Research Topics
| Axel SkyttheSummaryAffiliation: University of Southern Denmark Country: Denmark Publications
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Detail Information
Publications
The Danish Twin Registry in the new millenniumAxel Skytthe
The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winløws Vej 9B, DK 5000 Odense C, Denmark
Twin Res Hum Genet 9:763-71. 2006..This paper summarizes the newest extension of the register and gives examples of new developments and phenotypes studied...
Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) projectA Skytthe
Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winsløws Vej 9B, Odense, Denmark
Exp Gerontol 46:934-45. 2011..Thus, the GEHA project represents a unique source in the search for genes related to healthy ageing and longevity...
The Danish Twin RegistryAxel Skytthe
The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Scand J Public Health 39:75-8. 2011..The Danish Twin Registry is a unique source for studies of genetic, familial and environmental factors on life events, health conditions and diseases...- The Danish Twin Registry: 127 birth cohorts of twinsAxel Skytthe
The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Twin Res 5:352-7. 2002..The combination of survey data with data obtained by linkage to national health related registers enables follow-up studies both of the general twin population and of twins from clinical studies... - Risk of oral clefts in twinsDorthe Grosen
Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Epidemiology 22:313-9. 2011..Small studies have indicated that twinning increases the risk of oral cleft... - Recurrence risk for offspring of twins discordant for oral cleft: a population-based cohort study of the Danish 1936-2004 cleft twin cohortDorthe Grosen
Department of Epidemiology, University of Southern Denmark, Odense, Denmark
Am J Med Genet A 152:2468-74. 2010..This provides further evidence for a genetic component in cleft etiology and is useful information for genetic counseling of twin pairs discordant for clefting... - Cancer and longevity--is there a trade-off? A study of cooccurrence in Danish twin pairs born 1900-1918Kaare Christensen
The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense C, Denmark
J Gerontol A Biol Sci Med Sci 67:489-94. 2012..This hypothesis predicts that longevity in one twin is associated with increased cancer risk in the cotwin... - Genetic influence on human lifespan and longevityJacob vB Hjelmborg
Institute of Public Health, University of Southern Denmark, J B Winslovsvej 9 B, 5000, Odense C, Denmark
Hum Genet 119:312-21. 2006..These findings provide a support for the search for genes affecting longevity in humans, especially at advanced ages... - The danish twin registry: past and presentBent Harvald
The Danish Twin Registry, Epidemiology, Department of Public Health, University of Southern Denmark, Odense, Denmark
Twin Res 7:318-35. 2004..The Danish Twin Registry was established formally in 1954 and thus celebrates its 50th anniversary in 2004. Here we give an account of its founding and the early years, and a brief summary of more recent progress... - A cohort study of recurrence patterns among more than 54,000 relatives of oral cleft cases in Denmark: support for the multifactorial threshold model of inheritanceDorthe Grosen
Research Centre for the prevention of Infant Mortality and Congenital Illnesses, Institute of Public Health, University of Southern Denmark, JB Winsløws Vej 9, DK 5000 Odense, Denmark
J Med Genet 47:162-8. 2010..To determine if the anatomical severity of oral clefting affects familial recurrence in a large population based sample. To provide reliable recurrence risk estimates for oral cleft for first, second, and third degree relatives... - Age- and sex-differences in the validity of questionnaire-based zygosity in twinsLene Christiansen
The Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Twin Res 6:275-8. 2003..The results demonstrate that questionnaire based zygosity diagnosis can still be regarded as a valid and valuable classification method for most purposes... - Register-based research on twinsKaare Christensen
The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Scand J Public Health 39:185-90. 2011..CONCLUSION: The spectrum of register-based twin studies is very wide and have changed in accordance with methodological and data resource developments... - Do children of long-lived parents age more successfully?Henrik Frederiksen
Institute of Public Health, Epidemiology, University of Southern Denmark, Odense
Epidemiology 13:334-9. 2002..Long-lived individuals are rare and may be selected in part for the genetic factors that promote successful aging. The children of long-lived parents may therefore age more successfully than the children of short-lived parents... - The impact of genes on the occurrence of autoantibodies in rheumatoid arthritis. A study on disease discordant twin pairsAnders J Svendsen
The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Denmark Department of Rheumatology, Odense University Hospital, University of Southern Denmark, Denmark Electronic address
J Autoimmun 41:120-5. 2013..To assess the genetic effect on the occurrence of rheumatoid arthritis (RA) associated autoantibodies... - Twins with implanted pacemakers: Is there an increased mortality risk for the co-twin? A follow-up study based on the Danish Twin Registry and the Danish Pacemaker RegisterClaus Tveskov
The Danish Pacemaker Register, Department of Cardiology, Odense University Hospital, DK 5000 Odense C, Denmark
Europace 7:598-603. 2005..Untreated AVB is associated with increased mortality but SSS seems to have a good prognosis. The present study was designed to assess whether first-degree relatives of these patients have an increased mortality risk... - Time trends in waiting time to pregnancy among Danish twinsTina Kold Jensen
