Per Svenningsen

Summary

Affiliation: University of Southern Denmark
Country: Denmark

Publications

  1. doi request reprint Proteinuric diseases with sodium retention: Is plasmin the link?
    Per Svenningsen
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
    Clin Exp Pharmacol Physiol 39:117-24. 2012
  2. doi request reprint Urinary plasmin activates collecting duct ENaC current in preeclampsia
    Kristian B Buhl
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, J B Winsløwsvej 21, 3 DK 5000, Odense C, Denmark
    Hypertension 60:1346-51. 2012
  3. doi request reprint Regulation of renin secretion by renal juxtaglomerular cells
    Ulla G Friis
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, J B Winslowsvej 21, 3, 5000, Odense C, Denmark
    Pflugers Arch 465:25-37. 2013
  4. pmc Hypotonicity-induced Renin exocytosis from juxtaglomerular cells requires aquaporin-1 and cyclooxygenase-2
    Ulla G Friis
    Department of Physiology and Pharmacology, Institute of Medical Biology, University of Southern Denmark, DK 5000 Odense, Denmark
    J Am Soc Nephrol 20:2154-61. 2009
  5. doi request reprint Histamine-dependent prolongation by aldosterone of vasoconstriction in isolated small mesenteric arteries of the mouse
    Jeppe Schjerning
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Denmark
    Am J Physiol Heart Circ Physiol 304:H1094-102. 2013
  6. doi request reprint Physiological regulation of epithelial sodium channel by proteolysis
    Per Svenningsen
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, and Department of Nephrology Y, Odense University Hospital, Odense, Denmark
    Curr Opin Nephrol Hypertens 20:529-33. 2011
  7. doi request reprint T-type Ca(2+) channels facilitate NO-formation, vasodilatation and NO-mediated modulation of blood pressure
    Per Svenningsen
    Department of Cardiovascular and Renal Research, University of Southern Denmark, Winsløwparken 21, 3, Odense, DK 5000, Denmark
    Pflugers Arch 466:2205-14. 2014
  8. doi request reprint Plasmin in urine from patients with type 2 diabetes and treatment-resistant hypertension activates ENaC in vitro
    Kristian B Buhl
    aDepartment of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark bDepartment of Endocrinology, Research Unit for Cardiovascular and Metabolic Prevention cDepartment of Nephrology, Odense University Hospital, Odense, Denmark
    J Hypertens 32:1672-7; discussion 1677. 2014
  9. doi request reprint Diabetic nephropathy is associated with increased urine excretion of proteases plasmin, prostasin and urokinase and activation of amiloride-sensitive current in collecting duct cells
    Henrik Andersen
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense C, Denmark Department of Endocrinology, Odense University Hospital, Odense C, Denmark
    Nephrol Dial Transplant 30:781-9. 2015
  10. doi request reprint Urinary serine proteases and activation of ENaC in kidney--implications for physiological renal salt handling and hypertensive disorders with albuminuria
    Per Svenningsen
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
    Pflugers Arch 467:531-42. 2015

Collaborators

  • Ulla G Friis
  • Ole Skøtt
  • Paul M Vanhoutte
  • Kirsten Madsen
  • Hee Sup Shin
  • Boye L Jensen
  • Kristian B Buhl
  • Henrik Andersen
  • Maria Ravn Nielsen
  • Pernille B L Hansen
  • Britta Frederiksen-Møller
  • Jeppe Schjerning
  • Claus Bistrup
  • Rikke M Zachar
  • Mie Rytz
  • Jan Stener Jørgensen
  • Jan Erik Henriksen
  • Boye Lagerbon Jensen
  • Christina S Oxlund
  • Ib A Jacobsen
  • Torben R Uhrenholt
  • Bente Jespersen
  • Per Ovesen
  • Ambika Gulaveerasingam

