Søren H Sindrup

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint St. John's wort has no effect on pain in polyneuropathy
    S H Sindrup
    Department of Neurology, Odense University Hospital, Research Unit of Clinical Pharmacology, University of Southern Denmark, Odense, Denmark
    Pain 91:361-5. 2001
  2. ncbi request reprint Diagnostic yield by testing small fiber function in patients examined for polyneuropathy
    S H Sindrup
    Department of Neurology, Odense University Hospital, Denmark
    J Peripher Nerv Syst 6:214-8. 2001
  3. ncbi request reprint Pharmacotherapy of trigeminal neuralgia
    Søren H Sindrup
    Department of Neurology, Odense and Aarhus University Hospitals, Denmark
    Clin J Pain 18:22-7. 2002
  4. ncbi request reprint Venlafaxine versus imipramine in painful polyneuropathy: a randomized, controlled trial
    S H Sindrup
    Department of Neurology, University Hospitals, Odense, Denmark
    Neurology 60:1284-9. 2003
  5. ncbi request reprint Health-related quality of life and its predictive role for analgesic effect in patients with painful polyneuropathy
    Marit Otto
    Department of Neurology, Odense University Hospital, DK 5000 Odense C, Denmark
    Eur J Pain 11:572-8. 2007
  6. doi request reprint The anticonvulsant levetiracetam for the treatment of pain in polyneuropathy: a randomized, placebo-controlled, cross-over trial
    Jakob V Holbech
    Department of Neurology, Odense University Hospital, Denmark
    Eur J Pain 15:608-14. 2011
  7. ncbi request reprint Escitalopram in painful polyneuropathy: a randomized, placebo-controlled, cross-over trial
    Marit Otto
    Department of Neurology, Odense University Hospital, University of Southern Denmark, Sdr Boulevard 29, Odense C, Denmark
    Pain 139:275-83. 2008
  8. ncbi request reprint Pain phenomena and possible mechanisms in patients with painful polyneuropathy
    Marit Otto
    Department of Neurology, Odense University, Odense Universitetshospital, Neurologisk afdeling, Sdr Boulevard 29, DK 5000, Odense C, Denmark
    Pain 101:187-92. 2003
  9. ncbi request reprint Antidepressants in the treatment of neuropathic pain
    Søren H Sindrup
    Department of Neurology, Odense University Hospital, DK 5000 Odense, Denmark
    Basic Clin Pharmacol Toxicol 96:399-409. 2005
  10. ncbi request reprint Chronic neuropathic pain: mechanisms, drug targets and measurement
    Nanna B Finnerup
    Department of Neurology, Danish Pain Research Center, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    Fundam Clin Pharmacol 21:129-36. 2007

