Jakob Benedict Seidelin

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. doi request reprint ERK controls epithelial cell death receptor signalling and cellular FLICE-like inhibitory protein (c-FLIP) in ulcerative colitis
    Jakob Benedict Seidelin
    Department of Gastroenterology, Medical Section 54 O3, Herlev Hospital, Herlev Ringvej 75, 2730 Herlev, Denmark
    J Mol Med (Berl) 91:839-49. 2013
  2. ncbi request reprint Mucosal healing in ulcerative colitis: pathophysiology and pharmacology
    Jakob Benedict Seidelin
    Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    Adv Clin Chem 59:101-23. 2013
  3. doi request reprint IL-33 is upregulated in colonocytes of ulcerative colitis
    Jakob Benedict Seidelin
    Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Denmark
    Immunol Lett 128:80-5. 2010
  4. doi request reprint Aeromedical transport after acute myocardial infarction
    Jakob B Seidelin
    Euro Alarm A S, Copenhagen Ø, Denmark
    J Travel Med 16:96-100. 2009
  5. doi request reprint Attenuated apoptosis response to Fas-ligand in active ulcerative colitis
    Jakob B Seidelin
    Department of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Denmark
    Inflamm Bowel Dis 14:1623-9. 2008
  6. ncbi request reprint Upregulation of cIAP2 in regenerating colonocytes in ulcerative colitis
    Jakob B Seidelin
    University of Copenhagen, Copenhagen, Denmark
    Virchows Arch 451:1031-8. 2007
  7. ncbi request reprint Expression profiling of apoptosis-related genes in enterocytes isolated from patients with ulcerative colitis
    Jakob B Seidelin
    Department of Medical Gastroenterology C, Herlev Hospital, Copenhagen University, Denmark
    APMIS 114:508-17. 2006
  8. ncbi request reprint [Transdermal nicotine treatment of ulcerative colitis: a survey of a Cochrane review]
    Jakob Benedict Seidelin
    Helsingør Sygehus, Medicinsk afdeling, Helsingør
    Ugeskr Laeger 168:674-7. 2006
  9. doi request reprint Epithelial apoptosis: cause or consequence of ulcerative colitis?
    Jakob Benedict Seidelin
    Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Denmark
    Scand J Gastroenterol 44:1429-34. 2009
  10. doi request reprint A role for interleukin-33 in T(H)2-polarized intestinal inflammation?
    J B Seidelin
    Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Mucosal Immunol 4:496-502. 2011

