Thomas P J Solomon

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. doi request reprint Examining the effects of hyperglycemia on pancreatic endocrine function in humans: evidence for in vivo glucotoxicity
    Thomas P J Solomon
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Copenhagen 2100, Denmark
    J Clin Endocrinol Metab 97:4682-91. 2012
  2. pmc The effects of free-living interval-walking training on glycemic control, body composition, and physical fitness in type 2 diabetic patients: a randomized, controlled trial
    Kristian Karstoft
    Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes Care 36:228-36. 2013
  3. doi request reprint Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy
    Thine Hvid
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    Endocr Relat Cancer 20:621-32. 2013
  4. pmc Association between cardiorespiratory fitness and the determinants of glycemic control across the entire glucose tolerance continuum
    Thomas P J Solomon
    Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark Centre of Inflammation and Metabolism and Centre for Physical Activity Research, Rigshospitalet, Copenhagen, Denmark
    Diabetes Care 38:921-9. 2015
  5. doi request reprint Normal physical activity obliterates the deleterious effects of a high-caloric intake
    Rikke Krogh-Madsen
    Centre of Inflammation and Metabolism at Department of Infectious Diseases and Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    J Appl Physiol (1985) 116:231-9. 2014
  6. doi request reprint Impaired postprandial fullness in Type 2 diabetic subjects is rescued by acute exercise independently of total and acylated ghrelin
    Sine H Knudsen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 115:618-25. 2013
  7. doi request reprint Mechanisms behind the superior effects of interval vs continuous training on glycaemic control in individuals with type 2 diabetes: a randomised controlled trial
    Kristian Karstoft
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetologia 57:2081-93. 2014
  8. pmc Determining pancreatic β-cell compensation for changing insulin sensitivity using an oral glucose tolerance test
    Thomas P J Solomon
    Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark Centre of Inflammation and Metabolism and Centre for Physical Activity Research, Rigshospitalet, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 307:E822-9. 2014
  9. doi request reprint Hyperglycemia abolishes meal-induced satiety by a dysregulation of ghrelin and peptide YY3-36 in healthy overweight/obese humans
    Sine H Knudsen
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark and
    Am J Physiol Endocrinol Metab 306:E225-31. 2014
  10. pmc Glucagon like peptide-1-induced glucose metabolism in differentiated human muscle satellite cells is attenuated by hyperglycemia
    Charlotte J Green
    The Centre of Inflammation and Metabolism at Department of Infectious Diseases and Copenhagen Muscle Research Centre, Rigshospitalet, The Faculty of Health Sciences, University of Copenhagen, Denmark
    PLoS ONE 7:e44284. 2012

