Søren R Paludan

Summary

Affiliation: University of Aarhus
Country: Denmark

Publications

  1. pmc Type I interferon production during herpes simplex virus infection is controlled by cell-type-specific viral recognition through Toll-like receptor 9, the mitochondrial antiviral signaling protein pathway, and novel recognition systems
    Simon B Rasmussen
    Institute of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Virol 81:13315-24. 2007
  2. pmc HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6
    Regina Gonzalez-Dosal
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    PLoS Pathog 7:e1002250. 2011
  3. pmc Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING
    Christian K Holm
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    Nat Immunol 13:737-43. 2012
  4. pmc Induction of interferon-stimulated genes by Chlamydia pneumoniae in fibroblasts is mediated by intracellular nucleotide-sensing receptors
    Srikanth Chiliveru
    Department of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark
    PLoS ONE 5:e10005. 2010
  5. pmc Immune sensing of DNA
    Søren R Paludan
    Department of Biomedicine, University of Aarhus, Aarhus 8000, Denmark
    Immunity 38:870-80. 2013
  6. pmc Innate immune recognition and activation during HIV infection
    Trine H Mogensen
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, DK 8200, Aarhus N, Denmark
    Retrovirology 7:54. 2010
  7. pmc Streptococcus pneumoniae stabilizes tumor necrosis factor alpha mRNA through a pathway dependent on p38 MAPK but independent of Toll-like receptors
    Trine H Mogensen
    Department of Infectious Diseases, Skejby Hospital Aarhus University Hospital, DK 8200, Aarhus N, Denmark
    BMC Immunol 9:52. 2008
  8. ncbi request reprint Expression of TNF-alpha by herpes simplex virus-infected macrophages is regulated by a dual mechanism: transcriptional regulation by NF-kappa B and activating transcription factor 2/Jun and translational regulation through the AU-rich region of the 3' unt
    S R Paludan
    Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Immunol 167:2202-8. 2001
  9. pmc Recognition of herpesviruses by the innate immune system
    Søren R Paludan
    Department of Medical Microbiology and Immunology, The Bartholin Building, Aarhus University, DK 8000 Aarhus C, Denmark
    Nat Rev Immunol 11:143-54. 2011
  10. doi request reprint Innate recognition of intracellular pathogens: detection and activation of the first line of defense
    Simon B Rasmussen
    Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    APMIS 117:323-37. 2009

Detail Information

Publications70

  1. pmc Type I interferon production during herpes simplex virus infection is controlled by cell-type-specific viral recognition through Toll-like receptor 9, the mitochondrial antiviral signaling protein pathway, and novel recognition systems
    Simon B Rasmussen
    Institute of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Virol 81:13315-24. 2007
    ..Thus, during an HSV infection in vivo, multiple mechanisms of pathogen recognition are active, which operate in cell-type- and time-dependent manners to trigger expression of type I IFN and coordinate the antiviral response...
  2. pmc HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6
    Regina Gonzalez-Dosal
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    PLoS Pathog 7:e1002250. 2011
    ..In conclusion, these findings demonstrate that ROS are essential for effective activation of signaling pathways leading to a successful innate immune response against HSV infection...
  3. pmc Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING
    Christian K Holm
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    Nat Immunol 13:737-43. 2012
    ..We suggest that membrane fusion is sensed as a danger signal with potential implications for defense against enveloped viruses and various conditions of giant-cell formation...
  4. pmc Induction of interferon-stimulated genes by Chlamydia pneumoniae in fibroblasts is mediated by intracellular nucleotide-sensing receptors
    Srikanth Chiliveru
    Department of Medical Microbiology and Immunology, Aarhus University, Aarhus, Denmark
    PLoS ONE 5:e10005. 2010
    ..The infection triggers a host response contributing to both bacterial clearance and tissue damage. For instance, type I interferons (IFN)s have been demonstrated to exacerbate the course of Chlamydial lung infections in mice...
