Pernille Ravn

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. pmc Latent tuberculosis in HIV positive, diagnosed by the M. tuberculosis specific interferon-gamma test
    Inger Brock
    Department for Infectious Diseases, University Hospital, Hvidovre 2650, Denmark
    Respir Res 7:56. 2006
  2. pmc Tuberculosis burden in an urban population: a cross sectional tuberculosis survey from Guinea Bissau
    Morten Bjerregaard-Andersen
    Bandim Health Project, INDEPTH Network, Apartado 861, 1004 Bissau Codex, Guinea Bissau
    BMC Infect Dis 10:96. 2010
  3. ncbi request reprint [Screening for tuberculosis infection prior to medical therapy]
    Pernille Ravn
    Infektionsmedicinsk Afdeling O 107, Herlev Hospital, 2730 Herlev, Denmark
    Ugeskr Laeger 173:893-6. 2011
  4. ncbi request reprint [Extremely resistant tuberculosis in Africa. The Danish Society for Tropical Medicine and International Health]
    Pernille Ravn
    DSTMIS s sekretariat, Center for International Sundhed og Udvikling, Østerfarimagsgade 5, Bygning 16, DK 1014 København K
    Ugeskr Laeger 169:1135. 2007
  5. ncbi request reprint [A possible successor of the Mantoux test after 97 years]
    Pernille Ravn
    Ugeskr Laeger 167:2905-6. 2005
  6. ncbi request reprint [New diagnostic test for tuberculosis]
    Pernille Ravn
    Infektionsmedicinsk Enhed, Medicinsk Afdeling O 107, Herlev Hospital, DK 2730 Herlev
    Ugeskr Laeger 171:2635-9. 2009
  7. pmc Prospective evaluation of a whole-blood test using Mycobacterium tuberculosis-specific antigens ESAT-6 and CFP-10 for diagnosis of active tuberculosis
    Pernille Ravn
    Department of Infectious Diseases, Hvidovre Hospital, Kettegårds Alle 30, 2650 Hvidovre, Copenhagen, Denmark
    Clin Diagn Lab Immunol 12:491-6. 2005
  8. ncbi request reprint Reactivation of tuberculosis during immunosuppressive treatment in a patient with a positive QuantiFERON-RD1 test
    Pernille Ravn
    Department of Infectious Diseases, Hvidovre Hospital, Copenhagen, Denmark
    Scand J Infect Dis 36:499-501. 2004
  9. ncbi request reprint [Long-lasting disease after serious genital actinomycosis in a former IUD user]
    Pernille Ravn
    H S Hvidovre Hospital, Infektionsmedicinsk Afdeling, gynaekologisk afdeling og patologisk afdeling
    Ugeskr Laeger 164:4549-50. 2002
  10. pmc Dried plasma spots in the diagnosis of tuberculosis: IP-10 release assay on filter paper
    Martine G Aabye
    Copenhagen University Hospital, Hvidovre, Copenhagen, Denmark
    Eur Respir J 42:495-503. 2013

Detail Information

Publications37

  1. pmc Latent tuberculosis in HIV positive, diagnosed by the M. tuberculosis specific interferon-gamma test
    Inger Brock
    Department for Infectious Diseases, University Hospital, Hvidovre 2650, Denmark
    Respir Res 7:56. 2006
    ..We here report the results from the first patients screened...
  2. pmc Tuberculosis burden in an urban population: a cross sectional tuberculosis survey from Guinea Bissau
    Morten Bjerregaard-Andersen
    Bandim Health Project, INDEPTH Network, Apartado 861, 1004 Bissau Codex, Guinea Bissau
    BMC Infect Dis 10:96. 2010
    ..We conducted a cross sectional survey for pulmonary TB and TB symptoms in Bissau, Guinea-Bissau, in an urban cohort with known HIV prevalence. TB surveillance in the area is routinely based on passive case finding...
  3. ncbi request reprint [Screening for tuberculosis infection prior to medical therapy]
    Pernille Ravn
    Infektionsmedicinsk Afdeling O 107, Herlev Hospital, 2730 Herlev, Denmark
    Ugeskr Laeger 173:893-6. 2011
    ..Preventive chemotherapy is recommended for all individuals with latent TB infection before initiation of anti-TNFα as it is expected to reduce the risk of progression to active TB...
