Axel Skytthe

Summary

Affiliation: University of Southern Denmark
Country: Denmark

Publications

  1. ncbi request reprint The Danish Twin Registry in the new millennium
    Axel Skytthe
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winløws Vej 9B, DK 5000 Odense C, Denmark
    Twin Res Hum Genet 9:763-71. 2006
  2. pmc Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project
    A Skytthe
    Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winsløws Vej 9B, Odense, Denmark
    Exp Gerontol 46:934-45. 2011
  3. pmc The Danish Twin Registry
    Axel Skytthe
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Scand J Public Health 39:75-8. 2011
  4. ncbi request reprint The Danish Twin Registry: 127 birth cohorts of twins
    Axel Skytthe
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Twin Res 5:352-7. 2002
  5. pmc Risk of oral clefts in twins
    Dorthe Grosen
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Epidemiology 22:313-9. 2011
  6. pmc Recurrence risk for offspring of twins discordant for oral cleft: a population-based cohort study of the Danish 1936-2004 cleft twin cohort
    Dorthe Grosen
    Department of Epidemiology, University of Southern Denmark, Odense, Denmark
    Am J Med Genet A 152:2468-74. 2010
  7. pmc Cancer and longevity--is there a trade-off? A study of cooccurrence in Danish twin pairs born 1900-1918
    Kaare Christensen
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense C, Denmark
    J Gerontol A Biol Sci Med Sci 67:489-94. 2012
  8. pmc The Danish Twin Registry: linking surveys, national registers, and biological information
    Axel Skytthe
    The Danish Twin Registry, University of Southern Denmark, Odense, Denmark
    Twin Res Hum Genet 16:104-11. 2013
  9. ncbi request reprint The danish twin registry: past and present
    Bent Harvald
    The Danish Twin Registry, Epidemiology, Department of Public Health, University of Southern Denmark, Odense, Denmark
    Twin Res 7:318-35. 2004
  10. pmc A cohort study of recurrence patterns among more than 54,000 relatives of oral cleft cases in Denmark: support for the multifactorial threshold model of inheritance
    Dorthe Grosen
    Research Centre for the prevention of Infant Mortality and Congenital Illnesses, Institute of Public Health, University of Southern Denmark, JB Winsløws Vej 9, DK 5000 Odense, Denmark
    J Med Genet 47:162-8. 2010

Detail Information

Publications47

  1. ncbi request reprint The Danish Twin Registry in the new millennium
    Axel Skytthe
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winløws Vej 9B, DK 5000 Odense C, Denmark
    Twin Res Hum Genet 9:763-71. 2006
    ..This paper summarizes the newest extension of the register and gives examples of new developments and phenotypes studied...
  2. pmc Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project
    A Skytthe
    Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winsløws Vej 9B, Odense, Denmark
    Exp Gerontol 46:934-45. 2011
    ..Thus, the GEHA project represents a unique source in the search for genes related to healthy ageing and longevity...
  3. pmc The Danish Twin Registry
    Axel Skytthe
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Scand J Public Health 39:75-8. 2011
    ..The Danish Twin Registry is a unique source for studies of genetic, familial and environmental factors on life events, health conditions and diseases...
  4. ncbi request reprint The Danish Twin Registry: 127 birth cohorts of twins
    Axel Skytthe
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Twin Res 5:352-7. 2002
    ..The combination of survey data with data obtained by linkage to national health related registers enables follow-up studies both of the general twin population and of twins from clinical studies...
  5. pmc Risk of oral clefts in twins
    Dorthe Grosen
    Department of Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Epidemiology 22:313-9. 2011
    ..Small studies have indicated that twinning increases the risk of oral cleft...
  6. pmc Recurrence risk for offspring of twins discordant for oral cleft: a population-based cohort study of the Danish 1936-2004 cleft twin cohort
    Dorthe Grosen
    Department of Epidemiology, University of Southern Denmark, Odense, Denmark
    Am J Med Genet A 152:2468-74. 2010
    ..This provides further evidence for a genetic component in cleft etiology and is useful information for genetic counseling of twin pairs discordant for clefting...
