Stine Falsig Pedersen

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint P2 receptor-mediated signal transduction in Ehrlich ascites tumor cells
    S F Pedersen
    August Krogh Institute, Department of Biochemistry, University of Copenhagen, Denmark
    Biochim Biophys Acta 1374:94-106. 1998
  2. ncbi request reprint The Na+/H+ exchanger, NHE1, differentially regulates mitogen-activated protein kinase subfamilies after osmotic shrinkage in Ehrlich Lettre Ascites cells
    Stine Falsig Pedersen
    Dept of Molecular Biology, University of Copenhagen, Copenhagen, Denmark
    Cell Physiol Biochem 20:735-50. 2007
  3. ncbi request reprint Regulation of mitogen-activated protein kinase pathways by the plasma membrane Na+/H+ exchanger, NHE1
    Stine Falsig Pedersen
    Department of Molecular Biology, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Arch Biochem Biophys 462:195-201. 2007
  4. ncbi request reprint Roles of phospholipase A2 isoforms in swelling- and melittin-induced arachidonic acid release and taurine efflux in NIH3T3 fibroblasts
    Stine F Pedersen
    Department of Biochemistry, Institute for Molecular Biology and Physiology, Copenhagen, Denmark
    Am J Physiol Cell Physiol 291:C1286-96. 2006
  5. ncbi request reprint The Na+/H+ exchanger NHE1 in stress-induced signal transduction: implications for cell proliferation and cell death
    Stine Falsig Pedersen
    Department of Biochemistry, August Krogh Building, Institute for Molecular Biology and Physiology, University of Copenhagen, 13, Universitetsparken, DK 2100, Copenhagen, Denmark
    Pflugers Arch 452:249-59. 2006
  6. ncbi request reprint Physiology and pathophysiology of Na+/H+ exchange and Na+ -K+ -2Cl- cotransport in the heart, brain, and blood
    S F Pedersen
    Department of Biochemistry, Institute of Molecular Biology and Physiology, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 291:R1-25. 2006
  7. ncbi request reprint Comparative biology of the ubiquitous Na+/H+ exchanger, NHE1: lessons from erythrocytes
    Stine Falsig Pedersen
    Dept of Biochemistry, August Krogh Institute, University of Copenhagen, 13 Universitetsparken, DK 2100 Copenhagen, Denmark
    J Exp Zool A Comp Exp Biol 301:569-78. 2004
  8. ncbi request reprint Possible interrelationship between changes in F-actin and myosin II, protein phosphorylation, and cell volume regulation in Ehrlich ascites tumor cells
    S F Pedersen
    Department of Biochemistry, August Krogh Institute, University of Copenhagen, Denmark
    Exp Cell Res 277:57-73. 2002
  9. ncbi request reprint The cytoskeleton and cell volume regulation
    S F Pedersen
    Biochemistry Department, August Krogh Institute, Copenhagen, Denmark
    Comp Biochem Physiol A Mol Integr Physiol 130:385-99. 2001
  10. ncbi request reprint Role of the F-actin cytoskeleton in the RVD and RVI processes in Ehrlich ascites tumor cells
    S F Pedersen
    Biochemistry Department, August Krogh Institute, Copenhagen, DK 2100, Denmark
    Exp Cell Res 252:63-74. 1999

