Søren J Sørensen

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Making bio-sense of toxicity: new developments in whole-cell biosensors
    Søren J Sørensen
    Department of Microbiology, University of Copenhagen, Sølvgade 83H, 1307 Copenhagen K, Denmark
    Curr Opin Biotechnol 17:11-6. 2006
  2. ncbi request reprint Studying plasmid horizontal transfer in situ: a critical review
    Søren J Sørensen
    Department of Microbiology, Institute of Biology, University of Copenhagen, Sølvgade 83H, 1307 Copenhagen K, Denmark
    Nat Rev Microbiol 3:700-10. 2005
  3. pmc Microbial diversity of biofilm communities in microniches associated with the didemnid ascidian Lissoclinum patella
    Lars Behrendt
    Marine Biological Section, Department of Biology, University of Copenhagen, Helsingør, Denmark
    ISME J 6:1222-37. 2012
  4. doi request reprint Construction and use of flow cytometry optimized plasmid-sensor strains
    Martin Iain Bahl
    Department of Microbiology, University of Copenhagen, Copenhagen, Denmark
    Methods Mol Biol 532:257-68. 2009
  5. doi request reprint Persistence mechanisms of conjugative plasmids
    Martin Iain Bahl
    Department of Microbiology, University of Copenhagen, Copenhagen, Denmark
    Methods Mol Biol 532:73-102. 2009
  6. doi request reprint Type 3 fimbriae, encoded by the conjugative plasmid pOLA52, enhance biofilm formation and transfer frequencies in Enterobacteriaceae strains
    Mette Burmølle
    Department of Microbiology, University of Copenhagen, 1307 Copenhagen K, Denmark
    Microbiology 154:187-95. 2008
  7. ncbi request reprint The prevalence of the OqxAB multidrug efflux pump amongst olaquindox-resistant Escherichia coli in pigs
    Lars Hestbjerg Hansen
    Department of Microbiology, University of Copenhagen, 1307 Copenhagen K, Denmark
    Microb Drug Resist 11:378-82. 2005
  8. doi request reprint Acclimation of subsurface microbial communities to mercury
    Julia R de Lipthay
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    FEMS Microbiol Ecol 65:145-55. 2008
  9. pmc Biofilm growth and near-infrared radiation-driven photosynthesis of the chlorophyll d-containing cyanobacterium Acaryochloris marina
    Lars Behrendt
    Department of Biology, University of Copenhagen, Helsingør, Denmark
    Appl Environ Microbiol 78:3896-904. 2012
  10. doi request reprint All IncP-1 plasmid subgroups, including the novel epsilon subgroup, are prevalent in the influent of a Danish wastewater treatment plant
    Martin Iain Bahl
    Department of Biology, University of Copenhagen, Denmark
    Plasmid 62:134-9. 2009

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Making bio-sense of toxicity: new developments in whole-cell biosensors
    Søren J Sørensen
    Department of Microbiology, University of Copenhagen, Sølvgade 83H, 1307 Copenhagen K, Denmark
    Curr Opin Biotechnol 17:11-6. 2006
    ....
  2. ncbi request reprint Studying plasmid horizontal transfer in situ: a critical review
    Søren J Sørensen
    Department of Microbiology, Institute of Biology, University of Copenhagen, Sølvgade 83H, 1307 Copenhagen K, Denmark
    Nat Rev Microbiol 3:700-10. 2005
    ..Single-cell detection of donor, recipient and transconjugant bacteria in various natural environments, combined with individual-based mathematical models, has provided a new platform for HGT studies...
  3. pmc Microbial diversity of biofilm communities in microniches associated with the didemnid ascidian Lissoclinum patella
    Lars Behrendt
    Marine Biological Section, Department of Biology, University of Copenhagen, Helsingør, Denmark
    ISME J 6:1222-37. 2012
    ..In particular, we show that microenvironments and microbial diversity can vary significantly over scales of a few millimeters in such habitats; which is information easily lost by bulk sampling...
  4. doi request reprint Construction and use of flow cytometry optimized plasmid-sensor strains
    Martin Iain Bahl
    Department of Microbiology, University of Copenhagen, Copenhagen, Denmark
    Methods Mol Biol 532:257-68. 2009
    ....