Collaborators

Detail Information

Publications28

  1. doi request reprint ERK controls epithelial cell death receptor signalling and cellular FLICE-like inhibitory protein (c-FLIP) in ulcerative colitis
    Jakob Benedict Seidelin
    Department of Gastroenterology, Medical Section 54 O3, Herlev Hospital, Herlev Ringvej 75, 2730 Herlev, Denmark
    J Mol Med (Berl) 91:839-49. 2013
    ..The results explain the resistance to receptor mediated epithelial apoptosis in active UC. Oncogenic c-FLIP could promote propagation of DNA-damaged IECs and contribute to cancer development in UC...
  2. ncbi request reprint Mucosal healing in ulcerative colitis: pathophysiology and pharmacology
    Jakob Benedict Seidelin
    Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    Adv Clin Chem 59:101-23. 2013
    ....
  3. doi request reprint IL-33 is upregulated in colonocytes of ulcerative colitis
    Jakob Benedict Seidelin
    Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Denmark
    Immunol Lett 128:80-5. 2010
    ..This is the first study to describe that IL-33 is upregulated in UC. If IL-33 is driving a Th2-like cytokine response in UC, inhibition of the IL-33 T1/ST2 receptor pathway could be a future therapeutic option in UC...
  4. doi request reprint Aeromedical transport after acute myocardial infarction
    Jakob B Seidelin
    Euro Alarm A S, Copenhagen Ø, Denmark
    J Travel Med 16:96-100. 2009
    ..In 2004, we employed a risk evaluation-based decision-making system for repatriation of patients after AMI. The objective was to evaluate the safety of transports during 2005 managed by this system...
  5. doi request reprint Attenuated apoptosis response to Fas-ligand in active ulcerative colitis
    Jakob B Seidelin
    Department of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, Denmark
    Inflamm Bowel Dis 14:1623-9. 2008
    ..The aim was to investigate both the spontaneous and the cell death receptor ligand-induced apoptosis in UC...
  6. ncbi request reprint Upregulation of cIAP2 in regenerating colonocytes in ulcerative colitis
    Jakob B Seidelin
    University of Copenhagen, Copenhagen, Denmark
    Virchows Arch 451:1031-8. 2007
    ..This might play a role in regeneration of the epithelium but might additionally be implicated in carcinogenesis of UC...
  7. ncbi request reprint Expression profiling of apoptosis-related genes in enterocytes isolated from patients with ulcerative colitis
    Jakob B Seidelin
    Department of Medical Gastroenterology C, Herlev Hospital, Copenhagen University, Denmark
    APMIS 114:508-17. 2006
    ..Both receptor- and mitochondrion-dependent apoptosis pathways are well expressed in enterocytes. Mainly activation-dependent and cytoprotective genes were upregulated in ulcerative colitis...
  8. ncbi request reprint [Transdermal nicotine treatment of ulcerative colitis: a survey of a Cochrane review]
    Jakob Benedict Seidelin
    Helsingør Sygehus, Medicinsk afdeling, Helsingør
    Ugeskr Laeger 168:674-7. 2006
  9. doi request reprint Epithelial apoptosis: cause or consequence of ulcerative colitis?
    Jakob Benedict Seidelin
    Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Denmark
    Scand J Gastroenterol 44:1429-34. 2009
    ..The aim of the study was to investigate the relationship between epithelial apoptosis and clinical characteristics of UC...
  10. doi request reprint A role for interleukin-33 in T(H)2-polarized intestinal inflammation?
    J B Seidelin
    Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Mucosal Immunol 4:496-502. 2011
    ..As the IL-33/ST2 receptor axis can be manipulated by various blocking antibodies, this could be a potential therapeutic target in the future treatment of UC...
  11. pmc Evidence for impaired CARD15 signalling in Crohn's disease without disease linked variants
    Jakob Benedict Seidelin
    Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Denmark
    PLoS ONE 4:e7794. 2009
    ..However, only a small fraction of CD patients carry the disease linked CARD15 variants. The aim of this study was thus to investigate if changes could be found in CARD15 signalling in patients without disease associated CARD15 variants...
  12. pmc pcaGoPromoter--an R package for biological and regulatory interpretation of principal components in genome-wide gene expression data
    Morten Hansen
    Department of Cellular and Molecular Medicine, The Panum Institute, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e32394. 2012
    ..These tools give an overview of the input data via PCA, functional interpretation by gene ontology terms (biological processes), and an indication of the involvement of possible transcription factors...
  13. doi request reprint MAP kinases in inflammatory bowel disease
    Mehmet Coskun
    Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Herlev, Denmark
    Clin Chim Acta 412:513-20. 2011
    ....
  14. pmc miR-20b, miR-98, miR-125b-1*, and let-7e* as new potential diagnostic biomarkers in ulcerative colitis
    Mehmet Coskun
    Mehmet Coskun, Jacob Tveiten Bjerrum, Jakob Benedict Seidelin, Ole Haagen Nielsen, Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, DK 2730 Herlev, Denmark
    World J Gastroenterol 19:4289-99. 2013
    ..To use microarray-based miRNA profiling of colonic mucosal biopsies from patients with ulcerative colitis (UC), Crohn's disease (CD), and controls in order to identify new potential miRNA biomarkers in inflammatory bowel disease...
  15. pmc MicroRNAs in inflammatory bowel disease--pathogenesis, diagnostics and therapeutics
    Mehmet Coskun
    Department of Gastroenterology, Medical Section 54O3, University of Copenhagen, Herlev Hospital, DK 2730 Herlev, Denmark
    World J Gastroenterol 18:4629-34. 2012