Collaborators

Detail Information

Publications27

  1. ncbi request reprint P2 receptor-mediated signal transduction in Ehrlich ascites tumor cells
    S F Pedersen
    August Krogh Institute, Department of Biochemistry, University of Copenhagen, Denmark
    Biochim Biophys Acta 1374:94-106. 1998
    ....
  2. ncbi request reprint The Na+/H+ exchanger, NHE1, differentially regulates mitogen-activated protein kinase subfamilies after osmotic shrinkage in Ehrlich Lettre Ascites cells
    Stine Falsig Pedersen
    Dept of Molecular Biology, University of Copenhagen, Copenhagen, Denmark
    Cell Physiol Biochem 20:735-50. 2007
    ..Long-term shrinkage elicited caspase-3 activation and a loss of cell viability, which was augmented by ERK1/2 or JNK1/2 inhibition, and attenuated by p38 MAPK inhibition...
  3. ncbi request reprint Regulation of mitogen-activated protein kinase pathways by the plasma membrane Na+/H+ exchanger, NHE1
    Stine Falsig Pedersen
    Department of Molecular Biology, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Arch Biochem Biophys 462:195-201. 2007
    ..Here, we discuss the current evidence indicating the involvement of NHE1 in MAPK regulation, the mechanisms by which this may occur, and the possible physiological and pathophysiological relevance of this phenomenon...
  4. ncbi request reprint Roles of phospholipase A2 isoforms in swelling- and melittin-induced arachidonic acid release and taurine efflux in NIH3T3 fibroblasts
    Stine F Pedersen
    Department of Biochemistry, Institute for Molecular Biology and Physiology, Copenhagen, Denmark
    Am J Physiol Cell Physiol 291:C1286-96. 2006
    ....
  5. ncbi request reprint The Na+/H+ exchanger NHE1 in stress-induced signal transduction: implications for cell proliferation and cell death
    Stine Falsig Pedersen
    Department of Biochemistry, August Krogh Building, Institute for Molecular Biology and Physiology, University of Copenhagen, 13, Universitetsparken, DK 2100, Copenhagen, Denmark
    Pflugers Arch 452:249-59. 2006
    ..The pathophysiological importance of NHE1 in modulating the balance between cell proliferation and cell death in cancer and in ischemia/severe hypoxia will also be briefly addressed...
  6. ncbi request reprint Physiology and pathophysiology of Na+/H+ exchange and Na+ -K+ -2Cl- cotransport in the heart, brain, and blood
    S F Pedersen
    Department of Biochemistry, Institute of Molecular Biology and Physiology, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 291:R1-25. 2006
    ..With respect to pathophysiology, the focus is on ischemia and severe hypoxia where the roles of NHE1 and NKCC1 have been widely studied yet remain controversial and incompletely elucidated...
  7. ncbi request reprint Comparative biology of the ubiquitous Na+/H+ exchanger, NHE1: lessons from erythrocytes
    Stine Falsig Pedersen
    Dept of Biochemistry, August Krogh Institute, University of Copenhagen, 13 Universitetsparken, DK 2100 Copenhagen, Denmark
    J Exp Zool A Comp Exp Biol 301:569-78. 2004
    ..Sensitivity of NHE1 to oxygenation status has recently been described also in non-erythroid mammalian cells...
  8. ncbi request reprint Possible interrelationship between changes in F-actin and myosin II, protein phosphorylation, and cell volume regulation in Ehrlich ascites tumor cells
    S F Pedersen
    Department of Biochemistry, August Krogh Institute, University of Copenhagen, Denmark
    Exp Cell Res 277:57-73. 2002
    ..Implications for the possible interrelationship between changes in F-actin and myosin II, protein phosphorylation, and cell volume regulation are discussed...
  9. ncbi request reprint The cytoskeleton and cell volume regulation
    S F Pedersen
    Biochemistry Department, August Krogh Institute, Copenhagen, Denmark
    Comp Biochem Physiol A Mol Integr Physiol 130:385-99. 2001
    ..This suggests that the effect of CB is related to an effect other than F-actin depolymerization, possibly its F-actin severing activity...
  10. ncbi request reprint Role of the F-actin cytoskeleton in the RVD and RVI processes in Ehrlich ascites tumor cells
    S F Pedersen
    Biochemistry Department, August Krogh Institute, Copenhagen, DK 2100, Denmark
    Exp Cell Res 252:63-74. 1999
    ..The RVD and RVI processes are inhibited by 0.5 microM CB, but not by 0.5 microM CD, which is more specific for actin...
  11. doi request reprint The Na+/H+ exchanger NHE1, but not the Na+, HCO3(-) cotransporter NBCn1, regulates motility of MCF7 breast cancer cells expressing constitutively active ErbB2
    Gitte Lauritzen
    Section for Cell and Developmental Biology, Department of Biology, University of Copenhagen, DK 2100 Copenhagen, Denmark
    Cancer Lett 317:172-83. 2012
    ..These findings demonstrate that NHE1 inhibition can enhance cancer cell motility, adding an important facet to the understanding of NHE1 in cancer...
  12. pmc The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-alpha in the primary cilium
    Linda Schneider
    Department of Biology, University of Copenhagen, Copenhagen O, Denmark
    J Cell Biol 185:163-76. 2009
    ....
  13. doi request reprint HL-1 mouse cardiomyocyte injury and death after simulated ischemia and reperfusion: roles of pH, Ca2+-independent phospholipase A2, and Na+/H+ exchange
    Ann Dorit Andersen
    Department of Biology, Univesity of Copenhagen, DK 2100 Copenhagen, Denmark
    Am J Physiol Cell Physiol 296:C1227-42. 2009
    ..In addition to having clinically relevant implications, these findings can in part explain the contradictory results obtained from previous studies of iPLA(2)-VIA and NHE1 during cardiac I/R...
