Erik A Richter

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. pmc AMPK alpha1 activation is required for stimulation of glucose uptake by twitch contraction, but not by H2O2, in mouse skeletal muscle
    Thomas E Jensen
    Molecular Physiology Group, Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 3:e2102. 2008
  2. ncbi request reprint Partial restoration of dietary fat induced metabolic adaptations to training by 7 days of carbohydrate diet
    Jørn W Helge
    Copenhagen Muscle Research Centre, Department of Human Physiology, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 93:1797-805. 2002
  3. pmc Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise
    Adam J Rose
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Universitetsparken 13, Copenhagen, Denmark, 2100
    J Physiol 574:889-903. 2006
  4. ncbi request reprint PGC-1alpha: important for exercise performance?
    Henriette Pilegaard
    J Appl Physiol 104:1264-5. 2008
  5. pmc AMPK and the biochemistry of exercise: implications for human health and disease
    Erik A Richter
    Molecular Physiology Group, Department of Exercise and Sport Sciences, Copenhagen Muscle Research Centre, University of Copenhagen, August Krogh Building, 13 Universitetsparken, 2100 Copenhagen, Denmark
    Biochem J 418:261-75. 2009
  6. pmc Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle
    Lykke Sylow
    Molecular Physiology Group, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark
    Diabetes 62:1139-51. 2013
  7. doi request reprint Exercise, GLUT4, and skeletal muscle glucose uptake
    Erik A Richter
    Molecular Physiology Group, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark
    Physiol Rev 93:993-1017. 2013
  8. doi request reprint Can exercise mimetics substitute for exercise?
    Erik A Richter
    Molecular Physiology Group, Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, University of Copenhagen, Denmark
    Cell Metab 8:96-8. 2008
  9. doi request reprint Effects of contraction on localization of GLUT4 and v-SNARE isoforms in rat skeletal muscle
    Adam J Rose
    Molecular Physiology Group, Department of Exercise and Sport Sciences, Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 297:R1228-37. 2009
  10. pmc Exercise alleviates lipid-induced insulin resistance in human skeletal muscle-signaling interaction at the level of TBC1 domain family member 4
    Christian Pehmøller
    Department of Exercise and Sport Sciences, Molecular Physiology Group, University of Copenhagen, Copenhagen, Denmark
    Diabetes 61:2743-52. 2012

Detail Information

Publications91

  1. pmc AMPK alpha1 activation is required for stimulation of glucose uptake by twitch contraction, but not by H2O2, in mouse skeletal muscle
    Thomas E Jensen
    Molecular Physiology Group, Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 3:e2102. 2008
    ....
  2. ncbi request reprint Partial restoration of dietary fat induced metabolic adaptations to training by 7 days of carbohydrate diet
    Jørn W Helge
    Copenhagen Muscle Research Centre, Department of Human Physiology, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 93:1797-805. 2002
    ....
  3. pmc Ca2+-calmodulin-dependent protein kinase expression and signalling in skeletal muscle during exercise
    Adam J Rose
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Universitetsparken 13, Copenhagen, Denmark, 2100
    J Physiol 574:889-903. 2006
    ..These data indicate that CaMKII is the major multifunctional CaMK in skeletal muscle and its activation occurs rapidly and is sustained during continuous exercise, with the activation being greater during intense exercise...
  4. ncbi request reprint PGC-1alpha: important for exercise performance?
    Henriette Pilegaard
    J Appl Physiol 104:1264-5. 2008
  5. pmc AMPK and the biochemistry of exercise: implications for human health and disease
    Erik A Richter
    Molecular Physiology Group, Department of Exercise and Sport Sciences, Copenhagen Muscle Research Centre, University of Copenhagen, August Krogh Building, 13 Universitetsparken, 2100 Copenhagen, Denmark
    Biochem J 418:261-75. 2009
    ..We also discuss the potential role of AMPK activation in mediating the prevention and treatment by exercise of specific disorders associated with the metabolic syndrome, including Type 2 diabetes and Alzheimer's disease...
  6. pmc Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle
    Lykke Sylow
    Molecular Physiology Group, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark
    Diabetes 62:1139-51. 2013
    ....
  7. doi request reprint Exercise, GLUT4, and skeletal muscle glucose uptake
    Erik A Richter
    Molecular Physiology Group, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark
    Physiol Rev 93:993-1017. 2013
    ....
  8. doi request reprint Can exercise mimetics substitute for exercise?
    Erik A Richter
    Molecular Physiology Group, Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, University of Copenhagen, Denmark
    Cell Metab 8:96-8. 2008
    ..A recent paper in Cell by Narkar et al. (2008) shows that many of the adaptations in muscle phenotype elicited by exercise can be mimicked by genetic manipulation and drug treatment in mice...