Department of Environmental Medicine, University of Southern Denmark, Institute of Public Health, 5000 Odense C, Denmark
Hum Reprod 20:955-64. 2005..In a survey among female twins born from 1953 to 1976, their time to pregnancy did not differ from singletons and can be considered to represent the fecundity of the general population... - The Danish Twin Registry: linking surveys, national registers, and biological informationAxel Skytthe
The Danish Twin Registry, University of Southern Denmark, Odense, Denmark
Twin Res Hum Genet 16:104-11. 2013..Third, two examples of intensively studied twin cohorts are given. The new developments in the DTR in the last decade have facilitated the ongoing research and laid the groundwork for new research directions... - Longevity studies in GenomEUtwinAxel Skytthe
The Danish Twin Registry, Epidemiology Unit, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Twin Res 6:448-54. 2003..Finally, it will provide a resource for identifying unusual sibships (i.e., dizygotic twin pairs) where both survived to extreme ages, as a basis for discovering genetic variants of importance for extreme survival... - Parent's age and the risk of oral cleftsCamilla Bille
Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winsløwsvej 9, DK 5000 Odense C, Denmark
Epidemiology 16:311-6. 2005..The aim of this study is to determine the degree to which maternal age and paternal age independently influence the risk of having a child with oral clefts... - Genetic liability in stroke: a long-term follow-up study of Danish twinsSøren Bak
Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Stroke 33:769-74. 2002..We used a large, population-based twin register and nationwide registries of death and hospitalization with long-term follow-up to estimate the effect of genetic factors on the risk of stroke... - Comparison of academic performance of twins and singletons in adolescence: follow-up studyKaare Christensen
Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Odense C, Denmark
BMJ 333:1095. 2006..To determine whether twins in recent cohorts show similar academic performance in adolescence to singletons and to test the effect of birth weight on academic performance in twins and singletons... - Genetic influence on prolonged gestation: a population-based Danish twin studyMaja Laursen
Department of Epidemiology, Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Am J Obstet Gynecol 190:489-94. 2004..CONCLUSION: Maternal genes influence prolonged gestation. However, a substantial paternal genetic influence through the fetus was not found... - Familial resemblance in religiousness in a secular society: a twin studyDorte Hvidtjørn
Epidemiology Unit, Institute of Public Health, University of Southern Denmark, Odense, Denmark
Twin Res Hum Genet 16:544-53. 2013..We found a small tendency for increasing genetic influence with increasing age for some religious items, but not for all... - Handgrip strength among nonagenarians and centenarians in three European regionsBernard Jeune
Aging Research Center, and Epidemiology, Institute of Public Health, University of Southern Denmark, 5000 Odense C, Denmark
J Gerontol A Biol Sci Med Sci 61:707-12. 2006..Handgrip strength is an important predictor of disability and mortality among old people. The aim was to compare the grip strength among very old people in three regions of Europe... - On the origin of rheumatoid arthritis: the impact of environment and genes--a population based twin studyAnders J Svendsen
Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
PLoS ONE 8:e57304. 2013..The purpose of the present investigation was to provide an optimized estimate on the heritability of RA and to study the recurrence risk in a nationwide Caucasian twin population... - Genetic and environmental factors in alexithymia: a population-based study of 8,785 Danish twin pairsMichael Martini Jørgensen
Psychooncology Research Unit, Aarhus University Hospital, Aarhus, Denmark
Psychother Psychosom 76:369-75. 2007..The role of genetic and environmental factors for developing alexithymia is still unclear, and the aim of this study was to examine these factors in a large population-based sample of twins... - A novel sampling design to explore gene-longevity associations: the ECHA studyFrancesco De Rango
Department of Cell Biology, University of Calabria, Rende, Italy
Eur J Hum Genet 16:236-42. 2008..This will allow to dimension future sampling campaigns to study-genetic basis of human longevity... - Increased concordance of severe respiratory syncytial virus infection in identical twinsSimon Francis Thomsen
Department of Respiratory Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, Building 60 DK 2400 Copenhagen NV, Denmark
Pediatrics 121:493-6. 2008..We estimated differences in the severity of respiratory syncytial virus infection attributable to genetic and environmental factors... - Breast cancer onset in twins and women with bilateral diseaseMikael Hartman
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
J Clin Oncol 26:4086-91. 2008..Little is known of the onset of breast cancer in high-risk populations. We investigated the risk of breast cancer in twin sisters and in the contralateral breast taking family history into consideration... - Major genetic susceptibility for venous thromboembolism in men: a study of Danish twinsTorben Bjerregaard Larsen
Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark
Epidemiology 14:328-32. 2003..Although several genetic determinants (mutations or polymorphisms) have been associated with increased risk of venous thromboembolism, the overall influence of genetic factors on this disease is unknown... - A cohort study of Parkinson's disease and other neurodegenerative disorders in Danish weldersJon P Fryzek