  7. pmc Cancer and longevity--is there a trade-off? A study of cooccurrence in Danish twin pairs born 1900-1918
    Kaare Christensen
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense C, Denmark
    J Gerontol A Biol Sci Med Sci 67:489-94. 2012
    ..This hypothesis predicts that longevity in one twin is associated with increased cancer risk in the cotwin...
  8. pmc The Danish Twin Registry: linking surveys, national registers, and biological information
    Axel Skytthe
    The Danish Twin Registry, University of Southern Denmark, Odense, Denmark
    Twin Res Hum Genet 16:104-11. 2013
    ..Third, two examples of intensively studied twin cohorts are given. The new developments in the DTR in the last decade have facilitated the ongoing research and laid the groundwork for new research directions...
  9. ncbi request reprint The danish twin registry: past and present
    Bent Harvald
    The Danish Twin Registry, Epidemiology, Department of Public Health, University of Southern Denmark, Odense, Denmark
    Twin Res 7:318-35. 2004
    ..The Danish Twin Registry was established formally in 1954 and thus celebrates its 50th anniversary in 2004. Here we give an account of its founding and the early years, and a brief summary of more recent progress...
  10. pmc A cohort study of recurrence patterns among more than 54,000 relatives of oral cleft cases in Denmark: support for the multifactorial threshold model of inheritance
    Dorthe Grosen
    Research Centre for the prevention of Infant Mortality and Congenital Illnesses, Institute of Public Health, University of Southern Denmark, JB Winsløws Vej 9, DK 5000 Odense, Denmark
    J Med Genet 47:162-8. 2010
    ..To determine if the anatomical severity of oral clefting affects familial recurrence in a large population based sample. To provide reliable recurrence risk estimates for oral cleft for first, second, and third degree relatives...
  11. ncbi request reprint Genetic influence on human lifespan and longevity
    Jacob vB Hjelmborg
    Institute of Public Health, University of Southern Denmark, J B Winslovsvej 9 B, 5000, Odense C, Denmark
    Hum Genet 119:312-21. 2006
    ..These findings provide a support for the search for genes affecting longevity in humans, especially at advanced ages...
  12. ncbi request reprint Age- and sex-differences in the validity of questionnaire-based zygosity in twins
    Lene Christiansen
    The Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Twin Res 6:275-8. 2003
    ..The results demonstrate that questionnaire based zygosity diagnosis can still be regarded as a valid and valuable classification method for most purposes...
  13. pmc Register-based research on twins
    Kaare Christensen
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Scand J Public Health 39:185-90. 2011
    ..Finally, we illustrate how the co-twin control method in a register setting can be used to control for the effect of rearing environment and genetic factors in studies of the association between exposures and health...
  14. ncbi request reprint Do children of long-lived parents age more successfully?
    Henrik Frederiksen
    Institute of Public Health, Epidemiology, University of Southern Denmark, Odense
    Epidemiology 13:334-9. 2002
    ..Long-lived individuals are rare and may be selected in part for the genetic factors that promote successful aging. The children of long-lived parents may therefore age more successfully than the children of short-lived parents...
  15. doi request reprint The impact of genes on the occurrence of autoantibodies in rheumatoid arthritis. A study on disease discordant twin pairs
    Anders J Svendsen
    The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Denmark
    J Autoimmun 41:120-5. 2013
    ..To assess the genetic effect on the occurrence of rheumatoid arthritis (RA) associated autoantibodies...
  16. ncbi request reprint Twins with implanted pacemakers: Is there an increased mortality risk for the co-twin? A follow-up study based on the Danish Twin Registry and the Danish Pacemaker Register
    Claus Tveskov
    The Danish Pacemaker Register, Department of Cardiology, Odense University Hospital, DK 5000 Odense C, Denmark
    Europace 7:598-603. 2005
    ..Untreated AVB is associated with increased mortality but SSS seems to have a good prognosis. The present study was designed to assess whether first-degree relatives of these patients have an increased mortality risk...