  5. doi request reprint Persistence mechanisms of conjugative plasmids
    Martin Iain Bahl
    Department of Microbiology, University of Copenhagen, Copenhagen, Denmark
    Methods Mol Biol 532:73-102. 2009
    ..Finally, various molecular adaptations of plasmids to better match the genetic background of their bacterial host cell will be described...
  6. doi request reprint Type 3 fimbriae, encoded by the conjugative plasmid pOLA52, enhance biofilm formation and transfer frequencies in Enterobacteriaceae strains
    Mette Burmølle
    Department of Microbiology, University of Copenhagen, 1307 Copenhagen K, Denmark
    Microbiology 154:187-95. 2008
    ..pOLA52 is believed to represent the first example of a conjugative plasmid encoding type 3 fimbriae, resulting in enhanced conjugation frequencies and biofilm formation of the plasmid-harbouring strain...
  7. ncbi request reprint The prevalence of the OqxAB multidrug efflux pump amongst olaquindox-resistant Escherichia coli in pigs
    Lars Hestbjerg Hansen
    Department of Microbiology, University of Copenhagen, 1307 Copenhagen K, Denmark
    Microb Drug Resist 11:378-82. 2005
    ..Furthermore, horizontal transfer of olaquindox resistance from three olaquindox-resistant isolates was achieved using an olaquindox-sensitive E. coli as recipient...
  8. doi request reprint Acclimation of subsurface microbial communities to mercury
    Julia R de Lipthay
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    FEMS Microbiol Ecol 65:145-55. 2008
    ..The data in this study suggest a role for IncP-1 plasmids in the acclimation to mercury of surface as well as subsurface soil microbial communities...
  9. pmc Biofilm growth and near-infrared radiation-driven photosynthesis of the chlorophyll d-containing cyanobacterium Acaryochloris marina
    Lars Behrendt
    Department of Biology, University of Copenhagen, Helsingør, Denmark
    Appl Environ Microbiol 78:3896-904. 2012
    ..A. marina is well adapted to a biofilm growth mode under both visible and NIR irradiance and under O(2) conditions ranging from anoxia to hyperoxia, explaining its presence in natural niches with similar environmental conditions...
  10. doi request reprint All IncP-1 plasmid subgroups, including the novel epsilon subgroup, are prevalent in the influent of a Danish wastewater treatment plant
    Martin Iain Bahl
    Department of Biology, University of Copenhagen, Denmark
    Plasmid 62:134-9. 2009
    ..Additionally, the results confirm that wastewater constitutes a reservoir for the conjugative IncP-1 plasmids, which often harbor multiple antibiotic resistance genes...
  11. doi request reprint The ability of soil bacteria to receive the conjugative IncP1 plasmid, pKJK10, is different in a mixed community compared to single strains
    Claudia I de la Cruz-Perera
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    FEMS Microbiol Lett 338:95-100. 2013
    ..Our results indicate that the presence of a bacterial community impacts the plasmid permissiveness by affecting the ability of strains to receive the conjugative plasmid...
  12. pmc Sequencing of IncX-plasmids suggests ubiquity of mobile forms of a biofilm-promoting gene cassette recruited from Klebsiella pneumoniae
    Mette Burmølle
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e41259. 2012
    ....
  13. pmc Conjugative plasmid conferring resistance to olaquindox
    Anders Hay Sørensen
    Department of General Microbiology, University of Copenhagen, 1307 Copenhagen K, Denmark
    Antimicrob Agents Chemother 47:798-9. 2003
    ..It also confers resistance to ampicillin and chloramphenicol and has a high frequency of transfer between strains of E. coli. Plasmid-borne olaquindox resistance has not been demonstrated before...
  14. pmc Enhanced biofilm formation and increased resistance to antimicrobial agents and bacterial invasion are caused by synergistic interactions in multispecies biofilms
    Mette Burmølle
    Department of Microbiology, University of Copenhagen, Copenhagen, Denmark
    Appl Environ Microbiol 72:3916-23. 2006
    ..In summary, our data strongly indicate that synergistic effects promote biofilm biomass and resistance of the biofilm to antimicrobial agents and bacterial invasion in multispecies biofilms...
