Grith L Sorensen

Summary

Affiliation: University of Southern Denmark
Country: Denmark

Publications

  1. pmc Reduced influenza viral neutralizing activity of natural human trimers of surfactant protein D
    Kevan L Hartshorn
    Boston University School of Medicine, Department of Medicine, Boston, MA, USA
    Respir Res 8:9. 2007
  2. pmc Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis
    Anne Friesgaard Christensen
    Department of Rheumatology, Odense University Hospital, SDR, Boulevard 29, DK 5000 Odense C, Denmark
    Arthritis Res Ther 12:R39. 2010
  3. ncbi request reprint Genetic and environmental influences of surfactant protein D serum levels
    Grith L Sørensen
    Medical Biotechnology Center, Institute for Medical Biology, University of Southern Denmark, Winsloewparken 25 3, DK 5000 Odense, Denmark
    Am J Physiol Lung Cell Mol Physiol 290:L1010-7. 2006
  4. doi request reprint Multimeric and trimeric subunit SP-D are interconvertible structures with distinct ligand interaction
    Grith L Sorensen
    Medical Biotechnology Center, University of Southern Denmark, DK 5000 Odense C, Denmark
    Mol Immunol 46:3060-9. 2009
  5. ncbi request reprint Surfactant protein A and surfactant protein D variation in pulmonary disease
    Grith Lykke Sorensen
    Medical Biotechnology Center, University of Southern Denmark, Odense, Denmark
    Immunobiology 212:381-416. 2007
  6. ncbi request reprint Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity
    Grith L Sorensen
    Medical Biotechnology Center, University of Southern Denmark, Odense, Denmark
    Genet Epidemiol 31:31-41. 2007
  7. ncbi request reprint Surfactant protein D of the innate immune defence is inversely associated with human obesity and SP-D deficiency infers increased body weight in mice
    G L Sorensen
    Medical Biotechnology Center, University of Southern Denmark, Odense, Denmark
    Scand J Immunol 64:633-8. 2006
  8. doi request reprint CD163-L1 is an endocytic macrophage protein strongly regulated by mediators in the inflammatory response
    Jesper B Moeller
    Institute of Molecular Medicine, University of Southern Denmark, 5000 Odense, Denmark
    J Immunol 188:2399-409. 2012
  9. doi request reprint Ficolins and FIBCD1: soluble and membrane bound pattern recognition molecules with acetyl group selectivity
    Theresa Thomsen
    Institute of Molecular Medicine, University of Southern Denmark, Denmark
    Mol Immunol 48:369-81. 2011
  10. ncbi request reprint Surfactant protein D is proatherogenic in mice
    Grith L Sorensen
    Medical Biotechnology Center, University of Southern Denmark, Winsloewparken 25, 3, 5000 Odense C, Denmark
    Am J Physiol Heart Circ Physiol 290:H2286-94. 2006