  9. doi request reprint Effects of contraction on localization of GLUT4 and v-SNARE isoforms in rat skeletal muscle
    Adam J Rose
    Molecular Physiology Group, Department of Exercise and Sport Sciences, Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 297:R1228-37. 2009
    ..These findings suggest that VAMP2, VAMP5, and VAMP7 may be involved in translocation of GLUT4 during muscle contractions...
  10. pmc Exercise alleviates lipid-induced insulin resistance in human skeletal muscle-signaling interaction at the level of TBC1 domain family member 4
    Christian Pehmøller
    Department of Exercise and Sport Sciences, Molecular Physiology Group, University of Copenhagen, Copenhagen, Denmark
    Diabetes 61:2743-52. 2012
    ..The prophylactic effect of exercise on lipid-induced insulin resistance may involve augmented TBC1D4 signaling and glycogen synthase activation...
  11. doi request reprint Genetic impairment of AMPKalpha2 signaling does not reduce muscle glucose uptake during treadmill exercise in mice
    Stine J Maarbjerg
    Department of Exercise and Sport Sciences, Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 297:E924-34. 2009
    ..Collectively, these findings suggest that AMPKalpha2 signaling is not essential in regulating glucose uptake in mouse skeletal muscle during treadmill exercise and that other mechanisms play a central role...
  12. pmc Absence of humoral mediated 5'AMP-activated protein kinase activation in human skeletal muscle and adipose tissue during exercise
    Jonas Møller Kristensen
    Copenhagen Muscle Research Centre, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen Ø, Denmark
    J Physiol 585:897-909. 2007
    ..Also, with this type of exercise the catecholamines or other humoral factors do not seem to be physiological regulators of AMPK in the subcutaneous adipose tissue...
  13. pmc Lipid-induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling
    Louise D Høeg
    Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, University of Copenhagen, Denmark
    Diabetes 60:64-73. 2011
    ..Women also express higher muscle mRNA levels of proteins related to lipid metabolism than men. We therefore hypothesized that women would be less prone to lipid-induced insulin resistance...
  14. ncbi request reprint Role of AMPKalpha2 in basal, training-, and AICAR-induced GLUT4, hexokinase II, and mitochondrial protein expression in mouse muscle
    Sebastian B Jørgensen
    Dept of Human Physiology, Copenhagen Muscle Research Centre, Inst of Exercise and Sport Sciences, 13 Universitetsparken, Univ of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 292:E331-9. 2007
    ..However, the alpha2-KO did not reduce training-induced increases in HKII, GLUT4, COX-1, HAD, or CS protein in WG, suggesting that AMPKalpha2 may not be essential for metabolic adaptations of skeletal muscles to exercise training...
  15. pmc Regulation of hormone-sensitive lipase activity and Ser563 and Ser565 phosphorylation in human skeletal muscle during exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Physiol 560:551-62. 2004
    ..Apparently, HSL Ser565 phosphorylation by AMPK during exercise had no effect on HSL activity. Alternatively, other factors including ERK may have counterbalanced any effect of AMPK on HSL activity...
  16. ncbi request reprint Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle
    Sebastian B Jørgensen
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    FASEB J 19:1146-8. 2005
    ....
  17. ncbi request reprint 5'-AMP-activated protein kinase activity and protein expression are regulated by endurance training in human skeletal muscle
    Christian Frøsig
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 286:E411-7. 2004
    ..Except for the increase in gamma1 protein, all observed adaptations to training could be ascribed to local contraction-induced mechanisms, since they did not occur in the contralateral untrained muscle...
  18. pmc A Ca(2+)-calmodulin-eEF2K-eEF2 signalling cascade, but not AMPK, contributes to the suppression of skeletal muscle protein synthesis during contractions
    Adam J Rose
    Copenhagen Muscle Research Centre and Molecular Physiology Group, Department of Exercise and Sport Sciences, University of Copenhagen, Denmark
    J Physiol 587:1547-63. 2009
    ..In summary, in fast-twitch skeletal muscle, the inhibition of eEF2 activity by phosphorylation downstream of Ca(2+)-CaM-eEF2K signalling partially contributes to the suppression of protein synthesis during exercise/contractions...
  19. doi request reprint Reduced malonyl-CoA content in recovery from exercise correlates with improved insulin-stimulated glucose uptake in human skeletal muscle
    Christian Frøsig
    Copenhagen Muscle Research Centre, Molecular Physiology Group, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    Am J Physiol Endocrinol Metab 296:E787-95. 2009
    ..Collectively, this study indicates that reduced muscle MCoA content in recovery from exercise may be part of the adaptive response leading to improved insulin action on glucose uptake after exercise in human muscle...
  20. pmc AMPK and insulin action--responses to ageing and high fat diet
    Christian Frøsig
    Section of Molecular Physiology, The August Krogh Centre, Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 8:e62338. 2013
    ....