  4. ncbi request reprint [Extremely resistant tuberculosis in Africa. The Danish Society for Tropical Medicine and International Health]
    Pernille Ravn
    DSTMIS s sekretariat, Center for International Sundhed og Udvikling, Østerfarimagsgade 5, Bygning 16, DK 1014 København K
    Ugeskr Laeger 169:1135. 2007
  5. ncbi request reprint [A possible successor of the Mantoux test after 97 years]
    Pernille Ravn
    Ugeskr Laeger 167:2905-6. 2005
  6. ncbi request reprint [New diagnostic test for tuberculosis]
    Pernille Ravn
    Infektionsmedicinsk Enhed, Medicinsk Afdeling O 107, Herlev Hospital, DK 2730 Herlev
    Ugeskr Laeger 171:2635-9. 2009
    ..However, the specificity is high (92-97%), and the IGRAs may play an important role in the investigation for active tuberculosis and screening for latent tuberculosis infection in BCG vaccinated populations and immunosuppressed patients...
  7. pmc Prospective evaluation of a whole-blood test using Mycobacterium tuberculosis-specific antigens ESAT-6 and CFP-10 for diagnosis of active tuberculosis
    Pernille Ravn
    Department of Infectious Diseases, Hvidovre Hospital, Kettegårds Alle 30, 2650 Hvidovre, Copenhagen, Denmark
    Clin Diagn Lab Immunol 12:491-6. 2005
    ..The accuracy of the QFT-RD1 test will vary with the prevalence of LTBI. We suggest that the QFT-RD1 test could be a very useful supplementary tool for the diagnosis of TB...
  8. ncbi request reprint Reactivation of tuberculosis during immunosuppressive treatment in a patient with a positive QuantiFERON-RD1 test
    Pernille Ravn
    Department of Infectious Diseases, Hvidovre Hospital, Copenhagen, Denmark
    Scand J Infect Dis 36:499-501. 2004
    ..We suggest that RD1 based tests are evaluated further in immunocompromised patients...
  9. ncbi request reprint [Long-lasting disease after serious genital actinomycosis in a former IUD user]
    Pernille Ravn
    H S Hvidovre Hospital, Infektionsmedicinsk Afdeling, gynaekologisk afdeling og patologisk afdeling
    Ugeskr Laeger 164:4549-50. 2002
    ..Actinomycosis is a rare disease with a potentially high morbidity. Diagnosis is difficult, as symptoms are non-specific and culture is often negative...
  10. pmc Dried plasma spots in the diagnosis of tuberculosis: IP-10 release assay on filter paper
    Martine G Aabye
    Copenhagen University Hospital, Hvidovre, Copenhagen, Denmark
    Eur Respir J 42:495-503. 2013
    ..55). The DPS-based IP-10 test has comparable diagnostic accuracy to the QFT-TB and samples can be sent via conventional mail over long distances for analysis without affecting the results. ..
  11. ncbi request reprint [Comparison of QuantiFERON and tuberculin skin test in possible suspected tuberculosis infection]
    Micha Jepsen
    Hvidovre Hospital, Infektionsmedicinsk Afdeling, Hvidovre
    Ugeskr Laeger 171:2625-31. 2009
    ..Two cases of tuberculosis were diagnosed at a high school. A contact investigation using Mantoux test (TST) and QuantiFERON TB in Tube test (QFT) was conducted in order to compare QFT with TST...
  12. pmc Negative effect of smoking on the performance of the QuantiFERON TB gold in tube test
    Martine G Aabye
    Clinical Research Centre, Copenhagen University Hospital Hvidovre, Kettegårds Alle 30, 2650, Hvidovre, Denmark
    BMC Infect Dis 12:379. 2012
    ..The aim of this study was to evaluate the effect of smoking on IGRA performance in TB patients in a low and high TB prevalence setting respectively...
  13. ncbi request reprint Detecting a low prevalence of latent tuberculosis among health care workers in Denmark detected by M. tuberculosis specific IFN-gamma whole-blood test
    Bolette Soborg
    International Reference Laboratory of Mycobacteriology, Statens Serum Institute, Copenhagen, Denmark
    Scand J Infect Dis 39:554-9. 2007
    ..The QFT-TB may be useful in distinguishing persons with latent TB infection from persons with positive TST due to BCG vaccination and its use may reduce anxiety...
  14. doi request reprint Evaluation of QuantiFERON microtube, using 0.9 mL blood, for diagnosing tuberculosis infection
    Michala V Rose
    Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
    Eur Respir J 41:909-16. 2013
    ..The poor sensitivity and high indeterminate rate of both IFN-γ release assays in severely ill children, with immature or impaired immunity in an endemic setting, warrants further investigations...