  15. ncbi request reprint Impact of conjugal transfer on the stability of IncP-1 plasmid pKJK5 in bacterial populations
    Martin Iain Bahl
    Department of Microbiology, University of Copenhagen, Sølvgade, Copenhagen K, Denmark
    FEMS Microbiol Lett 266:250-6. 2007
    ..Furthermore, conjugation-proficient plasmids were able to spread infectiously in the bacterial mats initiated with various ratios of plasmid-harboring cells, resulting in a nearly exclusively plasmid-harboring population...
  16. pmc Conjugative transfer facilitates stable maintenance of IncP-1 plasmid pKJK5 in Escherichia coli cells colonizing the gastrointestinal tract of the germfree rat
    Martin Iain Bahl
    Department of Microbiology, University of Copenhagen, Sølvgade 83H, DK 1307 Copenhagen K, Denmark
    Appl Environ Microbiol 73:341-3. 2007
    ..Results show that the plasmid's ability to conjugate counteracts plasmid loss and is thus an important mechanism for the stable maintenance of IncP-1 plasmids within the gastrointestinal environment...
  17. doi request reprint Predominant genera of fecal microbiota in children with atopic dermatitis are not altered by intake of probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium animalis subsp. lactis Bi-07
    Nadja Larsen
    Department of Food Science, Faculty of Life Sciences, University of Copenhagen, Copenhagen, Denmark
    FEMS Microbiol Ecol 75:482-96. 2011
    ..The main conclusion of the study is that administration of L. acidophilus NCFM and B. lactis Bi-07 does not affect the composition and diversity of the main bacterial populations in feces...
  18. pmc Selection for Cu-tolerant bacterial communities with altered composition, but unaltered richness, via long-term Cu exposure
    Jeanette Berg
    Department of Agriculture and Ecology, University of Copenhagen, Frederiksberg, Denmark
    Appl Environ Microbiol 78:7438-46. 2012
    ..Our report highlights several bacterial taxa responding to Cu and thereby provides new guidelines for future studies aiming to explore the bacterial domain for members of metal-responding taxa...
  19. doi request reprint The fate of indigenous microbiota, starter cultures, Escherichia coli, Listeria innocua and Staphylococcus aureus in Danish raw milk and cheeses determined by pyrosequencing and quantitative real time (qRT)-PCR
    Wafa Masoud
    Department of Food Science, Food Microbiology, University of Copenhagen, Rolighedsvej 30, DK 1958 Frederiksberg C, Denmark
    Int J Food Microbiol 153:192-202. 2012
    ..The use of 16S rRNA gene pyrosequencing and qRT-PCR allows a deeper understanding of the behavior of indigenous microbiota, starter cultures and pathogenic bacteria in raw milk and cheeses...
  20. pmc Construction of a ColD cda promoter-based SOS-green fluorescent protein whole-cell biosensor with higher sensitivity toward genotoxic compounds than constructs based on recA, umuDC, or sulA promoters
    Anders Norman
    Department of Microbiology, University of Copenhagen, Sølvgade 83H, 1307 Copenhagen K, Denmark
    Appl Environ Microbiol 71:2338-46. 2005
    ....
  21. pmc Conjugative plasmids: vessels of the communal gene pool
    Anders Norman
    Department of Biology, Section for Evolution and Microbiology, University of Copenhagen, Copenhagen K, Denmark
    Philos Trans R Soc Lond B Biol Sci 364:2275-89. 2009
    ..This communal pool provides the prokaryotes with an important mechanistic framework for obtaining adaptability and functional diversity that alleviates the need for large genomes of specialized 'private genes'...
  22. pmc Plasmid-encoded multidrug efflux pump conferring resistance to olaquindox in Escherichia coli
    Lars Hestbjerg Hansen
    Department of Microbiology, University of Copenhagen, Sølvgade 83H, 1307 Copenhagen K, Denmark
    Antimicrob Agents Chemother 48:3332-7. 2004
    ..coli strain N43. In addition, we show that the efflux system is dependent on the host TolC outer membrane protein when expressed in E. coli...
