Helene Nørrelund

Summary

Affiliation: University of Copenhagen
Country: Denmark

Publications

  1. ncbi request reprint The protein-retaining effects of growth hormone during fasting involve inhibition of muscle-protein breakdown
    H Nørrelund
    Medical Department M, Aarhus Kommunehospital, Denmark
    Diabetes 50:96-104. 2001
  2. ncbi request reprint Abnormalities of whole body protein turnover, muscle metabolism and levels of metabolic hormones in patients with chronic heart failure
    H Nørrelund
    Medical Department M Endocrinology and Diabetes, Aarhus Universitets Hospital, Aarhus, Denmark
    J Intern Med 260:11-21. 2006
  3. ncbi request reprint Consequences of growth hormone deficiency for intermediary metabolism and effects of replacement
    Helene Nørrelund
    Medical Department M, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark
    Front Horm Res 33:103-20. 2005
  4. ncbi request reprint The metabolic role of growth hormone in humans with particular reference to fasting
    Helene Nørrelund
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, Aarhus Sygehus, Norrebrogade 44, DK 8000 Aarhus C, Denmark
    Growth Horm IGF Res 15:95-122. 2005
  5. ncbi request reprint Modulation of basal glucose metabolism and insulin sensitivity by growth hormone and free fatty acids during short-term fasting
    Helene Nørrelund
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 150:779-87. 2004
  6. ncbi request reprint The decisive role of free fatty acids for protein conservation during fasting in humans with and without growth hormone
    Helene Nørrelund
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 88:4371-8. 2003
  7. ncbi request reprint Effects of GH on urea, glucose and lipid metabolism, and insulin sensitivity during fasting in GH-deficient patients
    Helene Nørrelund
    Medical Dept M Endocrinology and Diabetes, Arhus Kommunehospital, DK 8000 Aarhus C, Denmark
    Am J Physiol Endocrinol Metab 285:E737-43. 2003
  8. ncbi request reprint Ghrelin immunoreactivity in human plasma is suppressed by somatostatin
    Helene Nørrelund
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Clin Endocrinol (Oxf) 57:539-46. 2002
  9. ncbi request reprint Effects of GH on protein metabolism during dietary restriction in man
    Helene Nørrelund
    Medical Department M Endocrinology and Diabetes, Aarhus Kommunehospital, Aarhus, Denmark
    Growth Horm IGF Res 12:198-207. 2002
  10. ncbi request reprint Continuation of growth hormone (GH) substitution during fasting in GH-deficient patients decreases urea excretion and conserves protein synthesis
    H Nørrelund
    Medical Department M Endocrinology and Diabetes, Aarhus Kommunehospital, Aarhus DK 8000, Denmark
    J Clin Endocrinol Metab 86:3120-9. 2001

