L Nybo

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint Effects of hyperthermia on cerebral blood flow and metabolism during prolonged exercise in humans
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Denmark
    J Appl Physiol 93:58-64. 2002
  2. pmc Cerebral ammonia uptake and accumulation during prolonged exercise in humans
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, August Krogh Institute, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    J Physiol 563:285-90. 2005
  3. ncbi request reprint Inadequate cerebral oxygen delivery and central fatigue during strenuous exercise
    Lars Nybo
    Institute of Exercise and Sport Sciences and Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Exerc Sport Sci Rev 35:110-8. 2007
  4. ncbi request reprint Exercise and heat stress: cerebral challenges and consequences
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, August Krogh Institute, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    Prog Brain Res 162:29-43. 2007
  5. ncbi request reprint Hyperthermia and fatigue
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Universitetsparken 13, Copenhagen Ø, Denmark
    J Appl Physiol 104:871-8. 2008
  6. doi request reprint Impact of carbohydrate supplementation during endurance training on glycogen storage and performance
    L Nybo
    Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Acta Physiol (Oxf) 197:117-27. 2009
  7. ncbi request reprint Cerebral perturbations provoked by prolonged exercise
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, August Krogh Institute, Universitetsparken 13, DK 2100 Copenhagen, Denmark
    Prog Neurobiol 72:223-61. 2004
  8. ncbi request reprint Neurohumoral responses during prolonged exercise in humans
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, August Krogh Institute, DK 2100 Copenhagen, Denmark
    J Appl Physiol 95:1125-31. 2003
  9. ncbi request reprint CNS fatigue and prolonged exercise: effect of glucose supplementation
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Med Sci Sports Exerc 35:589-94. 2003
  10. pmc Interleukin-6 release from the human brain during prolonged exercise
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Denmark
    J Physiol 542:991-5. 2002

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Effects of hyperthermia on cerebral blood flow and metabolism during prolonged exercise in humans
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Denmark
    J Appl Physiol 93:58-64. 2002
    ....
  2. pmc Cerebral ammonia uptake and accumulation during prolonged exercise in humans
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, August Krogh Institute, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    J Physiol 563:285-90. 2005
    ..The results let us suggest that during prolonged exercise the cerebral uptake and accumulation of ammonia may provoke fatigue, e.g. by affecting neurotransmitter metabolism...
  3. ncbi request reprint Inadequate cerebral oxygen delivery and central fatigue during strenuous exercise
    Lars Nybo
    Institute of Exercise and Sport Sciences and Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Exerc Sport Sci Rev 35:110-8. 2007
    ....
  4. ncbi request reprint Exercise and heat stress: cerebral challenges and consequences
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, August Krogh Institute, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    Prog Brain Res 162:29-43. 2007
    ..The complexity of brain fatigue response is discussed based on our own investigations and in the light of recent literature...
  5. ncbi request reprint Hyperthermia and fatigue
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Universitetsparken 13, Copenhagen Ø, Denmark
    J Appl Physiol 104:871-8. 2008
    ..Fatigue is an integrated phenomenon, and psychological factors, including the anticipation of fatigue, should not be neglected and the interaction between central and peripheral physiological factors also needs to be considered...
  6. doi request reprint Impact of carbohydrate supplementation during endurance training on glycogen storage and performance
    L Nybo
    Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Acta Physiol (Oxf) 197:117-27. 2009
    ..Therefore, we investigated how chronic training responses are affected by glucose ingestion...
  7. ncbi request reprint Cerebral perturbations provoked by prolonged exercise
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, August Krogh Institute, Universitetsparken 13, DK 2100 Copenhagen, Denmark
    Prog Neurobiol 72:223-61. 2004
    ..Therefore, strenuous exercise is a challenge not only to the cardiorespiratory and locomotive systems but also to the brain...