  15. pmc Challenges of loss to follow-up in tuberculosis research
    Thomas N Nissen
    Clinical Research Unit, Hvidovre Hospital, Hvidovre, Denmark
    PLoS ONE 7:e40183. 2012
    ....
  16. pmc Incubation of whole blood at 39°C augments gamma interferon (IFN-γ)-induced protein 10 and IFN-γ responses to Mycobacterium tuberculosis antigens
    Martine G Aabye
    Clinical Research Centre, University of Copenhagen, Hvidovre Hospital, Copenhagen 2650, Denmark
    Clin Vaccine Immunol 18:1150-6. 2011
    ..Incubation at fever-range temperature vividly increases CMI responsiveness to antigen stimulation in vitro in tuberculosis patients and may increase the sensitivity of CMI assays...
  17. doi request reprint IP-10 release assays in the diagnosis of tuberculosis infection: current status and future directions
    Morten Ruhwald
    Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Copenhagen, Denmark
    Expert Rev Mol Diagn 12:175-87. 2012
    ..We conclude the review by presenting limitations of the published works and outline recent developments and future directions...
  18. pmc Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients
    T Mark Doherty
    Department of Tuberculosis Immunology, Statens Serum Institute Hvidovre Hospital, Copenhagen, Denmark
    J Clin Microbiol 40:704-6. 2002
    ..We report that strong recognition of tuberculosis complex-specific antigen ESAT-6 by healthy household contacts of tuberculosis patients correlates with the subsequent development of active tuberculosis during a 2-year follow-up period...
  19. pmc QuantiFERON®-TB gold in-tube performance for diagnosing active tuberculosis in children and adults in a high burden setting
    Michala V Rose
    Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 7:e37851. 2012
    ....
  20. doi request reprint A multicentre evaluation of the accuracy and performance of IP-10 for the diagnosis of infection with M. tuberculosis
    Morten Ruhwald
    Clinical Research Centre 136, Copenhagen University, Hvidovre Hospital, 2650 Hvidovre, Denmark
    Tuberculosis (Edinb) 91:260-7. 2011
    ..tuberculosis. IP-10 appeared less influenced by infections other than TB; further studies are needed to test the clinical impact of these findings...
  21. pmc The impact of HIV infection and CD4 cell count on the performance of an interferon gamma release assay in patients with pulmonary tuberculosis
    Martine G Aabye
    Department of Infectious Diseases, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    PLoS ONE 4:e4220. 2009
    ....
  22. pmc Non-tuberculous mycobacteria and the performance of interferon gamma release assays in denmark
    Thomas Stig Hermansen
    Department of Thoracic Medicine and Infectious Disease, Nordsjaelland Hospital, Hillerød, Denmark International Reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark
    PLoS ONE 9:e93986. 2014
    ..Here we study the performance of the QFT in patients with NTM disease...
  23. pmc Improving T-cell assays for the diagnosis of latent TB infection: potential of a diagnostic test based on IP-10
    Morten Ruhwald
    Department of Infectious Diseases 144, Copenhagen University, Hvidovre Hospital, Hvidovre, Denmark
    PLoS ONE 3:e2858. 2008
    ..tuberculosis-infection in children. The aim of the study was to evaluate the performance of an IP-10 and IL-2 based tests for the diagnosis of M.tuberculosis-infection in recently exposed children from Nigeria...
  24. pmc Incidence, risk factors and mortality of tuberculosis in Danish HIV patients 1995-2007
    Gry A Taarnhøj
    Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    BMC Pulm Med 11:26. 2011
    ..We described incidence, risk factors and prognosis of TB in HIV-1 infected patients during pre (1995-1996), early (1997-1999), and late Highly Active Antiretroviral Therapy (HAART) (2000-2007) periods...
  25. ncbi request reprint [Development of tuberculosis after treatment with the TNF-alpha inhibitor infliximab]
    Morten Dahl
    Infektionsmedicinsk Afdeling, H S Hvidovre Hospital
    Ugeskr Laeger 167:527-8. 2005
  26. pmc IP-10, MCP-1, MCP-2, MCP-3, and IL-1RA hold promise as biomarkers for infection with M. tuberculosis in a whole blood based T-cell assay
    Morten Ruhwald
    Dep, of Infectious Diseases 144, Copenhagen University, Hvidovre Hospital, DK 2650 Hvidovre, Denmark
    BMC Res Notes 2:19. 2009
    ..Further studies are needed to explore the potential of these highly expressed novel biomarkers individually and in combination...