  21. pmc Role of 5'AMP-activated protein kinase in glycogen synthase activity and glucose utilization: insights from patients with McArdle's disease
    Jakob N Nielsen
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Denmark
    J Physiol 541:979-89. 2002
    ....
  22. ncbi request reprint The alpha2-5'AMP-activated protein kinase is a site 2 glycogen synthase kinase in skeletal muscle and is responsive to glucose loading
    Sebastian B Jørgensen
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes 53:3074-81. 2004
    ..The fact that alpha2-AMPK is a GS kinase that inactivates GS while simultaneously activating glucose transport suggests that a balanced view on the suitability for AMPK as an antidiabetic drug target should be taken...
  23. ncbi request reprint Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle
    Sebastian B Jørgensen
    Copenhagen Muscle Research Centre, Department of Human Physiology, 13 Universitetsparken, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Biol Chem 279:1070-9. 2004
    ..Alternatively, neither alpha-isoform of AMPK is involved in contraction-induced muscle glucose uptake...
  24. doi request reprint Higher intramuscular triacylglycerol in women does not impair insulin sensitivity and proximal insulin signaling
    Louise Høeg
    The Copenhagen Muscle Research Centre, Molecular Physiology Group, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen Ø, Denmark
    J Appl Physiol (1985) 107:824-31. 2009
    ..This was not explained by sex differences in proximal insulin signaling in women. In women, it seems that a high capillary density and type 1 muscle fiber expression may be important for insulin action...
  25. ncbi request reprint Regulation of 5'AMP-activated protein kinase activity and substrate utilization in exercising human skeletal muscle
    Jorgen F P Wojtaszewski
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 284:E813-22. 2003
    ..It is concluded that muscle AMPK activity and ACCbeta Ser(221) phosphorylation at rest and during exercise are sensitive to the fuel status of the muscle. During exercise, this dependence may in part be mediated by humoral factors...
  26. ncbi request reprint Possible CaMKK-dependent regulation of AMPK phosphorylation and glucose uptake at the onset of mild tetanic skeletal muscle contraction
    Thomas E Jensen
    Department of Human Physiology, Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 292:E1308-17. 2007
    ....
  27. ncbi request reprint 5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle
    Jakob N Nielsen
    Institute of Exercise and Sport Sciences, Copenhagen Muscle Research Centre, University of Copenhagen, Denmark
    J Appl Physiol (1985) 94:631-41. 2003
    ..01). In conclusion, trained human skeletal muscle has increased alpha(1)-AMPK protein levels and blunted AMPK activation during exercise...
  28. ncbi request reprint Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 288:E133-42. 2005
    ..They also suggest that, with high muscle glycogen, the availability of free carnitine may limit fat oxidation during exercise, due to its increased use for acetylcarnitine formation...
  29. doi request reprint Cafeteria diet-induced insulin resistance is not associated with decreased insulin signaling or AMPK activity and is alleviated by physical training in rats
    Nina Brandt
    Molecular Physiology Group, Department of Exercise and Sport Sciences, Copenhagen Muscle Research Centre, University of Copenhagen, 13 Universitetsparken, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 299:E215-24. 2010
    ..Thus, compared with previous studies of high-fat feeding, where insulin signaling is significantly impaired, the mechanism by which CAF diet induces insulin resistance seems different...
  30. pmc Exercise improves phosphatidylinositol-3,4,5-trisphosphate responsiveness of atypical protein kinase C and interacts with insulin signalling to peptide elongation in human skeletal muscle
    Christian Frøsig
    Copenhagen Muscle Research Centre, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, 13, Universitetsparken, DK 2100, Copenhagen, Denmark
    J Physiol 582:1289-301. 2007
    ..Furthermore, endurance exercise increased the responsiveness of aPKC to PIP3 providing a possible link to improved insulin-stimulated glucose uptake after exercise...
  31. pmc LKB1 regulates lipid oxidation during exercise independently of AMPK
    Jacob Jeppesen
    August Krogh Centre and Molecular Physiology Group, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes 62:1490-9. 2013
    ..Our findings demonstrate that LKB1 is a novel molecular regulator of major importance for FA oxidation but not glucose uptake in muscle during exercise...
  32. pmc Muscle metabolism during graded quadriceps exercise in man
    Jørn W Helge
    Copenhagen Muscle Research Centre, Department of Biomedical Sciences, Panum Institute, Blegdamsvej 3, DK 2200 N, Copenhagen, Denmark
    J Physiol 581:1247-58. 2007
    ..These findings are in contrast to whole body measurements performed during graded exercise involving a large muscle mass during which fat oxidation peaks at around 60% of ...
  33. pmc Effect of endurance exercise training on Ca2+ calmodulin-dependent protein kinase II expression and signalling in skeletal muscle of humans
    Adam J Rose
    Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Universitetsparken 13, Copenhagen, Denmark 2100
    J Physiol 583:785-95. 2007
    ..This may contribute to greater Ca(2+) mediated regulation during exercise and the altered muscle phenotype with training...
