P Videbech

..Furthermore, discontinuation of the drug should be tried after a couple of months, as one study suggests that the effect wears off. In addition, the drug is rather expensive...

..Furthermore, we wanted to compare the regions-of-interest (ROI) method with the functions-of-interest (FOI) approach...

..This situation mandates an investigation whether this leads to health-related problems...

..The authors performed a systematic review and meta-analysis of volumetric studies of the hippocampus in patients with mood disorders...

..We thus partly explain the poorer performance by increased frequency of WML in frontostriatal pathways in the depressed patients, impairing neurotransmission...

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..This is in accordance with a rapidly expanding literature suggesting an important role for this structure in major depression...

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..To clarify the relationship between cognitive functions and regional cerebral blood flow (rCBF) in a large group of depressed patients compared with healthy controls...

..Vascular risk factors such as hypertension and smoking may confound such findings. Our aim was to investigate the association between the localization and load of WMLs in late-onset MD with respect to vascular risk factors...

..To determine whether long-term course of treated major depression has an effect on the structure of the brain and the hippocampal volume...

..The group analysis did not allow any hypothesis on a possible pattern to the dysfunctions, but heterogeneity in the test performances calls for further analysis of the data in patient subgroups in relation to neuroimaging results...

..These results bring this latter test closer to being a specific test of prefrontal function...

..In conclusion, depression severity correlates with the tract-specific localization of WMLs. WMLs have a pronounced effect on white matter integrity in the pathways they intersect...

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..In 2005, a Neuropsychiatric Unit was established at the Psychiatric Hospital in Aarhus, Denmark to assess all patients with late-onset depression using a standard neuropsychiatric assessment program...

..The findings of the study may underline the importance of investigating bodily symptoms in depression and indicates a need for a specific physiotherapeutic treatment of patients with moderate to severe depression...

..It is particularly important to diagnose and treat depression in HCV patients as it constitutes a relative contraindication to antiviral treatment and may jeopardize therapeutic outcome...

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..We want to know whether nonresponse to antidepressants can be linked to aberrant neuroreceptor binding...

..From this perspective, patients may also gain useful insight into their own condition. Medical and psychological treatment interventions can be applied on different levels particularly in relation to the cognitive symptoms of depression...

..Unwanted effects led to considerable patient drop-out and premature termination of the study. The result suggests that alternative treatment delivery technology should be considered...

..The differential effect of ECT on depression score and pain processing indicate that mood and noxious processing are not medicated directly by the same systems but that a complex relationship between pain and depression exists...

..Studies investigating mortality secondary to electroconvulsive therapy (ECT) are few...

..The ECT continued, and the patient was successfully treated for the condition with administration of i.v. diazepam (5 mg) shortly after the end of each seizure...

..Use of electroconvulsive therapy (ECT) may have changed during the last decades due to advances in psychopharmacology and organizational changes of psychiatric care...