  5. pmc Immune sensing of DNA
    Søren R Paludan
    Department of Biomedicine, University of Aarhus, Aarhus 8000, Denmark
    Immunity 38:870-80. 2013
    ..We highlight new insights gained into how and why the immune system responds to both pathogen and self DNA and define important questions that now need to be addressed in the field of innate immune activation by DNA...
  6. pmc Innate immune recognition and activation during HIV infection
    Trine H Mogensen
    Department of Infectious Diseases, Aarhus University Hospital, Skejby, DK 8200, Aarhus N, Denmark
    Retrovirology 7:54. 2010
    ....
  7. pmc Streptococcus pneumoniae stabilizes tumor necrosis factor alpha mRNA through a pathway dependent on p38 MAPK but independent of Toll-like receptors
    Trine H Mogensen
    Department of Infectious Diseases, Skejby Hospital Aarhus University Hospital, DK 8200, Aarhus N, Denmark
    BMC Immunol 9:52. 2008
    ..Infections with S. pneumoniae evoke a strong inflammatory response, which plays a major role in the pathogenesis of pneumococcal disease...
  8. ncbi request reprint Expression of TNF-alpha by herpes simplex virus-infected macrophages is regulated by a dual mechanism: transcriptional regulation by NF-kappa B and activating transcription factor 2/Jun and translational regulation through the AU-rich region of the 3' unt
    S R Paludan
    Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Immunol 167:2202-8. 2001
    ..These results show that TNF-alpha production is induced by HSV-2 in macrophages through both transcriptional and translational regulation...
  9. pmc Recognition of herpesviruses by the innate immune system
    Søren R Paludan
    Department of Medical Microbiology and Immunology, The Bartholin Building, Aarhus University, DK 8000 Aarhus C, Denmark
    Nat Rev Immunol 11:143-54. 2011
    ....
  10. doi request reprint Innate recognition of intracellular pathogens: detection and activation of the first line of defense
    Simon B Rasmussen
    Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    APMIS 117:323-37. 2009
    ....
  11. ncbi request reprint Inhibition of NO production in macrophages by IL-13 is counteracted by Herpes simplex virus infection through tumor necrosis factor-alpha-induced activation of NK-kappa B
    S R Paludan
    Department of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    Eur Cytokine Netw 11:275-82. 2000
    ..This could imply that a sustained NO production would be focused to sites of active virus replication...
  12. ncbi request reprint Expression of genes for cytokines and cytokine-related functions in leukocytes infected with Herpes simplex virus: comparison between resistant and susceptible mouse strains
    Søren R Paludan
    Department of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, K 8000 Aarhus C, Denmark
    Eur Cytokine Netw 13:306-16. 2002
    ..Further analysis of these genes may provide new information about host defense against viral infections and could also lead to identification of the molecular basis for the pathological differences between infections with HSV-1 and -2...
  13. pmc Requirements for the induction of interleukin-6 by herpes simplex virus-infected leukocytes
    S R Paludan
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Virol 75:8008-15. 2001
    ..The results show that induction of IL-6 by HSV in leukocytes is dependent on PKR and cellular signaling through NF-kappaB and a p38-dependent pathway...
  14. pmc Virus-cell interactions regulating induction of tumor necrosis factor alpha production in macrophages infected with herpes simplex virus
    S R Paludan
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Virol 75:10170-8. 2001
    ....
  15. ncbi request reprint Viral activation of macrophages through TLR-dependent and -independent pathways
    Lene Malmgaard
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Immunol 173:6890-8. 2004
    ....
  16. pmc RIG-I-mediated activation of p38 MAPK is essential for viral induction of interferon and activation of dendritic cells: dependence on TRAF2 and TAK1
    Susie S Mikkelsen
    Institute of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Biol Chem 284:10774-82. 2009
    ..Thus, activation of p38 MAPK by RIG-I proceeds via a TRAF2-TAK1-dependent pathway, where the enzymatic activity of the kinase plays an essential role. The p38 MAPK in turn stimulates important processes in the innate antiviral response...
