S I S Rattan

Summary

Affiliation: University of Aarhus
Country: Denmark

Publications

  1. doi request reprint "I think that the small peptides are the best for healthy ageing...", an interview with Vladimir Khavinson
    Suresh I S Rattan
    Aarhus University, Aarhus, Denmark
    Biogerontology 14:1-8. 2013
  2. pmc Glucose metabolite glyoxal induces senescence in telomerase-immortalized human mesenchymal stem cells
    Simon Asbjørn Larsen
    Laboratory of Cellular Ageing, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark
    Chem Cent J 6:18. 2012
  3. doi request reprint Rationale and methods of discovering hormetins as drugs for healthy ageing
    Suresh I S Rattan
    Department of Molecular Biology and Genetics, Laboratory of Cellular Ageing, Aarhus University, Gustav Wieds Vej 10C, Aarhus C, Denmark
    Expert Opin Drug Discov 7:439-48. 2012
  4. doi request reprint Biogerontology: from here to where? The Lord Cohen Medal Lecture-2011
    Suresh I S Rattan
    Laboratory of Cellular Ageing, Department of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark
    Biogerontology 13:83-91. 2012
  5. doi request reprint Progress & prospects: gene therapy in aging
    S I S Rattan
    Laboratory of Cellular Ageing, Department of Molecular Biology, University of Aarhus, Aarhus, Denmark
    Gene Ther 16:3-9. 2009
  6. doi request reprint Increased molecular damage and heterogeneity as the basis of aging
    Suresh I S Rattan
    Laboratory of Cellular Ageing, Department of Molecular Biology, University of Aarhus, DK 8000 Aarhus C, Denmark
    Biol Chem 389:267-72. 2008
  7. ncbi request reprint Stress-mediated hormetic modulation of aging, wound healing, and angiogenesis in human cells
    Suresh I S Rattan
    Laboratory of Cellular Ageing, Department of Molecular Biology, University of Aarhus, Aarhus C, Denmark
    Ann N Y Acad Sci 1119:112-21. 2007
  8. pmc Anti-ageing strategies: prevention or therapy? Showing ageing from within
    Suresh I S Rattan
    Department of Molecular Biology, University of Aarhus, Denmark
    EMBO Rep 6:S25-9. 2005
  9. ncbi request reprint The science of healthy aging: genes, milieu, and chance
    Suresh I S Rattan
    Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK8000 Aarhus C, Denmark
    Ann N Y Acad Sci 1114:1-10. 2007
  10. ncbi request reprint Theories of biological aging: genes, proteins, and free radicals
    Suresh I S Rattan
    Laboratory of Cellular Ageing, Department of Molecular Biology, Danish Centre for Molecular Gerontology, University of Aarhus, Aarhus C, Denmark
    Free Radic Res 40:1230-8. 2006

Collaborators

Detail Information

Publications47

  1. doi request reprint "I think that the small peptides are the best for healthy ageing...", an interview with Vladimir Khavinson
    Suresh I S Rattan
    Aarhus University, Aarhus, Denmark
    Biogerontology 14:1-8. 2013
    ....
  2. pmc Glucose metabolite glyoxal induces senescence in telomerase-immortalized human mesenchymal stem cells
    Simon Asbjørn Larsen
    Laboratory of Cellular Ageing, Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark
    Chem Cent J 6:18. 2012
    ..abstract:..
  3. doi request reprint Rationale and methods of discovering hormetins as drugs for healthy ageing
    Suresh I S Rattan
    Department of Molecular Biology and Genetics, Laboratory of Cellular Ageing, Aarhus University, Gustav Wieds Vej 10C, Aarhus C, Denmark
    Expert Opin Drug Discov 7:439-48. 2012
    ..A promising strategy to slow down ageing and prevent or delay the onset of age-related diseases is that of mild stress-induced hormesis by using hormetins...
  4. doi request reprint Biogerontology: from here to where? The Lord Cohen Medal Lecture-2011
    Suresh I S Rattan
    Laboratory of Cellular Ageing, Department of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark
    Biogerontology 13:83-91. 2012
    ....