  17. ncbi request reprint Time trends in waiting time to pregnancy among Danish twins
    Tina Kold Jensen
    Department of Environmental Medicine, University of Southern Denmark, Institute of Public Health, 5000 Odense C, Denmark
    Hum Reprod 20:955-64. 2005
    ..In a survey among female twins born from 1953 to 1976, their time to pregnancy did not differ from singletons and can be considered to represent the fecundity of the general population...
  18. doi request reprint Heritability of health-related quality of life: SF-12 summary scores in a population-based nationwide twin cohort
    Troels Steenstrup
    Department of Biostatistics, University of Southern Denmark, Odense, Denmark
    Twin Res Hum Genet 16:670-8. 2013
    ..The present study aims to estimate the relative importance of genetic and environmental factors for health-related quality of life (HRQL) measured by the 12-item Short-Form Health Survey (SF-12)...
  19. doi request reprint Familial resemblance in religiousness in a secular society: a twin study
    Dorte Hvidtjørn
    Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Twin Res Hum Genet 16:544-53. 2013
    ..We found a small tendency for increasing genetic influence with increasing age for some religious items, but not for all...
  20. ncbi request reprint Longevity studies in GenomEUtwin
    Axel Skytthe
    The Danish Twin Registry, Epidemiology Unit, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Twin Res 6:448-54. 2003
    ..Finally, it will provide a resource for identifying unusual sibships (i.e., dizygotic twin pairs) where both survived to extreme ages, as a basis for discovering genetic variants of importance for extreme survival...
  21. pmc Parent's age and the risk of oral clefts
    Camilla Bille
    Epidemiology, Institute of Public Health, University of Southern Denmark, J B Winsløwsvej 9, DK 5000 Odense C, Denmark
    Epidemiology 16:311-6. 2005
    ..The aim of this study is to determine the degree to which maternal age and paternal age independently influence the risk of having a child with oral clefts...
  22. ncbi request reprint Genetic liability in stroke: a long-term follow-up study of Danish twins
    Søren Bak
    Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Stroke 33:769-74. 2002
    ..We used a large, population-based twin register and nationwide registries of death and hospitalization with long-term follow-up to estimate the effect of genetic factors on the risk of stroke...
  23. ncbi request reprint Genetic influence on prolonged gestation: a population-based Danish twin study
    Maja Laursen
    Department of Epidemiology, Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Am J Obstet Gynecol 190:489-94. 2004
    ..The purpose of this study was to test a possible genetic component to prolonged gestation...
  24. pmc Comparison of academic performance of twins and singletons in adolescence: follow-up study
    Kaare Christensen
    Danish Twin Registry, Institute of Public Health, University of Southern Denmark, Odense C, Denmark
    BMJ 333:1095. 2006
    ..To determine whether twins in recent cohorts show similar academic performance in adolescence to singletons and to test the effect of birth weight on academic performance in twins and singletons...
  25. ncbi request reprint Handgrip strength among nonagenarians and centenarians in three European regions
    Bernard Jeune
    Aging Research Center, and Epidemiology, Institute of Public Health, University of Southern Denmark, 5000 Odense C, Denmark
    J Gerontol A Biol Sci Med Sci 61:707-12. 2006
    ..Handgrip strength is an important predictor of disability and mortality among old people. The aim was to compare the grip strength among very old people in three regions of Europe...
  26. pmc On the origin of rheumatoid arthritis: the impact of environment and genes--a population based twin study
    Anders J Svendsen
    Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    PLoS ONE 8:e57304. 2013
    ..The purpose of the present investigation was to provide an optimized estimate on the heritability of RA and to study the recurrence risk in a nationwide Caucasian twin population...