Detail Information

Publications12

  1. doi request reprint Proteinuric diseases with sodium retention: Is plasmin the link?
    Per Svenningsen
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
    Clin Exp Pharmacol Physiol 39:117-24. 2012
    ..7. In this review, we will examine the evidence for a role of urinary serine protease activity in the development of sodium and water retention in diseases characterised by proteinuria with a focus on nephrotic syndrome...
  2. doi request reprint Urinary plasmin activates collecting duct ENaC current in preeclampsia
    Kristian B Buhl
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, J B Winsløwsvej 21, 3 DK 5000, Odense C, Denmark
    Hypertension 60:1346-51. 2012
    ..001). Preeclampsia is associated with urinary excretion of plasmin(ogen) and plasmin-dependent activation of ENaC by urine. Proteolytic activation of ENaC by plasmin may contribute to Na(+) retention and hypertension in preeclampsia...
  3. doi request reprint Regulation of renin secretion by renal juxtaglomerular cells
    Ulla G Friis
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, J B Winslowsvej 21, 3, 5000, Odense C, Denmark
    Pflugers Arch 465:25-37. 2013
    ..Connexin 40 is necessary for localization of JG cells in the vascular wall and for pressure- and macula densa-dependent suppression of renin release...
  4. pmc Hypotonicity-induced Renin exocytosis from juxtaglomerular cells requires aquaporin-1 and cyclooxygenase-2
    Ulla G Friis
    Department of Physiology and Pharmacology, Institute of Medical Biology, University of Southern Denmark, DK 5000 Odense, Denmark
    J Am Soc Nephrol 20:2154-61. 2009
    ....
  5. doi request reprint Histamine-dependent prolongation by aldosterone of vasoconstriction in isolated small mesenteric arteries of the mouse
    Jeppe Schjerning
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Denmark
    Am J Physiol Heart Circ Physiol 304:H1094-102. 2013
    ..The resulting activation of H2 receptors decreases the sensitivity to NO of vascular smooth muscle cells. Aldosterone may chronically affect vascular function through paracrine release of histamine...
  6. doi request reprint Physiological regulation of epithelial sodium channel by proteolysis
    Per Svenningsen
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, and Department of Nephrology Y, Odense University Hospital, Odense, Denmark
    Curr Opin Nephrol Hypertens 20:529-33. 2011
    ..Pathophysiogical, proteolytic activation of ENaC in kidney has been demonstrated in proteinuric disease...
  7. doi request reprint T-type Ca(2+) channels facilitate NO-formation, vasodilatation and NO-mediated modulation of blood pressure
    Per Svenningsen
    Department of Cardiovascular and Renal Research, University of Southern Denmark, Winsløwparken 21, 3, Odense, DK 5000, Denmark
    Pflugers Arch 466:2205-14. 2014
    ..Furthermore, Cav3.1 channels cluster with eNOS and promote formation of nitric oxide by the endothelium. The present findings suggest that this mechanism is important for the systemic impact of NO on peripheral resistance...
  8. doi request reprint Plasmin in urine from patients with type 2 diabetes and treatment-resistant hypertension activates ENaC in vitro
    Kristian B Buhl
    aDepartment of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark bDepartment of Endocrinology, Research Unit for Cardiovascular and Metabolic Prevention cDepartment of Nephrology, Odense University Hospital, Odense, Denmark
    J Hypertens 32:1672-7; discussion 1677. 2014
    ..It was hypothesized that patients with type 2 diabetes mellitus (T2DM) and treatment-resistant hypertension excrete plasmin(ogen) in urine in proportion to albumin and that plasmin confers to urine the ability to activate ENaC...
  9. doi request reprint Diabetic nephropathy is associated with increased urine excretion of proteases plasmin, prostasin and urokinase and activation of amiloride-sensitive current in collecting duct cells
    Henrik Andersen
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense C, Denmark Department of Endocrinology, Odense University Hospital, Odense C, Denmark
    Nephrol Dial Transplant 30:781-9. 2015
    ..It was hypothesized that aberrant glomerular filtration of serine proteases in DN causes proteolytic activation of the epithelial sodium channel (ENaC) in the kidney by excision of an inhibitory peptide tract from the γ subunit...
  10. doi request reprint Urinary serine proteases and activation of ENaC in kidney--implications for physiological renal salt handling and hypertensive disorders with albuminuria
    Per Svenningsen
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
    Pflugers Arch 467:531-42. 2015
    ....
  11. doi request reprint [249-POS]: Proteolytic activation of the epithelial sodium channel ENaC in preeclampsia examined with urinary exosomes
    Maria Ravn Nielsen
    Institute of Molecular Medicine, Cardiovascular and Renal Research, University of Southern Denmark, Odense, Denmark
    Pregnancy Hypertens 5:125-6. 2015
    ..Exosomes are membrane vesicles released into the urine from apical membranes of the kidney epithelial cells...
  12. ncbi request reprint Prostaglandin E2 EP2 and EP4 receptor activation mediates cAMP-dependent hyperpolarization and exocytosis of renin in juxtaglomerular cells
    Ulla G Friis
    Dept of Physiology and Pharmacology, University of Southern Denmark, DK 5000 Odense C, Denmark
    Am J Physiol Renal Physiol 289:F989-97. 2005
    ..Thus IP, EP2, and EP4 receptors are associated with JG cells, and their activation leads to rapid PKA-mediated exocytotic fusion and release of renin granules...