Per Svenningsen

Summary

Affiliation: University of Southern Denmark
Country: Denmark

Publications

  1. doi request reprint Proteinuric diseases with sodium retention: Is plasmin the link?
    Per Svenningsen
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
    Clin Exp Pharmacol Physiol 39:117-24. 2012
  2. doi request reprint Regulation of renin secretion by renal juxtaglomerular cells
    Ulla G Friis
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, J B Winslowsvej 21, 3, 5000, Odense C, Denmark
    Pflugers Arch 465:25-37. 2013
  3. doi request reprint Urinary plasmin activates collecting duct ENaC current in preeclampsia
    Kristian B Buhl
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, J B Winsløwsvej 21, 3 DK 5000, Odense C, Denmark
    Hypertension 60:1346-51. 2012
  4. pmc Hypotonicity-induced Renin exocytosis from juxtaglomerular cells requires aquaporin-1 and cyclooxygenase-2
    Ulla G Friis
    Department of Physiology and Pharmacology, Institute of Medical Biology, University of Southern Denmark, DK 5000 Odense, Denmark
    J Am Soc Nephrol 20:2154-61. 2009
  5. doi request reprint Histamine-dependent prolongation by aldosterone of vasoconstriction in isolated small mesenteric arteries of the mouse
    Jeppe Schjerning
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Denmark
    Am J Physiol Heart Circ Physiol 304:H1094-102. 2013
  6. ncbi request reprint Physiological regulation of epithelial sodium channel by proteolysis
    Per Svenningsen
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, and Department of Nephrology Y, Odense University Hospital, Odense, Denmark
    Curr Opin Nephrol Hypertens 20:529-33. 2011
  7. ncbi request reprint Plasmin in urine from patients with type 2 diabetes and treatment-resistant hypertension activates ENaC in vitro
    Kristian B Buhl
    aDepartment of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark bDepartment of Endocrinology, Research Unit for Cardiovascular and Metabolic Prevention cDepartment of Nephrology, Odense University Hospital, Odense, Denmark
    J Hypertens 32:1672-7. 2014
  8. ncbi request reprint Prostaglandin E2 EP2 and EP4 receptor activation mediates cAMP-dependent hyperpolarization and exocytosis of renin in juxtaglomerular cells
    Ulla G Friis
    Dept of Physiology and Pharmacology, University of Southern Denmark, DK 5000 Odense C, Denmark
    Am J Physiol Renal Physiol 289:F989-97. 2005

Collaborators

Detail Information

Publications8

  1. doi request reprint Proteinuric diseases with sodium retention: Is plasmin the link?
    Per Svenningsen
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
    Clin Exp Pharmacol Physiol 39:117-24. 2012
    ..7. In this review, we will examine the evidence for a role of urinary serine protease activity in the development of sodium and water retention in diseases characterised by proteinuria with a focus on nephrotic syndrome...
  2. doi request reprint Regulation of renin secretion by renal juxtaglomerular cells
    Ulla G Friis
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, J B Winslowsvej 21, 3, 5000, Odense C, Denmark
    Pflugers Arch 465:25-37. 2013
    ..Connexin 40 is necessary for localization of JG cells in the vascular wall and for pressure- and macula densa-dependent suppression of renin release...
  3. doi request reprint Urinary plasmin activates collecting duct ENaC current in preeclampsia
    Kristian B Buhl
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, J B Winsløwsvej 21, 3 DK 5000, Odense C, Denmark
    Hypertension 60:1346-51. 2012
    ..001). Preeclampsia is associated with urinary excretion of plasmin(ogen) and plasmin-dependent activation of ENaC by urine. Proteolytic activation of ENaC by plasmin may contribute to Na(+) retention and hypertension in preeclampsia...
  4. pmc Hypotonicity-induced Renin exocytosis from juxtaglomerular cells requires aquaporin-1 and cyclooxygenase-2
    Ulla G Friis
    Department of Physiology and Pharmacology, Institute of Medical Biology, University of Southern Denmark, DK 5000 Odense, Denmark
    J Am Soc Nephrol 20:2154-61. 2009
    ....
  5. doi request reprint Histamine-dependent prolongation by aldosterone of vasoconstriction in isolated small mesenteric arteries of the mouse
    Jeppe Schjerning
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Denmark
    Am J Physiol Heart Circ Physiol 304:H1094-102. 2013
    ..The resulting activation of H2 receptors decreases the sensitivity to NO of vascular smooth muscle cells. Aldosterone may chronically affect vascular function through paracrine release of histamine...
  6. ncbi request reprint Physiological regulation of epithelial sodium channel by proteolysis
    Per Svenningsen
    Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, and Department of Nephrology Y, Odense University Hospital, Odense, Denmark
    Curr Opin Nephrol Hypertens 20:529-33. 2011
    ..Pathophysiogical, proteolytic activation of ENaC in kidney has been demonstrated in proteinuric disease...
  7. ncbi request reprint Plasmin in urine from patients with type 2 diabetes and treatment-resistant hypertension activates ENaC in vitro
    Kristian B Buhl
    aDepartment of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark bDepartment of Endocrinology, Research Unit for Cardiovascular and Metabolic Prevention cDepartment of Nephrology, Odense University Hospital, Odense, Denmark
    J Hypertens 32:1672-7. 2014
    ..It was hypothesized that patients with type 2 diabetes mellitus (T2DM) and treatment-resistant hypertension excrete plasmin(ogen) in urine in proportion to albumin and that plasmin confers to urine the ability to activate ENaC...
  8. ncbi request reprint Prostaglandin E2 EP2 and EP4 receptor activation mediates cAMP-dependent hyperpolarization and exocytosis of renin in juxtaglomerular cells
    Ulla G Friis
    Dept of Physiology and Pharmacology, University of Southern Denmark, DK 5000 Odense C, Denmark
    Am J Physiol Renal Physiol 289:F989-97. 2005
    ..Thus IP, EP2, and EP4 receptors are associated with JG cells, and their activation leads to rapid PKA-mediated exocytotic fusion and release of renin granules...