hemoglobins and cytoplasmic domains of band 3 red cell membrane proteins
    Roy E Weber
    Zoophysiology Department, Institute of Biological Sciences, University of Aarhus, DK 8000 Aarhus, Denmark
    Am J Physiol Regul Integr Comp Physiol 287:R454-64. 2004
    ....
  12. ncbi Hemoglobin function in deep-sea and hydrothermal-vent endemic fish: Symenchelis parasitica (Anguillidae) and Thermarces cerberus (Zoarcidae)
    Roy E Weber
    Department of Zoophysiology, C F Møllers Alle, Building 131, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Exp Biol 206:2693-702. 2003
    ..In the cathodic S. parasitica Hb, similar reduction appears to be associated with endothermic conformational changes that accompany the oxygenation reaction...
  13. doi Thermodynamics of oxygenation-linked proton and lactate binding govern the temperature sensitivity of O2 binding in crustacean (Carcinus maenas) hemocyanin
    Roy E Weber
    Zoophysiology, Department of Biological Sciences, University of Aarhus, CF Møllers Alle 1131, DK 8000 Aarhus, Denmark
    J Exp Biol 211:1057-62. 2008
    ..The data demonstrate governing roles for lactate and proton ions in determining the temperature sensitivity of hemocyanin-O2 affinity in crustaceans...
  14. ncbi Novel mechanism for high-altitude adaptation in hemoglobin of the Andean frog Telmatobius peruvianus
    Roy E Weber
    Department of Zoophysiology, University of Aarhus, 131 C F Møllers Alle, DK 8000 Aarhus C, Denmark
    Am J Physiol Regul Integr Comp Physiol 283:R1052-60. 2002
    ..The findings are discussed in relation to other strategies for high-altitude adaptations in amphibians...
  15. doi Temperature dependence of haemoglobin-oxygen affinity in heterothermic vertebrates: mechanisms and biological significance
    R E Weber
    Zoophysiology, Institute of Biological Sciences, University of Aarhus, Aarhus, Denmark
    Acta Physiol (Oxf) 202:549-62. 2011
    ..and binding sites for the same effectors, indicating multiple evolutionary origins, but convergent physiological functionality (reductions in temperature dependence of O(2) -binding affinity that safeguard tissue O(2) supply)...
  16. ncbi Nonvertebrate hemoglobins: functions and molecular adaptations
    R E Weber
    Danish Centre for Respiratory Adaptation, Department of Zoophysiology, Institute of Biology, University of Aarhus, Aarhus, Denmark
    Physiol Rev 81:569-628. 2001
    ..The divergent and convergent evolutionary trends evident in the structures and functions of nonvertebrate Hbs appear to be adaptive in extending the inhabitable environment available to Hb-containing organisms...
  17. doi ATP-induced temperature independence of hemoglobin-O2 affinity in heterothermic billfish
    Roy E Weber
    Zoophysiology, Department of Biological Sciences, Aarhus University, Bygning 1131, C F Møllers Allé 3, DK 8000 Aarhus, Denmark
    J Exp Biol 213:1579-85. 2010
    ..The mechanism underlying this reduction in oxygenation enthalpy differs fundamentally from that in tuna, supporting independent evolution of this trait in these scombroid lineages...
  18. ncbi Oxygen equilibria of cathodic eel hemoglobin analysed in terms of the MWC model and Adair's successive oxygenation theory
    R J Feuerlein
    Department of Zoophysiology, University of Aarhus, Denmark
    J Comp Physiol B 165:597-606. 1996
    ..A molecular mechanism for the reverse Bohr effect is suggested...
  19. ncbi Interaction between haemoglobin and synthetic peptides of the N-terminal cytoplasmic fragment of trout band 3 (AE1) protein
    F B Jensen
    Institute of Biology, Odense University, DK 5230 Odense M, Denmark
    J Exp Biol 201:2685-90. 1998
    ..In trout Hb IV, the presence of negatively charged Asp at position NA2 of the beta-chains (in contrast to positive or neutral residues in mammalian Hb) may weaken any interaction with the highly negatively charged peptides...
  20. ncbi Hydrogen ion titrations of the anodic and cathodic haemoglobin components of the European eel Anguilla anguilla
    C J Brauner
    Danish Center for Respiratory Adaptation, Department of Zoophysiology, Aarhus University, Building 131, Denmark
    J Exp Biol 201:2507-14. 1998
    ..We conclude that the anodic component, which constitutes two-thirds of the haemoglobin in the eel, plays the predominant role in CO2 transport and pH homeostasis in vivo...
  21. ncbi ATP-induced reverse temperature effect in isohemoglobins from the endothermic porbeagle shark (Lamna nasus)
    Christina Larsen
    Department of Zoophysiology, Institute of Biological Sciences, University of Aarhus, Building 131, 8000 Aarhus, Denmark
    J Biol Chem 278:30741-7. 2003
    ..The mechanism behind the reverse temperature effect resembles that found in the bluefin tuna (Thunnus thynnus), an endothermic teleost, thus evidencing further convergent evolution...
