P C Tfelt-Hansen

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. pmc Nitric oxide-induced headache may arise from extracerebral arteries as judged from tolerance to isosorbide-5-mononitrate
    Ingelise Christiansen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    J Headache Pain 9:215-20. 2008
  2. ncbi Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy
    P Tfelt-Hansen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Drugs 60:1259-87. 2000
  3. ncbi Increasing the effect of triptans in migraine
    Peer Tfelt-Hansen
    Danish Headache Centre, Department of Neurology, University of Copenhagen, Glostrup Hospital, DK 2600 Glostrup, Denmark
    Lancet 368:1313-4. 2006
  4. ncbi A review of evidence-based medicine and meta-analytic reviews in migraine
    P Tfelt-Hansen
    Danish Headache Centre, Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    Cephalalgia 26:1265-74. 2006
  5. pmc Treatment with sumatriptan 50 mg in the mild phase of migraine attacks in patients with infrequent attacks: a randomised, double-blind, placebo-controlled study
    Peer Tfelt-Hansen
    Danish Headache Center, Department of Neurology, University of Copenhagen, Glostrup Hospital, DK 2600, Glostrup, Denmark
    J Headache Pain 7:389-94. 2006
  6. ncbi [Cluster headache (Horton's headache)]
    Peer Tfelt-Hansen
    Amtssygehuset i Glostrup, Dansk Hovedpinecenter, Neurologisk afdeling, Glostrup
    Ugeskr Laeger 168:4417-22. 2006
  7. pmc Acute pharmacotherapy of migraine, tension-type headache, and cluster headache
    Peer Tfelt-Hansen
    Dept of Neurology, Glostrup Hospital, DK 2600, Glostrup, Denmark
    J Headache Pain 8:127-34. 2007
  8. ncbi Pharmacokinetic and pharmacodynamic variability as possible causes for different drug responses in migraine. A comment
    P Tfelt-Hansen
    Danish Headache Centre, Depatment of Neurology, Glostrup Hospital, DK 2600 Glostrup, Denmark
    Cephalalgia 27:1091-3. 2007
  9. ncbi Over-the-counter triptans for migraine : what are the implications?
    Peer Tfelt-Hansen
    Department of Neurology, Danish Headache Centre, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    CNS Drugs 21:877-83. 2007
  10. pmc Parenteral vs. oral sumatriptan and naratriptan: plasma levels and efficacy in migraine. a comment
    Peer Tfelt-Hansen
    Danish Headache Centre, Department of Neurology, University of Copenhagen, Glostrup Hospital, DK 2600, Glostrup, Denmark
    J Headache Pain 8:273-6. 2007

Detail Information

Publications35

  1. pmc Nitric oxide-induced headache may arise from extracerebral arteries as judged from tolerance to isosorbide-5-mononitrate
    Ingelise Christiansen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    J Headache Pain 9:215-20. 2008
    ..Due to a variety of other possible pain-inducing effects of nitric oxide our results do not exclude cerebral arteries...
  2. ncbi Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy
    P Tfelt-Hansen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark
    Drugs 60:1259-87. 2000
    ..The place of triptans compared with non-triptan drugs in migraine therapy remains to be established and further RCTs are required...
  3. ncbi Increasing the effect of triptans in migraine
    Peer Tfelt-Hansen
    Danish Headache Centre, Department of Neurology, University of Copenhagen, Glostrup Hospital, DK 2600 Glostrup, Denmark
    Lancet 368:1313-4. 2006
  4. ncbi A review of evidence-based medicine and meta-analytic reviews in migraine
    P Tfelt-Hansen
    Danish Headache Centre, Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    Cephalalgia 26:1265-74. 2006
    ..Head-to-head comparisons should remain the 'gold standard' and meta-analyses are a useful supplement in cases when comparative trials are relatively small and when no comparative trials exist...
  5. pmc Treatment with sumatriptan 50 mg in the mild phase of migraine attacks in patients with infrequent attacks: a randomised, double-blind, placebo-controlled study
    Peer Tfelt-Hansen
    Danish Headache Center, Department of Neurology, University of Copenhagen, Glostrup Hospital, DK 2600, Glostrup, Denmark
    J Headache Pain 7:389-94. 2006
    ..003) and most AEs were mild or moderate. In this migraine population with infrequent attacks, sumatriptan was superior to placebo and was generally well tolerated...
  6. ncbi [Cluster headache (Horton's headache)]
    Peer Tfelt-Hansen
    Amtssygehuset i Glostrup, Dansk Hovedpinecenter, Neurologisk afdeling, Glostrup
    Ugeskr Laeger 168:4417-22. 2006
    ..The attack can be treated with oxygen or subcutaneous sumatriptan, and verapamil, ergotamine and prednisolone can be successfully used for prophylaxis. Early diagnosis and specific treatment are emphazised...
  7. pmc Acute pharmacotherapy of migraine, tension-type headache, and cluster headache
    Peer Tfelt-Hansen
    Dept of Neurology, Glostrup Hospital, DK 2600, Glostrup, Denmark
    J Headache Pain 8:127-34. 2007
    ..Only 17-32% become pain free after these drugs. For attacks of cluster headache oxygen and subcutaneous sumatriptan can be used. Intranasal triptans can be an alternative...
