Affiliation: University of Aarhus
- The long-term effects of a life-prolonging heat treatment on the Drosophila melanogaster transcriptome suggest that heat shock proteins extend lifespanP Sarup
Aarhus Centre for Environmental Stress Research ACES, Department of Bioscience, Aarhus University, Ny Munkegade 114, Building 1540, 8000 Aarhus C, Denmark Department of Molecular Biology and Genetics, Center for Quantitative Genetics and Genomics, Aarhus University, Blichers alle 20, 8830 Tjele, Denmark Electronic address
Exp Gerontol 50:34-9. 2014..We conclude that the heat shock response, and Hsp70 in particular, may be central to the heat-induced increase in the average lifespan in flies that are exposed to mild heat stress early in life...
- The metabolic profile of long-lived Drosophila melanogasterPernille Sarup
Department of Bioscience, Integrative Ecology and Evolution, Aarhus University, Aarhus, Denmark
PLoS ONE 7:e47461. 2012..Links between longevity and choline concentration is also found in mice making this metabolite an obvious target for further study...
- Local adaptation of stress related traits in Drosophila buzzatii and Drosophila simulans in spite of high gene flowP Sarup
Aarhus Centre for Environmental Stress Research ACES, Ecology and Genetics Department of Biology, University of Aarhus, Ny Munkegade, Aarhus C, Denmark
J Evol Biol 22:1111-22. 2009..buzzatii than D. simulans. We found clinal variation, as some traits showed significant linear regressions on altitude, but more on altitude cubed...
- Candidate genes detected in transcriptome studies are strongly dependent on genetic backgroundPernille Sarup
Department of Biological Sciences, Aarhus University, Aarhus, Denmark
PLoS ONE 6:e15644. 2011....
- Life extension and the position of the hormetic zone depends on sex and genetic background in Drosophila melanogasterPernille Sarup
Department of Biological Sciences, Ecology and Genetics, Aarhus Centre for Environmental Stress Research, Aarhus University, Denmark
Biogerontology 12:109-17. 2011....
- Flies selected for longevity retain a young gene expression profilePernille Sarup
Aarhus Centre for Environmental Stress Research ACES, Department of Biological Sciences, Aarhus University, Ny Munkegade 114, Aarhus C, Denmark
Age (Dordr) 33:69-80. 2011..Investigating these genes would provide new knowledge of the pathways that affect life span in invertebrates and, potentially, mammals...
- Developmental acclimation affects clinal variation in stress resistance traits in Drosophila buzzatiiP Sarup
Aarhus Centre for Environmental Stress Research ACES, Department of Biological Sciences, Ecology and Genetics, Aarhus University, Aarhus C, Denmark
J Evol Biol 23:957-65. 2010..This result emphasizes the importance of determining whether populations originating from different environments differ in their plastic responses to stress...
- Climatic adaptation of Drosophila buzzatii populations in southeast AustraliaP Sarup
Aarhus Centre for Environmental Stress Research ACES, Department of Ecology and Genetics, University of Aarhus, Ny Munkegade, Buildg 540, DK 8000 Aarhus C, Denmark
Heredity (Edinb) 96:479-86. 2006..These results highlight the complex challenges imposed by the environment on the adaptive process...
- Laboratory selection for increased longevity in Drosophila melanogaster reduces field performanceJanneke Wit
Department of Bioscience, Integrative Ecology and Evolution, Aarhus University, Ny Munkegade 114 116, DK 8000 Aarhus C, Denmark Electronic address
Exp Gerontol 48:1189-95. 2013..Control lines were better able to locate a resource compared to longevity selected lines of the same age, suggesting that longevity comes at a cost in early life field fitness, supporting the antagonistic pleiotropy theory of ageing...
- Confirming candidate genes for longevity by RT-qPCR using two different genetic backgrounds and selection methodsJanneke Wit
Department of Bioscience, Integrative Ecology and Evolution, Aarhus University, NyMunkegade 114 116, DK 8000 Aarhus C, Denmark
J Insect Physiol 59:255-62. 2013..We found one robust candidate gene for longevity, CG32638. Three other genes, CG8934, mRpS10 and Spn43Ad, showed a tendency to be involved in life span determination in both backgrounds tested...
- Longevity for free? Increased reproduction with limited trade-offs in Drosophila melanogaster selected for increased life spanJanneke Wit
Department of Bioscience, Integrative Ecology and Evolution, Aarhus University, Ny Munkegade 114 116, DK 8000 Aarhus C, Denmark
Exp Gerontol 48:349-57. 2013..Males from longevity selected lines were slower at recovering from a chill induced coma and resting metabolic rate increased with age, but did not correlate with life span...
- Evolutionary theory and studies of model organisms predict a cautiously positive perspective on the therapeutic use of hormesis for healthy aging in humansJesper G Sørensen
Department of Terrestrial Ecology, National Environmental Research Institute, Aarhus University, Vejlsøvej 25, Silkeborg, Denmark
Dose Response 8:53-7. 2009..One obstacle is the development of precise treatments optimized for single individuals. Only then can we progress with the use of hormesis as a therapeutic tool for humans...
- Heat and cold-induced male sterility in Drosophila buzzatii: genetic variation among populations for the duration of sterilityJ H Vollmer
Department of Ecology and Genetics, University of Aarhus, Ny Munkegade, 8000 Aarhus C, Denmark
Heredity (Edinb) 92:257-62. 2004..Significant differences in viability were found among development temperatures, but not among lines, and viability and the duration of sterility seem to be genetically independent...