Affiliation: University of Southern Denmark
- Proteinuric diseases with sodium retention: Is plasmin the link?Per Svenningsen
Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
Clin Exp Pharmacol Physiol 39:117-24. 2012..7. In this review, we will examine the evidence for a role of urinary serine protease activity in the development of sodium and water retention in diseases characterised by proteinuria with a focus on nephrotic syndrome...
- Urinary plasmin activates collecting duct ENaC current in preeclampsiaKristian B Buhl
Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, J B Winsløwsvej 21, 3 DK 5000, Odense C, Denmark
Hypertension 60:1346-51. 2012..001). Preeclampsia is associated with urinary excretion of plasmin(ogen) and plasmin-dependent activation of ENaC by urine. Proteolytic activation of ENaC by plasmin may contribute to Na(+) retention and hypertension in preeclampsia...
- Physiological regulation of epithelial sodium channel by proteolysisPer Svenningsen
Department of Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, and Department of Nephrology Y, Odense University Hospital, Odense, Denmark
Curr Opin Nephrol Hypertens 20:529-33. 2011..Pathophysiogical, proteolytic activation of ENaC in kidney has been demonstrated in proteinuric disease...
- Hypotonicity-induced Renin exocytosis from juxtaglomerular cells requires aquaporin-1 and cyclooxygenase-2Ulla G Friis
Department of Physiology and Pharmacology, Institute of Medical Biology, University of Southern Denmark, DK 5000 Odense, Denmark
J Am Soc Nephrol 20:2154-61. 2009....