  27. ncbi request reprint Major genetic susceptibility for venous thromboembolism in men: a study of Danish twins
    Torben Bjerregaard Larsen
    Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark
    Epidemiology 14:328-32. 2003
    ..Although several genetic determinants (mutations or polymorphisms) have been associated with increased risk of venous thromboembolism, the overall influence of genetic factors on this disease is unknown...
  28. doi request reprint Breast cancer onset in twins and women with bilateral disease
    Mikael Hartman
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    J Clin Oncol 26:4086-91. 2008
    ..Little is known of the onset of breast cancer in high-risk populations. We investigated the risk of breast cancer in twin sisters and in the contralateral breast taking family history into consideration...
  29. doi request reprint Increased concordance of severe respiratory syncytial virus infection in identical twins
    Simon Francis Thomsen
    Department of Respiratory Medicine, Bispebjerg Hospital, Bispebjerg Bakke 23, Building 60 DK 2400 Copenhagen NV, Denmark
    Pediatrics 121:493-6. 2008
    ..We estimated differences in the severity of respiratory syncytial virus infection attributable to genetic and environmental factors...
  30. ncbi request reprint A novel sampling design to explore gene-longevity associations: the ECHA study
    Francesco De Rango
    Department of Cell Biology, University of Calabria, Rende, Italy
    Eur J Hum Genet 16:236-42. 2008
    ..This will allow to dimension future sampling campaigns to study-genetic basis of human longevity...
  31. ncbi request reprint Genetic and environmental factors in alexithymia: a population-based study of 8,785 Danish twin pairs
    Michael Martini Jørgensen
    Psychooncology Research Unit, Aarhus University Hospital, Aarhus, Denmark
    Psychother Psychosom 76:369-75. 2007
    ..The role of genetic and environmental factors for developing alexithymia is still unclear, and the aim of this study was to examine these factors in a large population-based sample of twins...
  32. ncbi request reprint The effect of losing the twin and losing the partner on mortality
    Cecilia Tomassini
    Age Concern Institute of Gerontology, King s College, London, UK
    Twin Res 5:210-7. 2002
    ..The latter confirms the influence of genetic factors on survival, while the mortality trajectory with a peak in the second year after the death of the co-twin is consistent with the existence of a twin bereavement effect...
  33. ncbi request reprint Evidence for an association of methylene tetrahydrofolate reductase polymorphism C677T and an increased risk of fractures: results from a population-based Danish twin study
    Lise Bathum
    Department of Clinical Biochemistry, Odense University Hospital, 5000, Denmark
    Osteoporos Int 15:659-64. 2004
    ..In conclusion, we here provide evidence for a significant impact of the MTHFR genotype on the occurrence of fractures in an elderly Danish population...
  34. ncbi request reprint Is the risk of bipolar disorder in twins equal to the risk in singletons? A nationwide register-based study
    Ulla Kläning
    Mood Disorder Research Unit of Clinical Psychiatric Research, Aarhus University Psychiatric Hospital, Skovagervej 2, 8240 Risskov, Denmark
    J Affect Disord 81:141-5. 2004
    ..The aim of the present study was to investigate whether these findings also apply to bipolar disorder...
  35. ncbi request reprint A possible association between the genetic predisposition for dizygotic twinning and schizophrenia
    Ulla Kläning
    Centre of Clinical Psychiatric Research, Mood Disorder Research Unit, Psychiatric Hospital in Aarhus, Skovagervej 2, 8240 Risskov, Denmark
    Schizophr Res 58:31-5. 2002
    ..The aim of the present study is to evaluate whether genes influencing the rate of dizygotic twinning and genes of importance for developing schizophrenia can be associated...
  36. ncbi request reprint Is the natural twinning rate still declining?
    Anne Maria Herskind
    Epidemiology 16:591-2. 2005
  37. ncbi request reprint Risk for multiple sclerosis in dizygotic and monozygotic twins
    Thomas Hansen
    National Institute of Public Health, Oster Farimagsgade 5, DK 1399 Kobenhavn K, Denmark
    Mult Scler 11:500-3. 2005
    ....
