Michael Hecht Olsen

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Opposite effects of losartan and atenolol on natriuretic peptides in patients with hypertension and left ventricular hypertrophy: a LIFE substudy
    Michael H Olsen
    Glostrup University Hospital, Glostrup, Denmark
    J Hypertens 23:1083-90. 2005
  2. doi request reprint Changes in subclinical organ damage vs. in Framingham risk score for assessing cardiovascular risk reduction during continued antihypertensive treatment: a LIFE substudy
    Michael H Olsen
    Department of Internal Medicine, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Denmark
    J Hypertens 29:997-1004. 2011
  3. ncbi request reprint Losartan but not atenolol reduce carotid artery hypertrophy in essential hypertension. A LIFE substudy
    Michael H Olsen
    Departemtn fo Clinical Physiology and Nuclear Medicine, Glostrup University Hospital, Copenhagen, Denmark
    Blood Press 14:177-83. 2005
  4. ncbi request reprint N-terminal pro brain natriuretic peptide is inversely related to metabolic cardiovascular risk factors and the metabolic syndrome
    Michael H Olsen
    Research Center for Prevention and Health, Glostrup University Hospital, DK 2600 Glostrup, Denmark
    Hypertension 46:660-6. 2005
  5. ncbi request reprint Aortic valve sclerosis and albuminuria predict cardiovascular events independently in hypertension: a losartan intervention for endpoint-reduction in hypertension (LIFE) substudy
    Michael H Olsen
    Department of Internal Medicine, Glostrup University Hospital, Glostrup, Denmark
    Am J Hypertens 18:1430-6. 2005
  6. ncbi request reprint High-sensitivity C-reactive protein is only weakly related to cardiovascular damage after adjustment for traditional cardiovascular risk factors
    Michael H Olsen
    Research Center for Prevention and Health, Glostrup University, Denmark
    J Hypertens 24:655-61. 2006
  7. ncbi request reprint Reductions in albuminuria and in electrocardiographic left ventricular hypertrophy independently improve prognosis in hypertension: the LIFE study
    Michael H Olsen
    Glostrup University Hospital, Denmark
    J Hypertens 24:775-81. 2006
  8. ncbi request reprint N-terminal brain natriuretic peptide predicted cardiovascular events stronger than high-sensitivity C-reactive protein in hypertension: a LIFE substudy
    Michael H Olsen
    Department of Internal Medicine, Glostrup University Hospital, Glostrup, Denmark
    J Hypertens 24:1531-9. 2006
  9. ncbi request reprint N-terminal pro-brain natriuretic peptide, but not high sensitivity C-reactive protein, improves cardiovascular risk prediction in the general population
    Michael H Olsen
    Research Center for Prevention and Health, Department of Clinical Physiology and Nuclear Medicine, Glostrup University Hospital, DK 2600 Glostrup, Denmark
    Eur Heart J 28:1374-81. 2007
  10. ncbi request reprint Cardiovascular risk prediction by N-terminal pro brain natriuretic peptide and high sensitivity C-reactive protein is affected by age and sex
    Michael H Olsen
    Research Center for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark
    J Hypertens 26:26-34. 2008

Detail Information

Publications42

  1. ncbi request reprint Opposite effects of losartan and atenolol on natriuretic peptides in patients with hypertension and left ventricular hypertrophy: a LIFE substudy
    Michael H Olsen
    Glostrup University Hospital, Glostrup, Denmark
    J Hypertens 23:1083-90. 2005
    ..Therefore, we investigated the influence of blood pressure (BP) reduction with losartan versus atenolol on N-terminal pro-atrial natriuretic peptide (Nt-proANP) and N-terminal pro-brain natriuretic peptide (Nt-proBNP)...
  2. doi request reprint Changes in subclinical organ damage vs. in Framingham risk score for assessing cardiovascular risk reduction during continued antihypertensive treatment: a LIFE substudy
    Michael H Olsen
    Department of Internal Medicine, Glostrup Hospital, University of Copenhagen, DK 2600 Glostrup, Denmark
    J Hypertens 29:997-1004. 2011
    ....
