Grith L Sorensen

Summary

Affiliation: University of Southern Denmark
Country: Denmark

Publications

  1. doi request reprint Association between the surfactant protein D (SFTPD) gene and subclinical carotid artery atherosclerosis
    Grith L Sorensen
    Department of Cancer and Inflammation, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark Electronic address
    Atherosclerosis 246:7-12. 2016
  2. doi request reprint Surfactant protein D is a candidate biomarker for subclinical tobacco smoke-induced lung damage
    Sofie L Johansson
    Cardiovascular and Renal Research, Institute of Molecular Medicine, Univ of Southern Denmark, Odense, Denmark
    Am J Physiol Lung Cell Mol Physiol 306:L887-95. 2014
  3. pmc Enzyme-linked immunosorbent assay characterization of basal variation and heritability of systemic microfibrillar-associated protein 4
    Susanne Gjørup Sækmose
    Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark Department of Clinical Immunology, Region Sjaelland, Naestved Hospital, Naestved, Denmark Department of Clinical Immunology, Odense University Hospital, Odense, Denmark
    PLoS ONE 8:e82383. 2013
  4. pmc Surfactant protein d deficiency in mice is associated with hyperphagia, altered fat deposition, insulin resistance, and increased basal endotoxemia
    Jacob V Stidsen
    Cardiovascular and Renal Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark
    PLoS ONE 7:e35066. 2012
  5. pmc Reduced influenza viral neutralizing activity of natural human trimers of surfactant protein D
    Kevan L Hartshorn
    Boston University School of Medicine, Department of Medicine, Boston, MA, USA
    Respir Res 8:9. 2007
  6. pmc Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis
    Anne Friesgaard Christensen
    Department of Rheumatology, Odense University Hospital, SDR, Boulevard 29, DK 5000 Odense C, Denmark
    Arthritis Res Ther 12:R39. 2010
  7. ncbi request reprint Genetic and environmental influences of surfactant protein D serum levels
    Grith L Sørensen
    Medical Biotechnology Center, Institute for Medical Biology, University of Southern Denmark, Winsloewparken 25 3, DK 5000 Odense, Denmark
    Am J Physiol Lung Cell Mol Physiol 290:L1010-7. 2006
  8. doi request reprint Multimeric and trimeric subunit SP-D are interconvertible structures with distinct ligand interaction
    Grith L Sorensen
    Medical Biotechnology Center, University of Southern Denmark, DK 5000 Odense C, Denmark
    Mol Immunol 46:3060-9. 2009
  9. ncbi request reprint Surfactant protein A and surfactant protein D variation in pulmonary disease
    Grith Lykke Sorensen
    Medical Biotechnology Center, University of Southern Denmark, Odense, Denmark
    Immunobiology 212:381-416. 2007
  10. ncbi request reprint Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity
    Grith L Sorensen
    Medical Biotechnology Center, University of Southern Denmark, Odense, Denmark
    Genet Epidemiol 31:31-41. 2007