  17. ncbi request reprint Induction of RANTES/CCL5 by herpes simplex virus is regulated by nuclear factor kappa B and interferon regulatory factor 3
    Jesper Melchjorsen
    Department of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Gen Virol 84:2491-5. 2003
    ..Taken together, these data suggest that HSV induces transcriptional activation of the RANTES gene through the transcription factors NF-kappa B and IRF-3...
  18. pmc From the Cover: IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication
    Martin R Jakobsen
    Department of Biomedicine and Aarhus Research Center for Innate Immunology, Aarhus University, 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 110:E4571-80. 2013
    ..Thus, IFI16 is a sensor for DNA forms produced during the lentiviral replication cycle and regulates HIV-1 replication in macrophages. ..
  19. pmc Activation of innate defense against a paramyxovirus is mediated by RIG-I and TLR7 and TLR8 in a cell-type-specific manner
    Jesper Melchjorsen
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    J Virol 79:12944-51. 2005
    ..Therefore, there appears to be a large degree of cell-type specificity in the mechanisms used by the host to recognize infecting viruses...
  20. pmc Lambda interferon (IFN-lambda), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo
    Nina Ank
    Institute of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Virol 80:4501-9. 2006
    ....
  21. ncbi request reprint An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity
    Nina Ank
    Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Immunol 180:2474-85. 2008
    ..In this compartment, epithelial cells responded to IFN-lambda and directly restricted virus replication. Our data suggest type III IFN to target a specific subset of cells and to contribute to the antiviral response evoked by TLRs...
  22. pmc Suppression of proinflammatory cytokine expression by herpes simplex virus type 1
    Trine H Mogensen
    Department of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Virol 78:5883-90. 2004
    ..Thus, HSV is able to suppress expression of proinflammatory cytokines by decreasing the stability of mRNAs, thereby potentially impeding the antiviral host response to infection...
  23. pmc Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors
    Kristy A Horan
    Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark
    J Immunol 190:2311-9. 2013
    ..Thus, proteasomal degradation of herpesvirus capsids releases DNA to the cytoplasm for recognition by DNA sensors...
  24. ncbi request reprint TLR2 and TLR9 synergistically control herpes simplex virus infection in the brain
    Louise N Sørensen
    Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Immunol 181:8604-12. 2008
    ..Thus, TLR2 and TLR9 synergistically stimulate innate antiviral activities, thereby protecting against HSV infection in the brain...
  25. doi request reprint TLR3 ligand polyinosinic:polycytidylic acid induces IL-17A and IL-21 synthesis in human Th cells
    Christian K Holm
    Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Immunol 183:4422-31. 2009
    ..This is the first report to show that the TLR3 ligand poly(I:C) can directly induce the synthesis of IL-17A and IL-21 and drive differentiation of human naive CD4+ T cells...
  26. doi request reprint Inflammatory cytokines break down intrinsic immunological tolerance of human primary keratinocytes to cytosolic DNA
    Srikanth Chiliveru
    Department of Biomedicine, Aarhus University, Aarhus DK 8000, Denmark
    J Immunol 192:2395-404. 2014
    ..Collectively, this work suggests that inflammatory environments in the skin can lead to breakdown of tolerance for DNA in keratinocytes, which could contribute to the development of inflammatory diseases. ..
  27. pmc Expression of type III interferon (IFN) in the vaginal mucosa is mediated primarily by dendritic cells and displays stronger dependence on NF-kappaB than type I IFNs
    Marie B Iversen
    Department of Medical Microbiology and Immunology, Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Virol 84:4579-86. 2010
    ..Thus, the type I and III IFN genes are not induced through entirely identical pathways, which indicates differential expression of these two types of IFNs under certain conditions...
  28. pmc Herpes simplex virus selectively induces expression of the CC chemokine RANTES/CCL5 in macrophages through a mechanism dependent on PKR and ICP0
    Jesper Melchjorsen
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Virol 76:2780-8. 2002
    ..By contrast, the ability of an ICP0-deficient HSV-1 mutant to induce RANTES expression was compromised. Thus, HSV selectively induces expression of RANTES in macrophages through a mechanism dependent on cellular PKR and viral ICP0...