Collaborators

Detail Information

Publications15

  1. doi request reprint Examining the effects of hyperglycemia on pancreatic endocrine function in humans: evidence for in vivo glucotoxicity
    Thomas P J Solomon
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Copenhagen 2100, Denmark
    J Clin Endocrinol Metab 97:4682-91. 2012
    ..Investigating the impact of hyperglycemia on pancreatic endocrine function promotes our understanding of the pathophysiology of hyperglycemia-related disease...
  2. pmc The effects of free-living interval-walking training on glycemic control, body composition, and physical fitness in type 2 diabetic patients: a randomized, controlled trial
    Kristian Karstoft
    Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes Care 36:228-36. 2013
    ....
  3. doi request reprint Endurance training improves insulin sensitivity and body composition in prostate cancer patients treated with androgen deprivation therapy
    Thine Hvid
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    Endocr Relat Cancer 20:621-32. 2013
    ..05) not observed in the patients (P=0.64). In response to endurance training, ADT-treated prostate cancer patients exhibited improved insulin sensitivity and body composition to a similar degree as eugonadal men...
  4. pmc Association between cardiorespiratory fitness and the determinants of glycemic control across the entire glucose tolerance continuum
    Thomas P J Solomon
    Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark Centre of Inflammation and Metabolism and Centre for Physical Activity Research, Rigshospitalet, Copenhagen, Denmark
    Diabetes Care 38:921-9. 2015
    ....
  5. doi request reprint Normal physical activity obliterates the deleterious effects of a high-caloric intake
    Rikke Krogh-Madsen
    Centre of Inflammation and Metabolism at Department of Infectious Diseases and Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    J Appl Physiol (1985) 116:231-9. 2014
    ..In conclusion, we find evidence to support that habitual physical activity may prevent pathophysiological symptoms associated with diet-induced obesity. ..
  6. doi request reprint Impaired postprandial fullness in Type 2 diabetic subjects is rescued by acute exercise independently of total and acylated ghrelin
    Sine H Knudsen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 115:618-25. 2013
    ..Our data suggest that the presence of T2DM likely drives suppressed ghrelin levels and poor appetite regulation, but a single exercise bout is sufficient to restore oral glucose-induced fullness independently of ghrelin. ..
  7. doi request reprint Mechanisms behind the superior effects of interval vs continuous training on glycaemic control in individuals with type 2 diabetes: a randomised controlled trial
    Kristian Karstoft
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetologia 57:2081-93. 2014
    ..We hypothesised that IWT, more than CWT, would improve insulin sensitivity including skeletal muscle insulin signalling, insulin secretion and disposition index (DI)...
  8. pmc Determining pancreatic β-cell compensation for changing insulin sensitivity using an oral glucose tolerance test
    Thomas P J Solomon
    Department of Biomedical Sciences, Panum Institute, University of Copenhagen, Copenhagen, Denmark Centre of Inflammation and Metabolism and Centre for Physical Activity Research, Rigshospitalet, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 307:E822-9. 2014
    ....
  9. doi request reprint Hyperglycemia abolishes meal-induced satiety by a dysregulation of ghrelin and peptide YY3-36 in healthy overweight/obese humans
    Sine H Knudsen
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark and
    Am J Physiol Endocrinol Metab 306:E225-31. 2014
    ..In conclusion, hyperglycemia abolishes meal-induced satiety and dysregulates postprandial responses of the gut hormones PYY3-36 and ghrelin in overweight/obese healthy humans. ..
  10. pmc Glucagon like peptide-1-induced glucose metabolism in differentiated human muscle satellite cells is attenuated by hyperglycemia
    Charlotte J Green
    The Centre of Inflammation and Metabolism at Department of Infectious Diseases and Copenhagen Muscle Research Centre, Rigshospitalet, The Faculty of Health Sciences, University of Copenhagen, Denmark
    PLoS ONE 7:e44284. 2012
    ..Furthermore, while the pancreatic effects of GLP-1 are glucose-dependent, the glucose-dependency of its extra-pancreatic effects has not been examined...
  11. doi request reprint The acute effects of interval- Vs continuous-walking exercise on glycemic control in subjects with type 2 diabetes: a crossover, controlled study
    Kristian Karstoft
    The Centre of Inflammation and Metabolism K K, B K P, T P J S and The Centre for Physical Activity Research K K, B K P, T P J S, Department of Infectious Diseases and Clinical Medical Research Center, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark Department of Biomedical Sciences C S C, T P J S, Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark and Nordic Bioscience C S C, DK 2730 Herlev, Denmark
    J Clin Endocrinol Metab 99:3334-42. 2014
    ..Glycemic control improves with physical activity, but the optimal exercise mode is unknown...
  12. doi request reprint Direct effect of incretin hormones on glucose and glycerol metabolism and hemodynamics
    Kristian Karstoft
    Centre of Inflammation and Metabolism and Centre for Physical Activity Research, Department of Infectious Diseases, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 308:E426-33. 2015
    ..On the contrary, during hyperglycemia, GIP increases femoral artery blood flow with no effect on glucose metabolism, whereas GLP-1 increases glucose disposal, potentially due to increased insulin levels...
  13. doi request reprint The effects of TNF-α on GLP-1-stimulated plasma glucose kinetics
    Louise Lehrskov-Schmidt
    Centre of Inflammation and Metabolism and the Centre for Physical Activity Research Lo L S, La L S, S T N, K M, T P J S, Department of Infectious Diseases, Rigshospitalet, Novo Nordisk Foundation Centre for Basic Metabolic Research and Department of Biomedical Sciences J J H, Faculty of Health Sciences, Neurointensive Care Unit K M, Department of Neuroanesthesiology, Rigshospitalet, Faculty of Health Sciences, and Department of Biomedical Sciences P J S, Panum Institute, University of Copenhagen, Copenhagen 2200, Denmark
    J Clin Endocrinol Metab 100:E616-22. 2015
    ..Glucagon-like peptide-1 (GLP-1) analogs have recently been promoted as antihyperglycemic agents in critically ill patients with systemic inflammation, but the effects of TNF-α on glucose metabolism during GLP-1 administration are unknown...
  14. doi request reprint Changes in insulin sensitivity precede changes in body composition during 14 days of step reduction combined with overfeeding in healthy young men
    Sine Haugaard Knudsen
    The Centre of Inflammation and Metabolism, Department of Infectious Diseases and CMRC, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 113:7-15. 2012
    ....
  15. doi request reprint Increased shelterin mRNA expression in peripheral blood mononuclear cells and skeletal muscle following an ultra-long-distance running event
    Matthew J Laye
    The Center of Inflammation and Metabolism, Department of Infectious Diseases and Copenhagen Muscle Research Center, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol (1985) 112:773-81. 2012
    ..We have provided the first evidence that, in humans, proteins within and associated with the shelterin complex increase at the mRNA level in response to a physiological stress differentially in PBMCs and skeletal muscle...