  34. doi request reprint A new method to study changes in microvascular blood volume in muscle and adipose tissue: real-time imaging in humans and rat
    Kim A Sjøberg
    Molecular Physiology Group, Department of Exercise and Sport Sciences, University of Copenhagen, Denmark
    Am J Physiol Heart Circ Physiol 301:H450-8. 2011
    ..Because of real-time imaging, the method has wide applications for determining MBV in different organs during various physiological or pathophysiological conditions...
  35. pmc Genetic disruption of AMPK signaling abolishes both contraction- and insulin-stimulated TBC1D1 phosphorylation and 14-3-3 binding in mouse skeletal muscle
    Christian Pehmøller
    Molecular Physiology Group, Copenhagen Muscle Research Centre, Dept of Exercise and Sport Sciences, Univ of Copenhagen, DK 2100, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 297:E665-75. 2009
    ..Thus, TBC1D1 is differentially regulated in response to insulin and contraction. This study provides genetic evidence to support an important role for AMPK in regulating TBC1D1 in response to both of these physiological stimuli...
  36. ncbi request reprint AS160 phosphorylation is associated with activation of alpha2beta2gamma1- but not alpha2beta2gamma3-AMPK trimeric complex in skeletal muscle during exercise in humans
    Jonas T Treebak
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 292:E715-22. 2007
    ..Furthermore, we show that AMPK complexes in skeletal muscle are activated differently depending on exercise intensity and duration...
  37. ncbi request reprint Caffeine-induced Ca(2+) release increases AMPK-dependent glucose uptake in rodent soleus muscle
    Thomas E Jensen
    Department of Exercise and Sport Sciences, Copenhagen Muscle Research Center, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 293:E286-92. 2007
    ..We conclude that a SR Ca(2+)-activated CaMKK may control alpha(1)-AMPK activation and be necessary for caffeine-stimulated glucose uptake in mouse soleus muscle...
  38. ncbi request reprint Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160
    Christian Frøsig
    Copenhagen Muscle Research Centre, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes 56:2093-102. 2007
    ....
  39. ncbi request reprint Interleukin-6 release from human skeletal muscle during exercise: relation to AMPK activity
    Christopher MacDonald
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Denmark
    J Appl Physiol (1985) 95:2273-7. 2003
    ..Alternatively, both AMPK and IL-6 are independent sensors of a low muscle glycogen concentration during exercise. In addition, leg release of IL-6 cannot alone explain the increase in plasma IL-6 during exercise...
  40. doi request reprint Adiponectin concentration is associated with muscle insulin sensitivity, AMPK phosphorylation, and ceramide content in skeletal muscles of men but not women
    Louise D Høeg
    The August Krogh Centre, Molecular Physiology Group, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Appl Physiol (1985) 114:592-601. 2013
    ..The lower skeletal muscle AdipoR1 protein expression and lower expression of adiponectin-sensitive type 2 muscle fibers in women than in men may explain the apparent lesser sensitivity to adiponectin in women...
  41. ncbi request reprint Exercise signalling to glucose transport in skeletal muscle
    Erik A Richter
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Universitetsparken 13, 2100 Copenhagen Ø, Denmark
    Proc Nutr Soc 63:211-6. 2004
    ..Furthermore, the p38 mitogen-activated protein kinase may be involved in activating the GLUT4 translocated to the surface membrane. Nevertheless, the picture is incomplete, and fibre type differences also seem to be involved...
  42. pmc Rac1 signaling is required for insulin-stimulated glucose uptake and is dysregulated in insulin-resistant murine and human skeletal muscle
    Lykke Sylow
    Molecular Physiology Group, Department of Nutrition, Exercise, and Sports, August Krogh Centre, University of Copenhagen, Copenhagen, Denmark
    Diabetes 62:1865-75. 2013
    ..These findings show that Rac1 is a regulator of insulin-stimulated glucose uptake and a novel candidate involved in skeletal muscle insulin resistance...
  43. pmc Exercise rapidly increases eukaryotic elongation factor 2 phosphorylation in skeletal muscle of men
    Adam J Rose
    Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, Department of Human Physiology, Copenhagen University, Denmark
    J Physiol 569:223-8. 2005
    ..Given that eEF2 phosphorylation inhibits eEF2 activity and mRNA translation, these findings suggest that the inhibition of protein synthesis in contracting skeletal muscle is due to the Ca(2)(+)-induced stimulation of eEF2 kinase...
  44. pmc Exercise-induced TBC1D1 Ser237 phosphorylation and 14-3-3 protein binding capacity in human skeletal muscle
    Christian Frøsig
    Molecular Physiology Group, Department of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Physiol 588:4539-48. 2010
    ..Furthermore, we show that the catalytic α2 AMPK subunit is the main (but probably not the only) donor of AMPK activity regulating TBC1D1 Ser237 phosphorylation in mouse EDL muscle...