  29. pmc Chitosan/siRNA nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages for anti-inflammatory treatment in a murine arthritis model
    Kenneth A Howard
    Interdisciplinary Nanoscience Center iNANO, University of Aarhus, Aarhus C, Denmark
    Mol Ther 17:162-8. 2009
    ..This work demonstrates nanoparticle-mediated TNF-alpha knockdown in peritoneal macrophages as a method to reduce both local and systemic inflammation, thereby presenting a novel strategy for arthritis treatment...
  30. doi request reprint Differential regulation of the OASL and OAS1 genes in response to viral infections
    Jesper Melchjorsen
    Department of Molecular Biology, University of Aarhus, Denmark
    J Interferon Cytokine Res 29:199-207. 2009
    ..Furthermore, the behavior of the OASL gene is consistent with the behavior of an antiviral gene...
  31. pmc Early innate recognition of herpes simplex virus in human primary macrophages is mediated via the MDA5/MAVS-dependent and MDA5/MAVS/RNA polymerase III-independent pathways
    Jesper Melchjorsen
    Department of Infectious Diseases, Aarhus University Hospital Skejby, and Department of Medical Microbiology and Immunology, University of Aarhus, Brendstrupgaardsvej 100, DK 8200 Aarhus N, Denmark
    J Virol 84:11350-8. 2010
    ..Thus, innate recognition of HSV by human primary macrophages occurs via two distinct intracellular nucleotide-sensing pathways responsible for induction of IFNs and inflammatory cytokine expression, respectively...
  32. ncbi request reprint Activation of NF-kappa B in virus-infected macrophages is dependent on mitochondrial oxidative stress and intracellular calcium: downstream involvement of the kinases TGF-beta-activated kinase 1, mitogen-activated kinase/extracellular signal-regulated kin
    Trine H Mogensen
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Immunol 170:6224-33. 2003
    ....
  33. pmc Activation of autophagy by α-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genes
    Simon B Rasmussen
    Department of Biomedicine, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Immunol 187:5268-76. 2011
    ..Thus, our data suggest that HSV-1 genomic DNA induces autophagy in nonpermissive cells in a stimulator of IFN gene-dependent manner...
  34. ncbi request reprint Interferon (IFN)-alpha/beta, interleukin (IL)-12 and IL-18 coordinately induce production of IFN-gamma during infection with herpes simplex virus type 2
    Lene Malmgaard
    Department of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Gen Virol 84:2497-500. 2003
    ..Our data suggest that IFN-gamma production is induced during HSV-2 infection through the coordinated action of IFN-alpha/beta, IL-12 and IL-18...
  35. doi request reprint Antiviral and immunological effects of tenofovir microbicide in vaginal herpes simplex virus 2 infection
    Line Vibholm
    Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
    AIDS Res Hum Retroviruses 28:1404-11. 2012
    ..Therefore, this model would be suitable for evaluating present and future microbicide candidates. Furthermore, the present study warrants further investigation of TDF in microbicides...
  36. pmc TLR3 deficiency renders astrocytes permissive to herpes simplex virus infection and facilitates establishment of CNS infection in mice
    Line S Reinert
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    J Clin Invest 122:1368-76. 2012
    ..Thus, TLR3 acts in astrocytes to sense HSV-2 infection immediately after entry into the CNS, possibly preventing HSV from spreading beyond the neurons mediating entry into the CNS...
  37. pmc Genomic HIV RNA induces innate immune responses through RIG-I-dependent sensing of secondary-structured RNA
    Randi K Berg
    Department of Infectious Diseases, Aarhus University Hospital Skejby, Aarhus, Denmark
    PLoS ONE 7:e29291. 2012
    ..However, knowledge on specific HIV PAMPs and cellular PRRs responsible for inducing innate immune responses remains sparse...
  38. pmc Crystal structure of interleukin-21 receptor (IL-21R) bound to IL-21 reveals that sugar chain interacting with WSXWS motif is integral part of IL-21R
    Ole J Hamming
    Department of Molecular Biology and Genetics, Aarhus University, Aarhus C, Denmark
    J Biol Chem 287:9454-60. 2012
    ..The glycan thus transforms the V-shaped receptor into an A-frame. This finding offers a novel structural explanation of the role of the class I cytokine signature motif...