Collaborators

Detail Information

Publications23

  1. ncbi request reprint The protein-retaining effects of growth hormone during fasting involve inhibition of muscle-protein breakdown
    H Nørrelund
    Medical Department M, Aarhus Kommunehospital, Denmark
    Diabetes 50:96-104. 2001
    ....
  2. ncbi request reprint Abnormalities of whole body protein turnover, muscle metabolism and levels of metabolic hormones in patients with chronic heart failure
    H Nørrelund
    Medical Department M Endocrinology and Diabetes, Aarhus Universitets Hospital, Aarhus, Denmark
    J Intern Med 260:11-21. 2006
    ..The present study was undertaken to identify disturbances of basal glucose, lipid and protein metabolism...
  3. ncbi request reprint Consequences of growth hormone deficiency for intermediary metabolism and effects of replacement
    Helene Nørrelund
    Medical Department M, Aarhus University Hospital, Aarhus Sygehus, Aarhus, Denmark
    Front Horm Res 33:103-20. 2005
  4. ncbi request reprint The metabolic role of growth hormone in humans with particular reference to fasting
    Helene Nørrelund
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, Aarhus Sygehus, Norrebrogade 44, DK 8000 Aarhus C, Denmark
    Growth Horm IGF Res 15:95-122. 2005
  5. ncbi request reprint Modulation of basal glucose metabolism and insulin sensitivity by growth hormone and free fatty acids during short-term fasting
    Helene Nørrelund
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Eur J Endocrinol 150:779-87. 2004
    ..The present study was designed to test the degree to which the insulin antagonistic effects of GH on glucose metabolism are mediated through stimulation of lipolysis during fasting...
  6. ncbi request reprint The decisive role of free fatty acids for protein conservation during fasting in humans with and without growth hormone
    Helene Nørrelund
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    J Clin Endocrinol Metab 88:4371-8. 2003
    ..The finding that inhibition of lipolysis eliminates the ability of GH to restrict fasting protein loss indicates that stimulation of lipolysis is the principal protein-conserving mechanism of GH...
  7. ncbi request reprint Effects of GH on urea, glucose and lipid metabolism, and insulin sensitivity during fasting in GH-deficient patients
    Helene Nørrelund
    Medical Dept M Endocrinology and Diabetes, Arhus Kommunehospital, DK 8000 Aarhus C, Denmark
    Am J Physiol Endocrinol Metab 285:E737-43. 2003
    ..07 +/- 0.22 mg. kg-1. min-1, P < 0.01] during fasting with GH replacement. In conclusion, continued GH replacement during fasting in GH-deficient adults decreases insulin sensitivity, increases lipid utilization, and conserves protein...
  8. ncbi request reprint Ghrelin immunoreactivity in human plasma is suppressed by somatostatin
    Helene Nørrelund
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, DK 8000 Aarhus C, Denmark
    Clin Endocrinol (Oxf) 57:539-46. 2002
    ....
  9. ncbi request reprint Effects of GH on protein metabolism during dietary restriction in man
    Helene Nørrelund
    Medical Department M Endocrinology and Diabetes, Aarhus Kommunehospital, Aarhus, Denmark
    Growth Horm IGF Res 12:198-207. 2002
    ....
  10. ncbi request reprint Continuation of growth hormone (GH) substitution during fasting in GH-deficient patients decreases urea excretion and conserves protein synthesis
    H Nørrelund
    Medical Department M Endocrinology and Diabetes, Aarhus Kommunehospital, Aarhus DK 8000, Denmark
    J Clin Endocrinol Metab 86:3120-9. 2001
    ..In summary, continued GH substitution during fasting conserves nitrogen, which involves stimulation or maintenance of protein synthesis. Our data support the importance of GH replacement in hypopituitary adults...
  11. ncbi request reprint Effects of lowering circulating free fatty acid levels on protein metabolism in adult growth hormone deficient patients
    Steen Nielsen
    Medical Department M, Aarhus University Hospital, Aarhus C, Denmark
    Growth Horm IGF Res 12:425-33. 2002
    ..The increase in serum urea and a doubling of net forearm phenylalanine release after lowering of FFA strongly indicate that the overall effect is catabolic and supports a pivotal protein conserving role of lipids...
  12. ncbi request reprint Whole body and forearm substrate metabolism in hyperthyroidism: evidence of increased basal muscle protein breakdown
    Anne Lene Dalkjaer Riis
    Medical Dept M, Aarhus Univ Hospital, DK 8000 Aarhus C, Denmark
    Am J Physiol Endocrinol Metab 288:E1067-73. 2005
    ..These abnormalities can explain the clinical manifestations of sarcopenia and myopathy...
  13. ncbi request reprint Elevated regional lipolysis in hyperthyroidism
    Anne Lene Dalkjaer Riis