  5. doi request reprint Progress & prospects: gene therapy in aging
    S I S Rattan
    Laboratory of Cellular Ageing, Department of Molecular Biology, University of Aarhus, Aarhus, Denmark
    Gene Ther 16:3-9. 2009
    ..Whether genetic redesigning can be achieved in the wake of numerous and complex epigenetic factors that effectively determine the life course and the life span of an individual still appears to be a 'mission impossible'...
  6. doi request reprint Increased molecular damage and heterogeneity as the basis of aging
    Suresh I S Rattan
    Laboratory of Cellular Ageing, Department of Molecular Biology, University of Aarhus, DK 8000 Aarhus C, Denmark
    Biol Chem 389:267-72. 2008
    ..Mild stress-induced hormesis by physical, biological and nutritional methods, including hormetins, represents a promising strategy for achieving healthy aging and for preventing age-related diseases...
  7. ncbi request reprint Stress-mediated hormetic modulation of aging, wound healing, and angiogenesis in human cells
    Suresh I S Rattan
    Laboratory of Cellular Ageing, Department of Molecular Biology, University of Aarhus, Aarhus C, Denmark
    Ann N Y Acad Sci 1119:112-21. 2007
    ..These data add to the ever-growing body of evidence in support of the view that mild stress-induced hormesis can be a useful approach for the modulation, intervention, and prevention of aging and age-related impairments...
  8. pmc Anti-ageing strategies: prevention or therapy? Showing ageing from within
    Suresh I S Rattan
    Department of Molecular Biology, University of Aarhus, Denmark
    EMBO Rep 6:S25-9. 2005
  9. ncbi request reprint The science of healthy aging: genes, milieu, and chance
    Suresh I S Rattan
    Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK8000 Aarhus C, Denmark
    Ann N Y Acad Sci 1114:1-10. 2007
    ....
  10. ncbi request reprint Theories of biological aging: genes, proteins, and free radicals
    Suresh I S Rattan
    Laboratory of Cellular Ageing, Department of Molecular Biology, Danish Centre for Molecular Gerontology, University of Aarhus, Aarhus C, Denmark
    Free Radic Res 40:1230-8. 2006
    ..Such a theory also establishes the basis for testing and developing effective means of intervention, prevention and modulation of aging...
  11. ncbi request reprint Hormesis in aging
    Suresh I S Rattan
    Laboratory of Cellular Ageing, Department of Molecular Biology, University of Aarhus, Aarhus C, Denmark
    Ageing Res Rev 7:63-78. 2008
    ..The established scientific foundations of hormesis are ready to pave the way for new and effective approaches in aging research and intervention...
  12. ncbi request reprint Hormetic prevention of molecular damage during cellular aging of human skin fibroblasts and keratinocytes
    Suresh I S Rattan
    Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK8000 Aarhus C, Denmark
    Ann N Y Acad Sci 1100:424-30. 2007
    ..We are also testing the above effects of RMHS in combination with potential hormetic molecules, such as curcumin, on aging, longevity, and differentiation of human cells in culture...
  13. pmc Hormesis can and does work in humans
    Suresh I S Rattan
    Laboratory of Cellular Ageing, Department of Molecular Biology, Aarhus University, Gustav Wieds Vej 10, Aarhus C, Denmark
    Dose Response 8:58-63. 2009
    ....
  14. ncbi request reprint Second IRCHAL conference and the communication of biogerontology to health care personnel
    Suresh I S Rattan
    Danish Centre for Molecular Gerontology, Department of Molecular Biology, University of Aarhus
    Biogerontology 6:223-4. 2005
  15. ncbi request reprint Understanding and modulating ageing
    Suresh I S Rattan
    Danish Centre for Molecular Gerontology, Department of Molecular Biology, University of Aarhus, Aarhus, Denmark
    IUBMB Life 57:297-304. 2005
    ..A combination of molecular, physiological and psychological modulatory approaches can realize "healthy ageing" as an achievable goal in the not-so-distant future...
  16. doi request reprint Principles and practice of hormetic treatment of aging and age-related diseases
    Suresh Is Rattan
    Laboratory of Cellular Ageing, Department of Molecular Biology, University of Aarhus, Aarhus C, Denmark
    Hum Exp Toxicol 27:151-4. 2008
    ..Its clinical applications include prevention and treatment of diabetes, cataract, osteoporosis, dementia and some cancers...