  8. ncbi Pharmacokinetic and pharmacodynamic variability as possible causes for different drug responses in migraine. A comment
    P Tfelt-Hansen
    Danish Headache Centre, Depatment of Neurology, Glostrup Hospital, DK 2600 Glostrup, Denmark
    Cephalalgia 27:1091-3. 2007
    ..In theory, there should probably be a 10-fold variation in doses available, but in clinical practice a fourfold difference in doses will probably cover the needs of most patients...
  9. ncbi Over-the-counter triptans for migraine : what are the implications?
    Peer Tfelt-Hansen
    Department of Neurology, Danish Headache Centre, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    CNS Drugs 21:877-83. 2007
    ..We welcome this development, but recognise that advice at the point of sale is crucial for effective and safe use of these drugs...
  10. pmc Parenteral vs. oral sumatriptan and naratriptan: plasma levels and efficacy in migraine. a comment
    Peer Tfelt-Hansen
    Danish Headache Centre, Department of Neurology, University of Copenhagen, Glostrup Hospital, DK 2600, Glostrup, Denmark
    J Headache Pain 8:273-6. 2007
    ..This most likely due to a quicker rise in blood concentrations after subcutaneous injections.. In designing new therapies for migraine one should aim at a quick absorption of the drug, which will probably result in an increased efficacy...
  11. pmc Pharmacogenomics and migraine: possible implications
    Peer Tfelt-Hansen
    Danish Headache Centre, Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup 2600, Denmark
    J Headache Pain 9:13-8. 2008
    ..Pharmacogenomics will most likely in the future be one part of our therapeutic armamentarium and will provide a stronger scientific basis for optimizing drug therapy on the basis of each patient's genetic constitution...
  12. doi History of the use of ergotamine and dihydroergotamine in migraine from 1906 and onward
    P C Tfelt-Hansen
    Danish Headache Centre, Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    Cephalalgia 28:877-86. 2008
    ..In an American review of 2003 it was suggested that ergotamine may be considered in the treatment of selected patients with moderate to severe migraine...
  13. doi Maximum effect of triptans in migraine? A comment
    P Tfelt-Hansen
    Danish Headache Centre, Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    Cephalalgia 28:767-8. 2008
    ..These results indicate that subcutaneous naratriptan in a high dose can overcome central sensitization that occurs in migraine attacks...
  14. ncbi [Triptanes in the treatment of migraine. A review based on three Cochrane reviews]
    Peer Tfelt-Hansen
    Dansk Hovedpinecenter, Amtssygehuset i Glostrup, Neurologisk afdeling, Glostrup
    Ugeskr Laeger 168:1850-3. 2006
  15. pmc Understanding clinical trials in migraine
    Peer Tfelt-Hansen
    The Danish Headache Center, Department of Neurology, University of Copenhagen, Glostrup Hospital, DK 2600, Glostrup, Denmark
    J Headache Pain 7:101-8. 2006
    ..Relationship between meta-analyses and head-to-head comparative trials is reviewed; and it is concluded that head-to-head comparisons remain the "golden standard" with meta-analyses as a useful supplement...
  16. ncbi History of headache research in Denmark
    P Tfelt-Hansen
    Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    Cephalalgia 21:748-52. 2001
    ..From the middle of the 1980s the pathophysiology of tension-type headache has been investigated and recent results indicate central sensitization in patients with chronic tension-type headache...
  17. pmc The effect of rizatriptan, ergotamine, and their combination on human peripheral arteries: a double-blind, placebo-controlled, crossover study in normal subjects
    Peer Tfelt-Hansen
    Department of Neurology, Bispebjerg Hospital, Copenhagen, Denmark
    Br J Clin Pharmacol 54:38-44. 2002
    ..To compare the peripheral vasoconstrictor effects of ergotamine, rizatriptan, and their combination, in normal subjects...
  18. ncbi [Use of propranolol for migraine prophylaxis]
    Peer Tfelt-Hansen
    Amtssygehuset i Glostrup, Dansk Hovedpinecenter, Neurologisk afdeling
    Ugeskr Laeger 167:1181-3. 2005
  19. ncbi Sum of Pain Intensity Differences (SPID) in migraine trials. A comment based on four rizatriptan trials
    P Tfelt-Hansen
    Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    Cephalalgia 22:664-6. 2002
    ..In assessing treatment response (rizatriptan and sumatriptan versus placebo, rizatriptan versus sumatriptan, within-treatment dose effects), SPID usually yielded similar results to the more easily understood pain-free measure...
  20. ncbi Ergotamine, dihydroergotamine: current uses and problems
    P Tfelt-Hansen
    Department of Neurology, Glostrup Hospital, Glostrup, Denmark
    Curr Med Res Opin 17:s30-4. 2001
    ..The intranasal dose of DHE , between 1 and 2 mg, should also be tailored to the individual patient. In order to avoid drug-induced headache ergotamine and DHE should not be used daily...