  45. pmc Role of AMPK in skeletal muscle metabolic regulation and adaptation in relation to exercise
    Sebastian B Jørgensen
    Department of Human Physiology, Copenhagen Muscle Research Centre, Inst of Exercise and Sport Sciences, 13 Universitetsparken, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Physiol 574:17-31. 2006
    ..Finally, AMPK has a well established role in regulating expression of genes encoding various enzymes in muscle, and this issue is discussed in relation to adaptation of skeletal muscle to exercise training...
  46. ncbi request reprint Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle
    Jørgen F P Wojtaszewski
    Copenhagen Muscle Research Centre, Institute of Exercise and Sports Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes 51:284-92. 2002
    ..Because the glycogen level did not affect adenine nucleotide concentrations, our data suggest that glycogen may directly affect the activation state of AMPK in skeletal muscle...
  47. doi request reprint Protein kinase Cα activity is important for contraction-induced FXYD1 phosphorylation in skeletal muscle
    Martin Thomassen
    Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 301:R1808-14. 2011
    ..In conclusion, exercise induces FXYD1 phosphorylation at multiple sites in human skeletal muscle. In mouse muscles, contraction-induced changes in FXYD1 ser68 phosphorylation are fiber-type specific and dependent on PKCα activity...
  48. ncbi request reprint Increased atypical PKC activity in endurance-trained human skeletal muscle
    Jakob N Nielsen
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100, Copenhagen, Denmark
    Biochem Biophys Res Commun 312:1147-53. 2003
    ..Protein expression of the kinases was similar in trained and sedentary muscle. The increased aPKC activity in exercise-trained subjects could be important in explaining the enhanced insulin action in these individuals...
  49. ncbi request reprint AMPK activity and isoform protein expression are similar in muscle of obese subjects with and without type 2 diabetes
    Kurt Højlund
    Department of Human Physiology, Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 286:E239-44. 2004
    ..These data suggest that impaired insulin action on glycogen synthesis and lipid oxidation in skeletal muscle of obese type 2 diabetic subjects is unlikely to involve changes in AMPK expression and activity...
  50. doi request reprint Knockout of the predominant conventional PKC isoform, PKCalpha, in mouse skeletal muscle does not affect contraction-stimulated glucose uptake
    Thomas E Jensen
    Department of Exercise and Sport Sciences, Sectionof Human Physiology, University of Copenhagen, Copenhagen Muscle Research Centre, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 297:E340-8. 2009
    ..Thus the effect of the PKC blockers on glucose uptake is either nonspecific working on other parts of contraction-induced signaling or the remaining cPKC isoforms are sufficient for stimulating glucose uptake during contractions...
  51. ncbi request reprint Effects of acute exercise and training on insulin action and sensitivity: focus on molecular mechanisms in muscle
    Jørgen F P Wojtaszewski
    Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, University of Copenhagen, Denmark
    Essays Biochem 42:31-46. 2006
    ..The present review explores the molecular mechanisms involved in both the acute and chronic effects of exercise on insulin sensitivity in skeletal muscle...
  52. doi request reprint Na,K-ATPase activity in mouse muscle is regulated by AMPK and PGC-1α
    Maria S Ingwersen
    Department of Biology, University of Copenhagen, Denmark
    J Membr Biol 242:1-10. 2011
    ..Phosphorylation of the Na,K-ATPase subunit PLM is an important regulatory mechanism...
  53. doi request reprint Endurance training per se increases metabolic health in young, moderately overweight men
    Pernille Nordby
    Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    Obesity (Silver Spring) 20:2202-12. 2012
    ....
  54. pmc The effect of graded exercise on IL-6 release and glucose uptake in human skeletal muscle
    Jørn W Helge
    Copenhagen Muscle Research Centre, Rigshospitalet, Department of Medical Physiology, Panum Institute, University of Copenhagen, Denmark
    J Physiol 546:299-305. 2003
    ..The observation of a relationship between IL-6 release and muscle glycogen store both at rest and after exercise suggests that IL-6 may act as a carbohydrate sensor...
  55. doi request reprint Skeletal muscle eEF2 and 4EBP1 phosphorylation during endurance exercise is dependent on intensity and muscle fiber type
    Adam J Rose
    Molecular Physiology Group, Copenhagen Muscle Research Centre, Dept of Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Universitetsparken 13, Copenhagen, Denmark, 2100
    Am J Physiol Regul Integr Comp Physiol 296:R326-33. 2009
    ..e., 4EBP1) and elongation (i.e., eEF2) steps, with eEF2 phosphorylation contributing at all exercise intensities but 4EBP1 dephosphorylation contributing to a greater extent at high vs. low exercise intensities...