  17. doi request reprint Testing the hormetic nature of homeopathic interventions through stress response pathways
    Suresh I S Rattan
    Laboratory of Cellular Ageing, Department of Molecular Biology, Aarhus University, Aarhus, Denmark
    Hum Exp Toxicol 29:551-4. 2010
    ....
  18. ncbi request reprint Aging intervention, prevention, and therapy through hormesis
    Suresh I S Rattan
    Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
    J Gerontol A Biol Sci Med Sci 59:705-9. 2004
    ....
  19. ncbi request reprint Synthesis, modification and turnover of proteins during aging
    Suresh I S Rattan
    Laboratory of Cellular Aging, Department of Molecular Biology, Aarhus University, DK8000 Aarhus C, Denmark
    Adv Exp Med Biol 694:1-13. 2010
    ..Understanding the proteomic spectrum and its functional implications during aging can facilitate developing effective means of intervention, prevention and therapy of aging and age-related diseases...
  20. ncbi request reprint Gerontomodulatory and youth-preserving effects of zeatin on human skin fibroblasts undergoing aging in vitro
    Suresh I S Rattan
    Laboratory of Cellular Ageing, Danish Centre for Molecular Gerontology, Department of Molecular Biology, University of Aarhus, Aarhus C, Denmark
    Rejuvenation Res 8:46-57. 2005
    ....
  21. doi request reprint Targeting the age-related occurrence, removal, and accumulation of molecular damage by hormesis
    Suresh I S Rattan
    Laboratory of Cellular Ageing, Department of Molecular Biology, Aarhus University, Aarhus, Denmark
    Ann N Y Acad Sci 1197:28-32. 2010
    ..The main molecular pathways for achieving such hormetic effects are through targeting the processes for the repair and removal of molecular damage, which can slow aging...
  22. ncbi request reprint Glyoxal-induced premature senescence in human fibroblasts
    Henrik Sejersen
    Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK8000 Aarhus C, Denmark
    Ann N Y Acad Sci 1100:518-23. 2007
    ....
  23. ncbi request reprint MAP kinases and heat shock-induced hormesis in human fibroblasts during serial passaging in vitro
    Elise R Nielsen
    Laboratory of Cellular Ageing, Danish Centre for Molecular Gerontology, Department of Molecular Biology, University of Aarhus, Denmark
    Ann N Y Acad Sci 1067:343-8. 2006
    ..RMHS further exaggerated these effects, which suggests that age-related changes in MAP kinases may be an adaptive response for better cell survival...
  24. ncbi request reprint Curcumin's biphasic hormetic response on proteasome activity and heat-shock protein synthesis in human keratinocytes
    Rehab E Ali
    Laboratory of Cellular Ageing, Danish Centre for Molecular Gerontology, Department of Molecular Biology, University of Aarhus, Denmark
    Ann N Y Acad Sci 1067:394-9. 2006
    ..On the other hand, the level of the small hsp27 was unaffected by curcumin concentrations of 0.3-1 microM, while it decreased by 34% at 10 microM...
  25. ncbi request reprint Slowing down aging from within: mechanistic aspects of anti-aging hormetic effects of mild heat stress on human cells
    Suresh I S Rattan
    Laboratory of Cellular Ageing, Danish Centre for Molecular Gerontology, Department of Molecular Biology, University of Aarhus, Aarhus, Denmark
    Acta Biochim Pol 51:481-92. 2004
    ....
  26. ncbi request reprint Mild stress-induced stimulation of heat-shock protein synthesis and improved functional ability of human fibroblasts undergoing aging in vitro
    Jannik Fonager
    Laboratory of Cellular Ageing, Department of Molecular Biology, Danish Centre for Molecular Gerontology, University of Aarhus, Gustav Wieds Vej 10 C, DK 8000 Aarhus C, Denmark
    Exp Gerontol 37:1223-8. 2002
    ....
  27. doi request reprint Dicarbonyl-induced accelerated aging in vitro in human skin fibroblasts
    Henrik Sejersen
    Laboratory of Cellular Ageing, Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10 C, 8000, Aarhus, Denmark
    Biogerontology 10:203-11. 2009
    ....