Collaborators

Detail Information

Publications21

  1. doi request reprint Association between the surfactant protein D (SFTPD) gene and subclinical carotid artery atherosclerosis
    Grith L Sorensen
    Department of Cancer and Inflammation, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark Electronic address
    Atherosclerosis 246:7-12. 2016
    ..We hypothesized that plasma SP-D (pSP-D) and SP-D gene (SFTPD) single nucleotide polymorphisms (SNPs) are risk factors for atherosclerosis...
  2. doi request reprint Surfactant protein D is a candidate biomarker for subclinical tobacco smoke-induced lung damage
    Sofie L Johansson
    Cardiovascular and Renal Research, Institute of Molecular Medicine, Univ of Southern Denmark, Odense, Denmark
    Am J Physiol Lung Cell Mol Physiol 306:L887-95. 2014
    ..The data and derived conclusion warrant confirmation in a longitudinal population following chronic obstructive pulmonary disease initiation and development...
  3. pmc Enzyme-linked immunosorbent assay characterization of basal variation and heritability of systemic microfibrillar-associated protein 4
    Susanne Gjørup Sækmose
    Cardiovascular and Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark Department of Clinical Immunology, Region Sjaelland, Naestved Hospital, Naestved, Denmark Department of Clinical Immunology, Odense University Hospital, Odense, Denmark
    PLoS ONE 8:e82383. 2013
    ..Moreover, we aimed to determine confounders influencing the basal sMFAP4 variability and the genetic contribution to the basal variation...
  4. pmc Surfactant protein d deficiency in mice is associated with hyperphagia, altered fat deposition, insulin resistance, and increased basal endotoxemia
    Jacob V Stidsen
    Cardiovascular and Renal Research, Institute for Molecular Medicine, University of Southern Denmark, Odense, Denmark
    PLoS ONE 7:e35066. 2012
    ..The data suggest SP-D as a regulator of energy intake and body composition and an inhibitor of metabolic endotoxemia. SP-D may play a causal role at the crossroads of inflammation, obesity, and insulin resistance...
  5. pmc Reduced influenza viral neutralizing activity of natural human trimers of surfactant protein D
    Kevan L Hartshorn
    Boston University School of Medicine, Department of Medicine, Boston, MA, USA
    Respir Res 8:9. 2007
    ..We recently reported that the Thr/Thr 11 form of SP-D is associated with low serum levels and assembles predominantly as trimers as opposed to the more common multimeric forms of SP-D...
  6. pmc Circulating surfactant protein -D is low and correlates negatively with systemic inflammation in early, untreated rheumatoid arthritis
    Anne Friesgaard Christensen
    Department of Rheumatology, Odense University Hospital, SDR, Boulevard 29, DK 5000 Odense C, Denmark
    Arthritis Res Ther 12:R39. 2010
    ....
  7. ncbi request reprint Genetic and environmental influences of surfactant protein D serum levels
    Grith L Sørensen
    Medical Biotechnology Center, Institute for Medical Biology, University of Southern Denmark, Winsloewparken 25 3, DK 5000 Odense, Denmark
    Am J Physiol Lung Cell Mol Physiol 290:L1010-7. 2006
    ..19), additive genetic effects (h(2) = 0.42), and the effect of the Met11Thr variations (q(2) = 0.39)...
  8. doi request reprint Multimeric and trimeric subunit SP-D are interconvertible structures with distinct ligand interaction
    Grith L Sorensen
    Medical Biotechnology Center, University of Southern Denmark, DK 5000 Odense C, Denmark
    Mol Immunol 46:3060-9. 2009
    ..In conclusion, purified trimeric and multimeric SP-D represent separate and only partly interconvertible molecular populations with distinct biochemical properties...
  9. ncbi request reprint Surfactant protein A and surfactant protein D variation in pulmonary disease
    Grith Lykke Sorensen
    Medical Biotechnology Center, University of Southern Denmark, Odense, Denmark
    Immunobiology 212:381-416. 2007
    ..The aim of this review is to summarize studies on genetic polymorphisms, structural variants, and serum levels of human SP-A and SP-D and their associations with human pulmonary disease...
  10. ncbi request reprint Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity
    Grith L Sorensen
    Medical Biotechnology Center, University of Southern Denmark, Odense, Denmark
    Genet Epidemiol 31:31-41. 2007
    ..34 [0.25;0.42]. The data indicate a strong genetic influence for the serum levels of MBL and for MASP-2 activity with a significant genetic correlation between the two traits...
  11. ncbi request reprint Surfactant protein D of the innate immune defence is inversely associated with human obesity and SP-D deficiency infers increased body weight in mice
    G L Sorensen
    Medical Biotechnology Center, University of Southern Denmark, Odense, Denmark
    Scand J Immunol 64:633-8. 2006
    ..0001) in males on normal chow. Fat percentage was significantly increased by 17% in the Spd-/- male mice (P = 0.003). We conclude, that there is an association between low levels or absent SP-D and obesity...