  3. ncbi request reprint Losartan but not atenolol reduce carotid artery hypertrophy in essential hypertension. A LIFE substudy
    Michael H Olsen
    Departemtn fo Clinical Physiology and Nuclear Medicine, Glostrup University Hospital, Copenhagen, Denmark
    Blood Press 14:177-83. 2005
    ..We wanted to investigate whether treatment with losartan, an angiotensin II receptor blocker, induced regression of carotid artery hypertrophy as compared to the beta-receptor blocker, atenolol...
  4. ncbi request reprint N-terminal pro brain natriuretic peptide is inversely related to metabolic cardiovascular risk factors and the metabolic syndrome
    Michael H Olsen
    Research Center for Prevention and Health, Glostrup University Hospital, DK 2600 Glostrup, Denmark
    Hypertension 46:660-6. 2005
    ..The metabolic syndrome was associated with lower Nt-proBNP levels and shifted the positive relationship between Nt-proBNP and pulse pressure to the right, creating a possible link between the metabolic syndrome and hypertension...
  5. ncbi request reprint Aortic valve sclerosis and albuminuria predict cardiovascular events independently in hypertension: a losartan intervention for endpoint-reduction in hypertension (LIFE) substudy
    Michael H Olsen
    Department of Internal Medicine, Glostrup University Hospital, Glostrup, Denmark
    Am J Hypertens 18:1430-6. 2005
    ..We aimed to investigate whether they predicted cardiovascular (CV) events independently in patients with hypertension and electrocardiographic left ventricular (LV) hypertrophy...
  6. ncbi request reprint High-sensitivity C-reactive protein is only weakly related to cardiovascular damage after adjustment for traditional cardiovascular risk factors
    Michael H Olsen
    Research Center for Prevention and Health, Glostrup University, Denmark
    J Hypertens 24:655-61. 2006
    ....
  7. ncbi request reprint Reductions in albuminuria and in electrocardiographic left ventricular hypertrophy independently improve prognosis in hypertension: the LIFE study
    Michael H Olsen
    Glostrup University Hospital, Denmark
    J Hypertens 24:775-81. 2006
    ..We wanted to investigate whether these prognostic improvements were independent...
  8. ncbi request reprint N-terminal brain natriuretic peptide predicted cardiovascular events stronger than high-sensitivity C-reactive protein in hypertension: a LIFE substudy
    Michael H Olsen
    Department of Internal Medicine, Glostrup University Hospital, Glostrup, Denmark
    J Hypertens 24:1531-9. 2006
    ....
  9. ncbi request reprint N-terminal pro-brain natriuretic peptide, but not high sensitivity C-reactive protein, improves cardiovascular risk prediction in the general population
    Michael H Olsen
    Research Center for Prevention and Health, Department of Clinical Physiology and Nuclear Medicine, Glostrup University Hospital, DK 2600 Glostrup, Denmark
    Eur Heart J 28:1374-81. 2007
    ..The aim of this study was to determine whether they predicted CV events independently of established CV risk factors and whether they did so in an additive fashion...
  10. ncbi request reprint Cardiovascular risk prediction by N-terminal pro brain natriuretic peptide and high sensitivity C-reactive protein is affected by age and sex
    Michael H Olsen
    Research Center for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark
    J Hypertens 26:26-34. 2008
    ....
  11. doi request reprint Impact of the metabolic syndrome on the predictive values of new risk markers in the general population
    M H Olsen
    Research Center for Prevention and Health, Glostrup University Hospital, Copenhagen, Denmark
    J Hum Hypertens 22:634-40. 2008
    ..5 and 93%, respectively. In apparently healthy subjects, high hsCRP was associated with CEP primarily in subjects without MetS, high Nt-proBNP in subjects with elements of MetS and UACR independently of MetS...
  12. doi request reprint New risk markers may change the HeartScore risk classification significantly in one-fifth of the population
    M H Olsen
    Research Center for Prevention and Health, Glostrup, Denmark
    J Hum Hypertens 23:105-12. 2009
    ..Additional use of UACR and hsCRP in subjects with low-moderate risk and UACR and Nt-proBNP in subjects with known diabetes of cardiovascular disease changed HeartScore risk classification significantly in 19% of the population...