  27. ncbi request reprint CXCL10/IP-10 release is induced by incubation of whole blood from tuberculosis patients with ESAT-6, CFP10 and TB7.7
    Morten Ruhwald
    Department of Infectious Diseases 144, Copenhagen University Hospital, Kettegaards Alle 30, DK 2650 Hvidovre, Denmark
    Microbes Infect 9:806-12. 2007
    ..tuberculosis specific stimulation and sensitivity appeared superior to the Quantiferon test. Our findings suggest that CXCL10 may serve as an alternative or additional marker for the immunodiagnosis of tuberculosis...
  28. pmc Specific T-cell epitopes for immunoassay-based diagnosis of Mycobacterium tuberculosis infection
    Inger Brock
    Department of Infectious Disease Immunology, Statens Serum Institute, Artillerivej 5, DK 2300 Copenhagen S, Denmark
    J Clin Microbiol 42:2379-87. 2004
    ..In a validation experiment with new experimental groups, the sensitivities obtained were 57% for the combination of peptides and 90% for the combination of the peptides, ESAT-6, and CFP-10. This combination gave a specificity of 95%...
  29. ncbi request reprint Evaluation of Mycobacterium tuberculosis--specific antibody responses in populations with different levels of exposure from Tanzania, Ethiopia, Brazil, and Denmark
    Soren T Hoff
    Department of Infectious Diseases Immunology, Statens Serum Institute, Copenhagen S, Denmark
    Clin Infect Dis 45:575-82. 2007
    ..A key question remaining is the extent to which the disappointing performance of current tests is associated with a high background prevalence of latent TB...
  30. ncbi request reprint Immune reconstitution inflammatory syndrome in HIV-infected patients receiving antiretroviral therapy : pathogenesis, clinical manifestations and management
    Devesh J Dhasmana
    Department of Respiratory Medicine, Harefield Hospital, Middlesex, UK
    Drugs 68:191-208. 2008
    ..In this review, we discuss research relating to pathogenesis, the range of clinical manifestations, treatment options and prevention issues...
  31. pmc Risk for tuberculosis among children
    Hiroshi Nakaoka
    Liverpool School of Tropical Medicine, Liverpool, United Kingdom
    Emerg Infect Dis 12:1383-8. 2006
    ..TST may underestimate risk for infection with TB in children...
  32. ncbi request reprint Immune reconstitution syndrome in tuberculosis and HIV-co-infected patients: Th1 explosion or cytokine storm?
    Morten Ruhwald
    AIDS 21:882-4. 2007
  33. ncbi request reprint The effect on cartilage of different forms of application of postmenopausal estrogen therapy: comparison of oral and transdermal therapy
    Pernille Ravn
    Center for Clinical and Basic Research, Ballerup Byvej 222, DK 2750 Ballerup, Denmark
    Bone 35:1216-21. 2004
    ..However, long-term clinical trials are needed to further investigate this issue...
  34. ncbi request reprint Pulsed estrogen therapy in prevention of postmenopausal osteoporosis. A 2-year randomized, double blind, placebo-controlled study
    Therese F Nielsen
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, DK 2750, Ballerup, Denmark
    Osteoporos Int 15:168-74. 2004
    ..This study demonstrates that pulsed estrogen therapy at the dose of 150 microg and 300-microg per day prevents bone loss in a dose-dependant manner at each site studied, and normalizes bone turnover markers to premenopausal levels...
  35. ncbi request reprint Alendronate has a residual effect on bone mass in postmenopausal Danish women up to 7 years after treatment withdrawal
    Yu Z Bagger
    Center for Clinical and Basic Research A S, Ballerup Byvej 222, Ballerup, Denmark
    Bone 33:301-7. 2003
    ..The rate of bone loss after withdrawal of alendronate corresponded to the normal postmenopausal rate of bone loss. A residual effect on BMD was found up to 7 yr after treatment withdrawal...
  36. ncbi request reprint Bisphosphonates for prevention of postmenopausal osteoporosis
    Pernille Ravn
    Center for Clinical and Basic Research, Ballerup
    Dan Med Bull 49:1-18. 2002
    ..1998b, Rosen et al. 1998, and 2000)...
  37. ncbi request reprint Prevention of postmenopausal bone loss: six-year results from the Early Postmenopausal Intervention Cohort Study
    Michael R McClung
    Oregon Osteoporosis Center, 5050 Northeast Hoyt, Suite 651, Portland, Oregon 97213, USA
    J Clin Endocrinol Metab 89:4879-85. 2004
    ..5, 10.3, and 8.9% of women taking placebo, 2.5 mg alendronate, or 5 mg alendronate daily, respectively. Therapy with alendronate is an effective and promising strategy for the prevention of postmenopausal osteoporosis...