  8. ncbi request reprint Neurohumoral responses during prolonged exercise in humans
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, August Krogh Institute, DK 2100 Copenhagen, Denmark
    J Appl Physiol 95:1125-31. 2003
    ....
  9. ncbi request reprint CNS fatigue and prolonged exercise: effect of glucose supplementation
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Med Sci Sports Exerc 35:589-94. 2003
    ..This study investigated whether CNS activation of the skeletal muscles was affected by prolonged exercise with or without glucose supplementation...
  10. pmc Interleukin-6 release from the human brain during prolonged exercise
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Denmark
    J Physiol 542:991-5. 2002
    ..In conclusion, IL-6 is released from the brain during prolonged exercise in humans and it appears that the duration of the exercise rather than the increase in body temperature dictates the cerebral IL-6 response...
  11. ncbi request reprint Hyperthermia and central fatigue during prolonged exercise in humans
    L Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2200 Copenhagen Ø, Denmark
    J Appl Physiol 91:1055-60. 2001
    ..In conclusion, these data demonstrate that the ability to generate force during a prolonged MVC is attenuated with hyperthermia, and the impaired performance is associated with a reduction in the voluntary activation percentage...
  12. ncbi request reprint Perceived exertion is associated with an altered brain activity during exercise with progressive hyperthermia
    L Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Appl Physiol 91:2017-23. 2001
    ....
  13. pmc Inadequate heat release from the human brain during prolonged exercise with hyperthermia
    Lars Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Denmark
    J Physiol 545:697-704. 2002
    ..20 +/- 0.06 J g(-1) min(-1). The present results indicate that the average brain temperature is at least 0.2 degrees C higher than that of the body core during exercise with or without hyperthermia...
  14. doi request reprint Cycling in the heat: performance perspectives and cerebral challenges
    L Nybo
    Department of Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Copenhagen, Denmark
    Scand J Med Sci Sports 20:71-9. 2010
    ....
  15. doi request reprint Recreational soccer is an effective health-promoting activity for untrained men
    P Krustrup
    University of Copenhagen, Department of Exercise and Sport Sciences, Copenhagen Muscle Research Centre, The August Krogh Building, Universitetsparken 13, Copenhagen 2100 Ø, Denmark
    Br J Sports Med 43:825-31. 2009
    ....
  16. doi request reprint Cerebral oxygenation is reduced during hyperthermic exercise in humans
    P Rasmussen
    Department of Anaesthesia, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    Acta Physiol (Oxf) 199:63-70. 2010
    ..Heat stress challenges exercise capacity as expressed by increased rating of perceived exertion (RPE)...
  17. doi request reprint Positive performance and health effects of a football training program over 12 weeks can be maintained over a 1-year period with reduced training frequency
    M B Randers
    Department of Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Copenhagen, Denmark
    Scand J Med Sci Sports 20:80-9. 2010
    ....
  18. doi request reprint Performance enhancements and muscular adaptations of a 16-week recreational football intervention for untrained women
    J Bangsbo
    Department of Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Copenhagen, Denmark
    Scand J Med Sci Sports 20:24-30. 2010
    ..Thus, football can be used as an activity to elevate the physical capacity of untrained women...
  19. doi request reprint Beneficial effects of recreational football on the cardiovascular risk profile in untrained premenopausal women
    P Krustrup
    Department of Exercise and Sport Sciences, Section of Human Physiology, Copenhagen Muscle Research Centre, Section of Human Physiology, University of Copenhagen, Copenhagen, Denmark
    Scand J Med Sci Sports 20:40-9. 2010
    ..In conclusion, regular recreational football training has significant favorable effects on the cardiovascular risk profile in untrained premenopausal women and is at the least as efficient as continuous running...
  20. pmc Middle cerebral artery blood velocity is reduced with hyperthermia during prolonged exercise in humans
    L Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Denmark
    J Physiol 534:279-86. 2001
    ..5. The present results demonstrate that the development of hyperthermia during prolonged exercise is associated with a marked reduction in MCA V(mean)...