  22. ncbi Mutant hemoglobins (alpha 119-Ala and beta 55-Ser): functions related to high-altitude respiration in geese
    R E Weber
    Department of Zoophysiology, Aarhus University, Denmark
    J Appl Physiol (1985) 75:2646-55. 1993
    ..Adaptations securing Hb-O2 binding at extreme altitude are discussed...
  23. ncbi The anodic hemoglobin of Anguilla anguilla. Molecular basis for allosteric effects in a root-effect hemoglobin
    A Fago
    Department of Zoophysiology, Institute of Biological Sciences, Building 131, University of Aarhus, 8000 Aarhus C, Denmark
    J Biol Chem 272:15628-35. 1997
    ....
  24. ncbi Oxygen binding by single red blood cells from the red-eared turtle Trachemys scripta
    S Frische
    Danish Centre for Respiratory Adaptation, Department of Zoophysiology, University of Aarhus, 8000 Aarhus C, Denmark
    J Appl Physiol (1985) 90:1679-84. 2001
    ..The considerable variation in oxygen affinity between individual red blood cells calls for its incorporation in models of tissue oxygenation...
  25. ncbi Allosteric effect of water in fish and human hemoglobins
    Christian Hundahl
    Department of Zoophysiology, Institute of Biological Sciences, C F Møllers Alle 131, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Biol Chem 278:42769-73. 2003
    ..Addition of cofactors strongly increases the number of water molecules bound to eel hemoglobin A (as in human hemoglobin) but only weakly affects water binding to eel hemoglobin C...
  26. ncbi The archaeogastropod mollusc Haliotis iris: tissue and blood metabolites and allosteric regulation of haemocyanin function
    Jane W Behrens
    Department of Zoophysiology, Institute Biological Sciences, University of Aarhus, DK 8000 Aarhus, Denmark
    J Exp Biol 205:253-63. 2002
    ....
  27. ncbi Effects of water activity on oxygen-binding in high-molecular weight, extracellular invertebrate hemoglobin and hemocyanin
    Christian Hundahl
    Department of Zoophysiology, Institute of Biology, Building 131, University of Aarhus, Aarhus C DK 8000, Denmark
    Comp Biochem Physiol B Biochem Mol Biol 136:83-90. 2003
    ....
  28. ncbi Oxygen binding properties of non-mammalian nerve globins
    Christian Hundahl
    Zoophysiology, Institute of Biological Sciences, University of Aarhus, Denmark
    FEBS J 273:1323-9. 2006
    ..These results demonstrate a remarkable diversity in oxygenation characteristics of vertebrate and invertebrate nerve haemoglobins that clearly reflect distinct physiological roles...
  29. ncbi Functional properties of neuroglobin and cytoglobin. Insights into the ancestral physiological roles of globins
    Angela Fago
    Department of Zoophysiology, Institute of Biological Sciences, Aarhus University, Aarhus C, Denmark
    IUBMB Life 56:689-96. 2004
    ..The O2 binding properties of cytoglobin, which is upregulated upon hypoxia, are consistent with a role for this protein in O2-requiring reactions, such as those catalysed by hydroxylases...
  30. ncbi Antagonistic interaction between oxygenation-linked lactate and CO2 binding to human hemoglobin
    Mette Søby Nielsen
    Zoophysiology, Department of Biological Sciences, University of Aarhus, DK8000 Aarhus, Denmark
    Comp Biochem Physiol A Mol Integr Physiol 146:429-34. 2007
    ....
  31. ncbi Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin. Molecular mechanisms and physiological significance
    Angela Fago
    Department of Zoophysiology, Institute of Biological Sciences, C F Møllers Alle 131, Aarhus University, DK 8000 Aarhus C, Denmark
    J Biol Chem 279:44417-26. 2004
    ..In contrast, the lower O2 affinity in NGB does not appear compatible with a physiological role involving mitochondrial O2 supply at the low O2 tensions found within neurons...
  32. ncbi Effects of short-term hypoxia on neuroglobin levels and localization in mouse brain tissues
    C Hundahl
    Department of Zoophysiology, Institute of Biology, University of Aarhus, Denmark
    Neuropathol Appl Neurobiol 31:610-7. 2005
    ..The lack of Ngb up-regulation in the brain is consistent with results from previous long-term hypoxic experiments, suggesting that Ngb is not regulated by pure hypoxia in vivo...
  33. ncbi Water regulates oxygen binding in hagfish (Myxine glutinosa) hemoglobin
    Gabriele Müller
    Department of Zoophysiology, Institute of Biology, Building 131, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Exp Biol 206:1389-95. 2003
    ..Our data show that water may act as an allosteric effector for hemoglobin within intact red cells and even in animals that do not experience large variations in blood osmolality...