  28. doi request reprint Hormetic modulation of differentiation of normal human epidermal keratinocytes undergoing replicative senescence in vitro
    Ulrich Berge
    Laboratory of Cellular Ageing, Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK8000 Aarhus C, Denmark
    Exp Gerontol 43:658-62. 2008
    ....
  29. ncbi request reprint Aging, anti-aging, and hormesis
    Suresh I S Rattan
    Department of Molecular Biology, Danish Centre for Molecular Gerontology, University of Aarhus, Gustav Wieds Vej, DK 8000 Aarhus C, Denmark
    Mech Ageing Dev 125:285-9. 2004
    ..A recent approach is that of applying hormesis in aging research and therapy, which is based on the principle of stimulation of maintenance and repair pathways by repeated exposure to mild stress...
  30. ncbi request reprint Hormetic mechanisms of anti-aging and rejuvenating effects of repeated mild heat stress on human fibroblasts in vitro
    Suresh I S Rattan
    Department of Molecular Biology, University of Aarhus, Denmark
    Rejuvenation Res 7:40-8. 2004
    ..Hormesis, therefore, can be an effective approach for modulating aging, for preventing or delaying the onset of age-related diseases, and for improving the quality of life in old age...
  31. pmc Mild heat stress stimulates 20S proteasome and its 11S activator in human fibroblasts undergoing aging in vitro
    Rasmus Beedholm
    Laboratory of Cellular Ageing, Danish Centre for Molecular Gerontology, Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10 C, DK 8000 Aarhus C, Denmark
    Cell Stress Chaperones 9:49-57. 2004
    ..In contrast to this, the proteasomal system in late-passage senescent cells appears to be less responsive to the stimulatory effects of mild heat shock...
  32. ncbi request reprint Sugar-induced premature aging and altered differentiation in human epidermal keratinocytes
    Ulrich Berge
    Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK8000 Aarhus C, Denmark
    Ann N Y Acad Sci 1100:524-9. 2007
    ..This experimental model can be useful to study the effects of potential antiaging interventions...
  33. ncbi request reprint Proteasomal oscillation during mild heat shock in aging human skin fibroblasts
    David Christian Kraft
    Laboratory of Cellular Aging, Danish Centre for Molecular Gerontology, Department of Molecular Biology, University of Aarhus, Denmark
    Ann N Y Acad Sci 1067:224-7. 2006
    ..This proteasomal oscillation, as an innate cellular reaction to heat and aging, however, is independent of 20S proteasome protein levels and nuclear factor-E2-related factor 2 (Nrf2) transactivation...
  34. ncbi request reprint Phage-displayed antibodies for the detection of glycated proteasome in aging cells
    Regina Gonzalez-Dosal
    Danish Centre of Molecular Gerontology, Department of Molecular Biology, University of Aarhus, Denmark
    Ann N Y Acad Sci 1067:474-8. 2006
    ..Using one of them, Ab3, we have observed a five-fold increase of CML-alpha7 in old human skin fibroblasts in comparison with young fibroblasts and telomerase-immortalized bone marrow cells (hTERT-BMCs)...
  35. ncbi request reprint Hormetic action of mild heat stress decreases the inducibility of protein oxidation and glycoxidation in human fibroblasts
    Philippe Verbeke
    Danish Centre for Molecular Gerontology, Department of Molecular and Structural Biology, University of Aarhus
    Biogerontology 3:117-20. 2002
    ..1 mM glyoxal for 48 h generated CML only in control cells. Such modulation of the level of damaged proteins is most likely related to the beneficial effects of hormesis resulting from exposure to mild stress...
  36. ncbi request reprint Mechanisms of hormesis through mild heat stress on human cells
    Suresh I S Rattan
    Danish Centre for Molecular Genetics, Department of Molecular Biology, University of Aarhus, Gustav Wieds Vej 10C, DK 8000 Aarhus C, Denmark
    Ann N Y Acad Sci 1019:554-8. 2004
    ....
  37. pmc Reduced heat shock response in human mononuclear cells during aging and its association with polymorphisms in HSP70 genes
    Ripudaman Singh
    Department of Human Genetics, University of Aarhus, Aarhus C, Denmark
    Cell Stress Chaperones 11:208-15. 2006
    ..These data consolidate our other observations that the CC genotype is unfavorable for human longevity and provide a functional explanation in terms of variations in HSR...