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital and Institute of Experimental Clinical Science, Aarhus University, Aarhus 8000, Denmark
    J Clin Endocrinol Metab 87:4747-53. 2002
    ..01), 166 +/- 21(CTR) (P < 0.01)]. These results suggest that femoral and abdominal adipose tissue contribute equally to the excessive rate of lipolysis in hyperthyroidism and that both tissues are resistant to the actions of insulin...
  14. ncbi request reprint The effect of growth hormone on the insulin-like growth factor system during fasting
    Helene Nørrelund
    Medical Department M Endocrinology and Diabetes, Aarhus Kommunehospital, Aarhus, Denmark
    J Clin Endocrinol Metab 88:3292-8. 2003
    ..In conclusion, the major new finding of the present study is that the GH hypersecretion seen during short-term fasting is not merely secondary to a reduction in IGF bioactivity...
  15. ncbi request reprint The role of growth hormone in the regulation of protein metabolism with particular reference to conditions of fasting
    Niels Møller
    Medical Department M Endocrinology and Diabetes, Arhus Kommunehospital, Arhus, Denmark
    Horm Res 59:62-8. 2003
    ..Some of the most recent studies in the field have demonstrated a decisive role of stimulation of lipolysis and high circulating levels of FFA in orchestrating the maintenance of the protein pool of the body...
  16. ncbi request reprint Somatropin and glucose homeostasis: considerations for patient management
    Jens O L Jørgensen
    Medical Department M Endocrinology and Diabetes, Institute of Experimental Clinical Research, Aarhus University Hospital, Aarhus, Denmark
    Treat Endocrinol 1:229-34. 2002
    ..In the latter regard, it is important to realize that dosage requirements are lower in adults compared with children, and that the dosage will probably need to be reduced with age in the individual patient...
  17. doi request reprint Suppression of circulating free fatty acids with acipimox in chronic heart failure patients changes whole body metabolism but does not affect cardiac function
    Mads Halbirk
    Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark
    Am J Physiol Heart Circ Physiol 299:H1220-5. 2010
    ....
  18. doi request reprint Failing heart of patients with type 2 diabetes mellitus can adapt to extreme short-term increases in circulating lipids and does not display features of acute myocardial lipotoxicity
    Roni Nielsen
    Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
    Circ Heart Fail 6:845-52. 2013
    ....
  19. ncbi request reprint Continuation of growth hormone therapy versus placebo in transition-phase patients with growth hormone deficiency: impact on body composition, insulin sensitivity, and thyroid function
    Jens O L Jørgensen
    Medical Department M Endocrinology and Diabetes, Aarhus University Hospital, Aarhus, Denmark
    J Pediatr Endocrinol Metab 15:1355-60. 2002
    ....
  20. pmc Effect of acute hyperglycemia on left ventricular contractile function in diabetic patients with and without heart failure: two randomized cross-over studies
    Roni Nielsen
    Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
    PLoS ONE 8:e53247. 2013
    ..It is unknown whether changes in circulating glucose levels due to short-term insulin discontinuation affect left ventricular contractile function in type 2 diabetic patients with (T2D-HF) and without (T2D-nonHF) heart failure...
  21. ncbi request reprint Growth hormone and glucose homeostasis
    Jens O L Jørgensen
    Medical Department M Endocrinology and Diabetes and Institute of Experimental Clinical Research, Arhus University Hospital, Arhus, Denmark
    Horm Res 62:51-5. 2004
    ..Insulin therapy may cause hypoglycaemia and GH substitution may cause hyperglycaemia. Such untoward effects should be minimized by carefully monitoring the individual patient...
  22. ncbi request reprint Adaptation of nonrevascularized human hibernating and chronically stunned myocardium to long-term chronic myocardial ischemia
    Henrik Wiggers
    Department of Cardiology, Skejby Hospital, Aarhus University Hospital, Aarhus, Denmark
    Am J Cardiol 98:1574-80. 2006
    ..In chronically stunned regions, adaptation may be less complete than in hibernating myocardium...
  23. ncbi request reprint Influence of insulin and free fatty acids on contractile function in patients with chronically stunned and hibernating myocardium
    Henrik Wiggers
    Department of Cardiology, Skejby Hospital, Aarhus Univ Hospital, DK 8200 Aarhus N, Denmark
    Am J Physiol Heart Circ Physiol 289:H938-46. 2005
    ..Metabolic modulation does not influence contractile function in CST and HIB regions. Chronic ischemic myocardium has preserved ability to adapt to extreme, short-term changes in substrate supply at rest and after maximal exercise...