International Epidemiology Institute, Rockville, Maryland, USA
J Occup Environ Med 47:466-72. 2005..We sought to evaluate rates of hospitalizations for neurodegenerative disorders in a cohort of Danish metal manufacturing employees... - A possible association between the genetic predisposition for dizygotic twinning and schizophreniaUlla Kläning
Centre of Clinical Psychiatric Research, Mood Disorder Research Unit, Psychiatric Hospital in Aarhus, Skovagervej 2, 8240 Risskov, Denmark
Schizophr Res 58:31-5. 2002..The aim of the present study is to evaluate whether genes influencing the rate of dizygotic twinning and genes of importance for developing schizophrenia can be associated... - Evidence for an association of methylene tetrahydrofolate reductase polymorphism C677T and an increased risk of fractures: results from a population-based Danish twin studyLise Bathum
Department of Clinical Biochemistry, Odense University Hospital, 5000, Denmark
Osteoporos Int 15:659-64. 2004..In conclusion, we here provide evidence for a significant impact of the MTHFR genotype on the occurrence of fractures in an elderly Danish population... - Is the risk of bipolar disorder in twins equal to the risk in singletons? A nationwide register-based studyUlla Kläning
Mood Disorder Research Unit of Clinical Psychiatric Research, Aarhus University Psychiatric Hospital, Skovagervej 2, 8240 Risskov, Denmark
J Affect Disord 81:141-5. 2004..The aim of the present study was to investigate whether these findings also apply to bipolar disorder... - The effect of losing the twin and losing the partner on mortalityCecilia Tomassini
Age Concern Institute of Gerontology, King s College, London, UK
Twin Res 5:210-7. 2002..The latter confirms the influence of genetic factors on survival, while the mortality trajectory with a peak in the second year after the death of the co-twin is consistent with the existence of a twin bereavement effect... - Is the natural twinning rate still declining?Anne Maria Herskind
Epidemiology 16:591-2. 2005 - Risk for multiple sclerosis in dizygotic and monozygotic twinsThomas Hansen
National Institute of Public Health, Oster Farimagsgade 5, DK 1399 Kobenhavn K, Denmark
Mult Scler 11:500-3. 2005.... - Bio-social determinants of fertilityHans Peter Kohler
Department of Sociology, University of Pennsylvania, Philadelphia, 19104 6299, USA
Int J Androl 29:46-53. 2006..Moreover, genetic variance can change over short periods of time or across educational levels, specifically for females, and the relevance of genetic variance seems to increase during times of increasing reproductive choice... - Association between height and coronary heart disease mortality: a prospective study of 35,000 twin pairsKarri Silventoinen
Department of Public Health, University of Helsinki, Helsinki, Finland
Am J Epidemiol 163:615-21. 2006..14, 95% CI: 1.01, 1.28). The inverse association between height and CHD mortality found within monozygotic discordant twin pairs suggests that this association is because of environmental factors that directly affect height and CHD risk... - Twins and their health cost: consequences of multiple births on parental health and mortality in Denmark and England and WalesCecilia Tomassini
Centre for Population Studies, London School of Hygiene and Tropical Medicine, UK
Twin Res Hum Genet 9:444-9. 2006..Overall similar health and mortality was found for twin parents and the whole population although both life table methods and survival analysis suggested a slight excess mortality among older cohorts of twin mothers in England and Wales... - Low birth weight is not associated with thyroid autoimmunity: a population-based twin studyThomas Heiberg Brix
Department of Endocrinology and Metabolism, Odense University Hospital, Sdr Boulevard 29, 5000 Odense C, Denmark
J Clin Endocrinol Metab 91:3499-502. 2006..The effect of these confounders can be minimized through investigation of twin pairs... - The heritability of cause-specific mortality: a correlated gamma-frailty model applied to mortality due to respiratory diseases in Danish twins born 1870-1930Andreas Wienke
Max Planck Institute for Demographic Research, Rostock, Germany
Stat Med 22:3873-87. 2003..Environmental influences are non-shared with exception of frailty with respect to respiratory diseases in males, where the shared environment plays an important role... - Heritability of adult body height: a comparative study of twin cohorts in eight countriesKarri Silventoinen
Department of Public Health, University of Helsinki, Finland
Twin Res 6:399-408. 2003..Our results indicate that, in general, there are only minor differences in the genetic architecture of height between affluent Caucasian populations, especially among men... - Risk of suicide in twins: 51 year follow up studyCecilia Tomassini
Centre for Population Studies, London School of Hygiene and Tropical Medicine, London WC1 E7HT
BMJ 327:373-4. 2003 - Risk of lung cancer according to mild steel and stainless steel weldingAnita Rath Sørensen
Aarhus University Hospital, Department of Occupational Medicine, Aarhus, Denmark
Scand J Work Environ Health 33:379-86. 2007..This question was addressed in a cohort with a long follow-up and quantified estimates of individual exposure to welding fume particulates... - The heritability of CHD mortality in danish twins after controlling for smoking and BMIAndreas Wienke
Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle Wittenberg, Halle, Germany
Twin Res Hum Genet 8:53-9. 2005..55 (0.13) in a DE model after controlling for smoking and BMI. This analysis underlines the existence of a substantial genetic influence on individual frailty associated with mortality caused by CHD...