L T Sørensen

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. doi Wound healing and infection in surgery: the pathophysiological impact of smoking, smoking cessation, and nicotine replacement therapy: a systematic review
    Lars Tue Sørensen
    Copenhagen Wound Healing Center and Department of Surgery K, Bispebjerg Hospital, University of Copenhagen, Denmark
    Ann Surg 255:1069-79. 2012
  2. ncbi Wound healing and infection in surgery. The clinical impact of smoking and smoking cessation: a systematic review and meta-analysis
    Lars Tue Sørensen
    Department of Surgery K, Bispebjerg Hospital and Research Centre for Prevention and Health, University of Copenhagen, DK 2400 Copenhagen, Denmark
    Arch Surg 147:373-83. 2012
  3. doi Effect of smoking, smoking cessation, and nicotine patch on wound dimension, vitamin C, and systemic markers of collagen metabolism
    Lars Tue Sørensen
    Copenhagen Wound Healing Center, Bispebjerg Hospital, Copenhagen, Denmark
    Surgery 148:982-90. 2010
  4. doi Smoking attenuates wound inflammation and proliferation while smoking cessation restores inflammation but not proliferation
    Lars Tue Sørensen
    Copenhagen Wound Healing Center, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
    Wound Repair Regen 18:186-92. 2010
  5. doi Effect of smoking, abstention, and nicotine patch on epidermal healing and collagenase in skin transudate
    Lars Tue Sørensen
    Copenhagen Wound Healing Center, Bispebjerg Hospital, DK 2400 Copenhagen NV, Denmark
    Wound Repair Regen 17:347-53. 2009
  6. doi Acute effects of nicotine and smoking on blood flow, tissue oxygen, and aerobe metabolism of the skin and subcutis
    Lars Tue Sørensen
    Copenhagen Wound Healing Center, Department of Surgery, Bispebjerg Hospital, Copenhagen, Denmark
    J Surg Res 152:224-30. 2009
  7. ncbi Strategies of smoking cessation intervention before hernia surgery--effect on perioperative smoking behavior
    L T Sørensen
    Department of Surgery, Bispebjerg Hospital, University of Copenhagen, 2400 Copenhagen NV, Denmark
    Hernia 11:327-33. 2007
  8. ncbi Risk factors for mortality and postoperative complications after gastrointestinal surgery
    Lars Tue Sørensen
    Department of Surgical Gastroenterology, Bispebjerg Hospital, 2400 Copenhagen, Denmark
    J Gastrointest Surg 11:903-10. 2007
  9. ncbi Effect of lifestyle, gender and age on collagen formation and degradation
    Lars Tue Sørensen
    Department of Surgery, Bispebjerg Hospital, 2400 Copenhagen NV, Denmark
    Hernia 10:456-61. 2006
  10. ncbi Transdermal nicotine patch enhances type I collagen synthesis in abstinent smokers
    Lars T Sørensen
    Copenhagen Wound Healing Center, and Department of Surgery, Bispebjerg Hospital, University of Copenhagen, Denmark
    Wound Repair Regen 14:247-51. 2006