  39. pmc Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible gene- like receptors, which synergize to induce type I interferon production
    Simon B Rasmussen
    Institute of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Gen Virol 90:74-8. 2009
    ..Thus, RLRs are important for recognition of HSV infection, and cooperate with the Toll pathway to induce an antiviral response...
  40. pmc Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family
    Hans Henrik Gad
    Centre for Structural Biology, Department of Molecular Biology, Aarhus University, Gustav, Wieds Vej 10, 8000 Arhus C, Denmark
    J Biol Chem 284:20869-75. 2009
    ..In particular, we found an interesting similarity between IFN-lambda and IL-22, and we suggest that IFN-lambda and IL-22 possess parallel functions, protecting epithelial tissue against viral and bacterial infections, respectively...
  41. pmc DNA recognition in immunity and disease
    Christian K Holm
    Department of Biomedicine, Wilhelm Meyers Allé 4, University of Aarhus, 8000 Aarhus, Denmark
    Curr Opin Immunol 25:13-8. 2013
    ..A better understanding of DNA recognition pathways can provide new insights into infectious, inflammatory and autoimmune diseases...
  42. pmc TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults
    Rasmus Offersen
    Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark
    Hum Vaccin Immunother 8:1042-7. 2012
    ..These findings suggests that CPG 7909 as adjuvant to pneumococcal conjugate vaccine induces cellular memory to pneumococcal polysaccharides in HIV-patients, independently of the humoral response...
  43. doi request reprint Mitochondria-derived reactive oxygen species negatively regulates immune innate signaling pathways triggered by a DNA virus, but not by an RNA virus
    Regina Gonzalez-Dosal
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    Biochem Biophys Res Commun 418:806-10. 2012
    ..Thus, localized mitochondrial ROS exerts negative modulation of innate immune responses to the DNA virus HSV-2 but not the RNA virus SeV...
  44. doi request reprint Mechanisms of type III interferon expression
    Marie B Iversen
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus C, Denmark
    J Interferon Cytokine Res 30:573-8. 2010
    ..Thus, the mechanisms governing type III IFN expression play an important part in dictating the biology of this antiviral cytokine...
  45. pmc Age-dependent role for CCR5 in antiviral host defense against herpes simplex virus type 2
    Nina Ank
    Institute of Medical Microbiology and Immunology, University of Aarhus, Denmark
    J Virol 79:9831-41. 2005
    ..Altogether, this study shows that CCR5 plays an age-dependent role in host defense against HSV-2 by supporting both the innate and adaptive immune response...
  46. pmc T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication
    Randi K Berg
    Department of Infectious Diseases, Aarhus University Hospital Skejby, Aarhus, Denmark
    PLoS ONE 9:e84513. 2014
    ..This phenomenon could contribute to the high permissiveness of CD4+ T cells for HIV-1. ..
  47. ncbi request reprint Expression and function of chemokines during viral infections: from molecular mechanisms to in vivo function
    Jesper Melchjorsen
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    J Leukoc Biol 74:331-43. 2003
    ..In this review, we discuss the role of chemokines in host-defense against virus infections, and we also look deeper into the virus-cell interactions that trigger chemokine expression as well as the cellular signaling cascades involved...
  48. ncbi request reprint Reading the viral signature by Toll-like receptors and other pattern recognition receptors
    Trine H Mogensen
    Department of Infectious Diseases, Skejby Hospital, Aarhus, Denmark
    J Mol Med (Berl) 83:180-92. 2005
    ..Finally, we look into what is currently known about the role of PRRs in viral infections in vivo...
  49. pmc Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity
    Helle Kristiansen
    Department of Molecular Biology, Aarhus University, Gustav Wieds Vej 10C, Aarhus, Denmark
    J Virol 84:11898-904. 2010
    ..Thus, the OAS protein represents the first direct antiviral compound released by virus-infected cells...