  21. ncbi request reprint Association between fatigue and failure to preserve cerebral energy turnover during prolonged exercise
    L Nybo
    Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Acta Physiol Scand 179:67-74. 2003
    ..This study evaluated if the fatigue and apathy arising during exercise with hypoglycaemia could relate to a lowering of the cerebral metabolic rates of glucose and oxygen...
  22. doi request reprint Activity profile and physiological response to football training for untrained males and females, elderly and youngsters: influence of the number of players
    M B Randers
    Department of Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Copenhagen, Denmark
    Scand J Med Sci Sports 20:14-23. 2010
    ..Thus, small-sided football games appear to have the potential to create physiological adaptations and improve performance with regular training for a variety of study groups...
  23. ncbi request reprint Effect of two different intense training regimens on skeletal muscle ion transport proteins and fatigue development
    Magni Mohr
    Copenhagen Muscle Research Centre, Institute of Exercise and Sport Sciences, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    Am J Physiol Regul Integr Comp Physiol 292:R1594-602. 2007
    ..Adaptations with training do have an effect on the metabolic response to exercise and specific improvement in work capacity...
  24. ncbi request reprint Enhanced cerebral CO2 reactivity during strenuous exercise in man
    P Rasmussen
    Department of Human Physiology, Institute of Exercise and Sports Sciences, University of Copenhagen, Denmark
    Eur J Appl Physiol 96:299-304. 2006
    ..The results suggest that during exercise changes in cerebral blood flow are dominated by the arterial carbon dioxide tension...
  25. doi request reprint Recreational football as a health promoting activity: a topical review
    P Krustrup
    Department of Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Copenhagen, Denmark
    Scand J Med Sci Sports 20:1-13. 2010
    ..Taken together, recreational football appears to effectively stimulate musculoskeletal, metabolic and cardiovascular adaptations of importance for health and thereby reduces the risk of developing life-style diseases...
  26. ncbi request reprint Reduced volume but increased training intensity elevates muscle Na+-K+ pump alpha1-subunit and NHE1 expression as well as short-term work capacity in humans
    F Marcello Iaia
    Department of Exercise and Sport Sciences, Section of Human Physiology, Copenhagen Muscle Research Center, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 294:R966-74. 2008
    ..Furthermore, performance during intense exercise can be improved and endurance performance maintained even with a reduction in training volume if the intensity of training is very high...
  27. ncbi request reprint Cerebral metabolism is influenced by muscle ischaemia during exercise in humans
    Mads K Dalsgaard
    Department of Anaesthesia and The Copenhagen Muscle Research Centre, Rigshospitalet, University of Copenhagen, Denmark
    Exp Physiol 88:297-302. 2003
    ..5 +/- 0.3 (P < 0.05). The results support the hypothesis that during exercise, cerebral metabolism is influenced both by the mental effort to exercise and by sensory input from skeletal muscles...
  28. ncbi request reprint Cerebral changes during exercise in the heat
    Bodil Nielsen
    Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Sports Med 33:1-11. 2003
    ..The causal relationship between the circulatory changes, the EEG changes and the hyperthermia-induced central fatigue is at the present not well understood and future studies should focus on this aspect...
  29. ncbi request reprint CNS fatigue provoked by prolonged exercise in the heat
    Lars Nybo
    Section of Human Physiology, Department of Exercise and Sport Sciences, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen O, Denmark
    Front Biosci (Elite Ed) 2:779-92. 2010
    ....
  30. ncbi request reprint Environmental heat stress, hyperammonemia and nucleotide metabolism during intermittent exercise
    Magni Mohr
    Institute of Exercise and Sport Sciences, Department of Human Physiology, August Krogh Institute, University of Copenhagen, Universitetsparken 13, 2100, Copenhagen Ø, Denmark
    Eur J Appl Physiol 97:89-95. 2006
    ....