  38. ncbi request reprint Heat-shock protein 70 genes and human longevity: a view from Denmark
    Ripudaman Singh
    Department of Human Genetics, Bartholin Building, University of Aarhus, Denmark
    Ann N Y Acad Sci 1067:301-8. 2006
    ..We also found an age-dependant decline in the ability of peripheral blood mononuclear cells to respond to heat stress in terms of Hsp70 induction...
  39. ncbi request reprint Kinetin-induced differentiation of normal human keratinocytes undergoing aging in vitro
    Ulrich Berge
    Laboratory of Cellular Ageing, Danish Centre for Molecular Gerontology, Department of Molecular Biology, University of Aarhus, Denmark
    Ann N Y Acad Sci 1067:332-6. 2006
    ..These results suggest that the rate, extent, and quality of differentiation depend on the inducing agent, and that kinetin may be useful in promoting the differentiation of human keratinocytes, especially in the presence of calcium...
  40. ncbi request reprint Preincubation with the proteasome inhibitor MG-132 enhances proteasome activity via the Nrf2 transcription factor in aging human skin fibroblasts
    David Christian Kraft
    Laboratory of Cellular Ageing, Danish Centre for Molecular Gerontology, Department of Molecular Biology, University of Aarhus, Denmark
    Ann N Y Acad Sci 1067:420-4. 2006
    ....
  41. ncbi request reprint Heat shock-induced enhancement of osteoblastic differentiation of hTERT-immortalized mesenchymal stem cells
    Rune Nørgaard
    Laboratory of Cellular Ageing, Danish Centre for Molecular Gerontology, Department of Molecular Biology, University of Aarhus, Denmark
    Ann N Y Acad Sci 1067:443-7. 2006
    ..Our results indicate that the exposure of cells to mild heat stress enhances the extent of differentiation of hMSCs by 12% to 42%. These effects are an expression of the phenomenon of mild stress-induced hormesis...
  42. ncbi request reprint Lifespan extension of Drosophila melanogaster through hormesis by repeated mild heat stress
    Miriam J Hercus
    Aarhus Centre for Environmental Stress Research, Department of Ecology and Genetics, University of Aarhus, Ny Munkegade, Building 540, DK 8000 Aarhus C, Denmark
    Biogerontology 4:149-56. 2003
    ..The mild heat stress had no impact on egg viability. The mild heat stress exposures increased resistance to potentially lethal heat stress and levels of Hsp70 expression in heat-exposed flies were higher than those in controls...
  43. ncbi request reprint Geroprotection by glycerol: insights to its mechanisms and clinical potentials
    Custer C Deocaris
    National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Japan
    Ann N Y Acad Sci 1067:488-92. 2006
    ..This was accompanied by decrease in p53, an upregulation of a stress chaperone mortalin/mtHsp70, and an increase in proteasome activity in the presence of oxidative stress...
  44. ncbi request reprint TLC-based detection of methylated cytosine: application to aging epigenetics
    Mirosława Z Barciszewska
    Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Noskowskiego 12, Poznan 61 704, Poland
    Biogerontology 8:673-8. 2007
    ..This method can be useful for screening potential modulators of aging at the level of epigenetic alterations...
  45. ncbi request reprint At the heart of aging: is it metabolic rate or stability?
    S Jay Olshansky
    School of Public Health, University of Illinois at Chicago, 60612, USA
    Biogerontology 6:291-5. 2005
    ..For now there is reason to believe that Demetrius' theory deserves further consideration - whether it meets the test of a paradigm shift has yet to be determined...
  46. ncbi request reprint Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework
    Edward J Calabrese
    School of Public Health, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA
    Toxicol Appl Pharmacol 222:122-8. 2007
    ....
  47. ncbi request reprint Genetics of human longevity with emphasis on the relevance of HSP70 as candidate genes
    Ripudaman Singh
    Department of Clinical Genetics, Vejle Hospital, Denmark
    Front Biosci 12:4504-13. 2007
    ..Stress response genes, particularly HSP70, are now the major candidates in the gene-longevity association studies...