  23. pmc Design and synthesis of a quintessential self-transmissible IncX1 plasmid, pX1.0
    Lars H Hansen
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 6:e19912. 2011
    ..Our results demonstrate the immediate applicability of recent advances made within the field of synthetic biology for designing and constructing DNA systems, previously existing only in silica...
  24. ncbi request reprint Establishment and early succession of a multispecies biofilm composed of soil bacteria
    Mette Burmølle
    Department of Microbiology, University of Copenhagen, Copenhagen K, Denmark
    Microb Ecol 54:352-62. 2007
    ..Thus, the biofilm flow model proved useful for investigations of how intrinsic phenotypic traits of individual species affect the succession in an early soil biofilm consortium...
  25. pmc Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults
    Nadja Larsen
    Department of Food Science, University of Copenhagen, Frederiksberg, Denmark
    PLoS ONE 5:e9085. 2010
    ..The aim of this study was to assess the differences between the composition of the intestinal microbiota in humans with type 2 diabetes and non-diabetic persons as control...
  26. ncbi request reprint The multiple antibiotic resistance IncP-1 plasmid pKJK5 isolated from a soil environment is phylogenetically divergent from members of the previously established alpha, beta and delta sub-groups
    Martin Iain Bahl
    Department of Microbiology, University of Copenhagen, Sølvgade 83H, 1307 Copenhagen K, Denmark
    Plasmid 58:31-43. 2007
    ....
  27. pmc Gut microbiota composition is correlated to grid floor induced stress and behavior in the BALB/c mouse
    Katja Maria Bangsgaard Bendtsen
    Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e46231. 2012
    ..It is concluded that grid floor housing changes the GM composition, which seems to influence certain anxiety-related parameters...
  28. doi request reprint Investigating the Diversity of Pseudomonas spp. in Soil Using Culture Dependent and Independent Techniques
    Lili Li
    Section for Microbiology, Department of Biology, University of Copenhagen, Universitetsparken 15, Bygning 1, 2100, Copenhagen, Denmark
    Curr Microbiol 67:423-30. 2013
    ..This indicates that NAA 1:100 medium is highly selective for Pseudomonas species, and reveals the ability of NAA 1:100 medium to culture mostly the dominant Pseudomonas species in soil. ..
  29. pmc Endolithic chlorophyll d-containing phototrophs
    Lars Behrendt
    Marine Biological Laboratory, Department of Biology, University of Copenhagen, Helsingør, Denmark
    ISME J 5:1072-6. 2011
    ..This finding suggests an important role of Chl d-containing cyanobacteria in a range of hitherto unexplored endolithic habitats, where NIR light-driven oxygenic photosynthesis may be significant...
  30. doi request reprint Biofilms in chronic infections - a matter of opportunity - monospecies biofilms in multispecies infections
    Mette Burmølle
    Department of Biology, University of Copenhagen, Denmark
    FEMS Immunol Med Microbiol 59:324-36. 2010
    ..We discuss these differences from both the diagnostic and the scientific point of view...
  31. ncbi request reprint The cda GenoTox assay: a new and sensitive method for detection of environmental genotoxins, including nitroarenes and aromatic amines
    Trine G Østergaard
    Department of Microbiology, University of Copenhagen, Sølvgade 83H, 1307 Copenhagen K, Denmark
    Mutat Res 631:77-84. 2007
    ..This resulted in an assay that was able to detect the nitroarene 1-nitropyrene and the aromatic amine 2-aminoanthracene with high sensitivity...
  32. ncbi request reprint Direct detection and quantification of horizontal gene transfer by using flow cytometry and gfp as a reporter gene
    Søren J Sørensen
    Department of General Microbiology, Institute of Molecular Biology, University of Copenhagen, Sølvgade 83 H, DK 1307, Copenhagen, Denmark
    Curr Microbiol 47:129-33. 2003
    ..The method presented here provided simple and precise quantification of horizontal gene transfer between both Escherichia coli and Pseudomonas putida strains...