  13. doi request reprint Prognostic importance of hemoglobin in hypertensive patients with electrocardiographic left ventricular hypertrophy: the Losartan Intervention For End point reduction in hypertension (LIFE) study
    Michael Hecht Olsen
    Department of Internal Medicine, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    Am Heart J 157:177-84. 2009
    ..The prognostic importance of hemoglobin is controversial. We investigated the prognostic importance of baseline and in-treatment hemoglobin in the LIFE study...
  14. ncbi request reprint Effects of losartan compared with atenolol on lipids in patients with hypertension and left ventricular hypertrophy: the Losartan Intervention For Endpoint reduction in hypertension study
    Michael Hecht Olsen
    Glostrup University Hospital, Glostrup, Denmark
    J Hypertens 27:567-74. 2009
    ..Beta-blockers and angiotensin II receptor blockers have different effects on lipids...
  15. ncbi request reprint Urine albumin/creatinine ratio, high sensitivity C-reactive protein and N-terminal pro brain natriuretic peptide--three new cardiovascular risk markers--do they improve risk prediction and influence treatment?
    Michael H Olsen
    Research Center for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark
    Curr Vasc Pharmacol 8:134-9. 2010
    ....
  16. ncbi request reprint [Cardiovascular risk profile and anti-hypertensive treatment]
    Michael Hecht Olsen
    Kardiologisk Sektion, Den Kardiovaskulaere Forskningsenhed, Medicinsk Afdeling M, Glostrup Hospital, DK 2600 Glostrup
    Ugeskr Laeger 171:2008-11. 2009
    ....
  17. ncbi request reprint [Microalbuminuria]
    Michael Hecht Olsen
    Glostrup Hospital, Medicinsk Afdeling M, Kardiologisk Sektion, Den Kardiovaskulaere Forskningsenhed, Glostrup
    Ugeskr Laeger 171:2097-100. 2009
    ..Accordingly, albuminuria--an integrated measure of cardiovascular risk--should be monitored and reduced through intensified antihypertensive treatment in combination with careful correction of other cardiovascular risk factors...
  18. ncbi request reprint [Hypertension and the metabolic syndrome]
    Michael Hecht Olsen
    Glostrup Hospital, Kardiologisk Sektion, Den Kardiovaskulaere Forskningsenhed og Medicinsk Afdeling M, Glostrup
    Ugeskr Laeger 171:2107-9. 2009
    ..However, the metabolic syndrome is of clinical importance as it makes the treating physician test for other elements of the syndrome in patients with one of the elements, e.g. hypertension...
  19. ncbi request reprint Long-term treatment with losartan versus atenolol improves insulin sensitivity in hypertension: ICARUS, a LIFE substudy
    Michael H Olsen
    Department of Clinical Physiology and Nuclear Medicine, Glostrup University Hospital, Copenhagen, Denmark
    J Hypertens 23:891-8. 2005
    ..We hypothesized that treatment with losartan as compared to atenolol would improve insulin sensitivity through regression of peripheral vascular hypertrophy/rarefaction...
  20. ncbi request reprint Markers of collagen synthesis is related to blood pressure and vascular hypertrophy: a LIFE substudy
    M H Olsen
    Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, University of Copenhagen, Denmark
    J Hum Hypertens 19:301-7. 2005
    ....
  21. ncbi request reprint Are left ventricular mass, geometry and function related to vascular changes and/or insulin resistance in long-standing hypertension? ICARUS: a LIFE substudy
    M H Olsen
    Department of Clinical Physiology and Nuclear Medicine, Glostrup University Hospital, Copenhagen, Denmark
    J Hum Hypertens 17:305-11. 2003
    ..This may suggest that systemic vascular hypertrophy contributes to abnormal diastolic LV relaxation in patients with hypertension and electrocardiographic LV hypertrophy...
  22. ncbi request reprint Left ventricular hypertrophy is associated with reduced vasodilatory capacity in the brachial artery in patients with longstanding hypertension. A LIFE substudy
    Michael Hecht Olsen
    Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, University of Copenhagen, Denmark
    Blood Press 11:285-92. 2002
    ..Whether similar relations exist in patients with longstanding hypertension and target organ damage remain to be elucidated...
  23. ncbi request reprint Is cardiovascular remodeling in patients with essential hypertension related to more than high blood pressure? A LIFE substudy. Losartan Intervention For Endpoint-Reduction in Hypertension
    Michael Hecht Olsen
    Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    Am Heart J 144:530-7. 2002
    ..However, the relative influence of elevated blood pressure (BP) and various neurohormonal factors on cardiovascular remodeling in hypertension is unclear...
