L L Thomsen

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint The genetic spectrum of a population-based sample of familial hemiplegic migraine
    L L Thomsen
    Danish Headache Center, University of Copenhagen, Department of Neurology Glostrup Hospital, Copenhagen, Denmark
    Brain 130:346-56. 2007
  2. ncbi request reprint Sporadic hemiplegic migraine
    L L Thomsen
    Danish Headache Centre, University of Copenhagen and Department of Neurology, Glostrup University Hospital, Glostrup, Copenhagen, 2600 Denmark
    Cephalalgia 24:1016-23. 2004
  3. doi request reprint Screen for CACNA1A and ATP1A2 mutations in sporadic hemiplegic migraine patients
    L L Thomsen
    Danish Headache Centre, University of Copenhagen, Department of Neurology, Glostrup Hospital, Glostrup, Denmark
    Cephalalgia 28:914-21. 2008
  4. ncbi request reprint Sporadic hemiplegic migraine is an aetiologically heterogeneous disorder
    L L Thomsen
    The Danish Headache Centre, University of Copenhagen, Department of Neurology, Glostrup Hospital, Denmark
    Cephalalgia 23:921-8. 2003
  5. ncbi request reprint Increased risk of migraine with typical aura in probands with familial hemiplegic migraine and their relatives
    L L Thomsen
    Department of Neurology, The Danish Headache Center, Glostrup Hospital, University of Copenhagen, Denmark
    Eur J Neurol 10:421-7. 2003
  6. ncbi request reprint Evidence for a separate type of migraine with aura: sporadic hemiplegic migraine
    Lise L Thomsen
    Danish Headache Center, Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Neurology 60:595-601. 2003
  7. ncbi request reprint An epidemiological survey of hemiplegic migraine
    L Lykke Thomsen
    The Danish Headache Center, University of Copenhagen, Department of Neurology, Glostrup Hospital, Ndr Ringvej Ringvej 57, DK 2600 Glostrup, Denmark
    Cephalalgia 22:361-75. 2002
  8. doi request reprint Delayed migraine-like headache in healthy volunteers after a combination of acetazolamide and glyceryl trinitrate
    D Daugaard
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Copenhagen, Denmark
    Cephalalgia 29:1294-300. 2009
  9. doi request reprint Familial hemiplegic migraine type 2 does not share hypersensitivity to nitric oxide with common types of migraine
    J M Hansen
    Danish Headache Centre and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Cephalalgia 28:367-75. 2008
  10. ncbi request reprint Effects of the non-selective phosphodiesterase inhibitor pentoxifylline on regional cerebral blood flow and large arteries in healthy subjects
    C Kruuse
    Department of Neurology, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup Copenhagen, Denmark
    Eur J Neurol 7:629-38. 2000