  50. ncbi request reprint Interferon (IFN)-gamma and Herpes simplex virus/tumor necrosis factor-alpha synergistically induce nitric oxide synthase 2 in macrophages through cooperative action of nuclear factor-kappa B and IFN regulatory factor-1
    S R Paludan
    Department of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK-8000 Aarhus C, Denmark
    Eur Cytokine Netw 12:297-308. 2001
    ....
  51. pmc Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway
    Kathrine Hansen
    Department of Biomedicine, Aarhus University, Aarhus, Denmark Aarhus Research Centre for Innate Immunology, Aarhus University, Aarhus, Denmark
    EMBO J 33:1654-66. 2014
    ..Thus, Listeria DNA is a major trigger of IFNβ expression in human myeloid cells and is sensed to activate a pathway dependent on IFI16, cGAS and STING. ..
  52. pmc Type III interferon (IFN) induces a type I IFN-like response in a restricted subset of cells through signaling pathways involving both the Jak-STAT pathway and the mitogen-activated protein kinases
    Zhangle Zhou
    Department of Human Genetics, University of Aarhus, Denmark
    J Virol 81:7749-58. 2007
    ..We also tested the activation of mitogen-activated protein (MAP) kinases by type III IFN and found that type III IFN relies strongly upon both p38 and JNK MAP kinases for gene induction...
  53. ncbi request reprint IFN-lambda: novel antiviral cytokines
    Nina Ank
    Institute of Medical Microbiology and Immunology, University of Aarhus, Denmark
    J Interferon Cytokine Res 26:373-9. 2006
    ..Here, we review the literature on IFN-lambda and discuss the current knowledge of the functions and mechanisms of action of IFN-lambda...
  54. pmc Caught in translation: innate restriction of HIV mRNA translation by a schlafen family protein
    Martin R Jakobsen
    Department of Biomedicine, University of Aarhus, Aarhus, Denmark
    Cell Res 23:320-2. 2013
    ..A publication now describes a novel strategy employed by HIV-infected cells to restrict viral replication, which involves inhibition of viral mRNA translation by the ISG Schlafen 11...
  55. ncbi request reprint Role of mitogen-activated protein kinases, nuclear factor-kappaB, and interferon regulatory factor 3 in Toll-like receptor 4-mediated activation of HIV long terminal repeat
    Randi S Berg
    Department of Infectious Diseases, Skejby Hospital, Aarhus, Denmark
    APMIS 117:124-32. 2009
    ..Neither of the mitogen-activated protein kinases ERK1/2, JNK, or p38 nor the transcription factor interferon regulatory factor 3 were involved in the direct transactivation of HIV-LTR through stimulation of TLR4...
  56. ncbi request reprint Induction of cytokine expression by herpes simplex virus in human monocyte-derived macrophages and dendritic cells is dependent on virus replication and is counteracted by ICP27 targeting NF-kappaB and IRF-3
    Jesper Melchjorsen
    Department of Viral Diseases and Immunology, National Public Health Institute, Helsinki, Finland
    J Gen Virol 87:1099-108. 2006
    ..It is further identified that viral IE-gene expression interferes with the antiviral response in human macrophages and ICP27 is identified as an important viral protein counteracting the early innate immune response...
  57. ncbi request reprint Effect of IL-4 and IL-13 on IFN-gamma-induced production of nitric oxide in mouse macrophages infected with herpes simplex virus type 2
    S R Paludan
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus C, Denmark
    FEBS Lett 414:61-4. 1997
    ..The beneficial effect of a sustained NO production in foci of virus infection is suggested...
  58. ncbi request reprint Synergistic action of pro-inflammatory agents: cellular and molecular aspects
    S R Paludan
    Department of Medical Microbiology and Immunology, University of Aarhus, Denmark
    J Leukoc Biol 67:18-25. 2000
    ..Cooperative activity of proinflammatory agents profoundly influences the immune response to infections and the efficiency of cellular clearance mechanisms...
  59. ncbi request reprint Interleukin-21 mRNA expression during virus infections
    Christian Holm
    Institute of Medical Microbiology and Immunology, Bartholin Building, University of Aarhus, 8000 Aarhus C, Denmark
    Cytokine 33:41-5. 2006
    ..Thus, our data suggest a role for IL-21 in the early stages of adaptive immune response against virus infections...