  56. pmc EMG-normalised kinase activation during exercise is higher in human gastrocnemius compared to soleus muscle
    Thomas E Jensen
    Molecular Physiology Group, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e31054. 2012
    ..This may be due to the combined subtle effects of a higher type I muscle fiber content and higher training status in soleus compared to gastrocnemius muscle...
  57. pmc Differential effect of bicycling exercise intensity on activity and phosphorylation of atypical protein kinase C and extracellular signal-regulated protein kinase in skeletal muscle
    Erik A Richter
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sports Sciences, University of Copenhagen, 13 Universitetsparken, DK 2100 Copenhagen, Denmark
    J Physiol 560:909-18. 2004
    ..In addition, increase in muscle activity of aPKC or ERK1/2 during exercise is not closely related to energy demands of the muscle but may serve other regulatory or permissive functions in muscle...
  58. pmc Regulation and function of Ca2+-calmodulin-dependent protein kinase II of fast-twitch rat skeletal muscle
    Adam J Rose
    Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Universitetsparken 13, Copenhagen, Denmark, 2100
    J Physiol 580:993-1005. 2007
    ..CaMKII may signal through trisk95 to modulate Ca(2+) release in fast-twitch rat skeletal muscle during exercise/contraction...
  59. ncbi request reprint Invited review: effect of acute exercise on insulin signaling and action in humans
    Jørgen F P Wojtaszewski
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sports Sciences, University of Copenhagen, Denmark
    J Appl Physiol 93:384-92. 2002
    ..Finally, 5'-AMP-activated protein kinase has recently entered the stage as a promising player in explaining at least a part of the mechanism by which exercise enhances insulin action...
  60. ncbi request reprint Decreased insulin action in skeletal muscle from patients with McArdle's disease
    Jakob N Nielsen
    Copenhagen Muscle Research Center, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2400 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 282:E1267-75. 2002
    ..The data further suggest that skeletal muscle glycogen levels play an important role in the regulation of insulin-stimulated glycogen synthase activity...
  61. ncbi request reprint Role of AMPK in skeletal muscle gene adaptation in relation to exercise
    Sebastian B Jørgensen
    Department of Human Physiology, Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, 13 Universitetsparken, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Appl Physiol Nutr Metab 32:904-11. 2007
    ..Although decreased AMPK activity in muscle causes reduced protein expression of mitochondrial enzymes in the basal state, AMPK does not appear to be indispensable for exercise-training induced increase in mitochondrial enzyme expression...
  62. doi request reprint Acute exercise and physiological insulin induce distinct phosphorylation signatures on TBC1D1 and TBC1D4 proteins in human skeletal muscle
    Jonas T Treebak
    The August Krogh Centre, Department of Nutrition, Exercise and Sports, Section of Molecular Physiology, University of Copenhagen, Universitetsparken 13 DK 2100, Copenhagen, Denmark
    J Physiol 592:351-75. 2014
    ....
  63. doi request reprint Akt and Rac1 signaling are jointly required for insulin-stimulated glucose uptake in skeletal muscle and downregulated in insulin resistance
    Lykke Sylow
    Molecular Physiology Group, Department of Nutrition, Exercise and Sports, August Krogh Centre, University of Copenhagen, Denmark Electronic address
    Cell Signal 26:323-31. 2014
    ..There may thus be multiple treatment targets for improving insulin sensitivity in muscle. ..
  64. doi request reprint Improved insulin sensitivity after exercise: focus on insulin signaling
    Christian Frøsig
    The Copenhagen Muscle Research Centre, Molecular Physiology Group, Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Obesity (Silver Spring) 17:S15-20. 2009
    ..Although the functional interpretation is lacking, these novel observations may present a breakthrough in understanding the beneficial interplay between exercise and insulin action...
  65. pmc Regulation of glucose and glycogen metabolism during and after exercise
    Thomas E Jensen
    Molecular Physiology Group, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    J Physiol 590:1069-76. 2012
    ....
  66. ncbi request reprint Muscle- and fibre type-specific expression of glucose transporter 4, glycogen synthase and glycogen phosphorylase proteins in human skeletal muscle
    Jens R Daugaard
    Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Pflugers Arch 447:452-6. 2004
    ..These findings imply that it is not possible to generalize fibre type-dependent protein expression on the basis of biopsies from only one muscle...
  67. ncbi request reprint Skeletal muscle glucose uptake during exercise: how is it regulated?
    Adam J Rose
    Department of Human Physiology, Institute of Exercise and Sport Sciences, Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    Physiology (Bethesda) 20:260-70. 2005
    ....
  68. doi request reprint Regulatory mechanisms of skeletal muscle protein turnover during exercise
    Adam J Rose
    Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, Universitetsparken 13, Copenhagen, Denmark
    J Appl Physiol (1985) 106:1702-11. 2009
    ..Further work with available and new techniques will undoubtedly reveal the functional significance and signaling mechanisms behind changes in skeletal muscle protein turnover during exercise...