  21. doi History of migraine with aura and cortical spreading depression from 1941 and onwards
    P C Tfelt-Hansen
    Department of Neurology, University of Copenhagen, Glostrup Hospital, Danish Headache Centre, Glostrup, Denmark
    Cephalalgia 30:780-92. 2010
    ..They moved attention from ischaemia to CSD and thereby to the brain itself, and paved the way for subsequent discoveries of brainstem mechanisms...
  22. ncbi The phosphodiesterase 3 inhibitor cilostazol dilates large cerebral arteries in humans without affecting regional cerebral blood flow
    Steffen Birk
    Danish Headache Center and Department of Neurology, University of Copenhagen, Glostrup University Hospital, Glostrup, Copenhagen, Denmark
    J Cereb Blood Flow Metab 24:1352-8. 2004
    ..6 +/- 8.6% (P < 0.001 vs. baseline). Adverse events, especially headache, were common. The findings suggest that cilostazol is an interesting candidate for future clinical trials of delayed cerebral vasospasm...
  23. doi Triptans vs other drugs for acute migraine. Are there differences in efficacy? A comment
    Peer Tfelt-Hansen
    Danish Headache Centre, Department of Neurology, University of Copenhagen, Glostrup Hospital, Glostrup, Denmark
    Headache 48:601-5. 2008
    ..It is suggested that based on current evidence, effervescent aspirin should be the first-line drug for the treatment of migraine. Aspirin is also much cheaper than the triptans...
  24. ncbi [Numbness of the chin as a paraneoplastic syndrome]
    Cornelia Rogojan
    Neurologisk afdeling, Glostrup Hospital, DK 2600 Glostrup
    Ugeskr Laeger 170:3135-6. 2008
    ..She was operated for a localised thyroid cancer. At follow-up, 6 years later, she was in good health without any symptoms apart from numbness of the chin...
  25. pmc Contractile responses to ergotamine and dihydroergotamine in the perfused middle cerebral artery of rat
    Peer Tfelt-Hansen
    Department of Neurology, Copenhagen University Hospital, Glostrup, Denmark
    J Headache Pain 8:83-9. 2007
    ..The contractions were typically slow in on and off set (about 30-60 min). The long duration of ergots should be investigated further in an attempt to design drugs with less recurrence...
  26. ncbi Rofecoxib in the acute treatment of migraine: a randomized controlled clinical trial
    Joel Saper
    Michigan Head Pain and Neurological Institute, Ann Arbor, USA
    Headache 46:264-75. 2006
    ..To investigate the efficacy, tolerability, and safety of rofecoxib and ibuprofen for acute migraine treatment...
  27. ncbi Triptan medications to treat acute migraine
    Peer Tfelt-Hansen
    Lancet 359:1152; author reply 1152-3. 2002
  28. doi Acute migraine therapy: recent evidence from randomized comparative trials
    Anna Mett
    Wolters Kluwer Health Adis, Auckland, New Zealand
    Curr Opin Neurol 21:331-7. 2008
    ..5) It is unclear whether triptans offer clinically relevant benefits over aspirin or NSAIDs in migraine patients. Thus NSAIDs, particularly effervescent aspirin, should be considered the first-line treatment of migraine attacks...
  29. ncbi The truth about frovatriptan
    Peer Tfelt-Hansen
    Headache 43:699-700; author reply 697-9. 2003
  30. doi Predictors of migraine headache recurrence: a pooled analysis from the eletriptan database
    David W Dodick
    Department of Neurology, Mayo Clinic, Scottsdale, AZ 85259, USA
    Headache 48:184-93. 2008
    ....
  31. ncbi Topiramate in migraine prophylaxis--results from a placebo-controlled trial with propranolol as an active control
    Hans Christoph Diener
    Department of Neurology, University Essen, Hufelandstr 55, 45122 Essen, Germany
    J Neurol 251:943-50. 2004
    ..No unusual or unexpected safety risks emerged. These findings demonstrate that TPM 100 mg/d is effective in migraine prophylaxis. TPM 100 mg/d and PROP 160 mg/d exhibited similar efficacy profiles...
  32. ncbi Endothelium-dependent relaxant responses to selective 5-HT(1B/1D) receptor agonists in the isolated middle cerebral artery of the rat
    Jacob Hansen-Schwartz
    Department of Internal Medicine, University Hospital of Lund, Lund, Sweden
    J Vasc Res 40:561-6. 2003
    ..The difference in observations between the experimental models may be related to the maintenance of shear stress in the arteriograph...
  33. ncbi Methodological issues in systematic reviews of headache trials: adapting historical diagnostic classifications and outcome measures to present-day standards
    Douglas C McCrory
    Duke University Medical Center, Center for Clinical Health Policy Research Durham, NC, USA
    Headache 45:459-65. 2005
    ....
  34. ncbi Efficacy of frovatriptan
    Peer Tfelt-Hansen
    Headache 47:934; discussion 934. 2007
  35. ncbi Gastric emptying in migraine
    Peer Tfelt-Hansen
    Headache 47:929; author reply 929-30. 2007