  31. doi request reprint Reduced volume and increased training intensity elevate muscle Na+-K+ pump alpha2-subunit expression as well as short- and long-term work capacity in humans
    Jens Bangsbo
    Department of Exercise and Sport Sciences, Section of Human Physiology, Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol 107:1771-80. 2009
    ....
  32. ncbi request reprint Capillary-oxygenation-level-dependent near-infrared spectrometry in frontal lobe of humans
    Peter Rasmussen
    Copenhagen Muscle Research Centre, Department of Anaesthesia, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark
    J Cereb Blood Flow Metab 27:1082-93. 2007
    ....
  33. ncbi request reprint The Yo-Yo IR2 test: physiological response, reliability, and application to elite soccer
    Peter Krustrup
    Institute of Exercise and Sport Sciences, Department of Human Physiology, August Krogh Institute, University of Copenhagen, Copenhagen, Denmark
    Med Sci Sports Exerc 38:1666-73. 2006
    ..To examine the physiological response, reliability, and validity of the Yo-Yo intermittent recovery level 2 test (Yo-Yo IR2)...
  34. ncbi request reprint Muscle temperature and sprint performance during soccer matches--beneficial effect of re-warm-up at half-time
    M Mohr
    Department of Human Physiology, Institute of Exercise and Sport Sciences, August Krogh Institute, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen Ø, Denmark
    Scand J Med Sci Sports 14:156-62. 2004
    ....
  35. pmc Pro- and anti-angiogenic factors in human skeletal muscle in response to acute exercise and training
    B Hoier
    Department of Exercise and Sport Sciences, University of Copenhagen, Universitetsparken 13, DK 2100 Copenhagen, Denmark
    J Physiol 590:595-606. 2012
    ..The lack of effect of training on basal muscle VEGF protein levels and VEGF secretion during exercise suggests that increased VEGF levels are not a prerequisite for exercise-induced capillary growth in healthy muscle...
  36. doi request reprint Effect of 2-wk intensified training and inactivity on muscle Na+-K+ pump expression, phospholemman (FXYD1) phosphorylation, and performance in soccer players
    Martin Thomassen
    Copenhagen Muscle Research Centre, Department of Exercise and Sport Sciences, Section of Human Physiology, University of Copenhagen, Copenhagen, Denmark
    J Appl Physiol 108:898-905. 2010
    ..Resting phosphorylation status of the Na(+)-K(+) pump is changed by training and inactivity and may play a role in performance during repeated, intense exercise...
  37. doi request reprint Muscle adaptations and performance enhancements of soccer training for untrained men
    Peter Krustrup
    Department of Exercise and Sport Sciences, Section of Human Physiology, Copenhagen Muscle Research Centre, University of Copenhagen, The August Krogh Building, Universitetsparken 13, Copenhagen 2100, Denmark
    Eur J Appl Physiol 108:1247-58. 2010
    ....
  38. doi request reprint Adipose triglyceride lipase in human skeletal muscle is upregulated by exercise training
    Thomas J Alsted
    University of Copenhagen, The August Krogh Bldg 13, Universitetsparken, DK, 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 296:E445-53. 2009
    ..These results suggest that ATGL in addition to HSL may be important for human skeletal muscle lipolysis...
  39. ncbi request reprint Minor amounts of plasma medium-chain fatty acids and no improved time trial performance after consuming lipids
    Bodil Vistisen
    BioCentrum DTU, The Technical University of Denmark, Lyngby, Denmark
    J Appl Physiol 95:2434-43. 2003
    ..A higher level of plasma phospholipid fatty acids in the CHO+MLM compared with the CHO group was probably due to endogenous phospholipid release into chylomicrons...
  40. ncbi request reprint Viewpoint: Fatigue mechanisms determining exercise performance: integrative physiology is systems physiology
    Lars Nybo
    J Appl Physiol 104:1543-4. 2008