  14. doi request reprint Monovalent ions control proliferation of Ehrlich Lettre ascites cells
    Thomas Kjaer Klausen
    Section of Cell and Developmental Biology, Dept of Biology, The August Krogh Bldg, Univ of Copenhagen, 13 Universitetsparken, DK 2100, Copenhagen Ø, Denmark
    Am J Physiol Cell Physiol 299:C714-25. 2010
    ..Our results suggest that Na+ regulates ELA cell proliferation by regulating intracellular pH while Cl(-) may regulate proliferation by fine-tuning of E(m) in S phase and altered Ca2+ signaling...
  15. ncbi request reprint Multiple PLA2 isoforms regulate taurine release in NIH3T3 mouse fibroblasts
    Ian Henry Lambert
    Dept of Biochemistry, Institute for Molecular Biology and Physiology, The August Krogh Building, 13, Universitetsparken, DK 2100 Copenhagen, Denmark
    Adv Exp Med Biol 583:99-108. 2006
  16. ncbi request reprint H-ras transformation sensitizes volume-activated anion channels and increases migratory activity of NIH3T3 fibroblasts
    Linda Schneider
    Department of Molecular Biology, University of Copenhagen, 13 Universitetsparken, 2100 Copenhagen, Oe, Denmark
    Pflugers Arch 455:1055-62. 2008
    ..We suggest that H-ras modulates the volume set point of VRAC and thus facilitates transient changes of cell volume required for faster cell migration...
  17. ncbi request reprint A novel NHE1 from red blood cells of the winter flounder: regulation by multiple signaling pathways
    Stine Falsig Pedersen
    Dept of Biochemistry, August Krogh Institute, 13, Universitetsparken, DK 2100 Copenhagen O, Denmark
    Adv Exp Med Biol 559:89-98. 2004
  18. ncbi request reprint Effectors and signaling events activated by cell shrinkage in ehrlich ascites tumor cells: implications for cell proliferation and programmed cell death
    Else K Hoffmann
    Dept of Biochemistry, August Krogh Institute, 13, Universitetsparken, DK 2100 Copenhagen O, Denmark
    Adv Exp Med Biol 559:169-78. 2004
  19. doi request reprint Hyperosmotic stress strongly potentiates serum response factor (SRF)-dependent transcriptional activity in Ehrlich Lettré Ascites cells through a mechanism involving p38 mitogen-activated protein kinase
    Andrej Gorbatenko
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    J Cell Physiol 226:2857-68. 2011
    ..We suggest that these events contribute to shrinkage-induced changes in gene transcription and death/survival balance...
  20. ncbi request reprint Induction of group VIA phospholipase A2 activity during in vitro ischemia in C2C12 myotubes is associated with changes in the level of its splice variants
    K A Poulsen
    Dept of Molecular Biology, Univ of Copenhagen, Universitetsparken 13, Copenhagen Ø DK 2100, Denmark
    Am J Physiol Cell Physiol 293:C1605-15. 2007
    ..iPLA(2)-VIA activation may be modulated by changes in the levels of active and inactive iPLA(2)-VIA isoforms...
  21. ncbi request reprint Mechanical stress induces release of ATP from Ehrlich ascites tumor cells
    S Pedersen
    August Krogh Institute, Department of Biochemistry, Universitetsparken 13, University of Copenhagen, DK 2100, Copenhagen O, Denmark
    Biochim Biophys Acta 1416:271-84. 1999
    ....
  22. ncbi request reprint Activation of PLA2 isoforms by cell swelling and ischaemia/hypoxia
    I H Lambert
    Institute for Molecular Biology and Physiology, The August Krogh Building, Universitetsparken, Copenhagen Ø, Denmark
    Acta Physiol (Oxf) 187:75-85. 2006
    ..Here, we review data that illustrates that stress-induced PLA2 activity involves various PLA2 subtypes and that the PLA2 in question is determined by the cell type and the physiological stress condition...
  23. doi request reprint Ion channels and transporters in cancer: pathophysiology, regulation, and clinical potential
    Stine Falsig Pedersen
    Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Cancer Res 73:1658-61. 2013
    ..Future research should be directed toward further elucidating the mechanisms and developing therapeutic applications...
  24. doi request reprint Osmosensory mechanisms in cellular and systemic volume regulation
    Stine Falsig Pedersen
    Department of Biology, University of Copenhagen, Universitetsparken 13, DK 2100, Copenhagen, Denmark
    J Am Soc Nephrol 22:1587-97. 2011
    ....
  25. ncbi request reprint Transient receptor potential channels in mechanosensing and cell volume regulation
    Stine Falsig Pedersen
    Department of Molecular Biology, University of Copenhagen, Copenhagen, Denmark
    Methods Enzymol 428:183-207. 2007
    ....
  26. doi request reprint Propionic acid secreted from propionibacteria induces NKG2D ligand expression on human-activated T lymphocytes and cancer cells
    Lars Andresen
    Department of Veterinary Disease Biology, University of Copenhagen, Copenhagen, Denmark
    J Immunol 183:897-906. 2009
    ..We propose that propionate, produced either by bacteria or during cellular metabolism, has significant immunoregulatory function and may be cancer prophylactic...
  27. doi request reprint NBCn1 and NHE1 expression and activity in DeltaNErbB2 receptor-expressing MCF-7 breast cancer cells: contributions to pHi regulation and chemotherapy resistance
    G Lauritzen
    Section for Cell and Developmental Biology, Department of Biology, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen O, Denmark
    Exp Cell Res 316:2538-53. 2010
    ..These findings warrant studies of NHE1 as a potential target in breast cancer and demonstrate that in spite of their similar transport functions, NHE1 and NBCn1 serve different functions in MCF-7 cells...