  60. doi request reprint Type III IFNs: new layers of complexity in innate antiviral immunity
    Nina Ank
    Institute of Medical Microbiology and Immunology, University of Aarhus, Denmark
    Biofactors 35:82-7. 2009
    ..In this review, we describe the current knowledge on the role of type III IFNs in antiviral defense...
  61. doi request reprint Tenofovir selectively regulates production of inflammatory cytokines and shifts the IL-12/IL-10 balance in human primary cells
    Jesper Melchjorsen
    Department of Infectious Diseases, Aarhus University Hospital Skejby, Aarhus, Denmark
    J Acquir Immune Defic Syndr 57:265-75. 2011
    ....
  62. ncbi request reprint Blocking CC chemokine receptor (CCR) 1 and CCR5 during herpes simplex virus type 2 infection in vivo impairs host defence and perturbs the cytokine response
    L N Sørensen
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    Scand J Immunol 59:321-33. 2004
    ..Altogether, the results suggest that CCR1 and/or CCR5 are important for both viral clearance and eventual control of the immune response...
  63. pmc Sensing the hybrid--a novel PAMP for TLR9
    Søren B Jensen
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    EMBO J 33:529-30. 2014
    ..In this issue of The EMBO Journal, Rigby et al identify RNA-DNA hybrids as a novel PAMP specifically recognized by TLR9 in dendritic cells. ..
  64. pmc Interleukin-21 receptor signalling is important for innate immune protection against HSV-2 infections
    Sine K Kratholm
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    PLoS ONE 8:e81790. 2013
    ..Collectively our data demonstrate the novel finding that the IL-21R plays a critical role in regulating innate immune responses against HSV-2 infection. ..
  65. ncbi request reprint Delivery of siRNA from lyophilized polymeric surfaces
    Morten Ø Andersen
    Interdisciplinary Nanoscience Center iNANO, University of Aarhus, 8000 Aarhus C, Denmark
    Biomaterials 29:506-12. 2008
    ....
  66. ncbi request reprint Long-term renal effects of a neutralizing RAGE antibody in obese type 2 diabetic mice
    Allan Flyvbjerg
    Medical Department M and Medical Research Laboratories, Institute of Experimental Clinical Research, Aarhus University Hospital, Aarhus, Denmark
    Diabetes 53:166-72. 2004
    ..In conclusion, RAGE is an important pathogenetic factor in the renal changes in an animal model of type 2 diabetes...
  67. pmc Mannan-binding lectin modulates the response to HSV-2 infection
    M Gadjeva
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    Clin Exp Immunol 138:304-11. 2004
    ..0369). This suggests that lack of MBL-mediated complement activation increases susceptibility to viral infection...
  68. doi request reprint Toll2011 at Lago di Garda: studying danger sensors by the guard towers at the lake
    Søren R Paludan
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    Nat Immunol 12:805-8. 2011
    ..At the Toll2011 Meeting, recent advances in the field of innate immunity were presented and discussed. These insights have set new directions for both basic and translational research in this important field...
  69. ncbi request reprint Virus-cell interactions: impact on cytokine production, immune evasion and tumor growth
    T H Mogensen
    Department of Medical Microbiology and Immunology, The Bartholin Building, University of Aarhus, DK-8000 Aarhus, Denmark
    Eur Cytokine Netw 12:382-90. 2001
    ..This review describes how virus infections affect cellular signal transduction and the mechanisms through which certain viruses modulate this response to dampen the immune response or prevent cell death...
  70. ncbi request reprint Two neisseria meningitidis strains with different ability to stimulate toll-like receptor 4 through the MyD88-independent pathway
    T H Mogensen
    Department of Infectious Diseases, Skejby Hospital, Aarhus, Denmark
    Scand J Immunol 64:646-54. 2006
    ..These data therefore provide molecular insight into activation of the inflammatory response by N. meningitidis, which is one of the key events in the pathogenesis of meningococcal disease...