  12. doi request reprint MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation
    Anders Schlosser
    From the Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark A S, B P, L E H, K K, G B K, H W J, J B M, K K M, L K D, P B L H, J S, U H, G L S Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark E M F Department of Pathology, Odense University Hospital, Odense, Denmark O N Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany C W, J H, M O Biomedical Research in Endstage and Obstructive Lung Disease Hannover BREATH, Member of the German Center for Lung Research DZL, Hannover, Germany C W, J H, M O REBIRTH Cluster of Excellence, Hannover, Germany C W, J H, Department of Medical Oncology
    Arterioscler Thromb Vasc Biol 36:122-33. 2016
    ..The role of MFAP4 in vascular biology is unknown. We aimed to test the hypothesis that MFAP4 would enhance integrin-dependent VSMC activation...
  13. ncbi request reprint Surfactant protein D is proatherogenic in mice
    Grith L Sorensen
    Medical Biotechnology Center, University of Southern Denmark, Winsloewparken 25, 3, 5000 Odense C, Denmark
    Am J Physiol Heart Circ Physiol 290:H2286-94. 2006
    ..The effect is likely to be due to the observed disturbances of plasma lipid metabolism and alteration of the inflammatory process, which underlie the reduced susceptibility to atherosclerosis in Spd-/- mice...
  14. doi request reprint Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation
    Bartosz Pilecki
    From the Department of Cancer and Inflammation Research, Institute of Molecular Medicine, Faculty of Health Sciences, University of Southern Denmark, 5000 Odense C, Denmark
    J Biol Chem 291:1103-14. 2016
    ..Furthermore, we found that MFAP4 actively promotes tropoelastin self-assembly. In conclusion, our data identify MFAP4 as a new ligand of microfibrils and tropoelastin involved in proper elastic fiber organization. ..
  15. doi request reprint CD163-L1 is an endocytic macrophage protein strongly regulated by mediators in the inflammatory response
    Jesper B Moeller
    Institute of Molecular Medicine, University of Southern Denmark, 5000 Odense, Denmark
    J Immunol 188:2399-409. 2012
    ..We postulate that CD163-L1 functions as a scavenger receptor for one or several ligands that might have a role in resolution of inflammation...
  16. doi request reprint Ficolins and FIBCD1: soluble and membrane bound pattern recognition molecules with acetyl group selectivity
    Theresa Thomsen
    Institute of Molecular Medicine, University of Southern Denmark, Denmark
    Mol Immunol 48:369-81. 2011
    ..This review presents current knowledge on acetyl binding FReD-containing molecules, and discusses structural resemblance but also diversity in recognition of acetylated ligands...
  17. ncbi request reprint Serum surfactant protein D is correlated to development of dementia and augmented mortality
    Mads Nybo
    Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Odense, Denmark
    Clin Immunol 123:333-7. 2007
    ..95-6.90). Cox regression controlling for the same variables showed that hazard ratio of death was 1.43 (1.06-1.92) in the highest quartile. SP-D concentration thus correlates to development of dementia as well as to augmented mortality...
  18. pmc The recognition unit of FIBCD1 organizes into a noncovalently linked tetrameric structure and uses a hydrophobic funnel (S1) for acetyl group recognition
    Theresa Thomsen
    Medical Biotechnology Center, University of Southern Denmark, 5000 Odense, Denmark
    J Biol Chem 285:1229-38. 2010
    ..We suggest that the spatial organization of the FIBCD1-FReDs determine the molecular pattern recognition specificity and subsequent biological functions...
  19. doi request reprint Protective effects of surfactant protein D treatment in 1,3-β-glucan-modulated allergic inflammation
    Dalia Fakih
    Department of Cancer and Inflammation Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark Department of Biology, Faculty of Sciences II, Lebanese University, Fanar, Lebanon Laboratory of Immunology, Faculty of Public Health, Lebanese University, Fanar, Lebanon
    Am J Physiol Lung Cell Mol Physiol 309:L1333-43. 2015
    ..Our data suggest that treatment with high-dose SP-D protects from mold-induced exacerbations of allergic asthma. ..
  20. doi request reprint Microfibrillar-associated protein 4 modulates airway smooth muscle cell phenotype in experimental asthma
    Bartosz Pilecki
    Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
    Thorax 70:862-72. 2015
    ..In the current study we investigated the role of MFAP4 in experimental allergic asthma...
  21. pmc No effect of ablation of surfactant protein-D on acute cerebral infarction in mice
    Kate L Lambertsen
    Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, JB Winsloewsvej 25, 2, DK 5000 Odense C, Denmark
    J Neuroinflammation 11:123. 2014
    ..We investigated whether SP-D affected cerebral ischemic infarction and ischemia-induced inflammatory responses in mice...