Collaborators

Detail Information

Publications18

  1. doi Wound healing and infection in surgery: the pathophysiological impact of smoking, smoking cessation, and nicotine replacement therapy: a systematic review
    Lars Tue Sørensen
    Copenhagen Wound Healing Center and Department of Surgery K, Bispebjerg Hospital, University of Copenhagen, Denmark
    Ann Surg 255:1069-79. 2012
    ..The aim was to clarify how smoking and nicotine affects wound healing processes and to establish if smoking cessation and nicotine replacement therapy reverse the mechanisms involved...
  2. ncbi Wound healing and infection in surgery. The clinical impact of smoking and smoking cessation: a systematic review and meta-analysis
    Lars Tue Sørensen
    Department of Surgery K, Bispebjerg Hospital and Research Centre for Prevention and Health, University of Copenhagen, DK 2400 Copenhagen, Denmark
    Arch Surg 147:373-83. 2012
    ..To clarify the evidence on smoking and postoperative healing complications across surgical specialties and to determine the impact of perioperative smoking cessation intervention...
  3. doi Effect of smoking, smoking cessation, and nicotine patch on wound dimension, vitamin C, and systemic markers of collagen metabolism
    Lars Tue Sørensen
    Copenhagen Wound Healing Center, Bispebjerg Hospital, Copenhagen, Denmark
    Surgery 148:982-90. 2010
    ..Postoperative wound disruption and tissue-destructive disorders are more frequent in smokers than in nonsmokers. Impaired wound healing and altered connective tissue turnover are suggested mechanisms, but exact details remain unknown...
  4. doi Smoking attenuates wound inflammation and proliferation while smoking cessation restores inflammation but not proliferation
    Lars Tue Sørensen
    Copenhagen Wound Healing Center, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
    Wound Repair Regen 18:186-92. 2010
    ..These findings suggest a pathophysiologic mechanism for postoperative wound infection and dehiscence in smokers and why smoking cessation appears to reduce wound infection but not dehiscence...
  5. doi Effect of smoking, abstention, and nicotine patch on epidermal healing and collagenase in skin transudate
    Lars Tue Sørensen
    Copenhagen Wound Healing Center, Bispebjerg Hospital, DK 2400 Copenhagen NV, Denmark
    Wound Repair Regen 17:347-53. 2009
    ..These findings suggest sustained impaired wound healing in smokers and potential reversibility of extracellular matrix degradation...
  6. doi Acute effects of nicotine and smoking on blood flow, tissue oxygen, and aerobe metabolism of the skin and subcutis
    Lars Tue Sørensen
    Copenhagen Wound Healing Center, Department of Surgery, Bispebjerg Hospital, Copenhagen, Denmark
    J Surg Res 152:224-30. 2009
    ..Nicotine released from tobacco smoke causing reduction in blood flow has been suggested as causative for postoperative wound complications in smokers, but the mechanism remains unknown...
  7. ncbi Strategies of smoking cessation intervention before hernia surgery--effect on perioperative smoking behavior
    L T Sørensen
    Department of Surgery, Bispebjerg Hospital, University of Copenhagen, 2400 Copenhagen NV, Denmark
    Hernia 11:327-33. 2007
    ..Our objective was to study the effect on perioperative smoking behavior and on postoperative wound infection of different types of low-intensive intervention before herniotomy...
  8. ncbi Risk factors for mortality and postoperative complications after gastrointestinal surgery
    Lars Tue Sørensen
    Department of Surgical Gastroenterology, Bispebjerg Hospital, 2400 Copenhagen, Denmark
    J Gastrointest Surg 11:903-10. 2007
    ..We aimed to assess risk factors predictive of poor surgical outcome across different gastrointestinal operations related to the patient, the disease, the treatment, and the organization of care...
  9. ncbi Effect of lifestyle, gender and age on collagen formation and degradation
    Lars Tue Sørensen
    Department of Surgery, Bispebjerg Hospital, 2400 Copenhagen NV, Denmark
    Hernia 10:456-61. 2006
    ..Yet, evidence from animal and human studies suggests that these exogenous and endogenous factors may have a negative impact on collagen metabolism, enhancing degradation and impairing formation...
  10. ncbi Transdermal nicotine patch enhances type I collagen synthesis in abstinent smokers
    Lars T Sørensen
    Copenhagen Wound Healing Center, and Department of Surgery, Bispebjerg Hospital, University of Copenhagen, Denmark
    Wound Repair Regen 14:247-51. 2006
    ..05). We conclude that 20 days of abstinence from smoking does not affect collagen deposition in granulation tissue. However, in abstinent smokers, transdermal nicotine patches appears to increase type I collagen synthesis...
  11. ncbi Smoking is a risk factor for incisional hernia
    Lars Tue Sørensen
    Department of Surgery, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
    Arch Surg 140:119-23. 2005
    ..Based on previous findings of smoking as a risk factor for wound complications and recurrence of groin hernia, we studied whether smoking is associated with incisional hernia...
  12. pmc Abstinence from smoking reduces incisional wound infection: a randomized controlled trial
    Lars Tue Sorensen
    Copenhagen Wound Healing Center, Bispebjerg University Hospital, Copenhagen Hospital Corporation, DK 2400 Copenhagen NV, Denmark
    Ann Surg 238:1-5. 2003
    ..Clinical studies show that the incidence of postoperative wound complications is higher in smokers than nonsmokers. In this study, we evaluated the effect of abstinence from smoking on incisional wound infection...
  13. ncbi Short-term pre-operative smoking cessation intervention does not affect postoperative complications in colorectal surgery: a randomized clinical trial
    Lars Tue Sørensen
    Department of Surgical Gastroenterology, Bispebjerg University Hospital, DK 2400 Copenhagen NV, Denmark
    Colorectal Dis 5:347-52. 2003
    ..We tested the hypothesis that short-term pre-operative cessation of smoking in colorectal surgery decreases the incidence of postoperative tissue and wound complications...
  14. ncbi Smoking as a risk factor for wound healing and infection in breast cancer surgery
    L T Sørensen
    Department of Surgical Gastroenterology K, Bispebjerg University Hospital, Copenhagen Hospital Corporation, Denmark
    Eur J Surg Oncol 28:815-20. 2002
    ..However, the significance of smoking as a risk factor for wound infection, skin flap necrosis, and epidermolysis when adjusting for other potential risk factors remains to be studied...
  15. ncbi Effect of smoking and abstention on oxidative burst and reactivity of neutrophils and monocytes
    Lars Tue Sørensen
    Copenhagen Wound Healing Center, the Department of Surgical Gastroenterology, Bispebjerg Hospital, University of Copenhagen, DK 2400 Copenhagen, Denmark
    Surgery 136:1047-53. 2004
    ..Smoking is associated with surgical wound infections, impaired wound healing, and tissue-destructive disorders. The mechanisms are largely unknown, but changes in the function and activity of inflammatory cells may be involved...
  16. pmc Risk factors for tissue and wound complications in gastrointestinal surgery
    Lars Tue Sørensen
    Department of Surgical Gastroenterology, Bispebjerg Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen, Denmark
    Ann Surg 241:654-8. 2005
    ..Surgical site infections and disruption of sutured tissue are frequent complications following surgery. We aimed to assess risk factors predictive of tissue and wound complications in open gastrointestinal surgery...
  17. ncbi Smoking and skin disease
    S F Thomsen
    Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark
    Skin Therapy Lett 15:4-7. 2010
    ..Most likely, alteration of inflammatory cell function and extracellular matrix turnover caused by smoking-induced oxidative stress are involved in the pathophysiologic mechanisms...
  18. ncbi Thromboembolic prophylaxis as a risk factor for postoperative complications after breast cancer surgery
    Esbern Friis
    Department of Surgical Gastroenterology K, H S Bispebjerg University Hospital, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark
    World J Surg 28:540-3. 2004
    ..After operations for breast cancer we found that LMWH was significantly associated with postoperative hematoma and sugillation compared to TED stockings for perioperative thromboembolic prophylaxis...