    ..Here, we provide a short review of the current state-of-the-art of miRNAs in IBD pathogenesis, diagnostics and therapeutics...
  16. ncbi request reprint [The role of micro-ribonucleic acid in disease development]
    Budiman Widjaya
    Gastroenheden, Medicinsk Sektion, Herlev Hospital, DK 2730 Herlev, Denmark
    Ugeskr Laeger 171:3441-4. 2009
    ..The manipulation of the expression of one or several specific miRNAs could prove to be a promising treatment option, and may improve diagnostics and therapeutics in future patient care...
  17. ncbi request reprint Continuous cytokine exposure of colonic epithelial cells induces DNA damage
    Jakob B Seidelin
    Department of Gastroenterology C, Herlev Hospital, Copenhagen University, Herlev, Denmark
    Eur J Gastroenterol Hepatol 17:363-9. 2005
    ..NO as well as other ROS are potential DNA damaging agents. The aim was to determine the effect of long-term cytokine exposure on NO formation and DNA damage in epithelial cells...
  18. doi request reprint Biological treatment of Crohn's disease
    Ole Haagen Nielsen
    Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark ohn dadlnet dk
    Dig Dis 30:121-33. 2012
    ..In some situations, the risks (i.e. immunogenicity, serious infections and the promotion of neoplasia) may, however, not outweigh the benefits of biological treatment...
  19. doi request reprint Outcome after discontinuation of infliximab in patients with inflammatory bowel disease in clinical remission: an observational Danish single center study
    Casper Steenholdt
    Dept of Gastroenterology, Herlev Hospital, Denmark
    Scand J Gastroenterol 47:518-27. 2012
    ....
  20. doi request reprint Pathogenesis and biomarkers of carcinogenesis in ulcerative colitis
    Sigrun Thorsteinsdottir
    Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, 75 Herlev Ringvej, DK 2730 Herlev, Denmark
    Nat Rev Gastroenterol Hepatol 8:395-404. 2011
    ..Several other new biomarkers, including senescence markers and α-methylacyl-CoA-racemase, might be future candidates for preneoplastic markers in ulcerative colitis...
  21. doi request reprint Diagnosis of ulcerative colitis before onset of inflammation by multivariate modeling of genome-wide gene expression data
    Jørgen Olsen
    Department of Cellular and Molecular Medicine, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    Inflamm Bowel Dis 15:1032-8. 2009
    ..Previous studies indicate that CD cannot be diagnosed by molecular and histological diagnostic tools using colonic biopsies without microscopic signs of inflammation, but it is unknown if this is also the case for UC...
  22. ncbi request reprint Simple and efficient method for isolation and cultivation of endoscopically obtained human colonocytes
    Jakob B Seidelin
    Department of Medical Gastroenterology C, Herlev Hospital, University of Copenhagen, DK 2730 Herlev, Denmark
    Am J Physiol Gastrointest Liver Physiol 285:G1122-8. 2003
    ..CM had similar viability supporting effects to FCS. Other supplements had no effects. A simple method is presented, which makes cultivation of colonocytes obtained at endoscopy possible for up to 72 h...
  23. doi request reprint Muramyl dipeptide responsive pathways in Crohn's disease: from NOD2 and beyond
    Mohammad Salem
    Department of Gastroenterology D, Medical Section, Herlev Hospital, University of Copenhagen, Herlev Ringvej 75, 2730, Herlev, Denmark
    Cell Mol Life Sci 70:3391-404. 2013
    ..The important aspects of NOD2 and non-NOD2 mediated effects of MDP for the development of CD are highlighted, as well as how alterations in these pathways might translate into the development of new therapeutic strategies. ..
  24. ncbi request reprint Continuous interferon-gamma or tumor necrosis factor-alpha exposure of enterocytes attenuates cell death responses
    Jakob B Seidelin
    Department of Gastroenterology C, Herlev Hospital, Copenhagen University, Copenhagen, Denmark
    Cytokine 27:113-9. 2004
    ..Increased proliferation and decreased cell death response may act as a counter regulatory mechanism that limits the damaging effects of cytokines...
  25. ncbi request reprint Soluble L-selectin levels predict survival in sepsis
    Jakob B Seidelin
    Department of Gastroenterology C, Herlev Hospital, University of Copenhagen, Denmark
    Intensive Care Med 28:1613-8. 2002
    ..To evaluate serum soluble L-selectin as a prognostic factor for survival in patients with sepsis...
  26. ncbi request reprint Transcriptome changes during intestinal cell differentiation
    Mehrdad Tadjali
    Department of Medical Biochemistry and Genetics, Biochemical Laboratory C, The Panum Institute, University of Copenhagen, Denmark
    Biochim Biophys Acta 1589:160-7. 2002
    ..In a screen of eight transcripts one - SART3 - was identified as a marker for human colonic crypts...
  27. ncbi request reprint Insulin-like growth factor binding protein 3 in inflammatory bowel disease
    Irena Kirman
    Department of Surgery, Columbia University, New York, New York, USA
    Dig Dis Sci 50:780-4. 2005
    ..The level of intact IGFBP-3 is decreased in IBD patients with moderate to severe disease activity. This decrease may be linked to altered IGFBP-3 production or to increased cleavage by proteases other than MMP-9...
  28. ncbi request reprint [Apoptosis in chronic inflammatory bowel disease. The importance for pathogenesis and treatment]
    Jakob Benedict Seidelin
    Medicinsk Gastroenterologisk Afdeling C, Amtssygehuset i Herlev, Herlev Ringvej, DK 2730 Herlev
    Ugeskr Laeger 165:790-2. 2003
    ..This review focuses on the regulation of epithelial and leucocyte apoptosis in the IBD colon. Furthermore, the implications for present and future therapeutic strategies are discussed...