  34. ncbi Effects of magnesium and calcium on the oxygenation reaction of erythrocruorin from the marine polychaete Arenicola marina and the terrestrial oligochaete Lumbricus terrestris
    Takehiko Ochiai
    Department of Biology, Fukushima Medical University School of Medicine, Japan
    Zoolog Sci 19:995-1000. 2002
    ..These results reveal that Arenicola and Lumbricus belong to classes 1) and 3), respectively, and that the oxygenation function of both Ers may be controlled by effective utilization of the more dominant of the divalent cations Mg and Ca...
  35. doi Linked analysis of large cooperative, allosteric systems: the case of the giant HBL hemoglobins
    Nadja Hellmann
    Institute for Molecular Biophysics, Johannes Gutenberg University, Mainz, Germany
    Methods Enzymol 436:463-85. 2008
    ..Possible advantages of a hierarchical cooperative model compared to a linear extension of the MWC model are discussed...
  36. ncbi Respiratory adaptations in a deep-sea orbiniid polychaete from Gulf of Mexico brine pool NR-1: metabolic rates and hemoglobin structure/function relationships
    Stephane Hourdez
    Department of Biology, 208 Mueller Lab, Pennsylvania State University, University Park, PA 16802, USA
    J Exp Biol 205:1669-81. 2002
    ..However, these polychaetes can withstand extended periods of anoxia both in the absence and presence of 1 mmol l(-1) sulfide (TL50=approx. 5.5 and 4 days, respectively)...
  37. ncbi Reactivity studies of the Fe(III) and Fe(II)NO forms of human neuroglobin reveal a potential role against oxidative stress
    Susanna Herold
    Laboratorium für Anorganische Chemie, Eidgenossische Technische Hochschule Honggerberg, CH 8093 Zurich, Switzerland
    J Biol Chem 279:22841-7. 2004
    ..Taken together, our data indicate that human neuroglobin may be an efficient scavenger of reactive oxidizing species and thus may play a role in the cellular defense against oxidative stress...
  38. ncbi Oxygen binding and its allosteric control in hemoglobin of the primitive branchiopod crustacean Triops cancriformis
    Ralph Pirow
    Institute of Zoophysiology, University of Munster, Germany
    FEBS J 274:3374-91. 2007
    ....
  39. ncbi Does altitudinal difference modulate the respiratory properties in subterranean rodents' (Cryptomys hottentotus mahali) blood?
    Marna S Broekman
    Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Pretoria 0002, South Africa
    Physiol Behav 88:77-81. 2006
    ..The data indicate that the oxygen-transporting properties of mole-rat blood do not change markedly with increased elevation and that burrowing mammals are a priori hypoxia-adapted...
  40. ncbi Nested allosteric interactions in extracellular hemoglobin of the leech Macrobdella decora
    Nadja Hellmann
    Institute for Molecular Biophysics, University of Mainz, Jakob Welder Weg 26, 55128 Mainz, Germany
    J Biol Chem 278:44355-60. 2003
    ..Thus, besides hemocyanins and GroEL, the hexagonal bilayer hemoglobins represent another class of proteins in which the hierarchical quaternary structure provides the basis for nested interaction in their functional properties...
  41. ncbi Temperature alters the respiratory surface area of crucian carp Carassius carassius and goldfish Carassius auratus
    Jørund Sollid
    Department of Molecular Biosciences, University of Oslo, PO Box 1041, N 0316 Oslo, Norway
    J Exp Biol 208:1109-16. 2005
    ..As ambient oxygen and temperature can both induce the remodelling of the gills, the response appears primarily to be an adaptation to the oxygen demand of the fish...
  42. ncbi Molecular and functional adaptations in deep-sea hemoglobins
    Stephane Hourdez
    Equipe Ecophysiologie, CNRS UPMC UMR 7127, Station Biologique, 29680 Roscoff, France
    J Inorg Biochem 99:130-41. 2005
    ..These high affinities permit uptake of oxygen from hypoxic waters and the strong Bohr effects favor its release in the metabolizing acidic organs...
  43. ncbi Neuroglobin and cytoglobin in search of their role in the vertebrate globin family
    Thomas Hankeln
    Institute of Molecular Genetics, Johannes Gutenberg University of Mainz, D 55099 Mainz, Germany
    J Inorg Biochem 99:110-9. 2005
    ..Cytoglobin is predominantly expressed in fibroblasts and related cell types, but also in distinct nerve cell populations. Much less is known about its function, although in fibroblasts it might be involved in collagen synthesis...
  44. ncbi Characterization of a globin-coupled oxygen sensor with a gene-regulating function
    Liesbet Thijs
    Department of Biomedical Sciences, University of Antwerp, Universiteitsplein 1, B 2610, Antwerp, Belgium
    J Biol Chem 282:37325-40. 2007
    ..Besides sensing ligands, in vitro data suggest that AvGReg(178) may have a role in O(2)-mediated NO-detoxification, yielding metAvGReg(178) and nitrate...
  45. ncbi Erythrocyte signal transduction pathways, their oxygenation dependence and functional significance
    Nadezhda N Barvitenko
    I M Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St Petersburg
    Cell Physiol Biochem 15:1-18. 2005
    ....