Rasmus S Pedersen

Summary

Affiliation: University of Southern Denmark
Country: Denmark

Publications

  1. ncbi request reprint A cytochrome P450 phenotyping cocktail causing unexpected adverse reactions in female volunteers
    Rasmus Steen Pedersen
    Institute of Public Health, Clinical Pharmacology, University of Southern Denmark, J B Winslowsvej 19, 5000, Odense, Denmark
    Eur J Clin Pharmacol 69:1997-9. 2013
  2. doi request reprint Linkage disequilibrium between the CYP2C19*17 allele and wildtype CYP2C8 and CYP2C9 alleles: identification of CYP2C haplotypes in healthy Nordic populations
    Rasmus S Pedersen
    Institute of Public Health, Clinical Pharmacology, University of Southern Denmark, Odense, Denmark
    Eur J Clin Pharmacol 66:1199-205. 2010
  3. ncbi request reprint Cytochrome P4502C9 (CYP2C9) genotypes in a Nordic population in Denmark
    Rasmus Steen Pedersen
    Institute of Public Health, Research Unit of Clinical Pharmacology, Faculty of Health Sciences, University of Southern Denmark, DK 5000 Odense C, Denmark
    Basic Clin Pharmacol Toxicol 94:151-2. 2004
  4. pmc The effects of human CYP2C8 genotype and fluvoxamine on the pharmacokinetics of rosiglitazone in healthy subjects
    Rasmus S Pedersen
    Clinical Pharmacology, University of Southern Denmark and Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Odense, Denmark
    Br J Clin Pharmacol 62:682-9. 2006
  5. ncbi request reprint Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers
    Rasmus Steen Pedersen
    Institute of Public Health, Clinical Pharmacology, University of Southern Denmark, Winslowparken 19, 5000, Odense C, Denmark
    Eur J Clin Pharmacol 62:513-21. 2006
  6. ncbi request reprint Tramadol as a new probe for cytochrome P450 2D6 phenotyping: a population study
    Rasmus Steen Pedersen
    Institute of Public Health, Fuculty of Health Sciences, Clinical Pharmacology, University of Southern Denmark, Winslowparken 19, DK 5000 Odense C, Denmark
    Clin Pharmacol Ther 77:458-67. 2005
  7. doi request reprint A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin
    Mette M H Christensen
    aInstitute of Public Health, Clinical Pharmacology, University of Southern Denmark bDepartment of Clinical Genetics cDepartment of Clinical Chemistry and Pharmacology dDepartment of Endocrinology, Odense University Hospital, Odense, Denmark
    Pharmacogenet Genomics 23:526-34. 2013
  8. doi request reprint Inhibitory effect of oral contraceptives on CYP2C19 activity is not significant in carriers of the CYP2C19*17 allele
    Rasmus S Pedersen
    Institute of Public Health, Clinical Pharmacology, University of Southern Denmark, Odense, Denmark
    Clin Exp Pharmacol Physiol 40:683-8. 2013
  9. doi request reprint The hypoalgesic effect of oxycodone in human experimental pain models in relation to the CYP2D6 oxidation polymorphism
    Stine T Zwisler
    Clinical Pharmacology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Basic Clin Pharmacol Toxicol 104:335-44. 2009
  10. ncbi request reprint The relative bioavailability of loratadine administered as a chewing gum formulation in healthy volunteers
    Lene Noehr-Jensen
    Institute of Public Health, Clinical Pharmacology, University of Southern Denmark, Winslowparken 19, Denmark
    Eur J Clin Pharmacol 62:437-45. 2006