Collaborators

Detail Information

Publications23

  1. ncbi request reprint The genetic spectrum of a population-based sample of familial hemiplegic migraine
    L L Thomsen
    Danish Headache Center, University of Copenhagen, Department of Neurology Glostrup Hospital, Copenhagen, Denmark
    Brain 130:346-56. 2007
    ..The existence of many small families in the Danish FHM cohort may reflect less bias in FHM family ascertainment and/or more locus heterogeneity than described previously...
  2. ncbi request reprint Sporadic hemiplegic migraine
    L L Thomsen
    Danish Headache Centre, University of Copenhagen and Department of Neurology, Glostrup University Hospital, Glostrup, Copenhagen, 2600 Denmark
    Cephalalgia 24:1016-23. 2004
    ..All cases with motor weakness should be classified as either FHM or SHM...
  3. doi request reprint Screen for CACNA1A and ATP1A2 mutations in sporadic hemiplegic migraine patients
    L L Thomsen
    Danish Headache Centre, University of Copenhagen, Department of Neurology, Glostrup Hospital, Glostrup, Denmark
    Cephalalgia 28:914-21. 2008
    ..Only very few DNA variants were identified in 100 SHM patients, and regardless of whether the identified variants are causal the CACNA1A and ATP1A2 genes are not major genes in SHM...
  4. ncbi request reprint Sporadic hemiplegic migraine is an aetiologically heterogeneous disorder
    L L Thomsen
    The Danish Headache Centre, University of Copenhagen, Department of Neurology, Glostrup Hospital, Denmark
    Cephalalgia 23:921-8. 2003
    ..Our data suggest that SHM is a genetically heterogeneous disorder...
  5. ncbi request reprint Increased risk of migraine with typical aura in probands with familial hemiplegic migraine and their relatives
    L L Thomsen
    Department of Neurology, The Danish Headache Center, Glostrup Hospital, University of Copenhagen, Denmark
    Eur J Neurol 10:421-7. 2003
    ..These results are contrary to a sharing of genetic mechanisms between FHM and MO. Furthermore, they suggest that the genetic abnormality causing FHM may also cause attacks with the symptomatology of MA...
  6. ncbi request reprint Evidence for a separate type of migraine with aura: sporadic hemiplegic migraine
    Lise L Thomsen
    Danish Headache Center, Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Neurology 60:595-601. 2003
    ..To compare clinical characteristics of patients with sporadic hemiplegic migraine (SHM) with those of patients with migraine with typical aura (MA) and patients with familial hemiplegic migraine (FHM)...
  7. ncbi request reprint An epidemiological survey of hemiplegic migraine
    L Lykke Thomsen
    The Danish Headache Center, University of Copenhagen, Department of Neurology, Glostrup Hospital, Ndr Ringvej Ringvej 57, DK 2600 Glostrup, Denmark
    Cephalalgia 22:361-75. 2002
    ..The HM sex ratio (M:F) was 1:3. Based on the identified number of affected patients the prevalence of HM at the end of 1999 was estimated to be 0.01% in Denmark, where the familial and sporadic form were equally frequent...
  8. doi request reprint Delayed migraine-like headache in healthy volunteers after a combination of acetazolamide and glyceryl trinitrate
    D Daugaard
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Copenhagen, Denmark
    Cephalalgia 29:1294-300. 2009
    ..The fact that a suitable pharmacological intervention may trigger migraine in individuals with no prior migraine may suggest that the ability to develop migraine without aura is a quantitative genetic trait...
  9. doi request reprint Familial hemiplegic migraine type 2 does not share hypersensitivity to nitric oxide with common types of migraine
    J M Hansen
    Danish Headache Centre and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Cephalalgia 28:367-75. 2008
    ..GTN infusion failed to induce more migraine in FHM-2 patients than in controls. The pathophysiological pathways underlying migraine headache in FHM-2 may be different from the common types of migraine...
  10. ncbi request reprint Effects of the non-selective phosphodiesterase inhibitor pentoxifylline on regional cerebral blood flow and large arteries in healthy subjects
    C Kruuse
    Department of Neurology, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup Copenhagen, Denmark
    Eur J Neurol 7:629-38. 2000
    ..A possible minor dilatation of the middle cerebral artery and the temporal artery cannot be excluded. Any potential clinical effect of pentoxifylline is most likely mediated through non-vascular mechanisms...
  11. ncbi request reprint A population-based study of familial hemiplegic migraine suggests revised diagnostic criteria
    L L Thomsen
    Copenhagen Headache Center, Department of Neurology, Glostrup Hospital, Denmark
    Brain 125:1379-91. 2002
    ..Our results have significant implications for case finding in genetic studies and for clinical migraine differential diagnosis...