  69. doi request reprint Contraction intensity and feeding affect collagen and myofibrillar protein synthesis rates differently in human skeletal muscle
    Lars Holm
    Institute of Sports Medicine, Bispebjerg Hospital and Center of Healthy Aging, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 298:E257-69. 2010
    ..Furthermore, although functionally linked, the contractile and the supportive matrix structures upregulate their protein synthesis rate quite differently in response to feeding and contractile activity and intensity...
  70. doi request reprint Randomized and double-blinded pilot clinical study of the safety and anti-diabetic efficacy of the Rauvolfia-Citrus tea, as used in Nigerian traditional medicine
    Joan I A Campbell-Tofte
    Dept of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universtitetsparken 2, 2100 Copenhagen, Denmark
    J Ethnopharmacol 133:402-11. 2011
    ..The tea is made by boiling foliage of Rauvolfia vomitoria and fruits of Citrus aurantium and is used to treat diabetes in Nigerian folk medicine...
  71. pmc Higher skeletal muscle alpha2AMPK activation and lower energy charge and fat oxidation in men than in women during submaximal exercise
    Carsten Roepstorff
    The Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, Department of Human Physiology, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    J Physiol 574:125-38. 2006
    ....
  72. ncbi request reprint Gender differences in substrate utilization during submaximal exercise in endurance-trained subjects
    Carsten Roepstorff
    Department of Human Physiology, Copenhagen Muscle Research Centre, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 282:E435-47. 2002
    ..However, an effect of gender appears to occur in the utilization of the different lipid sources...
  73. ncbi request reprint GLUT4-containing vesicles are released from membranes by phospholipase D cleavage of a GPI anchor
    Søren Kristiansen
    Copenhagen Muscle Reseach Centre, Department of Human Physiology, Institute of Exercise and Sports Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 283:E374-82. 2002
    ..Fourth, the purified GLUT4 protein was recognized by an antibody raised specifically against GPI links. In conclusion, GLUT4-containing vesicles may be released from a membrane compartment by action of a GPI-PLD...
  74. ncbi request reprint Effects of creatine supplementation and exercise training on fitness in men 55-75 yr old
    Bert O Eijnde
    Exercise Physiology and Biomechanics Laboratory, Faculty of Physical Education and Physiotherapy, KU Leuvrn, B 3001 Leuven, Belgium
    J Appl Physiol 95:818-28. 2003
    ..Furthermore, the other measurements were not affected by CR. It is concluded that long-term creatine intake (5 g/day) in conjunction with exercise training does not beneficially impact physical fitness in men between 55 and 75 yr of age...
  75. ncbi request reprint Prior exercise increases basal and insulin-induced p38 mitogen-activated protein kinase phosphorylation in human skeletal muscle
    Farah S L Thong
    Programme in Cell Biology, The Hospital for Sick Children, Toronto, Ontario, Canada M5G 1X8
    J Appl Physiol (1985) 94:2337-41. 2003
    ..Because p38 MAPK has been suggested to play a necessary role in activation of GLUT-4 at the cell surface, the present data may suggest a putative role of p38 MAPK in the increased insulin sensitivity of skeletal muscle after exercise...
  76. ncbi request reprint Combined creatine and protein supplementation in conjunction with resistance training promotes muscle GLUT-4 content and glucose tolerance in humans
    Wim Derave
    Exercise Physiology and Biomechanics Laboratory, Department of Kinesiology, Katholieke Universiteit Leuven, 3001, Belgium
    J Appl Physiol (1985) 94:1910-6. 2003
    ..Furthermore, combined protein and creatine supplementation improved oral glucose tolerance, which is supposedly unrelated to the changes in muscle GLUT-4 expression...
  77. pmc The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity
    Benoit Viollet
    Department of Genetic, Development, and Molecular Pathology, Institut National de la Sante et de la Recherche Medicale INSERM, Centre National de la Recherche Scientifique CNRS, Rene Descartes University, Paris, France
    J Clin Invest 111:91-8. 2003
    ..Therefore, extramuscular AMPKalpha2 catalytic subunit is important for whole-body insulin action in vivo, probably through modulation of sympathetic nervous activity...
  78. ncbi request reprint Low birth weight and zygosity status is associated with defective muscle glycogen and glycogen synthase regulation in elderly twins
    Pernille Poulsen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    Diabetes 56:2710-4. 2007
    ....
  79. ncbi request reprint Caffeine-induced impairment of insulin action but not insulin signaling in human skeletal muscle is reduced by exercise
    Farah S L Thong
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Canada
    Diabetes 51:583-90. 2002
    ....