  24. ncbi request reprint A blood pressure independent association between glomerular albumin leakage and electrocardiographic left ventricular hypertrophy. The LIFE Study. Losartan Intervention For Endpoint reduction
    M H Olsen
    Copenhagen County University Hospital, Ringvejen, Glostrup, Denmark
    J Hum Hypertens 16:591-5. 2002
    ..As glomerular albumin leakage may represent generalised vascular damage we hypothesise a vascular relationship between cardiac and glomerular damage...
  25. ncbi request reprint Vasodilatory capacity and vascular structure in long-standing hypertension: a LIFE substudy. Losartan Intervention For Endpoint-Reduction in Hypertension
    Michael H Olsen
    Department of Clinical Physiology and Nuclear Medicine, Glostrup University Hospital, Copenhagen, Denmark
    Am J Hypertens 15:398-404. 2002
    ..However, it is unclear whether this impairment is explained solely by endothelial dysfunction, or whether it is associated with structural vascular changes and reduced vasodilatory capacity...
  26. ncbi request reprint Maximal exercise capacity is related to cardiovascular structure in patients with longstanding hypertension. A LIFE substudy. Losartan Intervention For Endpoint-Reduction in Hypertension
    M H Olsen
    Department of Clinical Physiology, Nuclear Medicine Glostrup Hospital, University of Copenhagen, Denmark
    Am J Hypertens 14:1205-10. 2001
    ....
  27. ncbi request reprint Endothelial dysfunction in resistance arteries is related to high blood pressure and circulating low density lipoproteins in previously treated hypertension
    M H Olsen
    Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, University of Copenhagen, Denmark
    Am J Hypertens 14:861-7. 2001
    ..However, its relationship to blood pressure (BP) load, vascular structure, and metabolic disturbances in patients with long-standing, previously treated hypertension is unclear...
  28. ncbi request reprint A possible link between endothelial dysfunction and insulin resistance in hypertension. A LIFE substudy. Losartan Intervention For Endpoint-Reduction in Hypertension
    M H Olsen
    Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, University of Copenhagen, Denmark
    Blood Press 9:132-9. 2000
    ....
  29. ncbi request reprint Influence of non-steady state during isoglycemic hyperinsulinemic clamp in hypertension. A LIFE substudy
    M H Olsen
    Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, University of Copenhagen, Denmark
    Blood Press 8:207-13. 1999
    ..However, a 2-h clamp results in lower insulin sensitivity values in elderly, hypertensive patients due to the fact that steady state is not reached, demonstrating a higher prevalence of insulin resistance in such a population...
  30. ncbi request reprint Association between vascular dysfunction and reduced myocardial flow reserve in patients with hypertension: a LIFE substudy
    M H Olsen
    Department of Clinical Physiology and Nuclear Medicine, Glostrup University Hospital, Glostrup, Denmark
    J Hum Hypertens 18:445-52. 2004
    ..This suggests that MFR is impaired by LV hypertrophy and structural/functional vascular damage in the coronary and noncoronary circulation...
  31. ncbi request reprint Is inappropriate left ventricular mass related to neurohormonal factors and/or arterial changes in hypertension? A LIFE substudy
    M H Olsen
    Department of Clinical Physiology and Nuclear Medicine, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
    J Hum Hypertens 18:437-43. 2004
    ..Alternatively, inappropriately high LV mass might be related to unmeasured factors such as local myocardial alterations in growth factors and/or genetic predisposition to develop excessive LV hypertrophy...
  32. ncbi request reprint Aortic valve sclerosis relates to cardiovascular events in patients with hypertension (a LIFE substudy)
    Michael H Olsen
    Department of Clinical Physiology and Nuclear Medicine, Glostrup University Hospital, DK 2600 Glostrup, Denmark
    Am J Cardiol 95:132-6. 2005
    ..AV sclerosis was associated with several CV risk factors and predicted CV events independently of prevalent CV disease and traditional CV risk factors, including LV mass and ejection fraction...
  33. ncbi request reprint Effect of losartan versus atenolol on aortic valve sclerosis (a LIFE substudy)
    Michael H Olsen
    Glostrup University Hospital, Glostrup, Denmark
    Am J Cardiol 94:1076-80. 2004
    ....