  38. ncbi request reprint Bio-social determinants of fertility
    Hans Peter Kohler
    Department of Sociology, University of Pennsylvania, Philadelphia, 19104 6299, USA
    Int J Androl 29:46-53. 2006
    ..Moreover, genetic variance can change over short periods of time or across educational levels, specifically for females, and the relevance of genetic variance seems to increase during times of increasing reproductive choice...
  39. ncbi request reprint Association between height and coronary heart disease mortality: a prospective study of 35,000 twin pairs
    Karri Silventoinen
    Department of Public Health, University of Helsinki, Helsinki, Finland
    Am J Epidemiol 163:615-21. 2006
    ..14, 95% CI: 1.01, 1.28). The inverse association between height and CHD mortality found within monozygotic discordant twin pairs suggests that this association is because of environmental factors that directly affect height and CHD risk...
  40. ncbi request reprint Twins and their health cost: consequences of multiple births on parental health and mortality in Denmark and England and Wales
    Cecilia Tomassini
    Centre for Population Studies, London School of Hygiene and Tropical Medicine, UK
    Twin Res Hum Genet 9:444-9. 2006
    ..Overall similar health and mortality was found for twin parents and the whole population although both life table methods and survival analysis suggested a slight excess mortality among older cohorts of twin mothers in England and Wales...
  41. ncbi request reprint Low birth weight is not associated with thyroid autoimmunity: a population-based twin study
    Thomas Heiberg Brix
    Department of Endocrinology and Metabolism, Odense University Hospital, Sdr Boulevard 29, 5000 Odense C, Denmark
    J Clin Endocrinol Metab 91:3499-502. 2006
    ..The effect of these confounders can be minimized through investigation of twin pairs...
  42. ncbi request reprint A cohort study of Parkinson's disease and other neurodegenerative disorders in Danish welders
    Jon P Fryzek
    International Epidemiology Institute, Rockville, Maryland, USA
    J Occup Environ Med 47:466-72. 2005
    ..We sought to evaluate rates of hospitalizations for neurodegenerative disorders in a cohort of Danish metal manufacturing employees...
  43. pmc Risk of suicide in twins: 51 year follow up study
    Cecilia Tomassini
    Centre for Population Studies, London School of Hygiene and Tropical Medicine, London WC1 E7HT
    BMJ 327:373-4. 2003
  44. ncbi request reprint Heritability of adult body height: a comparative study of twin cohorts in eight countries
    Karri Silventoinen
    Department of Public Health, University of Helsinki, Finland
    Twin Res 6:399-408. 2003
    ..Our results indicate that, in general, there are only minor differences in the genetic architecture of height between affluent Caucasian populations, especially among men...
  45. ncbi request reprint The heritability of cause-specific mortality: a correlated gamma-frailty model applied to mortality due to respiratory diseases in Danish twins born 1870-1930
    Andreas Wienke
    Max Planck Institute for Demographic Research, Rostock, Germany
    Stat Med 22:3873-87. 2003
    ..Environmental influences are non-shared with exception of frailty with respect to respiratory diseases in males, where the shared environment plays an important role...
  46. ncbi request reprint The heritability of CHD mortality in danish twins after controlling for smoking and BMI
    Andreas Wienke
    Institute of Medical Epidemiology, Biostatistics and Informatics, Martin Luther University Halle Wittenberg, Halle, Germany
    Twin Res Hum Genet 8:53-9. 2005
    ..55 (0.13) in a DE model after controlling for smoking and BMI. This analysis underlines the existence of a substantial genetic influence on individual frailty associated with mortality caused by CHD...
  47. ncbi request reprint Risk of lung cancer according to mild steel and stainless steel welding
    Anita Rath Sørensen
    Aarhus University Hospital, Department of Occupational Medicine, Aarhus, Denmark
    Scand J Work Environ Health 33:379-86. 2007
    ..This question was addressed in a cohort with a long follow-up and quantified estimates of individual exposure to welding fume particulates...