Collaborators

Detail Information

Publications12

  1. pmc Reduced influenza viral neutralizing activity of natural human trimers of surfactant protein D
    Kevan L Hartshorn
    Boston University School of Medicine, Department of Medicine, Boston, MA, USA
    Respir Res 8:9. 2007
    ..We recently reported that the Thr/Thr 11 form of SP-D is associated with low serum levels and assembles predominantly as trimers as opposed to the more common multimeric forms of SP-D...
  2. pmc Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis
    Anne Friesgaard Christensen
    Department of Rheumatology, Odense University Hospital, SDR, Boulevard 29, DK 5000 Odense C, Denmark
    Arthritis Res Ther 12:R39. 2010
    ....
  3. ncbi request reprint Genetic and environmental influences of surfactant protein D serum levels
    Grith L Sørensen
    Medical Biotechnology Center, Institute for Medical Biology, University of Southern Denmark, Winsloewparken 25 3, DK 5000 Odense, Denmark
    Am J Physiol Lung Cell Mol Physiol 290:L1010-7. 2006
    ..19), additive genetic effects (h(2) = 0.42), and the effect of the Met11Thr variations (q(2) = 0.39)...
  4. doi request reprint Multimeric and trimeric subunit SP-D are interconvertible structures with distinct ligand interaction
    Grith L Sorensen
    Medical Biotechnology Center, University of Southern Denmark, DK 5000 Odense C, Denmark
    Mol Immunol 46:3060-9. 2009
    ..In conclusion, purified trimeric and multimeric SP-D represent separate and only partly interconvertible molecular populations with distinct biochemical properties...
  5. ncbi request reprint Surfactant protein A and surfactant protein D variation in pulmonary disease
    Grith Lykke Sorensen
    Medical Biotechnology Center, University of Southern Denmark, Odense, Denmark
    Immunobiology 212:381-416. 2007
    ..The aim of this review is to summarize studies on genetic polymorphisms, structural variants, and serum levels of human SP-A and SP-D and their associations with human pulmonary disease...
  6. ncbi request reprint Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity
    Grith L Sorensen
    Medical Biotechnology Center, University of Southern Denmark, Odense, Denmark
    Genet Epidemiol 31:31-41. 2007
    ..34 [0.25;0.42]. The data indicate a strong genetic influence for the serum levels of MBL and for MASP-2 activity with a significant genetic correlation between the two traits...
  7. ncbi request reprint Surfactant protein D of the innate immune defence is inversely associated with human obesity and SP-D deficiency infers increased body weight in mice
    G L Sorensen
    Medical Biotechnology Center, University of Southern Denmark, Odense, Denmark
    Scand J Immunol 64:633-8. 2006
    ..0001) in males on normal chow. Fat percentage was significantly increased by 17% in the Spd-/- male mice (P = 0.003). We conclude, that there is an association between low levels or absent SP-D and obesity...
  8. doi request reprint CD163-L1 is an endocytic macrophage protein strongly regulated by mediators in the inflammatory response
    Jesper B Moeller
    Institute of Molecular Medicine, University of Southern Denmark, 5000 Odense, Denmark
    J Immunol 188:2399-409. 2012
    ..We postulate that CD163-L1 functions as a scavenger receptor for one or several ligands that might have a role in resolution of inflammation...
  9. doi request reprint Ficolins and FIBCD1: soluble and membrane bound pattern recognition molecules with acetyl group selectivity
    Theresa Thomsen
    Institute of Molecular Medicine, University of Southern Denmark, Denmark
    Mol Immunol 48:369-81. 2011
    ..This review presents current knowledge on acetyl binding FReD-containing molecules, and discusses structural resemblance but also diversity in recognition of acetylated ligands...
  10. ncbi request reprint Surfactant protein D is proatherogenic in mice
    Grith L Sorensen
    Medical Biotechnology Center, University of Southern Denmark, Winsloewparken 25, 3, 5000 Odense C, Denmark
    Am J Physiol Heart Circ Physiol 290:H2286-94. 2006
    ..The effect is likely to be due to the observed disturbances of plasma lipid metabolism and alteration of the inflammatory process, which underlie the reduced susceptibility to atherosclerosis in Spd-/- mice...
  11. ncbi request reprint Serum surfactant protein D is correlated to development of dementia and augmented mortality
    Mads Nybo
    Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Odense, Denmark
    Clin Immunol 123:333-7. 2007
    ..95-6.90). Cox regression controlling for the same variables showed that hazard ratio of death was 1.43 (1.06-1.92) in the highest quartile. SP-D concentration thus correlates to development of dementia as well as to augmented mortality...
  12. pmc The recognition unit of FIBCD1 organizes into a noncovalently linked tetrameric structure and uses a hydrophobic funnel (S1) for acetyl group recognition
    Theresa Thomsen
    Medical Biotechnology Center, University of Southern Denmark, 5000 Odense, Denmark
    J Biol Chem 285:1229-38. 2010
    ..We suggest that the spatial organization of the FIBCD1-FReDs determine the molecular pattern recognition specificity and subsequent biological functions...