Detail Information

Publications12

  1. ncbi request reprint A cytochrome P450 phenotyping cocktail causing unexpected adverse reactions in female volunteers
    Rasmus Steen Pedersen
    Institute of Public Health, Clinical Pharmacology, University of Southern Denmark, J B Winslowsvej 19, 5000, Odense, Denmark
    Eur J Clin Pharmacol 69:1997-9. 2013
    ..A four-drug cytochrome P450 (CYP) phenotyping cocktail was developed to rapidly and safely determine CYP2D6, CYP2C19, CYP2C9 and CYP1A2 enzyme activity and phenotype...
  2. doi request reprint Linkage disequilibrium between the CYP2C19*17 allele and wildtype CYP2C8 and CYP2C9 alleles: identification of CYP2C haplotypes in healthy Nordic populations
    Rasmus S Pedersen
    Institute of Public Health, Clinical Pharmacology, University of Southern Denmark, Odense, Denmark
    Eur J Clin Pharmacol 66:1199-205. 2010
    ..To determine the distribution of clinically important CYP2C genotypes and allele frequencies in healthy Nordic populations with special focus on linkage disequilibrium...
  3. ncbi request reprint Cytochrome P4502C9 (CYP2C9) genotypes in a Nordic population in Denmark
    Rasmus Steen Pedersen
    Institute of Public Health, Research Unit of Clinical Pharmacology, Faculty of Health Sciences, University of Southern Denmark, DK 5000 Odense C, Denmark
    Basic Clin Pharmacol Toxicol 94:151-2. 2004
  4. pmc The effects of human CYP2C8 genotype and fluvoxamine on the pharmacokinetics of rosiglitazone in healthy subjects
    Rasmus S Pedersen
    Clinical Pharmacology, University of Southern Denmark and Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Odense, Denmark
    Br J Clin Pharmacol 62:682-9. 2006
    ..To determine the effect of CYP2C8 genotype and of fluvoxamine on the pharmacokinetics of rosiglitazone...
  5. ncbi request reprint Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers
    Rasmus Steen Pedersen
    Institute of Public Health, Clinical Pharmacology, University of Southern Denmark, Winslowparken 19, 5000, Odense C, Denmark
    Eur J Clin Pharmacol 62:513-21. 2006
    ..To describe in detail the intravenous, single oral and multiple oral dose enantioselective pharmacokinetics of tramadol in CYP2D6 extensive metabolizers (EMs) and poor metabolizers (PMs)...
  6. ncbi request reprint Tramadol as a new probe for cytochrome P450 2D6 phenotyping: a population study
    Rasmus Steen Pedersen
    Institute of Public Health, Fuculty of Health Sciences, Clinical Pharmacology, University of Southern Denmark, Winslowparken 19, DK 5000 Odense C, Denmark
    Clin Pharmacol Ther 77:458-67. 2005
    ..Our objective was to investigate whether tramadol can be used as a probe for CYP2D6 phenotyping by determining the concordance between the 8-hour tramadol and 12-hour sparteine metabolic urinary ratios...
  7. doi request reprint A gene-gene interaction between polymorphisms in the OCT2 and MATE1 genes influences the renal clearance of metformin
    Mette M H Christensen
    aInstitute of Public Health, Clinical Pharmacology, University of Southern Denmark bDepartment of Clinical Genetics cDepartment of Clinical Chemistry and Pharmacology dDepartment of Endocrinology, Odense University Hospital, Odense, Denmark
    Pharmacogenet Genomics 23:526-34. 2013
    ..808G>T (rs316019) in OCT2 as well as the relevance of the gene-gene interactions between this SNP and (a) the promoter SNP g.-66T>C (rs2252281) in MATE1 and (b) the OCT1 reduced-function diplotypes...
  8. doi request reprint Inhibitory effect of oral contraceptives on CYP2C19 activity is not significant in carriers of the CYP2C19*17 allele
    Rasmus S Pedersen
    Institute of Public Health, Clinical Pharmacology, University of Southern Denmark, Odense, Denmark
    Clin Exp Pharmacol Physiol 40:683-8. 2013
    ..4) In conclusion, we have shown that OC intake inhibits CYP2C19 in homozygous carriers of the CYP2C19 wild type but that the inhibition is not significant in heterozygous and homozygous carriers of the CYP2C19*17 allele...
  9. doi request reprint The hypoalgesic effect of oxycodone in human experimental pain models in relation to the CYP2D6 oxidation polymorphism
    Stine T Zwisler
    Clinical Pharmacology, Institute of Public Health, University of Southern Denmark, Odense, Denmark
    Basic Clin Pharmacol Toxicol 104:335-44. 2009
    ..012, a difference of 12%, CI: 3%-22%). The plasma oxymorphone/oxycodone ratio was significantly lower in PM compared with EM (P < 0.001). Oxycodone analgesia seems to depend both on oxycodone itself and its metabolite oxymorphone...
  10. ncbi request reprint The relative bioavailability of loratadine administered as a chewing gum formulation in healthy volunteers
    Lene Noehr-Jensen
    Institute of Public Health, Clinical Pharmacology, University of Southern Denmark, Winslowparken 19, Denmark
    Eur J Clin Pharmacol 62:437-45. 2006
    ....
  11. ncbi request reprint Two separate dose-dependent effects of paroxetine: mydriasis and inhibition of tramadol's O-demethylation via CYP2D6
    Anette Green Nielsen
    Institute of Public Health, Clinical Pharmacology, University of Southern Denmark, Odense, Denmark
    Eur J Clin Pharmacol 66:655-60. 2010
    ..To investigate paroxetine's putative dose-dependent impact on pupil reaction and inhibition of the O-demethylation of tramadol...
  12. pmc Increased omeprazole metabolism in carriers of the CYP2C19*17 allele; a pharmacokinetic study in healthy volunteers
    R Michael Baldwin
    Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Br J Clin Pharmacol 65:767-74. 2008
    ..The CYP2C19*17 allele had been associated with a two- and fourfold decrease in omeprazole and S/R-mephenytoin metabolic ratios...