Collaborators

Detail Information

Publications17

  1. ncbi request reprint St. John's wort has no effect on pain in polyneuropathy
    S H Sindrup
    Department of Neurology, Odense University Hospital, Research Unit of Clinical Pharmacology, University of Southern Denmark, Odense, Denmark
    Pain 91:361-5. 2001
    ..09--0.33). Complete, good or moderate pain relief was experienced by nine patients with St. John's wort and two with placebo (P=0.07). In conclusion, St. John's wort has no significant effect on pain in polyneuropathy...
  2. ncbi request reprint Diagnostic yield by testing small fiber function in patients examined for polyneuropathy
    S H Sindrup
    Department of Neurology, Odense University Hospital, Denmark
    J Peripher Nerv Syst 6:214-8. 2001
    ..e. abnormal nerve conduction and/or abnormal quantitative testing of temperature sensation). In conclusion, quantitative testing of temperature sensation improves the diagnostic yield in patients examined for chronic polyneuropathy...
  3. ncbi request reprint Pharmacotherapy of trigeminal neuralgia
    Søren H Sindrup
    Department of Neurology, Odense and Aarhus University Hospitals, Denmark
    Clin J Pain 18:22-7. 2002
    ..Controlled trials testing the effect of some of these drugs, new drugs, and drug combinations are needed...
  4. ncbi request reprint Venlafaxine versus imipramine in painful polyneuropathy: a randomized, controlled trial
    S H Sindrup
    Department of Neurology, University Hospitals, Odense, Denmark
    Neurology 60:1284-9. 2003
    ..Venlafaxine is a serotonin and weak noradrenaline reuptake inhibitor antidepressant with a different profile of other pharmacologic actions from those of TCA...
  5. ncbi request reprint Health-related quality of life and its predictive role for analgesic effect in patients with painful polyneuropathy
    Marit Otto
    Department of Neurology, Odense University Hospital, DK 5000 Odense C, Denmark
    Eur J Pain 11:572-8. 2007
    ..Results show an impaired HRQL in painful polyneuropathy and suggest that HRQL may predict response to analgesic treatment...
  6. doi request reprint The anticonvulsant levetiracetam for the treatment of pain in polyneuropathy: a randomized, placebo-controlled, cross-over trial
    Jakob V Holbech
    Department of Neurology, Odense University Hospital, Denmark
    Eur J Pain 15:608-14. 2011
    ..This could have an impact on signaling in the nociceptive system, and a pilot study indicated relief of neuropathic pain with levetiracetam...
  7. ncbi request reprint Escitalopram in painful polyneuropathy: a randomized, placebo-controlled, cross-over trial
    Marit Otto
    Department of Neurology, Odense University Hospital, University of Southern Denmark, Sdr Boulevard 29, Odense C, Denmark
    Pain 139:275-83. 2008
    ..Currently, the drug cannot be recommended as a standard treatment in neuropathic pain...
  8. ncbi request reprint Pain phenomena and possible mechanisms in patients with painful polyneuropathy
    Marit Otto
    Department of Neurology, Odense University, Odense Universitetshospital, Neurologisk afdeling, Sdr Boulevard 29, DK 5000, Odense C, Denmark
    Pain 101:187-92. 2003
    ..sensitized small fibers as the single mechanism of pain is rare; and (4). pain symptomatology cannot predict pain mechanisms as being mainly deafferentation or sensitized small fibers...
  9. ncbi request reprint Antidepressants in the treatment of neuropathic pain
    Søren H Sindrup
    Department of Neurology, Odense University Hospital, DK 5000 Odense, Denmark
    Basic Clin Pharmacol Toxicol 96:399-409. 2005
    ..However, without head-to-head comparisons between antidepressants and other analgesics, it is not possible to provide real evidence-based treatment algorithms for neuropathic pain...
  10. ncbi request reprint Chronic neuropathic pain: mechanisms, drug targets and measurement
    Nanna B Finnerup
    Department of Neurology, Danish Pain Research Center, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    Fundam Clin Pharmacol 21:129-36. 2007
    ..The present review summarizes mechanisms of neuropathic pain, targets of currently used drugs, and measures used in neuropathic pain trials...
  11. ncbi request reprint Valproic acid has no effect on pain in polyneuropathy: a randomized, controlled trial
    Marit Otto
    Department of Neurology, Odense University Hospital, Denmark
    Neurology 62:285-8. 2004
    ..There was no significant difference between valproic acid and placebo in the rating of total pain (median, 5 in the valproic acid period vs 6 in the placebo period; p = 0.24) or in individual pain ratings...
  12. ncbi request reprint The NK1-receptor antagonist TKA731 in painful diabetic neuropathy: a randomised, controlled trial
    Søren H Sindrup
    Department of Neurology, Odense University Hospital, Denmark
    Eur J Pain 10:567-71. 2006
    ..4 mm vs. -11.6 mm, p = 0.664) nor for change in ratings of different pain symptoms (touch- or pressure-evoked pain, pain paroxysms, steady burning or deep aching pain) (p = 0.169-0.834)...
  13. doi request reprint A candidate gene study of serotonergic pathway genes and pain relief during treatment with escitalopram in patients with neuropathic pain shows significant association to serotonin receptor2C (HTR2C)
    Charlotte Brasch-Andersen
    Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark
    Eur J Clin Pharmacol 67:1131-7. 2011
    ..The aim of this study was to investigate the association between polymorphisms in genes involved in the serotonergic pathway and the effect of escitalopram on peripheral neuropathic pain...
  14. pmc An evidence-based algorithm for the treatment of neuropathic pain
    Nanna B Finnerup
    Department of Neurology, Danish Pain Research Center, Aarhus University Hospital, Aarhus, Denmark
    MedGenMed 9:36. 2007
    ..The purpose of this article is to discuss an evidence-based algorithm that can be implemented by the primary care physician in his/her daily clinical practice for the treatment of patients with neuropathic pain conditions...
  15. ncbi request reprint Specific effect of levetiracetam in experimental human pain models
    Thomas P Enggaard
    Institute of Public Health, Clinical Pharmacology, University of Southern Denmark, Odense University, Winslowparken 19, DK 5000 Odense C, Denmark
    Eur J Pain 10:193-8. 2006
    ..Levetiracetam is a new antiepileptic drug. There is only limited experience with levetiracetam in clinical neuropathic pain...
  16. ncbi request reprint The analgesic effect of tramadol after intravenous injection in healthy volunteers in relation to CYP2D6
    Thomas P Enggaard
    Clinical Pharmacology, University of Southern Denmark
    Anesth Analg 102:146-50. 2006
    ..The opioid effect of (+)-M1 appears to contribute to the analgesic effect of tramadol, but the monoaminergic effect of tramadol itself seems to create an analgesic effect...
  17. ncbi request reprint Spontaneous temporal changes and variability of peripheral nerve conduction analyzed using a random effects model
    Thomas Krøigård
    Department of Neurology, Odense University Hospital, Odense, Denmark
    J Clin Neurophysiol 31:387-91. 2014
    ..Nerve conduction studies have a high reproducibility, and variables are mainly unaltered during 6 months. This study provides a solid basis for the planning of future clinical trials assessing changes in nerve conduction...