  34. ncbi request reprint N-terminal pro-brain natriuretic peptide predicts cardiovascular events in patients with hypertension and left ventricular hypertrophy: a LIFE study
    Michael H Olsen
    Department of Clinical Physiology and Nuclear Medicine, Glostrup University Hospital, Glostrup, Denmark
    J Hypertens 22:1597-604. 2004
    ....
  35. ncbi request reprint Albuminuria predicts cardiovascular events independently of left ventricular mass in hypertension: a LIFE substudy
    M H Olsen
    Department of Clinical Physiology and Nuclear Medicine, Glostrup University Hospital, Glostrup, Denmark
    J Hum Hypertens 18:453-9. 2004
    ..01, (***)P<0.001. In conclusion, UACR predicted CEP and CV death independently of LV mass. CV death was predicted by UACR and LV mass in an additive manner after adjustment for Framingham risk score and history of CV disease...
  36. ncbi request reprint Positron emission tomographic evaluation of regulation of myocardial perfusion in physiological (elite athletes) and pathological (systemic hypertension) left ventricular hypertrophy
    Andreas Kjaer
    Department of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet University Hospital, Copenhagen, Denmark
    Am J Cardiol 96:1692-8. 2005
    ..Endothelial dysfunction may contribute to the reduced perfusion reserve seen in hypertensive LVH...
  37. ncbi request reprint 24-h Ambulatory blood pressure in patients with ECG-determined left ventricular hypertrophy: left ventricular geometry and urinary albumin excretion-a LIFE substudy
    N Wiinberg
    Department of Clinical Physiology and Nuclear Medicine, Frederiksberg University Hospital, Frederiksberg, Denmark
    J Hum Hypertens 18:391-6. 2004
    ..With regard to the relationship among BP, LV geometric patterns, and urine albumin excretion in this population, 24-h ambulatory BP did not provide additional information beyond the office BP...
  38. ncbi request reprint Effect of losartan on sudden cardiac death in people with diabetes: data from the LIFE study
    Lars H Lindholm
    Department of Public Health and Clinical Medicine, Umea University Hospital, SE 901 85, Umea, Sweden
    Lancet 362:619-20. 2003
    ..Our results suggest losartan affords better protection against cardiac death from arrhythmias for patients with diabetes mellitus than does atenolol. Importantly, our analyses were exploratory and require confirmation...
  39. ncbi request reprint Risk of new-onset diabetes in the Losartan Intervention For Endpoint reduction in hypertension study
    Lars H Lindholm
    Steno Diabetes Centre, Gentofte, Denmark
    J Hypertens 20:1879-86. 2002
    ..There has been uncertainty about the risk of new-onset diabetes in hypertensive individuals treated with different blood pressure-decreasing drugs...
  40. ncbi request reprint Long-term effects of a losartan- compared with an atenolol-based treatment regimen on carotid artery plaque development in hypertensive patients with left ventricular hypertrophy: ICARUS, a LIFE substudy
    Eigil Fossum
    Department of Cardiology, Ullevaal University Hospital, Oslo, Norway
    J Clin Hypertens (Greenwich) 8:169-73. 2006
    ..The difference in carotid plaque index increase between the treatment groups during 3 years of treatment could not be statistically linked to specific treatments in the present substudy...
  41. ncbi request reprint Effect of hemoglobin levels on cardiovascular outcomes in patients with isolated systolic hypertension and left ventricular hypertrophy (from the LIFE study)
    Marianne L Smebye
    Department of Nephrology, University of Oslo Ullevaal Hospital, Oslo, Norway
    Am J Cardiol 100:855-9. 2007
    ....
  42. doi request reprint High prevalence of risk factors in coronary artery disease in EUROPA gives HOPE for ACE inhibitors after PEACE
    Sune A Pedersen
    Department of Cardiology, Gentofte Hospital, Hellerup, Denmark
    Cardiology 111:63-7. 2008
    ..Routine use of ACE inhibitors (ACE-I) as secondary preventive therapy for all patients with coronary artery disease (CAD) is challenged by the PEACE trial. Currently it is unclear to what extent ACE-I should be used in CAD populations...