  12. ncbi request reprint Clinical characteristics of 362 patients with familial migraine with aura
    M K Eriksen
    Danish Headache Center, University of Copenhagen
    Cephalalgia 24:564-75. 2004
    ..There seems to be a correlation between more severe symptoms and familial aggregation. These results have both clinical and scientific implications...
  13. doi request reprint Familial hemiplegic migraine type 1 shows no hypersensitivity to nitric oxide
    J M Hansen
    Danish Headache Centre and Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Copenhagen, Denmark
    Cephalalgia 28:496-505. 2008
    ..This indicates that the pathophysiological pathways underlying migraine headache in FHM-1 may be different from the common types of migraine...
  14. ncbi request reprint The effect of propranolol on glyceryltrinitrate-induced headache and arterial response
    J F Tvedskov
    Danish Headache Centre, University of Copenhagen and Department of Neurology, Glostrup University Hospital, Glostrup, Denmark
    Cephalalgia 24:1076-87. 2004
    ..Propranolol does not constrict cerebral arteries, which therefore cannot be part of its mechanism of action in migraine...
  15. ncbi request reprint Prognosis of migraine with aura
    M K Eriksen
    Danish Headache Centre, Department of Neurology, University of Copenhagen, Glostrup Hospital, Nordre Ringvej 57, DK 2600 Glostrup, Denmark
    Cephalalgia 24:18-22. 2004
    ..Among those with attacks of MA at follow-up frequency of attacks and headache intensity was improved in 44% and 41% of the patients, respectively. The results point to a favourable evolution of MA and suggest possible predictive factors...
  16. pmc Sensitivity and specificity of the new international diagnostic criteria for migraine with aura
    M K Eriksen
    Danish Headache Center, University of Copenhagen, Department of Neurology, Glostrup Hospital, Nordre Ringvej 57, DK 2600 Glostrup, Denmark
    J Neurol Neurosurg Psychiatry 76:212-7. 2005
    ..Here we present the data underlying the new criteria for MA in the ICHD-2 classification...
  17. ncbi request reprint New international classification of migraine with aura (ICHD-2) applied to 362 migraine patients
    M K Eriksen
    Danish Headache Center, Department of Neurology, Glostrup Hospital, University of Copenhagen, Copenhagen, Denmark
    Eur J Neurol 11:583-91. 2004
    ..The variations between ICHD-2 subtypes of MA indicate that patients with similar subtype of MA share phenotype and very likely have similar underlying aetiology...
  18. ncbi request reprint The prophylactic effect of valproate on glyceryltrinitrate induced migraine
    J F Tvedskov
    Danish Headache Centre, University of Copenhagen
    Cephalalgia 24:576-85. 2004
    ..The size of the effect was similar to that of valproate in clinical trials. The GTN model may therefore be a valid tool for testing new prophylactic antimigraine drugs...
  19. ncbi request reprint The Visual Aura Rating Scale (VARS) for migraine aura diagnosis
    M K Eriksen
    Danish Headache Center, University of Copenhagen, and Department of Neurology, Glostrup Hospital, Nordre Ringvej 57, DK 2600 Glostrup, Denmark
    Cephalalgia 25:801-10. 2005
    ..VARS adds evidence based weights to a number of clearly specified characteristics; it is easy to learn, apply and teach and may therefore be a valuable addition to traditional ICHD-2 diagnosis...
  20. doi request reprint Habituation of evoked responses is greater in patients with familial hemiplegic migraine than in controls: a contrast with the common forms of migraine
    J M Hansen
    Danish Headache Center, Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, DK 2600 Glostrup, Copenhagen, Denmark
    Eur J Neurol 18:478-85. 2011
    ..FHM and the common forms of migraine are thought to belong to a spectrum of migraine phenotypes with similar pathophysiology, and we therefore examined whether an abnormal habituation pattern would also be found in FHM patients...
  21. ncbi request reprint Nitric oxide in primary headaches
    L L Thomsen
    Department of Neurology, The Lundbeck Institute, Skodsborg, Denmark
    Curr Opin Neurol 14:315-21. 2001
    ..Pilot trials have shown efficacy of a nitric oxide synthase inhibitor in both migraine attacks and chronic tension-type headache. These observations suggest new approaches to the pharmacological treatment of headache...
  22. pmc No relation between cephalic venous dilatation and pain in migraine
    D Daugaard
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    J Neurol Neurosurg Psychiatry 65:260-2. 1998
    ....
  23. ncbi request reprint Plasma levels of cAMP, cGMP and CGRP in sildenafil-induced headache
    C Kruuse
    Danish Headache Centre, University of Copenhagen
    Cephalalgia 24:547-53. 2004
    ....