  80. ncbi request reprint [5'-adenosine monophosphate-activated protein kinase and lifestyle-mediated diseases]
    Erik A Richter
    Københavns Universitet, Institut for Idraet, Center for Muskelforskning, Afdelingen for Human Fysiologi, København
    Ugeskr Laeger 168:896-900. 2006
    ..It is likely that part of the effect of physical activity in preventing the development of diseases related to a sedentary lifestyle is due to activation of AMPK...
  81. ncbi request reprint Increased phosphorylation of skeletal muscle glycogen synthase at NH2-terminal sites during physiological hyperinsulinemia in type 2 diabetes
    Kurt Højlund
    Diabetes Research Centre, University of Southern Denmark and Department of Endocrinology, Odense University Hospital, Kloevervaenget 6, DK 5000 Odense C, Denmark
    Diabetes 52:1393-402. 2003
    ..This phosphorylation abnormality likely caused the impaired GS activation and glucose storage, thereby contributing to skeletal muscle insulin resistance, and may therefore play a pathophysiological role in type 2 diabetes...
  82. pmc The effect of caffeine on glucose kinetics in humans--influence of adrenaline
    Danielle S Battram
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    J Physiol 569:347-55. 2005
    ....
  83. ncbi request reprint Increases in glycogenin and glycogenin mRNA accompany glycogen resynthesis in human skeletal muscle
    Jane Shearer
    Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada
    Am J Physiol Endocrinol Metab 289:E508-14. 2005
    ..This may facilitate rapid glycogen resynthesis by providing the glycogenin backbone of proglycogen, the major component of glycogen synthesized in early recovery...
  84. ncbi request reprint Glycogenin activity and mRNA expression in response to volitional exhaustion in human skeletal muscle
    Jane Shearer
    Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario, Canada
    J Appl Physiol (1985) 99:957-62. 2005
    ..Results show that glycogenin becomes inactivated with glycogen catabolism and that this event coincides with an increase in glycogenin gene expression as exercise and glycogenolysis progress...
  85. ncbi request reprint Impact of genetic versus environmental factors on the control of muscle glycogen synthase activation in twins
    Pernille Poulsen
    Steno Diabetes Center, Niels Steensens Vej 2, DK 2820 Gentofte, Denmark
    Diabetes 54:1289-96. 2005
    ..Moreover, GS activity was intact with increasing age, despite a significant reduction in nonoxidative glucose metabolism...
  86. ncbi request reprint Exercise in rats does not alter hypothalamic AMP-activated protein kinase activity
    Ulrika Andersson
    Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, DuCane Road, London W12 0NN, UK
    Biochem Biophys Res Commun 329:719-25. 2005
    ..Thus, changes in energy metabolism during or after exercise are likely not coordinated by changes in hypothalamic AMPK activity...
  87. ncbi request reprint AMPK-mediated AS160 phosphorylation in skeletal muscle is dependent on AMPK catalytic and regulatory subunits
    Jonas T Treebak
    Department of Molecular Medicine and Surgery, Section for Integrative Physiology, Karolinska Institute, von Eulers vag 4, 4th Floor, S 171 77 Stockholm, Sweden
    Diabetes 55:2051-8. 2006
    ..Contraction-mediated AS160 phosphorylation was also impaired in alpha2 AMPK KO and KD but not gamma3 AMPK KO mice. Our results implicate AS160 as a downstream target of AMPK...
  88. ncbi request reprint AMP kinase expression and activity in human skeletal muscle: effects of immobilization, retraining, and creatine supplementation
    Bert O Eijnde
    Exercise Physiology and Biomechanics Laboratory, Faculty of Kinesiology and Rehabilitation Sciences, Tervuursevest 101, B 3001 Leuven, Belgium
    J Appl Physiol (1985) 98:1228-33. 2005
    ..Furthermore, the present observations indicate that AMPK probably is not implicated in the previously reported beneficial effects of oral creatine supplementation on muscle during immobilization and rehabilitative weight training...
  89. ncbi request reprint Glucose phosphorylation is/is not a significant barrier to muscle glucose uptake by the working muscle
    Erik A Richter
    J Appl Physiol 101:1809; author reply 1810-1. 2006
  90. ncbi request reprint Altered skeletal muscle fiber composition and size precede whole-body insulin resistance in young men with low birth weight
    Christine B Jensen
    Steno Diabetes Center, Niels Steensens Vej 2, 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 92:1530-4. 2007
    ..Skeletal muscle mass, fiber composition, and capillary density are important determinants of muscle function and metabolism, and alterations have been implicated in the pathogenesis of insulin resistance...
  91. ncbi request reprint New creatine transporter assay and identification of distinct creatine transporter isoforms in muscle
    Bernd Walzel
    Institute of Cell Biology, Eidgenossische Technische Hochschule Zurich, Honggerberg, CH 8093 Zurich, Switzerland
    Am J Physiol Endocrinol Metab 283:E390-401. 2002
    ....